JP2013507966A5 - - Google Patents

Info

Publication number

JP2013507966A5

JP2013507966A5 JP2012535377A JP2012535377A JP2013507966A5 JP 2013507966 A5 JP2013507966 A5 JP 2013507966A5 JP 2012535377 A JP2012535377 A JP 2012535377A JP 2012535377 A JP2012535377 A JP 2012535377A JP 2013507966 A5 JP2013507966 A5 JP 2013507966A5

Authority

JP

Japan

Prior art keywords

antibody

sequence

hepsin

antibody according

seq

Prior art date

2010-10-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090001101 Hepsin Proteins 0.000 claims 12
• 102000004989 Hepsin Human genes 0.000 claims 12
• 238000000034 method Methods 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 6
• 102000012479 Serine Proteases Human genes 0.000 claims 5
• 108010022999 Serine Proteases Proteins 0.000 claims 5
• 239000003001 serine protease inhibitor Substances 0.000 claims 5
• 229940122055 Serine protease inhibitor Drugs 0.000 claims 4
• 101710102218 Serine protease inhibitor Proteins 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 230000012292 cell migration Effects 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• SUGXUUGGLDCZKB-UHFFFAOYSA-N 3,4-dichloroisocoumarin Chemical group C1=CC=C2C(Cl)=C(Cl)OC(=O)C2=C1 SUGXUUGGLDCZKB-UHFFFAOYSA-N 0.000 claims 2
• 101000872580 Homo sapiens Serine protease hepsin Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 102000046144 human HPN Human genes 0.000 claims 2
• 208000026278 immune system disease Diseases 0.000 claims 2
• 102000049853 macrophage stimulating protein Human genes 0.000 claims 2
• 108010053292 macrophage stimulating protein Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000035195 Peptidases Human genes 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229940127121 immunoconjugate Drugs 0.000 claims 1
• 230000000415 inactivating effect Effects 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1