TW201121566A - Anti-hepsin antibodies and methods using same - Google Patents

Anti-hepsin antibodies and methods using same Download PDF

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Publication number
TW201121566A
TW201121566A TW099135993A TW99135993A TW201121566A TW 201121566 A TW201121566 A TW 201121566A TW 099135993 A TW099135993 A TW 099135993A TW 99135993 A TW99135993 A TW 99135993A TW 201121566 A TW201121566 A TW 201121566A
Authority
TW
Taiwan
Prior art keywords
antibody
sequence
seq
hvr
cancer
Prior art date
Application number
TW099135993A
Other languages
English (en)
Chinese (zh)
Inventor
Rajkumar Ganesan
Daniel Kirchhofer
Paul M Moran
ying-nan Zhang
Original Assignee
Genentech Inc
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Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of TW201121566A publication Critical patent/TW201121566A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW099135993A 2009-10-22 2010-10-21 Anti-hepsin antibodies and methods using same TW201121566A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25395309P 2009-10-22 2009-10-22

Publications (1)

Publication Number Publication Date
TW201121566A true TW201121566A (en) 2011-07-01

Family

ID=43332807

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099135993A TW201121566A (en) 2009-10-22 2010-10-21 Anti-hepsin antibodies and methods using same

Country Status (17)

Country Link
US (1) US8435511B2 (https=)
EP (1) EP2491059B1 (https=)
JP (1) JP5814925B2 (https=)
KR (1) KR20120105447A (https=)
CN (1) CN102648211B (https=)
AR (1) AR078716A1 (https=)
AU (1) AU2010310585A1 (https=)
BR (1) BR112012009412A2 (https=)
CA (1) CA2778481A1 (https=)
ES (1) ES2534646T3 (https=)
IL (1) IL219136A0 (https=)
MX (1) MX2012004647A (https=)
NZ (1) NZ599337A (https=)
RU (1) RU2559533C2 (https=)
TW (1) TW201121566A (https=)
WO (1) WO2011050188A1 (https=)
ZA (1) ZA201202704B (https=)

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* Cited by examiner, † Cited by third party
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WO2007149932A2 (en) * 2006-06-22 2007-12-27 Genentech, Inc. Methods and compositions for targeting hepsin
US8450334B2 (en) 2008-06-11 2013-05-28 Fred Hutchinson Cancer Research Center Hepsin inhibitors
US8697386B2 (en) 2009-10-22 2014-04-15 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
CN102218057B (zh) * 2011-04-24 2012-08-08 吉林大学 3,4-二氯异香豆素在制备抗球虫病药物中的用途
WO2017162659A1 (en) 2016-03-24 2017-09-28 Bayer Pharma Aktiengesellschaft Intracellular hepsin as therapeutic target for the treatment of cancer with centrosome amplification
MX2022009584A (es) * 2020-02-05 2022-10-07 Navaux Inc Anticuerpos anti-hepsina y usos de los mismos.

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Publication number Publication date
MX2012004647A (es) 2012-06-19
CN102648211A (zh) 2012-08-22
RU2012120864A (ru) 2013-11-27
CN102648211B (zh) 2015-04-01
IL219136A0 (en) 2012-06-28
CA2778481A1 (en) 2011-04-28
KR20120105447A (ko) 2012-09-25
ZA201202704B (en) 2013-06-26
US20110262452A1 (en) 2011-10-27
AR078716A1 (es) 2011-11-30
BR112012009412A2 (pt) 2016-11-29
NZ599337A (en) 2013-05-31
AU2010310585A1 (en) 2012-05-03
WO2011050188A8 (en) 2012-04-12
EP2491059A1 (en) 2012-08-29
JP5814925B2 (ja) 2015-11-17
EP2491059B1 (en) 2015-02-25
RU2559533C2 (ru) 2015-08-10
HK1171032A1 (en) 2013-03-15
US8435511B2 (en) 2013-05-07
ES2534646T3 (es) 2015-04-27
WO2011050188A1 (en) 2011-04-28
JP2013507966A (ja) 2013-03-07

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