JP2015530989A5 - - Google Patents

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Publication number
JP2015530989A5
JP2015530989A5 JP2015526762A JP2015526762A JP2015530989A5 JP 2015530989 A5 JP2015530989 A5 JP 2015530989A5 JP 2015526762 A JP2015526762 A JP 2015526762A JP 2015526762 A JP2015526762 A JP 2015526762A JP 2015530989 A5 JP2015530989 A5 JP 2015530989A5
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JP
Japan
Prior art keywords
seq
amino acid
acid sequence
hvr
antibody
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2015526762A
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English (en)
Japanese (ja)
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JP2015530989A (ja
JP6352264B2 (ja
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Priority claimed from PCT/US2013/054664 external-priority patent/WO2014028446A1/en
Publication of JP2015530989A publication Critical patent/JP2015530989A/ja
Publication of JP2015530989A5 publication Critical patent/JP2015530989A5/ja
Application granted granted Critical
Publication of JP6352264B2 publication Critical patent/JP6352264B2/ja
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JP2015526762A 2012-08-13 2013-08-13 抗ｊａｇｇｅｄ抗体および使用方法 Active JP6352264B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682640P 2012-08-13 2012-08-13
US61/682,640 2012-08-13
US201361784332P 2013-03-14 2013-03-14
US61/784,332 2013-03-14
PCT/US2013/054664 WO2014028446A1 (en) 2012-08-13 2013-08-13 Anti-jagged anitbodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018082543A Division JP6619047B2 (ja) 2012-08-13 2018-04-23 抗ｊａｇｇｅｄ抗体および使用方法

Publications (3)

Publication Number Publication Date
JP2015530989A JP2015530989A (ja) 2015-10-29
JP2015530989A5 true JP2015530989A5 (https=) 2017-09-21
JP6352264B2 JP6352264B2 (ja) 2018-07-04

Family

ID=49004047

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2015526762A Active JP6352264B2 (ja) 2012-08-13 2013-08-13 抗ｊａｇｇｅｄ抗体および使用方法
JP2018082543A Active JP6619047B2 (ja) 2012-08-13 2018-04-23 抗ｊａｇｇｅｄ抗体および使用方法
JP2019204815A Active JP7366700B2 (ja) 2012-08-13 2019-11-12 抗ｊａｇｇｅｄ抗体および使用方法
JP2021131076A Withdrawn JP2021191275A (ja) 2012-08-13 2021-08-11 抗ｊａｇｇｅｄ抗体および使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018082543A Active JP6619047B2 (ja) 2012-08-13 2018-04-23 抗ｊａｇｇｅｄ抗体および使用方法
JP2019204815A Active JP7366700B2 (ja) 2012-08-13 2019-11-12 抗ｊａｇｇｅｄ抗体および使用方法
JP2021131076A Withdrawn JP2021191275A (ja) 2012-08-13 2021-08-11 抗ｊａｇｇｅｄ抗体および使用方法

Country Status (10)

Country Link
US (4) US10113002B2 (https=)
EP (1) EP2882776B1 (https=)
JP (4) JP6352264B2 (https=)
KR (2) KR20200143502A (https=)
CN (1) CN104520328B (https=)
BR (1) BR112015003032B1 (https=)
CA (1) CA2880271C (https=)
MX (2) MX381841B (https=)
RU (2) RU2666990C2 (https=)
WO (1) WO2014028446A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
EP2863948B1 (en) 2012-06-22 2018-10-24 Cytomx Therapeutics Inc. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
BR112015003032B1 (pt) 2012-08-13 2023-03-28 Genentech, Inc Anticorpos isolados, imunoconjugado, formulação farmacêutica e uso do anticorpo
WO2014110506A2 (en) * 2013-01-14 2014-07-17 The Trustees Of Columbia University In The City Of New York Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders
SG11201507427QA (en) * 2013-03-15 2015-10-29 Genentech Inc Compositions and methods for diagnosis and treatment of hepatic cancers
EA201691610A8 (ru) 2014-02-12 2018-05-31 Дженентек, Инк. Анти-jagged1 антитела и способы применения
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
JOP20190259A1 (ar) 2017-05-31 2019-10-31 Amgen Inc بروتينات ربط مولد ضد مضادة لـ jagged1

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US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US7667004B2 (en) 2001-04-17 2010-02-23 Abmaxis, Inc. Humanized antibodies against vascular endothelial growth factor
US20030170636A1 (en) * 2002-03-05 2003-09-11 Isis Pharmaceuticals Inc. Antisense modulation of jagged 2 expression
US20030185829A1 (en) * 2002-03-12 2003-10-02 Erich Koller Jagged 2 inhibitors for inducing apoptosis
US20040101847A1 (en) 2002-11-22 2004-05-27 Isis Pharmaceuticals Inc. Modulation of Notch2 expression
CA2496547A1 (en) 2002-08-29 2004-03-11 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
US7438907B2 (en) 2002-11-15 2008-10-21 Genmab A/S Human monoclonal antibodies against CD25
US7285269B2 (en) 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
US20050106667A1 (en) * 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
JP2007512348A (ja) * 2003-11-26 2007-05-17 ヘルス　リサーチ　インコーポレイテッド 形質細胞の治療のためのノッチ経路干渉剤の使用
DK1771482T3 (da) 2004-07-22 2014-10-20 Genentech Inc HER2-antistofsammensætning
US7423128B2 (en) * 2004-11-03 2008-09-09 Amgen Fremont Inc. Anti-properdin antibodies, and methods for making and using same
AT502055B1 (de) 2005-06-21 2007-11-15 Univ Wien Med Anti tumor medikament
US20080241150A1 (en) 2006-05-15 2008-10-02 The Brigham And Women's Hospital, Inc. Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
AU2007333805B2 (en) 2006-12-18 2013-07-25 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
MX2009008430A (es) 2007-02-09 2009-10-28 Genentech Inc Anticuerpos anti-robo4 y sus usos.
EP2155249A4 (en) 2007-05-15 2011-11-16 Oncomed Pharm Inc COMPOSITIONS AND METHOD FOR DIAGNOSIS AND TREATMENT OF CANCER
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
MX2010001395A (es) 2007-08-10 2010-03-10 Regeneron Pharma Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano.
JP2009078998A (ja) * 2007-09-26 2009-04-16 Univ Of Tokushima Ｊａｇｇｅｄ２を用いる制癌剤
JP2011516520A (ja) * 2008-04-07 2011-05-26 アブリンクス エン．ヴェー． Ｎｏｔｃｈ経路に指向性を有するアミノ酸配列及びその使用
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
AU2009294415B2 (en) 2008-09-19 2015-09-24 Medimmune Llc Antibodies directed to DLL4 and uses thereof
AR073717A1 (es) 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
RU2636046C2 (ru) 2009-01-12 2017-11-17 Сайтомкс Терапьютикс, Инк Композиции модифицированных антител, способы их получения и применения
WO2011063237A2 (en) * 2009-11-19 2011-05-26 Oncomed Pharmaceuticals, Inc. Jagged-binding agents and uses thereof
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
EP2863948B1 (en) 2012-06-22 2018-10-24 Cytomx Therapeutics Inc. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
BR112015003032B1 (pt) * 2012-08-13 2023-03-28 Genentech, Inc Anticorpos isolados, imunoconjugado, formulação farmacêutica e uso do anticorpo
SG11201507427QA (en) 2013-03-15 2015-10-29 Genentech Inc Compositions and methods for diagnosis and treatment of hepatic cancers
EA201691610A8 (ru) 2014-02-12 2018-05-31 Дженентек, Инк. Анти-jagged1 антитела и способы применения
CN106488775A (zh) * 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制

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