JP2013507907A - マイコバクテリアワクチン - Google Patents

マイコバクテリアワクチン Download PDF

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Publication number
JP2013507907A
JP2013507907A JP2012533696A JP2012533696A JP2013507907A JP 2013507907 A JP2013507907 A JP 2013507907A JP 2012533696 A JP2012533696 A JP 2012533696A JP 2012533696 A JP2012533696 A JP 2012533696A JP 2013507907 A JP2013507907 A JP 2013507907A
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Japan
Prior art keywords
fusion protein
domain
acid sequence
amino acid
seq
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JP2012533696A
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English (en)
Japanese (ja)
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JP2013507907A5 (enExample
Inventor
アレクサンドラ、ジェーン、スペンサー
マシュー、ガイ、コッティンガム
エイドリアン、ビビアン、シントン、ヒル
ファーガル、ヒル
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Imaxio SA
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Imaxio SA
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Application filed by Imaxio SA filed Critical Imaxio SA
Publication of JP2013507907A publication Critical patent/JP2013507907A/ja
Publication of JP2013507907A5 publication Critical patent/JP2013507907A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1289—Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012533696A 2009-10-16 2010-10-15 マイコバクテリアワクチン Pending JP2013507907A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0918154.6 2009-10-16
GBGB0918154.6A GB0918154D0 (en) 2009-10-16 2009-10-16 Mycobacterial vaccines
PCT/GB2010/051741 WO2011045612A1 (en) 2009-10-16 2010-10-15 Mycobacterial vaccines

Publications (2)

Publication Number Publication Date
JP2013507907A true JP2013507907A (ja) 2013-03-07
JP2013507907A5 JP2013507907A5 (enExample) 2013-11-28

Family

ID=41462453

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012533696A Pending JP2013507907A (ja) 2009-10-16 2010-10-15 マイコバクテリアワクチン

Country Status (14)

Country Link
US (1) US9181311B2 (enExample)
EP (1) EP2488549B1 (enExample)
JP (1) JP2013507907A (enExample)
KR (1) KR20120083899A (enExample)
CN (1) CN102666575B (enExample)
AU (1) AU2010308120B2 (enExample)
BR (1) BR112012008790A2 (enExample)
CA (1) CA2776001A1 (enExample)
EA (1) EA201270517A1 (enExample)
GB (1) GB0918154D0 (enExample)
NZ (1) NZ599259A (enExample)
PH (1) PH12012500849A1 (enExample)
WO (1) WO2011045612A1 (enExample)
ZA (1) ZA201202363B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520534A (ja) * 2013-03-18 2016-07-14 イマクシオＩｍａｘｉｏ インフルエンザ核タンパク質ワクチン
JP2019187441A (ja) * 2013-06-25 2019-10-31 アエラス グローバル ティービー ワクチン ファウンデーション 結核組成物及びそれを使用する方法

Families Citing this family (28)

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GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
SG11201500171YA (en) * 2012-07-10 2015-02-27 Transgene Sa Mycobacterial antigen vaccine
RU2677799C2 (ru) 2012-12-11 2019-01-21 Озивакс Сас Модифицированные суперспиральные белки с улучшенными свойствами
CN103290053A (zh) * 2013-05-17 2013-09-11 中国人民解放军第四军医大学 唾液腺导管细胞特异性启动子的腺病毒载体及其构建方法
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
WO2015109265A1 (en) * 2014-01-16 2015-07-23 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
CN104805063A (zh) * 2014-01-24 2015-07-29 中国人民解放军第三〇九医院 结核分枝杆菌潜伏感染相关蛋白及其制备和应用
WO2015157561A1 (en) * 2014-04-09 2015-10-15 La Jolla Institute For Allergy And Immunology Specific and unique t cell responses and molecular signatures for treatment and diagnosis of mycobacterium tuberculosis
EP3194969B1 (en) * 2014-08-29 2023-06-07 Centre National de la Recherche Scientifique (C.N.R.S.) Compositions useful in the diagnostic of latently infected mycobacterium tuberculosis
US10342863B2 (en) 2015-03-24 2019-07-09 Fred Hutchinson Cancer Research Center Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
CN106237317A (zh) * 2015-06-15 2016-12-21 复旦大学 由结核分枝杆菌抗原组成的结核疫苗
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
US10428122B2 (en) 2016-06-16 2019-10-01 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN108239660B (zh) * 2016-12-26 2021-08-10 上海生物制品研究所有限责任公司 一种重组结核病疫苗，其制备方法及应用
KR102945203B1 (ko) 2017-05-08 2026-03-31 시애틀 프로젝트 코포레이션 알파바이러스 신생항원 벡터
WO2019144139A1 (en) * 2018-01-22 2019-07-25 Oregon State University Immunogenic compositions comprising mycobacterium bovis surface proteins and uses thereof
KR20210090650A (ko) 2018-11-07 2021-07-20 그릿스톤 바이오, 인코포레이티드 알파바이러스 신생항원 벡터 및 인터페론 억제제
SG11202113187WA (en) 2019-05-30 2021-12-30 Gritstone Bio Inc Modified adenoviruses
CN110240637A (zh) * 2019-06-04 2019-09-17 华中农业大学 牛分枝杆菌免疫相关的分子伴侣蛋白GroEL2及其编码基因与应用
KR102193304B1 (ko) * 2019-10-24 2020-12-22 충남대학교산학협력단 Rv2299c-ESAT6-HspX-RipA 융합단백질의 BCG 백신 booster용 조성물
CN110724182B (zh) * 2019-11-15 2022-04-08 上海交通大学 提高菌阴结核感染检测敏感性的标志物组合及应用
WO2021119545A1 (en) * 2019-12-11 2021-06-17 Gritstone Bio, Inc. Durable vaccination
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
CN112979825A (zh) * 2021-02-04 2021-06-18 兰州大学 结核分枝杆菌融合蛋白lt29构建及其表达纯化方法和应用
CN113999865B (zh) * 2021-10-09 2023-06-16 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用
CN115920003B (zh) * 2022-08-31 2024-11-29 中国医学科学院病原生物学研究所 脂蛋白LprG及其基因作为抗结核分枝杆菌药物靶点的应用
CN116041543B (zh) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌多抗原融合蛋白及其编码基因和应用

Citations (4)

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JPH04506460A (ja) * 1990-01-26 1992-11-12 バイオジェン，インコーポレイテッド Ｃ４結合タンパク質の融合タンパク質
WO2007062819A2 (en) * 2005-11-30 2007-06-07 Imaxio Multimeric complexes of antigens and an adjuvant
JP2007528210A (ja) * 2003-08-12 2007-10-11 アヴィディス エスアー Ｃ４ｂｐコアタンパク質及び単量体抗原を含む生成物及びその使用
WO2008122817A2 (en) * 2007-04-10 2008-10-16 Isis Innovation Immunogenic compositions

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CN1284854C (zh) * 2003-03-06 2006-11-15 钟森 用于预防结核病和免疫治疗的嵌合型dna疫苗
SI1957528T1 (sl) * 2005-11-30 2013-02-28 University Of Copenhagen Nukleotidno cepivo
CN101428143B (zh) * 2008-12-09 2011-05-11 武汉大学 携带结核基因的减毒细菌载体结核疫苗及制备方法和应用

Patent Citations (4)

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JPH04506460A (ja) * 1990-01-26 1992-11-12 バイオジェン，インコーポレイテッド Ｃ４結合タンパク質の融合タンパク質
JP2007528210A (ja) * 2003-08-12 2007-10-11 アヴィディス エスアー Ｃ４ｂｐコアタンパク質及び単量体抗原を含む生成物及びその使用
WO2007062819A2 (en) * 2005-11-30 2007-06-07 Imaxio Multimeric complexes of antigens and an adjuvant
WO2008122817A2 (en) * 2007-04-10 2008-10-16 Isis Innovation Immunogenic compositions

Non-Patent Citations (2)

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JPN5012018115; ＯＧＵＮ　ＳＯＬＡＢＯＭＩ　Ａ: 'ＴＨＥ　ＯＬＩＧＯＭＥＲＩＺＡＴＩＯＮ　ＤＯＭＡＩＮ　ＯＦ　Ｃ４-ＢＩＮＤＩＮＧ　ＰＲＯＴＥＩＮ　（Ｃ４ＢＰ）　ＡＣＴＳ　ＡＳ　ＡＮ　ＡＤＪＵＶＡＮＴ，　ＡＮＤ　ＴＨＥ　ＦＵＳＩＯＮ　以下備考' ＩＮＦＥＣＴＩＯＮ　ＡＮＤ　ＩＭＭＵＮＩＴＹ Ｖ７６　Ｎ８, 200808, Ｐ３８１７-３８２３ *
JPN5012018116; ＭＣＳＨＡＮＥ　Ｈ: 'ＲＥＣＯＭＢＩＮＡＮＴ　ＭＯＤＩＦＩＥＤ　ＶＡＣＣＩＮＩＡ　ＶＩＲＵＳ　ＡＮＫＡＲＡ　ＥＸＰＲＥＳＳＩＮＧ　ＡＮＴＩＧＥＮ　８５Ａ　ＢＯＯＳＴＳ　ＢＣＧ-ＰＲＩＭＥＤ　以下備考' ＮＡＴＵＲＥ　ＭＥＤＩＣＩＮＥ Ｖ１０　Ｎ１１, 20041024, Ｐ１２４０-１２４４, ＮＡＴＵＲＥ　ＰＵＢＬＩＳＨＩＮＧ　ＧＲＯＵＰ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520534A (ja) * 2013-03-18 2016-07-14 イマクシオＩｍａｘｉｏ インフルエンザ核タンパク質ワクチン
JP2019187441A (ja) * 2013-06-25 2019-10-31 アエラス グローバル ティービー ワクチン ファウンデーション 結核組成物及びそれを使用する方法
JP7269806B2 (ja) 2013-06-25 2023-05-09 インターナショナル エイズ バクシーン イニシアティブ インコーポレイテッド 結核組成物及びそれを使用する方法

Also Published As

Publication number Publication date
BR112012008790A2 (pt) 2019-09-24
US20120282290A1 (en) 2012-11-08
EP2488549A1 (en) 2012-08-22
CN102666575A (zh) 2012-09-12
EP2488549B1 (en) 2015-07-29
PH12012500849A1 (en) 2014-03-24
GB0918154D0 (en) 2009-12-02
ZA201202363B (en) 2013-01-30
AU2010308120B2 (en) 2015-01-22
KR20120083899A (ko) 2012-07-26
WO2011045612A1 (en) 2011-04-21
CA2776001A1 (en) 2011-04-21
NZ599259A (en) 2014-03-28
CN102666575B (zh) 2015-07-15
EA201270517A1 (ru) 2012-12-28
AU2010308120A1 (en) 2012-05-03
US9181311B2 (en) 2015-11-10

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