NZ599259A - Mycobacterial vaccines - Google Patents

Mycobacterial vaccines

Info

Publication number
NZ599259A
NZ599259A NZ599259A NZ59925910A NZ599259A NZ 599259 A NZ599259 A NZ 599259A NZ 599259 A NZ599259 A NZ 599259A NZ 59925910 A NZ59925910 A NZ 59925910A NZ 599259 A NZ599259 A NZ 599259A
Authority
NZ
New Zealand
Prior art keywords
amino acid
fusion protein
acid sequence
stimulates
fragment
Prior art date
Application number
NZ599259A
Other languages
English (en)
Inventor
Alexandra Jane Spencer
Fergal Hill
Adrian Vivian Sinton Hill
Matthew Guy Cottingham
Original Assignee
Isis Innovation
Imaxio Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Imaxio Sa filed Critical Isis Innovation
Publication of NZ599259A publication Critical patent/NZ599259A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1289—Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NZ599259A 2009-10-16 2010-10-15 Mycobacterial vaccines NZ599259A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0918154.6A GB0918154D0 (en) 2009-10-16 2009-10-16 Mycobacterial vaccines
PCT/GB2010/051741 WO2011045612A1 (en) 2009-10-16 2010-10-15 Mycobacterial vaccines

Publications (1)

Publication Number Publication Date
NZ599259A true NZ599259A (en) 2014-03-28

Family

ID=41462453

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ599259A NZ599259A (en) 2009-10-16 2010-10-15 Mycobacterial vaccines

Country Status (14)

Country Link
US (1) US9181311B2 (enExample)
EP (1) EP2488549B1 (enExample)
JP (1) JP2013507907A (enExample)
KR (1) KR20120083899A (enExample)
CN (1) CN102666575B (enExample)
AU (1) AU2010308120B2 (enExample)
BR (1) BR112012008790A2 (enExample)
CA (1) CA2776001A1 (enExample)
EA (1) EA201270517A1 (enExample)
GB (1) GB0918154D0 (enExample)
NZ (1) NZ599259A (enExample)
PH (1) PH12012500849A1 (enExample)
WO (1) WO2011045612A1 (enExample)
ZA (1) ZA201202363B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN113999865A (zh) * 2021-10-09 2022-02-01 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用

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GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
SG11201500171YA (en) * 2012-07-10 2015-02-27 Transgene Sa Mycobacterial antigen vaccine
RU2677799C2 (ru) 2012-12-11 2019-01-21 Озивакс Сас Модифицированные суперспиральные белки с улучшенными свойствами
JP2016520534A (ja) * 2013-03-18 2016-07-14 イマクシオＩｍａｘｉｏ インフルエンザ核タンパク質ワクチン
CN103290053A (zh) * 2013-05-17 2013-09-11 中国人民解放军第四军医大学 唾液腺导管细胞特异性启动子的腺病毒载体及其构建方法
EP3013364B1 (en) * 2013-06-25 2022-08-03 International AIDS Vaccine Initiative, Inc. Tuberculosis compositions and methods of using the same
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
WO2015109265A1 (en) * 2014-01-16 2015-07-23 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
CN104805063A (zh) * 2014-01-24 2015-07-29 中国人民解放军第三〇九医院 结核分枝杆菌潜伏感染相关蛋白及其制备和应用
WO2015157561A1 (en) * 2014-04-09 2015-10-15 La Jolla Institute For Allergy And Immunology Specific and unique t cell responses and molecular signatures for treatment and diagnosis of mycobacterium tuberculosis
EP3194969B1 (en) * 2014-08-29 2023-06-07 Centre National de la Recherche Scientifique (C.N.R.S.) Compositions useful in the diagnostic of latently infected mycobacterium tuberculosis
US10342863B2 (en) 2015-03-24 2019-07-09 Fred Hutchinson Cancer Research Center Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
CN106237317A (zh) * 2015-06-15 2016-12-21 复旦大学 由结核分枝杆菌抗原组成的结核疫苗
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
US10428122B2 (en) 2016-06-16 2019-10-01 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN108239660B (zh) * 2016-12-26 2021-08-10 上海生物制品研究所有限责任公司 一种重组结核病疫苗，其制备方法及应用
KR102945203B1 (ko) 2017-05-08 2026-03-31 시애틀 프로젝트 코포레이션 알파바이러스 신생항원 벡터
WO2019144139A1 (en) * 2018-01-22 2019-07-25 Oregon State University Immunogenic compositions comprising mycobacterium bovis surface proteins and uses thereof
KR20210090650A (ko) 2018-11-07 2021-07-20 그릿스톤 바이오, 인코포레이티드 알파바이러스 신생항원 벡터 및 인터페론 억제제
SG11202113187WA (en) 2019-05-30 2021-12-30 Gritstone Bio Inc Modified adenoviruses
CN110240637A (zh) * 2019-06-04 2019-09-17 华中农业大学 牛分枝杆菌免疫相关的分子伴侣蛋白GroEL2及其编码基因与应用
KR102193304B1 (ko) * 2019-10-24 2020-12-22 충남대학교산학협력단 Rv2299c-ESAT6-HspX-RipA 융합단백질의 BCG 백신 booster용 조성물
CN110724182B (zh) * 2019-11-15 2022-04-08 上海交通大学 提高菌阴结核感染检测敏感性的标志物组合及应用
WO2021119545A1 (en) * 2019-12-11 2021-06-17 Gritstone Bio, Inc. Durable vaccination
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
CN112979825A (zh) * 2021-02-04 2021-06-18 兰州大学 结核分枝杆菌融合蛋白lt29构建及其表达纯化方法和应用
CN115920003B (zh) * 2022-08-31 2024-11-29 中国医学科学院病原生物学研究所 脂蛋白LprG及其基因作为抗结核分枝杆菌药物靶点的应用
CN116041543B (zh) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌多抗原融合蛋白及其编码基因和应用

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CN1284854C (zh) * 2003-03-06 2006-11-15 钟森 用于预防结核病和免疫治疗的嵌合型dna疫苗
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SI1957528T1 (sl) * 2005-11-30 2013-02-28 University Of Copenhagen Nukleotidno cepivo
EP1795540A1 (en) * 2005-11-30 2007-06-13 Imaxio Multimeric complexes of antigens and an adjuvant
GB0706912D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel viral vaccines
CN101428143B (zh) * 2008-12-09 2011-05-11 武汉大学 携带结核基因的减毒细菌载体结核疫苗及制备方法和应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113999865A (zh) * 2021-10-09 2022-02-01 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用
CN113999865B (zh) * 2021-10-09 2023-06-16 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用

Also Published As

Publication number Publication date
BR112012008790A2 (pt) 2019-09-24
US20120282290A1 (en) 2012-11-08
EP2488549A1 (en) 2012-08-22
CN102666575A (zh) 2012-09-12
EP2488549B1 (en) 2015-07-29
PH12012500849A1 (en) 2014-03-24
GB0918154D0 (en) 2009-12-02
ZA201202363B (en) 2013-01-30
AU2010308120B2 (en) 2015-01-22
KR20120083899A (ko) 2012-07-26
WO2011045612A1 (en) 2011-04-21
JP2013507907A (ja) 2013-03-07
CA2776001A1 (en) 2011-04-21
CN102666575B (zh) 2015-07-15
EA201270517A1 (ru) 2012-12-28
AU2010308120A1 (en) 2012-05-03
US9181311B2 (en) 2015-11-10

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PSEA Patent sealed
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 OCT 2015 BY CPA GLOBAL

Effective date: 20140926

LAPS Patent lapsed