JP2014195454A5 - - Google Patents
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- Publication number
- JP2014195454A5 JP2014195454A5 JP2014087047A JP2014087047A JP2014195454A5 JP 2014195454 A5 JP2014195454 A5 JP 2014195454A5 JP 2014087047 A JP2014087047 A JP 2014087047A JP 2014087047 A JP2014087047 A JP 2014087047A JP 2014195454 A5 JP2014195454 A5 JP 2014195454A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- receptor
- polypeptide
- protease
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 102000005962 receptors Human genes 0.000 claims 11
- 108020003175 receptors Proteins 0.000 claims 11
- 108091005804 Peptidases Proteins 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 10
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 10
- 210000004881 tumor cell Anatomy 0.000 claims 9
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 8
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 8
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims 8
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 8
- 101710142969 Somatoliberin Proteins 0.000 claims 8
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 8
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 8
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 claims 8
- 208000010916 pituitary tumor Diseases 0.000 claims 8
- 230000005945 translocation Effects 0.000 claims 7
- 108010056088 Somatostatin Proteins 0.000 claims 6
- 231100000065 noncytotoxic Toxicity 0.000 claims 6
- 230000002020 noncytotoxic effect Effects 0.000 claims 6
- 108010055044 Tetanus Toxin Proteins 0.000 claims 5
- 102000005157 Somatostatin Human genes 0.000 claims 4
- 210000001163 endosome Anatomy 0.000 claims 4
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 4
- 229960000553 somatostatin Drugs 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108010051479 Bombesin Proteins 0.000 claims 2
- 108010073466 Bombesin Receptors Proteins 0.000 claims 2
- 101800001586 Ghrelin Proteins 0.000 claims 2
- 108010016122 Ghrelin Receptors Proteins 0.000 claims 2
- 102100039256 Growth hormone secretagogue receptor type 1 Human genes 0.000 claims 2
- 101000581402 Homo sapiens Melanin-concentrating hormone receptor 1 Proteins 0.000 claims 2
- 108010002231 IgA-specific serine endopeptidase Proteins 0.000 claims 2
- 101800002739 Melanin-concentrating hormone Proteins 0.000 claims 2
- 102400001132 Melanin-concentrating hormone Human genes 0.000 claims 2
- 102100027375 Melanin-concentrating hormone receptor 1 Human genes 0.000 claims 2
- 108010057464 Prolactin Proteins 0.000 claims 2
- 102000003946 Prolactin Human genes 0.000 claims 2
- 102000056271 Prolactin-releasing peptide receptors Human genes 0.000 claims 2
- 108700024163 Prolactin-releasing peptide receptors Proteins 0.000 claims 2
- 101150056450 UTS2R gene Proteins 0.000 claims 2
- 108010011107 Urotensins Proteins 0.000 claims 2
- 210000000172 cytosol Anatomy 0.000 claims 2
- 230000028023 exocytosis Effects 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 claims 2
- ORRDHOMWDPJSNL-UHFFFAOYSA-N melanin concentrating hormone Chemical compound N1C(=O)C(C(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CCSC)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(NC(=O)C(N)CC(O)=O)C(C)O)CCSC)CSSCC(C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C1CC1=CC=C(O)C=C1 ORRDHOMWDPJSNL-UHFFFAOYSA-N 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000000813 peptide hormone Substances 0.000 claims 2
- 229940097325 prolactin Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 206010000599 Acromegaly Diseases 0.000 claims 1
- 102100028628 Bombesin receptor subtype-3 Human genes 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 102100034845 KiSS-1 receptor Human genes 0.000 claims 1
- 108010076800 Kisspeptin-1 Receptors Proteins 0.000 claims 1
- 101710138657 Neurotoxin Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000033052 Somatotropic adenoma Diseases 0.000 claims 1
- 102000012327 Urotensin II receptors Human genes 0.000 claims 1
- 108050002984 Urotensin II receptors Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000007375 bacterial translocation Effects 0.000 claims 1
- 108010063504 bombesin receptor subtype 3 Proteins 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000012202 endocytosis Effects 0.000 claims 1
- 208000020475 growth hormone-producing pituitary gland neoplasm Diseases 0.000 claims 1
- 201000010430 hormone producing pituitary cancer Diseases 0.000 claims 1
- 239000002581 neurotoxin Substances 0.000 claims 1
- 231100000618 neurotoxin Toxicity 0.000 claims 1
- 230000001817 pituitary effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000007377 viral translocation Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0810782.3A GB0810782D0 (en) | 2008-06-12 | 2008-06-12 | Suppression of cancers |
| GB0810785A GB0810785D0 (en) | 2008-06-12 | 2008-06-12 | Suppression of neuroendocrine diseases |
| GB0810785.6 | 2008-06-12 | ||
| GB0810782.3 | 2008-06-12 | ||
| GB0820884.5 | 2008-11-14 | ||
| GB0820884A GB0820884D0 (en) | 2008-11-14 | 2008-11-14 | Suppression of neuroendocrine diseases |
| GB0820965.2 | 2008-11-17 | ||
| GB0820965A GB0820965D0 (en) | 2008-11-17 | 2008-11-17 | Suppression of cancers |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513056A Division JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014195454A JP2014195454A (ja) | 2014-10-16 |
| JP2014195454A5 true JP2014195454A5 (enExample) | 2014-11-27 |
| JP5891258B2 JP5891258B2 (ja) | 2016-03-22 |
Family
ID=41417177
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513056A Active JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
| JP2014087047A Expired - Fee Related JP5891258B2 (ja) | 2008-06-12 | 2014-04-21 | 神経内分泌疾患の抑制 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513056A Active JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110171191A1 (enExample) |
| EP (3) | EP2719392B1 (enExample) |
| JP (2) | JP5728380B2 (enExample) |
| KR (1) | KR101642363B1 (enExample) |
| CN (2) | CN104328100B (enExample) |
| AU (1) | AU2009259033B2 (enExample) |
| BR (1) | BRPI0915888E2 (enExample) |
| CA (1) | CA2727082C (enExample) |
| ES (2) | ES2614990T3 (enExample) |
| IL (1) | IL209855A (enExample) |
| WO (1) | WO2009150469A2 (enExample) |
| ZA (1) | ZA201008536B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| GB0803068D0 (en) | 2008-02-20 | 2008-03-26 | Health Prot Agency | Cross-linked biological indicator |
| US10466245B2 (en) | 2008-02-20 | 2019-11-05 | The Secretary Of State For Health | Covalently linked thermostable kinase for decontamination process validation |
| CA2727082C (en) * | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| MX355543B (es) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Macrociclos peptidomiméticos. |
| GB201108108D0 (en) | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
| TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
| SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| EP3194618B1 (en) | 2014-09-15 | 2021-04-21 | Clifton Life Sciences LLC | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US20170326166A1 (en) * | 2014-10-17 | 2017-11-16 | University Of Virginia Patent Foundation | Compositions and methods for treating pituitary tumors |
| KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
| US20210277071A1 (en) | 2016-09-29 | 2021-09-09 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
| EP3375871A1 (en) * | 2017-03-13 | 2018-09-19 | SIT Biotech GmbH | Selective cell death-inducing enzyme system |
| JOP20190276A1 (ar) * | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
| BR112020006827A2 (pt) | 2018-01-29 | 2020-10-06 | Ipsen Biopharm Limited | neurotoxinas botulínicas clivando snare não neuronal |
| GB201900621D0 (en) | 2019-01-16 | 2019-03-06 | Ipsen Biopharm Ltd | Labelled polypeptides |
| CN110801512B (zh) * | 2019-11-15 | 2023-07-18 | 中国水产科学研究院黑龙江水产研究所 | 一种用于促进哲罗鲑性腺成熟的多肽及其应用 |
| CN111388651B (zh) * | 2020-05-09 | 2022-05-03 | 山东大学齐鲁医院 | Cst-14在制备骨质疏松症治疗药物中的应用 |
| CN113257370B (zh) * | 2021-05-12 | 2022-09-02 | 中国医学科学院北京协和医院 | 基于临床病理基本信息和vista检测的pnet复发风险预测模型 |
| WO2025155896A1 (en) * | 2024-01-19 | 2025-07-24 | Sling Therapeutics, Inc. | Use of inhibitors of insulin-like growth factor receptor-1 for growth hormone igf-secreting neoplasias |
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2009
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- 2009-06-11 WO PCT/GB2009/050665 patent/WO2009150469A2/en not_active Ceased
- 2009-06-11 CN CN201410295607.7A patent/CN104328100B/zh not_active Expired - Fee Related
- 2009-06-11 ES ES09762018.1T patent/ES2614990T3/es active Active
- 2009-06-11 KR KR1020117000251A patent/KR101642363B1/ko not_active Expired - Fee Related
- 2009-06-11 EP EP09762018.1A patent/EP2310028B1/en active Active
- 2009-06-11 US US12/996,643 patent/US20110171191A1/en not_active Abandoned
- 2009-06-11 AU AU2009259033A patent/AU2009259033B2/en not_active Ceased
- 2009-06-11 CN CN200980130069.3A patent/CN102112145B/zh not_active Expired - Fee Related
- 2009-06-11 JP JP2011513056A patent/JP5728380B2/ja active Active
- 2009-06-11 BR BRC10915888A patent/BRPI0915888E2/pt not_active IP Right Cessation
- 2009-06-11 ES ES13179177T patent/ES2750651T3/es active Active
- 2009-06-11 EP EP19175007.4A patent/EP3590956A1/en active Pending
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