JP2014195454A5 - - Google Patents
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- JP2014195454A5 JP2014195454A5 JP2014087047A JP2014087047A JP2014195454A5 JP 2014195454 A5 JP2014195454 A5 JP 2014195454A5 JP 2014087047 A JP2014087047 A JP 2014087047A JP 2014087047 A JP2014087047 A JP 2014087047A JP 2014195454 A5 JP2014195454 A5 JP 2014195454A5
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- peptide
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- polypeptide
- protease
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Claims (14)
- 先端巨大症の治療に使用するためのポリペプチドであって、
a.下垂体腫瘍細胞におけるエキソサイトーシス融合装置のタンパク質を切断することができる非細胞傷害性プロテアーゼ、
b.エンドサイトーシスを受けて、下垂体腫瘍細胞内のエンドソームに組み込まれ得る、前記下垂体腫瘍細胞上の結合部位に結合するペプチドターゲティング部分(TM)、及び
c.エンドソームの内部からエンドソーム膜を通過して前記下垂体腫瘍細胞の細胞質ゾル中に前記プロテアーゼを移行させる細菌又はウイルスの移行ドメイン
を含み、
クロストリジウムの神経毒の天然H CC 結合ドメインを欠如する
ポリペプチド。 - 下垂体腫瘍細胞が、ソマトトロピノーマに由来する、又はそれの原因となる、請求項1に記載のポリペプチド。
- TMが、成長ホルモン放出ホルモン(GHRH)受容体;ソマトスタチン(SST)受容体、コルチスタチン(CST)受容体;グレリン受容体;ボンベシン受容体;ウロテンシン受容体;メラニン凝集ホルモン受容体1;KiSS−1受容体;ゴナドトロピン放出ホルモン(GnRH)受容体;及び/又は、プロラクチン放出ペプチド受容体を含む群から選択される受容体に結合する、請求項1又は2に記載のポリペプチド。
- TMが、成長ホルモン放出ホルモン(GHRH)ペプチド、ソマトスタチンペプチド、コルチスタチンペプチド、グレリンペプチド、ボンベシンペプチド、ウロテンシンペプチド、メラニン凝集ホルモンペプチド、KISS−1ペプチド、ゴナドトロピン放出ホルモン(GnRH)ペプチド、又はプロラクチン放出ペプチドを含む、請求項1〜3のいずれかに記載のポリペプチド。
- 非細胞傷害性プロテアーゼが、クロストリジウムの神経毒L鎖又はIgAプロテアーゼを含む、請求項1〜4のいずれかに記載のポリペプチド。
- 移行ドメインが、クロストリジウムの神経毒移行ドメインを含む、請求項1〜5のいずれかに記載のポリペプチド。
- a.下垂体腫瘍細胞におけるエキソサイトーシス融合装置のタンパク質を切断することができる非細胞傷害性プロテアーゼ、
b.エンドサイトーシスを受けて、下垂体腫瘍細胞内のエンドソームに組み込まれ得る、前記下垂体腫瘍細胞上の結合部位に結合するペプチドターゲティング部分(TM)、及び
c.エンドソームの内部からエンドソーム膜を通過して前記下垂体腫瘍細胞の細胞質ゾル中に前記プロテアーゼを移行させる細菌又はウイルスの移行ドメイン
を含み、
クロストリジウムの神経毒の天然H CC 結合ドメインを欠如し、
配列番号7、8、9、10、11、12、13、14、15、16、18、19、20、21、22、23、24、26、27、28、29、30、31、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、又は94のいずれか1つに対して、少なくとも90〜92%、又は少なくとも95〜97%、又は少なくとも98〜99%の配列同一性を有するアミノ酸配列を含む
ポリペプチド。 - TMが、成長ホルモン放出ホルモン(GHRH)受容体;ソマトスタチン(SST)受容体、コルチスタチン(CST)受容体;グレリン受容体;ボンベシン受容体(例えばBRS−1、BRS−2、若しくはBRS−3);ウロテンシン受容体(例えばウロテンシンII受容体);メラニン凝集ホルモン受容体1;KiSS−1受容体;ゴナドトロピン放出ホルモン(GnRH)受容体;及び/又はプロラクチン放出ペプチド受容体を含む群から選択される受容体に結合する、請求項7に記載のポリペプチド。
- TMが、成長ホルモン放出ホルモン(GHRH)ペプチド、ソマトスタチンペプチド、コルチスタチンペプチド、グレリンペプチド、ボンベシンペプチド、ウロテンシンペプチド、メラニン凝集ホルモンペプチド、KISS−1ペプチド、ゴナドトロピン放出ホルモン(GnRH)ペプチド、又はプロラクチン放出ペプチドを含む、請求項7又は8に記載のポリペプチド。
- 移行ドメインが、クロストリジウムの神経毒移行ドメインを含み、及び/又は非細胞傷害性プロテアーゼが、クロストリジウムの神経毒プロテアーゼ若しくはIgAプロテアーゼを含む、請求項7〜9のいずれかに記載のポリペプチド。
- 請求項7〜10のいずれかに記載のポリペプチドをコードする核酸。
- 配列番号17又は25のいずれか1つに対して、少なくとも90〜94%、又は少なくとも95〜97%又は少なくとも98〜99%の配列同一性を有する核酸配列を含む、請求項11に記載のポリペプチドをコードする核酸。
- 非細胞傷害性プロテアーゼ成分と移行成分の間に位置する認識部位(切断部位)でポリペプチドを切断するプロテアーゼと、ポリペプチドとを接触させること、及び前記ポリペプチドを二重鎖ポリペプチドに変換することを含み、前記非細胞傷害性プロテアーゼ成分及び前記移行成分が、ジスルフィド結合によってともに結合される、請求項5に記載のポリペプチドを活性化させる方法。
- 請求項13の方法によって得ることができる二重鎖ポリペプチド。
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0810785A GB0810785D0 (en) | 2008-06-12 | 2008-06-12 | Suppression of neuroendocrine diseases |
GBGB0810782.3A GB0810782D0 (en) | 2008-06-12 | 2008-06-12 | Suppression of cancers |
GB0810785.6 | 2008-06-12 | ||
GB0810782.3 | 2008-06-12 | ||
GB0820884.5 | 2008-11-14 | ||
GB0820884A GB0820884D0 (en) | 2008-11-14 | 2008-11-14 | Suppression of neuroendocrine diseases |
GB0820965.2 | 2008-11-17 | ||
GB0820965A GB0820965D0 (en) | 2008-11-17 | 2008-11-17 | Suppression of cancers |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011513056A Division JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014195454A JP2014195454A (ja) | 2014-10-16 |
JP2014195454A5 true JP2014195454A5 (ja) | 2014-11-27 |
JP5891258B2 JP5891258B2 (ja) | 2016-03-22 |
Family
ID=41417177
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011513056A Active JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
JP2014087047A Expired - Fee Related JP5891258B2 (ja) | 2008-06-12 | 2014-04-21 | 神経内分泌疾患の抑制 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011513056A Active JP5728380B2 (ja) | 2008-06-12 | 2009-06-11 | 神経内分泌疾患の抑制 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110171191A1 (ja) |
EP (3) | EP2719392B1 (ja) |
JP (2) | JP5728380B2 (ja) |
KR (1) | KR101642363B1 (ja) |
CN (2) | CN104328100B (ja) |
AU (1) | AU2009259033B2 (ja) |
BR (1) | BRPI0915888E2 (ja) |
CA (1) | CA2727082C (ja) |
ES (2) | ES2614990T3 (ja) |
IL (1) | IL209855A (ja) |
WO (1) | WO2009150469A2 (ja) |
ZA (1) | ZA201008536B (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
GB0803068D0 (en) | 2008-02-20 | 2008-03-26 | Health Prot Agency | Cross-linked biological indicator |
US10466245B2 (en) | 2008-02-20 | 2019-11-05 | The Secretary Of State For Health | Covalently linked thermostable kinase for decontamination process validation |
EP2719392B1 (en) * | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
GB0820970D0 (en) * | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
GB201108108D0 (en) | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
AU2012326026B2 (en) | 2011-10-18 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocyles |
CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
CN107208132A (zh) | 2014-09-15 | 2017-09-26 | 克里夫顿生命科学有限责任公司 | 用于诊断胃肠胰神经内分泌瘤的组合物、方法和试剂盒 |
BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
US20170326166A1 (en) * | 2014-10-17 | 2017-11-16 | University Of Virginia Patent Foundation | Compositions and methods for treating pituitary tumors |
KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
US20210277071A1 (en) | 2016-09-29 | 2021-09-09 | Ipsen Biopharm Limited | Hybrid neurotoxins |
EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
EP3375871A1 (en) * | 2017-03-13 | 2018-09-19 | SIT Biotech GmbH | Selective cell death-inducing enzyme system |
JOP20190276A1 (ar) * | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
BR112020006827A2 (pt) | 2018-01-29 | 2020-10-06 | Ipsen Biopharm Limited | neurotoxinas botulínicas clivando snare não neuronal |
GB201900621D0 (en) | 2019-01-16 | 2019-03-06 | Ipsen Biopharm Ltd | Labelled polypeptides |
CN110801512B (zh) * | 2019-11-15 | 2023-07-18 | 中国水产科学研究院黑龙江水产研究所 | 一种用于促进哲罗鲑性腺成熟的多肽及其应用 |
CN111388651B (zh) * | 2020-05-09 | 2022-05-03 | 山东大学齐鲁医院 | Cst-14在制备骨质疏松症治疗药物中的应用 |
CN113257370B (zh) * | 2021-05-12 | 2022-09-02 | 中国医学科学院北京协和医院 | 基于临床病理基本信息和vista检测的pnet复发风险预测模型 |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291022A (en) | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
US4133782A (en) | 1976-06-07 | 1979-01-09 | The Salk Institute For Biological Studies | Somatostatin analogs with dissociated biological activities |
US4190575A (en) | 1977-12-27 | 1980-02-26 | American Home Products Corporation | Polypeptides related to somatostatin |
EP0000053B1 (en) | 1977-06-08 | 1981-05-27 | Merck & Co. Inc. | Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them |
US4211693A (en) | 1977-09-20 | 1980-07-08 | The Salk Institute For Biological Studies | Peptides with para-substituted phenylalanine |
LU78191A1 (de) | 1977-09-28 | 1979-05-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen cyclopeptiden |
JPS5819669B2 (ja) | 1978-10-28 | 1983-04-19 | 白井松新薬株式会社 | 新規生理活性ペプチド化合物及びその製造法 |
US4190648A (en) | 1979-03-13 | 1980-02-26 | Merck & Co., Inc. | Peptides having somatostatin activity |
US4316890A (en) | 1979-03-16 | 1982-02-23 | Ciba-Geigy Corporation | Peptides and processes for the manufacture thereof |
US4328214A (en) | 1979-07-04 | 1982-05-04 | Ciba-Geigy Corporation | Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture |
US4310518A (en) | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4235886A (en) | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4369179A (en) | 1979-12-14 | 1983-01-18 | Ciba-Geigy Corporation | Acylpeptides |
US4282143A (en) | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
US4360516A (en) | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
DE3264693D1 (en) | 1981-12-24 | 1985-08-14 | Ciba Geigy Ag | Cyclic octapeptides and pharmaceutical compositions thereof, and processes for their production and use |
FR2522655B1 (fr) | 1982-03-05 | 1987-03-06 | Sanofi Sa | Analogues de la somatostatine possedant une liaison du type hydrazide et medicaments en contenant |
US4522813A (en) | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4659693A (en) | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
US4632979A (en) | 1984-06-18 | 1986-12-30 | Tulane Educational Fund | Therapeutic LHRH analogs |
US4684620A (en) | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
US5003011A (en) | 1985-04-09 | 1991-03-26 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
US4650787A (en) | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
US4725577A (en) | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
US4585755A (en) | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
US4904642A (en) | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
US4853371A (en) | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
US4803261A (en) | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
HU906340D0 (en) | 1986-10-13 | 1991-04-29 | Sandoz Ag | Synthesis in solid phase for producing peptonic alcohols |
US4871717A (en) | 1987-01-07 | 1989-10-03 | Administrators Of The Tulane Educational Fund | Peptides |
US5084555A (en) | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
JP2795449B2 (ja) | 1987-09-24 | 1998-09-10 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | 治療用ペプチド |
EP0329295A1 (en) | 1988-02-01 | 1989-08-23 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
ZA895838B (en) | 1988-08-18 | 1991-03-27 | Syntex Inc | Pharmaceutical compounds |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
MC2144A1 (fr) | 1988-10-14 | 1992-02-19 | Univ Tulane | Peptides therapeutiques |
US5171835A (en) | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
CA2012115C (en) | 1989-03-15 | 2001-07-03 | Biomeasure, Inc. | Iodinated somatostatins |
KR0173119B1 (ko) | 1989-04-26 | 1999-02-01 | 닐 에이. 밴스로우 | 선형 소마토스타틴 유사체 |
DK0457888T3 (da) | 1989-12-08 | 1996-08-12 | Univ Tulane | Octapeptidanaloger af somatostatin med threonin i 6-stillingen |
ATE127476T1 (de) | 1990-04-06 | 1995-09-15 | Univ Tulane | Lhrh-analoge. |
EP0527914A4 (en) | 1990-05-04 | 1993-08-11 | The Administrators Of The Tulane University Educational Fund | Novel synthetic grf analogs |
JPH05506862A (ja) | 1990-05-09 | 1993-10-07 | ジ・アドミニストレイターズ・オブ・ザ・トゥーラン・エデュケイショナル・ファンド | 環状および鎖状の治療用ペプチド |
IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
HU207104B (en) | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
US6083915A (en) | 1991-05-10 | 2000-07-04 | Biomeasure, Inc. | Method for treating liver cancer |
US5240561A (en) | 1992-02-10 | 1993-08-31 | Industrial Progress, Inc. | Acid-to-alkaline papermaking process |
AU3658093A (en) | 1992-02-10 | 1993-09-03 | Seragen, Inc. | Desensitization to specific allergens |
US5656727A (en) | 1992-09-15 | 1997-08-12 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
WO1994011396A1 (en) | 1992-11-13 | 1994-05-26 | The Administrators Of The Tulane Educational Fund | Ghrh agonists |
WO1994011397A1 (en) | 1992-11-13 | 1994-05-26 | The Administrators Of The Tulane Educational Fund | Ghrh agonists |
GB9305735D0 (en) * | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
ATE284413T1 (de) | 1993-08-09 | 2004-12-15 | Sod Conseils Rech Applic | Therapeutische peptid derivate |
US5550212A (en) | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
AUPM985694A0 (en) | 1994-12-02 | 1995-01-05 | Farmer, Mostyn | Golf training aid |
US5792747A (en) | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
EP0737691B1 (en) | 1995-03-13 | 1998-09-09 | Biomeasure, Inc. | Bombesin analogs |
WO1996032126A1 (en) | 1995-04-14 | 1996-10-17 | The Administrators Of The Tulane Educational Fund | Analogs of growth hormone-releasing factor |
GB9508204D0 (en) * | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
US5942489A (en) | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
WO1998008528A1 (en) | 1996-08-30 | 1998-03-05 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
US5968903A (en) | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
WO1999058571A2 (de) | 1998-05-13 | 1999-11-18 | BioteCon Gesellschaft für Biotechnologische Entwicklung und Consulting mbH | Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung |
DK1098664T3 (da) | 1998-07-22 | 2003-11-17 | Osprey Pharmaceuticals Ltd | Sammensætninger og deres anvendelser til at behandle sekundær vævsskade og andre inflammatoriske tilstande og forstyrrelser |
JP2002521456A (ja) | 1998-07-30 | 2002-07-16 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | ソマトスタチン類似体の使用法 |
US20040071736A1 (en) * | 1998-08-25 | 2004-04-15 | Health Protection Agency | Methods and compounds for the treatment of mucus hypersecretion |
GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
US6057422A (en) | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
US6776990B2 (en) | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
CA2376506C (en) | 1999-06-04 | 2014-07-22 | Dean Sadat-Aalaee | Neuromedin b and somatostatin receptor agonists |
CA2380457A1 (en) * | 1999-08-25 | 2001-03-01 | Allergan Sales, Inc. | Activatable recombinant neurotoxins |
US20080032931A1 (en) * | 1999-08-25 | 2008-02-07 | Steward Lance E | Activatable clostridial toxins |
GB9922554D0 (en) * | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
US20030180289A1 (en) * | 1999-09-23 | 2003-09-25 | Foster Keith Alan | Inhibition of secretion from non-neuronal cells |
US7838008B2 (en) * | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
US6831059B2 (en) * | 2000-10-20 | 2004-12-14 | Allergan, Inc. | Compositions and methods for treating gonadotrophin related illnesses |
US6827931B1 (en) * | 2000-10-20 | 2004-12-07 | Allergan, Inc. | Method for treating endocrine disorders |
US20060153876A1 (en) * | 2003-02-24 | 2006-07-13 | Ira Sanders | Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease |
TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
EP1784420B1 (en) * | 2004-09-01 | 2008-12-03 | Allergan, Inc. | Degradable clostridial toxins |
GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
GB0426397D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
CA2595115C (en) * | 2004-12-01 | 2014-01-21 | Health Protection Agency | Fusion proteins for treating, preventing or ameliorating pain |
US8399400B2 (en) * | 2004-12-01 | 2013-03-19 | Syntaxin, Ltd. | Fusion proteins |
WO2006099590A2 (en) * | 2005-03-15 | 2006-09-21 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
DK2154151T3 (da) | 2005-09-19 | 2011-09-05 | Allergan Inc | Clostridiumtoksinaktiverbare clostridiumtoksiner |
EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
EP2038299A2 (en) | 2006-07-11 | 2009-03-25 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for non-clostridial toxin target cells |
EP2038298A2 (en) * | 2006-07-11 | 2009-03-25 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells |
JP5799397B2 (ja) * | 2008-06-12 | 2015-10-28 | イプセン・バイオイノベーション・リミテッドIpsen Bioinnovation Limited | 癌の抑制 |
EP2719392B1 (en) * | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
US10057187B1 (en) | 2015-05-27 | 2018-08-21 | Amazon Technologies, Inc. | Dynamic resource creation to connect client resources in a distributed system |
-
2009
- 2009-06-11 EP EP13179177.4A patent/EP2719392B1/en active Active
- 2009-06-11 AU AU2009259033A patent/AU2009259033B2/en not_active Ceased
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