JP2013507351A5 - - Google Patents
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- JP2013507351A5 JP2013507351A5 JP2012532676A JP2012532676A JP2013507351A5 JP 2013507351 A5 JP2013507351 A5 JP 2013507351A5 JP 2012532676 A JP2012532676 A JP 2012532676A JP 2012532676 A JP2012532676 A JP 2012532676A JP 2013507351 A5 JP2013507351 A5 JP 2013507351A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pyrazol
- phenyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000020167 Calcium release-activated calcium channel Human genes 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
- 108091022898 Calcium release-activated calcium channel Proteins 0.000 claims description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 8
- 229940002612 prodrug Drugs 0.000 claims description 8
- 239000000651 prodrug Substances 0.000 claims description 8
- 108091006146 Channels Proteins 0.000 claims description 7
- 101150060735 orai1 gene Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 101150105461 Stim1 gene Proteins 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 2
- -1 nitro, hydroxy Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 17
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 229920006395 saturated elastomer Polymers 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 150000001204 N-oxides Chemical class 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 101100043696 Drosophila melanogaster Stim gene Proteins 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 6
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 102100039319 Calcium release-activated calcium channel protein 1 Human genes 0.000 claims 3
- 101000745520 Homo sapiens Calcium release-activated calcium channel protein 1 Proteins 0.000 claims 3
- 101150066814 Orai3 gene Proteins 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 150000003857 carboxamides Chemical class 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- VTHOULHKCFBBGL-UHFFFAOYSA-N n-[4-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)thieno[2,3-c]pyrazole-5-carboxamide Chemical compound S1C=2N(C)N=C(C(F)(F)F)C=2C=C1C(=O)NC(C=C1)=CC=C1N1N=C(C(F)(F)F)C=C1C1CC1 VTHOULHKCFBBGL-UHFFFAOYSA-N 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- DKFYJQLJWMQVNV-UHFFFAOYSA-N 2-(benzimidazol-1-yl)-n-[4-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide Chemical compound C=1C=C(NC(=O)CN2C3=CC=CC=C3N=C2)C=CC=1N1N=C(C(F)(F)F)C=C1C1CC1 DKFYJQLJWMQVNV-UHFFFAOYSA-N 0.000 claims 1
- UNHGMHPBBDOIDD-UHFFFAOYSA-N C1(CC1)C1=NN(C(=C1)C1CC1)C1=CC=C(C=N1)NC(=O)C=1C=C2N=CC=NC2=CC1.C1(CC1)C1=NN(C(=C1)C1CC1)C1=CC=C(C=N1)NC(=O)C=1C=C2C=CC=NC2=CC1 Chemical compound C1(CC1)C1=NN(C(=C1)C1CC1)C1=CC=C(C=N1)NC(=O)C=1C=C2N=CC=NC2=CC1.C1(CC1)C1=NN(C(=C1)C1CC1)C1=CC=C(C=N1)NC(=O)C=1C=C2C=CC=NC2=CC1 UNHGMHPBBDOIDD-UHFFFAOYSA-N 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- 102100025027 E3 ubiquitin-protein ligase TRIM69 Human genes 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 101000830203 Homo sapiens E3 ubiquitin-protein ligase TRIM69 Proteins 0.000 claims 1
- WCQJVTYUCIYDSU-UHFFFAOYSA-N N1=CC=NC2=CC(=CC=C12)C(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1CC1)C1CC1.N1=CC=CC2=CC(=CC=C12)C(=O)N Chemical compound N1=CC=NC2=CC(=CC=C12)C(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1CC1)C1CC1.N1=CC=CC2=CC(=CC=C12)C(=O)N WCQJVTYUCIYDSU-UHFFFAOYSA-N 0.000 claims 1
- 102000004094 Stromal Interaction Molecule 1 Human genes 0.000 claims 1
- 108090000532 Stromal Interaction Molecule 1 Proteins 0.000 claims 1
- 108010030731 Stromal Interaction Molecule 2 Proteins 0.000 claims 1
- 102100035562 Stromal interaction molecule 2 Human genes 0.000 claims 1
- 125000000848 adenin-9-yl group Chemical group [H]N([H])C1=C2N=C([H])N(*)C2=NC([H])=N1 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940000406 drug candidate Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- RVVCOHUMRKGYOQ-UHFFFAOYSA-N n-[4-(3,5-dicyclopropylpyrazol-1-yl)phenyl]-2-imidazo[1,2-a]pyridin-2-ylacetamide;hydrochloride Chemical compound Cl.C=1N2C=CC=CC2=NC=1CC(=O)NC(C=C1)=CC=C1N1N=C(C2CC2)C=C1C1CC1 RVVCOHUMRKGYOQ-UHFFFAOYSA-N 0.000 claims 1
- JHUUUHBVXPRICU-UHFFFAOYSA-N n-[4-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]quinoxaline-6-carboxamide Chemical compound C=1C=C(NC(=O)C=2C=C3N=CC=NC3=CC=2)C=CC=1N1N=C(C(F)(F)F)C=C1C1CC1 JHUUUHBVXPRICU-UHFFFAOYSA-N 0.000 claims 1
- JVIJYZBGJKPMAQ-UHFFFAOYSA-N n-[6-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]pyridin-3-yl]-2h-benzotriazole-5-carboxamide Chemical compound C=1C=C(NC(=O)C=2C=C3N=NNC3=CC=2)C=NC=1N1N=C(C(F)(F)F)C=C1C1CC1 JVIJYZBGJKPMAQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 150000001669 calcium Chemical class 0.000 description 2
- JGUMDUSKGJDSFG-UHFFFAOYSA-N 5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide Chemical class CN1N=C(C(F)(F)F)C=C1C1=CC=C(C(N)=O)S1 JGUMDUSKGJDSFG-UHFFFAOYSA-N 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2439/CHE/2009 | 2009-10-08 | ||
| IN2439CH2009 | 2009-10-08 | ||
| IN2636/CHE/2009 | 2009-10-30 | ||
| IN2636CH2009 | 2009-10-30 | ||
| US26554009P | 2009-12-01 | 2009-12-01 | |
| US61/265,540 | 2009-12-01 | ||
| IN158CH2010 | 2010-01-25 | ||
| IN158/CHE/2010 | 2010-01-25 | ||
| IN1513CH2010 | 2010-06-02 | ||
| IN1514/CHE/2010 | 2010-06-02 | ||
| IN1513/CHE/2010 | 2010-06-02 | ||
| IN1514CH2010 | 2010-06-02 | ||
| IN2385/CHE/2010 | 2010-08-19 | ||
| IN2385CH2010 | 2010-08-19 | ||
| PCT/IB2010/002539 WO2011042798A1 (en) | 2009-10-08 | 2010-10-07 | Pyrazoles derivatives modulators of calcium release -activated calcium channel and methods for treatment of non- small cell lung cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160031A Division JP6266568B2 (ja) | 2009-10-08 | 2015-08-14 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507351A JP2013507351A (ja) | 2013-03-04 |
| JP2013507351A5 true JP2013507351A5 (https=) | 2013-11-14 |
| JP5909312B2 JP5909312B2 (ja) | 2016-04-26 |
Family
ID=43447834
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532676A Expired - Fee Related JP5909312B2 (ja) | 2009-10-08 | 2010-10-07 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
| JP2015160031A Expired - Fee Related JP6266568B2 (ja) | 2009-10-08 | 2015-08-14 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
| JP2017243778A Pending JP2018080176A (ja) | 2009-10-08 | 2017-12-20 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160031A Expired - Fee Related JP6266568B2 (ja) | 2009-10-08 | 2015-08-14 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
| JP2017243778A Pending JP2018080176A (ja) | 2009-10-08 | 2017-12-20 | カルシウム放出依存性カルシウムチャネルのピラゾール誘導体モジュレータおよび非小細胞肺癌の治療方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8993612B2 (https=) |
| EP (1) | EP2509974B1 (https=) |
| JP (3) | JP5909312B2 (https=) |
| CN (3) | CN104788430B (https=) |
| CA (1) | CA2784277C (https=) |
| DK (1) | DK2509974T3 (https=) |
| EA (1) | EA025302B8 (https=) |
| ES (1) | ES2676317T3 (https=) |
| HR (1) | HRP20181014T1 (https=) |
| HU (1) | HUE039261T2 (https=) |
| LT (1) | LT2509974T (https=) |
| PL (1) | PL2509974T3 (https=) |
| RS (1) | RS57441B1 (https=) |
| SI (1) | SI2509974T1 (https=) |
| SM (1) | SMT201800361T1 (https=) |
| TR (1) | TR201809711T4 (https=) |
| WO (1) | WO2011042798A1 (https=) |
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| US8377970B2 (en) * | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| US8993612B2 (en) * | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| AU2011248579A1 (en) | 2010-04-27 | 2012-11-29 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
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| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2609095A4 (en) | 2010-08-27 | 2014-06-18 | Calcimedica Inc | COMPOUNDS MODULATING INTRACELLULAR CALCIUM |
| US20120316182A1 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US20140242099A1 (en) * | 2011-10-28 | 2014-08-28 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| CN102433383B (zh) * | 2011-12-19 | 2015-07-08 | 上海吉凯基因化学技术有限公司 | 人stim1基因的用途及其相关药物 |
| WO2014059333A1 (en) | 2012-10-12 | 2014-04-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| US10130609B2 (en) | 2013-03-13 | 2018-11-20 | University Health Network | Pyrazole derivatives and their uses thereof |
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| EP2865758A1 (en) | 2013-10-22 | 2015-04-29 | Sylentis, S.A.U. | siRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene |
| JP6195684B2 (ja) * | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| EP2982982B1 (en) * | 2014-08-06 | 2017-10-04 | Université de Bretagne Occidentale (U.B.O.) | Method of screening of compounds using membrane STIM1 |
| HUE046914T2 (hu) | 2014-10-08 | 2020-04-28 | Redx Pharma Plc | N-piridinil-acetamid-származékok, mint a WNT jelátviteli út inhibitorai |
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| ES2825798T3 (es) * | 2015-01-13 | 2021-05-17 | Vivreon Biosciences Llc | Moduladores de canales de Ca2+ activados por liberación de Ca2+ (CRAC) y usos farmacéuticos de los mismos |
| ES3033759T3 (en) * | 2015-02-27 | 2025-08-07 | Calcimedica Inc | Pancreatitis treatment |
| CN108026050B (zh) * | 2015-08-03 | 2021-04-30 | 格兰马克药品股份有限公司 | 作为RORγ调节剂的新型化合物 |
| CA2995094A1 (en) | 2015-08-07 | 2017-02-16 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
| ITUA20164199A1 (it) | 2016-06-08 | 2017-12-08 | Univ Degli Studi Del Piemonte Orientale Amedeo Avogadro | Modulatori di soce compisizioni e relativi usi |
| MA47409A (fr) | 2017-02-06 | 2019-12-11 | Idorsia Pharmaceuticals Ltd | Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes |
| CN107475299A (zh) * | 2017-09-13 | 2017-12-15 | 信雅生物科技（苏州）有限公司 | 研究stim1基因在非小细胞肺癌中发挥作用的方法及其应用 |
| US20200237743A1 (en) | 2017-10-17 | 2020-07-30 | Rhizen Pharmaceuticals Sa | Crac channel modulators for treating esophageal cancer |
| WO2019082124A1 (en) * | 2017-10-26 | 2019-05-02 | Rhizen Pharmaceuticals Sa | COMPOSITION AND METHOD FOR THE TREATMENT OF LARGE B-CELL DIFFUSED LYMPHOMA |
| AU2018360367A1 (en) * | 2017-10-30 | 2020-05-28 | Rhizen Pharmaceuticals Sa | Calcium release-activated calcium channel modulators for treating hematological and solid cancers |
| SG11202102491RA (en) | 2018-09-14 | 2021-04-29 | Rhizen Pharmaceuticals A G | Compositions comprising a crac inhibitor and a corticosteroid and methods of use thereof |
| AU2019370200B2 (en) | 2018-10-30 | 2024-12-19 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
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-
2010
- 2010-10-06 US US12/899,410 patent/US8993612B2/en not_active Expired - Fee Related
- 2010-10-07 WO PCT/IB2010/002539 patent/WO2011042798A1/en not_active Ceased
- 2010-10-07 CN CN201510114126.6A patent/CN104788430B/zh not_active Expired - Fee Related
- 2010-10-07 CN CN201910890829.6A patent/CN110627724A/zh active Pending
- 2010-10-07 SI SI201031711T patent/SI2509974T1/en unknown
- 2010-10-07 TR TR2018/09711T patent/TR201809711T4/tr unknown
- 2010-10-07 PL PL10776149T patent/PL2509974T3/pl unknown
- 2010-10-07 LT LTEP10776149.6T patent/LT2509974T/lt unknown
- 2010-10-07 CA CA2784277A patent/CA2784277C/en not_active Expired - Fee Related
- 2010-10-07 CN CN201080055388.5A patent/CN102958925B/zh not_active Expired - Fee Related
- 2010-10-07 EA EA201290139A patent/EA025302B8/ru unknown
- 2010-10-07 DK DK10776149.6T patent/DK2509974T3/en active
- 2010-10-07 EP EP10776149.6A patent/EP2509974B1/en active Active
- 2010-10-07 HR HRP20181014TT patent/HRP20181014T1/hr unknown
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- 2010-10-07 ES ES10776149.6T patent/ES2676317T3/es active Active
- 2010-10-07 SM SM20180361T patent/SMT201800361T1/it unknown
- 2010-10-07 RS RS20180791A patent/RS57441B1/sr unknown
- 2010-10-07 JP JP2012532676A patent/JP5909312B2/ja not_active Expired - Fee Related
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