JP2013503861A5 - - Google Patents
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- Publication number
- JP2013503861A5 JP2013503861A5 JP2012527868A JP2012527868A JP2013503861A5 JP 2013503861 A5 JP2013503861 A5 JP 2013503861A5 JP 2012527868 A JP2012527868 A JP 2012527868A JP 2012527868 A JP2012527868 A JP 2012527868A JP 2013503861 A5 JP2013503861 A5 JP 2013503861A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorobenzoyl
- dichlorobenzyl
- triazole
- dichloro
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58444809A | 2009-09-04 | 2009-09-04 | |
| US12/584,448 | 2009-09-04 | ||
| PCT/US2010/002430 WO2011028288A1 (en) | 2009-09-04 | 2010-09-03 | Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
| US12/807,415 US8377973B2 (en) | 2009-09-04 | 2010-09-03 | Compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
| US12/807,415 | 2010-09-03 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015215891A Division JP2016026213A (ja) | 2009-09-04 | 2015-11-02 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503861A JP2013503861A (ja) | 2013-02-04 |
| JP2013503861A5 true JP2013503861A5 (https=) | 2013-10-10 |
Family
ID=43648255
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527868A Pending JP2013503861A (ja) | 2009-09-04 | 2010-09-03 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
| JP2015215891A Pending JP2016026213A (ja) | 2009-09-04 | 2015-11-02 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
| JP2017150532A Pending JP2017203038A (ja) | 2009-09-04 | 2017-08-03 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
| JP2020014827A Pending JP2020105178A (ja) | 2009-09-04 | 2020-01-31 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015215891A Pending JP2016026213A (ja) | 2009-09-04 | 2015-11-02 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
| JP2017150532A Pending JP2017203038A (ja) | 2009-09-04 | 2017-08-03 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
| JP2020014827A Pending JP2020105178A (ja) | 2009-09-04 | 2020-01-31 | 新規の組成物、ならびに５−アミノまたは置換アミノ１，２，３−トリアゾールおよびトリアゾールオロチン酸塩製剤を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8377973B2 (https=) |
| EP (2) | EP2473051B1 (https=) |
| JP (4) | JP2013503861A (https=) |
| KR (1) | KR101597338B1 (https=) |
| CN (2) | CN104817507A (https=) |
| AP (1) | AP3345A (https=) |
| AU (1) | AU2010290049B2 (https=) |
| BR (1) | BR112012004539A2 (https=) |
| CA (1) | CA2772075C (https=) |
| CL (1) | CL2012000582A1 (https=) |
| HK (1) | HK1212983A1 (https=) |
| IL (1) | IL218430A0 (https=) |
| MX (2) | MX2012002730A (https=) |
| MY (1) | MY159430A (https=) |
| NZ (2) | NZ598482A (https=) |
| PH (1) | PH12015502088A1 (https=) |
| RU (1) | RU2594155C2 (https=) |
| SG (1) | SG178413A1 (https=) |
| WO (1) | WO2011028288A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877785B2 (en) * | 2009-09-04 | 2014-11-04 | Tactical Therapeutics Inc | Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate |
| US9089570B2 (en) * | 2010-09-03 | 2015-07-28 | Tactical Therapeutics Inc | Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate |
| US10378059B2 (en) * | 2013-08-02 | 2019-08-13 | Tactical Therapeutics, Inc. | Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate |
| KR102623581B1 (ko) * | 2016-07-18 | 2024-01-11 | 일동제약(주) | 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물 |
| CN112083109B (zh) * | 2019-07-08 | 2021-05-25 | 广东银珠医药科技有限公司 | 羧胺三唑杂质及其制备方法和检测方法 |
| US20220168276A1 (en) * | 2020-08-05 | 2022-06-02 | Tactical Therapeotics Inc. | Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate |
| CN112358451B (zh) * | 2021-01-11 | 2021-04-13 | 广东银珠医药科技有限公司 | 羧胺三唑的合成方法 |
| CN113582935A (zh) * | 2021-08-27 | 2021-11-02 | 中国医学科学院放射医学研究所 | 一种炎症小体核苷酸结合寡聚化结构域样受体蛋白3抑制剂及其制备方法和应用 |
| CN113620892B (zh) * | 2021-10-12 | 2022-02-22 | 广东银珠医药科技有限公司 | 羧胺三唑单晶、制备方法及其组合物和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2415740C2 (de) | 1974-04-01 | 1983-12-01 | Servomed Arznei GmbH & Co Pharma KG, 8000 München | Verwendung von Orotsäure bei der analgetischen Behandlung mit Dextropropoxyphen, Natriumsalicylat oder Metamizol |
| US4590201A (en) | 1984-02-02 | 1986-05-20 | Merck & Co., Inc. | 5-amino or substituted amino 1,2,3-triazoles |
| US4847257A (en) * | 1987-08-20 | 1989-07-11 | Merck & Co., Inc. | 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents |
| JPH0356417A (ja) * | 1989-05-08 | 1991-03-12 | Merck & Co Inc | 抗転移剤として有用な５―アミノ又は置換アミノ１，２，３―トリアゾール類 |
| US5132315A (en) * | 1989-05-19 | 1992-07-21 | The United States Of America As Represented By The Department Of Health And Human Services | Therapeutic application of an anti-invasive compound |
| US5359078A (en) * | 1989-05-19 | 1994-10-25 | The United States Of America As Represented By The Department Of Health And Human Services | Signal transduction inhibitor compounds |
| CA2575902C (en) | 1995-07-21 | 2010-06-08 | Tactical Therapeutics Inc | Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide |
| US5728707A (en) * | 1995-07-21 | 1998-03-17 | Constantia Gruppe | Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide |
| TW403740B (en) * | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| WO2005116024A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections |
| US8034823B2 (en) * | 2005-02-22 | 2011-10-11 | Savvipharm Inc | Method of increasing drug oral bioavailability and compositions of less toxic orotate salts |
| KR20100059919A (ko) * | 2007-09-24 | 2010-06-04 | 코멘티스, 인코포레이티드 | 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물 |
| US20150323994A1 (en) * | 2014-05-07 | 2015-11-12 | Immersion Corporation | Dynamic haptic effect modification |
| JP2017150532A (ja) * | 2016-02-23 | 2017-08-31 | Ntn株式会社 | 回転伝達装置 |
-
2010
- 2010-09-03 MX MX2012002730A patent/MX2012002730A/es active IP Right Grant
- 2010-09-03 KR KR1020127008653A patent/KR101597338B1/ko active Active
- 2010-09-03 AP AP2012006187A patent/AP3345A/xx active
- 2010-09-03 MY MYPI2012000629A patent/MY159430A/en unknown
- 2010-09-03 RU RU2012111454/04A patent/RU2594155C2/ru active
- 2010-09-03 JP JP2012527868A patent/JP2013503861A/ja active Pending
- 2010-09-03 EP EP10814093.0A patent/EP2473051B1/en active Active
- 2010-09-03 AU AU2010290049A patent/AU2010290049B2/en active Active
- 2010-09-03 CN CN201510116934.6A patent/CN104817507A/zh active Pending
- 2010-09-03 CA CA2772075A patent/CA2772075C/en active Active
- 2010-09-03 CN CN201080050000.2A patent/CN102595904B/zh active Active
- 2010-09-03 WO PCT/US2010/002430 patent/WO2011028288A1/en not_active Ceased
- 2010-09-03 SG SG2012010294A patent/SG178413A1/en unknown
- 2010-09-03 NZ NZ598482A patent/NZ598482A/en unknown
- 2010-09-03 EP EP15178128.3A patent/EP2963023B1/en active Active
- 2010-09-03 US US12/807,415 patent/US8377973B2/en active Active
- 2010-09-03 BR BR112012004539-3A patent/BR112012004539A2/pt not_active Application Discontinuation
-
2012
- 2012-03-01 IL IL218430A patent/IL218430A0/en unknown
- 2012-03-02 CL CL2012000582A patent/CL2012000582A1/es unknown
- 2012-03-02 MX MX2014012090A patent/MX355198B/es unknown
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2013
- 2013-02-27 NZ NZ624636A patent/NZ624636A/en unknown
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2015
- 2015-09-11 PH PH12015502088A patent/PH12015502088A1/en unknown
- 2015-11-02 JP JP2015215891A patent/JP2016026213A/ja active Pending
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2016
- 2016-01-29 HK HK16101046.4A patent/HK1212983A1/zh unknown
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2017
- 2017-08-03 JP JP2017150532A patent/JP2017203038A/ja active Pending
-
2020
- 2020-01-31 JP JP2020014827A patent/JP2020105178A/ja active Pending