JP2010533166A5 - - Google Patents
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- Publication number
- JP2010533166A5 JP2010533166A5 JP2010515728A JP2010515728A JP2010533166A5 JP 2010533166 A5 JP2010533166 A5 JP 2010533166A5 JP 2010515728 A JP2010515728 A JP 2010515728A JP 2010515728 A JP2010515728 A JP 2010515728A JP 2010533166 A5 JP2010533166 A5 JP 2010533166A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- prophylactic
- active ingredient
- therapeutic agent
- fatty liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005606 carbostyryl group Chemical group 0.000 claims 1
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical group C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010515728A JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007181760 | 2007-07-11 | ||
| JP2007181760 | 2007-07-11 | ||
| JP2010515728A JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
| PCT/JP2008/062771 WO2009008539A1 (en) | 2007-07-11 | 2008-07-09 | Carbostyril derivatives including cilostazol for treating fatty liver |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014115759A Division JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533166A JP2010533166A (ja) | 2010-10-21 |
| JP2010533166A5 true JP2010533166A5 (https=) | 2011-05-19 |
| JP5558348B2 JP5558348B2 (ja) | 2014-07-23 |
Family
ID=39689465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515728A Expired - Fee Related JP5558348B2 (ja) | 2007-07-11 | 2008-07-09 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
| JP2014115759A Withdrawn JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014115759A Withdrawn JP2014185161A (ja) | 2007-07-11 | 2014-06-04 | シロスタゾールを含むカルボスチリル誘導体の脂肪肝治療剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8642618B2 (https=) |
| EP (1) | EP2162134A1 (https=) |
| JP (2) | JP5558348B2 (https=) |
| KR (2) | KR20100046188A (https=) |
| CN (1) | CN101778630A (https=) |
| AR (1) | AR067446A1 (https=) |
| CA (1) | CA2691632A1 (https=) |
| TW (1) | TW200908973A (https=) |
| WO (1) | WO2009008539A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101094934B1 (ko) * | 2010-10-22 | 2011-12-15 | 영남대학교 산학협력단 | 실로스타졸을 유효성분으로 함유하는 알코올성 간질환 치료 또는 예방용 약학조성물 |
| EP3263705A1 (en) * | 2016-06-28 | 2018-01-03 | DKFZ Deutsches Krebsforschungszentrum | Treatments of non-alcoholic steatohepatitis (nash) |
| US11207387B2 (en) | 2016-12-15 | 2021-12-28 | Talengen International Limited | Method and drug for preventing and treating obesity |
| WO2018107688A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗脂肪肝的方法 |
| WO2018107707A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种改善心脏病变的方法 |
| CA3212293A1 (en) * | 2021-05-11 | 2022-11-17 | Regeneron Pharmaceuticals, Inc. | Methods of treating liver diseases with phosphodiesterase 3b (pde3b) inhibitors |
| JP2024531507A (ja) * | 2021-08-31 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃａｍｐ応答性エレメント結合タンパク質３様３（ｃｒｅｂ３ｌ３）阻害剤による肝疾患の治療 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3944257B2 (ja) | 1995-12-07 | 2007-07-11 | 大塚製薬株式会社 | 肝実質細胞増殖因子産生増加剤 |
-
2008
- 2008-07-03 AR ARP080102879A patent/AR067446A1/es unknown
- 2008-07-09 US US12/667,875 patent/US8642618B2/en not_active Expired - Fee Related
- 2008-07-09 WO PCT/JP2008/062771 patent/WO2009008539A1/en not_active Ceased
- 2008-07-09 CA CA002691632A patent/CA2691632A1/en not_active Abandoned
- 2008-07-09 EP EP08791177A patent/EP2162134A1/en not_active Withdrawn
- 2008-07-09 KR KR1020107002982A patent/KR20100046188A/ko not_active Abandoned
- 2008-07-09 JP JP2010515728A patent/JP5558348B2/ja not_active Expired - Fee Related
- 2008-07-09 KR KR20157007589A patent/KR20150038739A/ko not_active Ceased
- 2008-07-09 CN CN200880024072A patent/CN101778630A/zh active Pending
- 2008-07-10 TW TW097126022A patent/TW200908973A/zh unknown
-
2013
- 2013-12-24 US US14/140,179 patent/US20140121241A1/en not_active Abandoned
-
2014
- 2014-06-04 JP JP2014115759A patent/JP2014185161A/ja not_active Withdrawn
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