JP2013503192A5 - - Google Patents
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- Publication number
- JP2013503192A5 JP2013503192A5 JP2012527033A JP2012527033A JP2013503192A5 JP 2013503192 A5 JP2013503192 A5 JP 2013503192A5 JP 2012527033 A JP2012527033 A JP 2012527033A JP 2012527033 A JP2012527033 A JP 2012527033A JP 2013503192 A5 JP2013503192 A5 JP 2013503192A5
- Authority
- JP
- Japan
- Prior art keywords
- residues
- antigen
- binding fragment
- monoclonal antibody
- mip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23801509P | 2009-08-28 | 2009-08-28 | |
| US61/238,015 | 2009-08-28 | ||
| PCT/US2010/047004 WO2011025962A1 (en) | 2009-08-28 | 2010-08-27 | Antikine antibodies that bind to multiple cc chemokines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016011829A Division JP2016135783A (ja) | 2009-08-28 | 2016-01-25 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013503192A JP2013503192A (ja) | 2013-01-31 |
| JP2013503192A5 true JP2013503192A5 (https=) | 2013-09-19 |
| JP6109571B2 JP6109571B2 (ja) | 2017-04-05 |
Family
ID=43628404
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527033A Active JP6109571B2 (ja) | 2009-08-28 | 2010-08-27 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
| JP2016011829A Pending JP2016135783A (ja) | 2009-08-28 | 2016-01-25 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016011829A Pending JP2016135783A (ja) | 2009-08-28 | 2016-01-25 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8313747B2 (https=) |
| EP (1) | EP2470671B1 (https=) |
| JP (2) | JP6109571B2 (https=) |
| KR (1) | KR101778813B1 (https=) |
| CN (1) | CN102782148B (https=) |
| AU (1) | AU2010286516B2 (https=) |
| BR (1) | BR112012004387A2 (https=) |
| CA (1) | CA2771781C (https=) |
| DK (1) | DK2470671T3 (https=) |
| ES (1) | ES2531561T3 (https=) |
| HR (1) | HRP20150162T1 (https=) |
| IN (1) | IN2012DN01769A (https=) |
| MX (1) | MX2012002427A (https=) |
| PL (1) | PL2470671T3 (https=) |
| PT (1) | PT2470671E (https=) |
| SI (1) | SI2470671T1 (https=) |
| SM (1) | SMT201500011B (https=) |
| WO (1) | WO2011025962A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2470671B1 (en) * | 2009-08-28 | 2014-12-24 | Regeneron Pharmaceuticals, Inc. | Antikine antibodies that bind to multiple cc chemokines |
| ES2800316T3 (es) * | 2011-06-13 | 2020-12-29 | Tla Targeted Immunotherapies Ab | Tratamiento del cáncer |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| EP2763540A4 (en) * | 2011-09-09 | 2015-04-22 | Univ Yale | COMPOSITIONS AND METHODS FOR THE EVALUATION AND TREATMENT OF INFLAMMATORY DISEASES AND DISEASES |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| TWI612059B (zh) * | 2013-03-15 | 2018-01-21 | 美國禮來大藥廠 | 泛－ＥＬＲ<sup>＋</sup>ＣＸＣ趨化因子抗體 |
| AU2014268316B2 (en) * | 2013-05-23 | 2019-10-10 | Takeda Pharmaceutical Company Limited | Anti-CCL2 and anti-LOXL2 combination therapy for treatment of scleroderma |
| JP6220222B2 (ja) * | 2013-10-28 | 2017-10-25 | シスメックス株式会社 | 関節リウマチの診断を補助するための方法、システム及びコンピュータプログラム製品 |
| NZ720769A (en) * | 2013-12-09 | 2022-10-28 | Allakos Inc | Anti-siglec-8 antibodies and methods of use thereof |
| DK3110446T3 (da) | 2014-02-28 | 2022-02-28 | Allakos Inc | Fremgangsmåder og sammensætninger til behandling af Siglec-8-associerede sygdomme |
| US10246508B2 (en) * | 2014-03-04 | 2019-04-02 | Chemomab Ltd. | Anti eotaxin-2 antibodies that recognize additional CCR3-binding chemokines |
| CN104198727A (zh) * | 2014-08-22 | 2014-12-10 | 广西南宁隆吉维特生物科技有限公司 | 人血清ccl2酶联免疫检测试剂盒及其制备和使用方法 |
| TWI566780B (zh) * | 2014-10-24 | 2017-01-21 | 國立陽明大學 | 巨噬細胞發炎蛋白－１β（ＭＩＰ－１β）抑制劑用於促進血管新生以改善組織缺血及糖尿病血管病變的用途 |
| CN113412818B (zh) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2018159787A1 (ja) * | 2017-03-01 | 2018-09-07 | 国立大学法人北海道大学 | 疾患モデル非ヒト動物の製造方法、疾患モデル非ヒト動物、該動物を用いた薬剤のスクリーニング方法及び疾患リスク判定方法 |
| KR102009040B1 (ko) * | 2017-04-05 | 2019-08-08 | 한국생명공학연구원 | Nk 세포 활성화 융합 단백질, nk 세포 및 이들을 포함하는 약제학적 조성물 |
| EP3618868A4 (en) | 2017-05-05 | 2021-02-24 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING ALLERGIC EYE DISEASES |
| WO2019037067A1 (zh) * | 2017-08-25 | 2019-02-28 | 法玛科技顾问股份有限公司 | 巨噬细胞发炎蛋白-1β(MIP-1β)抑制剂用以治疗及控管动脉粥状硬化的用途 |
| EP3694887A4 (en) | 2017-10-13 | 2022-02-23 | A & G Pharmaceutical, Inc. | MONOCLONAL ANTIBODIES AND CONJUGATES TO PROSTAGLANDIN F2 RECEPTOR INHIBITOR AND USES THEREOF |
| US11891439B2 (en) | 2017-12-28 | 2024-02-06 | Astute Medical, Inc. | Antibodies and assays for CCL14 |
| WO2019165397A1 (en) * | 2018-02-26 | 2019-08-29 | Cornell University | Quantitative biomarkers of ehv-1 susceptibility and protection |
| CA3099974A1 (en) * | 2018-05-11 | 2019-11-14 | Halcyon Therapeutics, Inc. | Binding proteins and chimeric antigen receptor t cells targeting gasp-1 granules and uses thereof |
| EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN110117329B (zh) * | 2019-04-03 | 2020-12-08 | 河北浓孚雨生物科技有限公司 | 包含趋化因子与结合伴侣的融合多肽及其用途 |
| CN114341178B (zh) * | 2019-07-02 | 2024-05-07 | 机敏医药股份有限公司 | Ccl14的抗体和检测 |
| KR102489282B1 (ko) * | 2019-07-02 | 2023-01-17 | 고려대학교 산학협력단 | Ccl4, ccl5, ccl20, 및 ccl21을 유효성분으로 포함하는 임신촉진용 조성물 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN113893331B (zh) * | 2020-07-06 | 2024-11-26 | 中国农业科学院特产研究所 | 一种诱导母鹿生茸的产品及其制备方法和诱导母鹿生茸的方法和应用 |
| WO2022011110A2 (en) * | 2020-07-08 | 2022-01-13 | Georgia Tech Research Corporation | Compositions and methods for the diagnosis and treatment of sars-cov-2 virus infection |
| EP4010378B1 (en) * | 2020-10-16 | 2026-05-06 | LaNova Medicines Limited | Anti-ccr8 monoclonal antibodies and uses thereof |
| CN115598111B (zh) * | 2021-07-08 | 2025-03-25 | 南京大学 | 基于邻位诱导免疫分析的特异性杂交瘤细胞化学发光筛选方法 |
| CN114990073A (zh) * | 2022-05-27 | 2022-09-02 | 河南农业大学 | 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US7018627B1 (en) | 1995-06-07 | 2006-03-28 | Icos Corporation | Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof |
| US6498015B1 (en) * | 1995-06-07 | 2002-12-24 | Icos Corporation | Methods of identifying agents that modulate the binding between MDC and an MDC receptor |
| US6316420B1 (en) * | 1998-07-28 | 2001-11-13 | Technion Research And Development Foundation Ltd. | DNA cytokine vaccines and use of same for protective immunity against multiple sclerosis |
| US6420346B1 (en) * | 2000-02-07 | 2002-07-16 | Rappaport Family Institute For Research In The Medical Sciences | Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis |
| NZ542784A (en) | 2002-08-19 | 2008-07-31 | Astrazeneca Ab | Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof |
| EP1567555A4 (en) * | 2002-11-27 | 2006-06-21 | Biogen Idec Inc | HUMANIZED ANTIBODIES AGAINST CHEMOTOXIC MONOCYTE PROTEINS |
| ATE426613T1 (de) * | 2004-12-21 | 2009-04-15 | Serono Lab | Cc-chemokin-antagonisten |
| ES2453592T3 (es) * | 2007-08-02 | 2014-04-08 | Novimmune Sa | Anticuerpos anti-RANTES y métodos de uso de los mismos |
| EP2470671B1 (en) * | 2009-08-28 | 2014-12-24 | Regeneron Pharmaceuticals, Inc. | Antikine antibodies that bind to multiple cc chemokines |
-
2010
- 2010-08-27 EP EP20100812667 patent/EP2470671B1/en active Active
- 2010-08-27 JP JP2012527033A patent/JP6109571B2/ja active Active
- 2010-08-27 IN IN1769DEN2012 patent/IN2012DN01769A/en unknown
- 2010-08-27 BR BR112012004387A patent/BR112012004387A2/pt active Search and Examination
- 2010-08-27 ES ES10812667.3T patent/ES2531561T3/es active Active
- 2010-08-27 WO PCT/US2010/047004 patent/WO2011025962A1/en not_active Ceased
- 2010-08-27 AU AU2010286516A patent/AU2010286516B2/en active Active
- 2010-08-27 PL PL10812667T patent/PL2470671T3/pl unknown
- 2010-08-27 DK DK10812667T patent/DK2470671T3/en active
- 2010-08-27 US US12/870,573 patent/US8313747B2/en active Active
- 2010-08-27 CN CN201080048961.XA patent/CN102782148B/zh not_active Expired - Fee Related
- 2010-08-27 SI SI201030901T patent/SI2470671T1/sl unknown
- 2010-08-27 PT PT10812667T patent/PT2470671E/pt unknown
- 2010-08-27 HR HRP20150162TT patent/HRP20150162T1/hr unknown
- 2010-08-27 KR KR1020127007885A patent/KR101778813B1/ko not_active Expired - Fee Related
- 2010-08-27 CA CA2771781A patent/CA2771781C/en active Active
- 2010-08-27 MX MX2012002427A patent/MX2012002427A/es active IP Right Grant
-
2012
- 2012-10-22 US US13/657,120 patent/US9005617B2/en active Active
-
2015
- 2015-01-16 SM SM201500011T patent/SMT201500011B/xx unknown
- 2015-02-24 US US14/630,112 patent/US20150166647A1/en not_active Abandoned
-
2016
- 2016-01-25 JP JP2016011829A patent/JP2016135783A/ja active Pending
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