IN2012DN01769A - - Google Patents

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Publication number
IN2012DN01769A
IN2012DN01769A IN1769DEN2012A IN2012DN01769A IN 2012DN01769 A IN2012DN01769 A IN 2012DN01769A IN 1769DEN2012 A IN1769DEN2012 A IN 1769DEN2012A IN 2012DN01769 A IN2012DN01769 A IN 2012DN01769A
Authority
IN
India
Prior art keywords
antikine
mip
antibodies
lß7ccl4
ccl3
Prior art date
Application number
Inventor
Allison Dan
Raport Carol
Original Assignee
Vlst Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlst Corp filed Critical Vlst Corp
Publication of IN2012DN01769A publication Critical patent/IN2012DN01769A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2

Abstract

An antikine antibody binds to two, three, four, five or more CC chemokines, such as RANTES/CCL5, MIP-lα/CCL3, MIP-lß7CCL4, or MCP-1/CCL2. Methods for affinity maturation and humanization of antikine antibodies as well as the production of hybridoma cell lines producing antikine antibodies by sequential immunization are also disclosed.
IN1769DEN2012 2009-08-28 2010-08-27 IN2012DN01769A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23801509P 2009-08-28 2009-08-28
PCT/US2010/047004 WO2011025962A1 (en) 2009-08-28 2010-08-27 Antikine antibodies that bind to multiple cc chemokines

Publications (1)

Publication Number Publication Date
IN2012DN01769A true IN2012DN01769A (en) 2015-06-05

Family

ID=43628404

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1769DEN2012 IN2012DN01769A (en) 2009-08-28 2010-08-27

Country Status (18)

Country Link
US (3) US8313747B2 (en)
EP (1) EP2470671B1 (en)
JP (2) JP6109571B2 (en)
KR (1) KR101778813B1 (en)
CN (1) CN102782148B (en)
AU (1) AU2010286516B2 (en)
BR (1) BR112012004387A2 (en)
CA (1) CA2771781C (en)
DK (1) DK2470671T3 (en)
ES (1) ES2531561T3 (en)
HR (1) HRP20150162T1 (en)
IN (1) IN2012DN01769A (en)
MX (1) MX2012002427A (en)
PL (1) PL2470671T3 (en)
PT (1) PT2470671E (en)
SI (1) SI2470671T1 (en)
SM (1) SMT201500011B (en)
WO (1) WO2011025962A1 (en)

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PL2470671T3 (en) * 2009-08-28 2015-05-29 Regeneron Pharma Antikine antibodies that bind to multiple cc chemokines
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WO2013036290A1 (en) * 2011-09-09 2013-03-14 Yale University Compositions and methods for assessing and treating inflammatory diseases and disorders
KR102134088B1 (en) 2012-08-24 2020-07-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
TWI612059B (en) * 2013-03-15 2018-01-21 美國禮來大藥廠 Pan-elr+ cxc chemokine antibodies
EP2999484B1 (en) * 2013-05-23 2019-09-11 Shire Human Genetic Therapies, Inc. Anti-ccl2 and anti-loxl2 combination therapy for treatment of scleroderma
JP6220222B2 (en) * 2013-10-28 2017-10-25 シスメックス株式会社 Method, system and computer program product for assisting diagnosis of rheumatoid arthritis
KR20230107382A (en) * 2013-12-09 2023-07-14 알라코스 인크. Anti-siglec-8 antibodies and methods of use thereof
US10183996B2 (en) 2014-02-28 2019-01-22 Allakos Inc. Methods and compositions for treating Siglec-8 associated diseases
EP3114139B1 (en) * 2014-03-04 2022-06-15 Chemomab Ltd. Anti eotaxin-2 antibodies that recognize additional ccr3-binding chemokines
CN104198727A (en) * 2014-08-22 2014-12-10 广西南宁隆吉维特生物科技有限公司 Human serum CCL2 enzyme-linked immunosorbent assay kit as well as preparation and use methods thereof
TWI576112B (en) * 2014-10-24 2017-04-01 國立陽明大學 Use of mip-1β inhibitor in protecting pancreatic islet and inhibiting the elevation of blood sugar level in diabetes mellitus
EP3808775B1 (en) 2014-12-09 2024-04-17 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
JP6846362B2 (en) 2015-06-17 2021-03-24 アラコス インコーポレイテッド Methods and Compositions for Treating Fibrous Diseases
US10604577B2 (en) 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
WO2018005519A2 (en) 2016-06-27 2018-01-04 The Regents Of The University Of California Cancer treatment combinations
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JP7122002B2 (en) 2017-03-01 2022-08-19 国立大学法人北海道大学 Method for producing a disease model non-human animal, disease model non-human animal, drug screening method using the animal, and disease risk determination method
US11655306B2 (en) * 2017-04-05 2023-05-23 Korea Research Institute Of Bioscience And Biotechnology NK cell-activating fusion protein, NK cell, and pharmaceutical composition including same
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WO2019037067A1 (en) * 2017-08-25 2019-02-28 法玛科技顾问股份有限公司 APPLICATION OF MACROPHAGE INFLAMMATORY PROTEIN-1β (MIP-1β) INHIBITOR IN TREATMENT AND CONTROL OF ATHEROSCLEROSIS
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Also Published As

Publication number Publication date
CA2771781A1 (en) 2011-03-03
EP2470671B1 (en) 2014-12-24
SMT201500011B (en) 2015-03-05
EP2470671A1 (en) 2012-07-04
KR20120091013A (en) 2012-08-17
CN102782148B (en) 2016-04-20
MX2012002427A (en) 2012-08-03
KR101778813B1 (en) 2017-09-14
US8313747B2 (en) 2012-11-20
AU2010286516B2 (en) 2016-10-06
CN102782148A (en) 2012-11-14
US20110059107A1 (en) 2011-03-10
DK2470671T3 (en) 2015-02-09
JP6109571B2 (en) 2017-04-05
HRP20150162T1 (en) 2015-05-08
AU2010286516A2 (en) 2012-06-14
JP2013503192A (en) 2013-01-31
AU2010286516A1 (en) 2012-03-08
PL2470671T3 (en) 2015-05-29
US20130108640A1 (en) 2013-05-02
CA2771781C (en) 2019-01-15
JP2016135783A (en) 2016-07-28
WO2011025962A1 (en) 2011-03-03
EP2470671A4 (en) 2013-04-03
RU2012111820A (en) 2013-10-10
US20150166647A1 (en) 2015-06-18
PT2470671E (en) 2015-02-05
ES2531561T3 (en) 2015-03-17
US9005617B2 (en) 2015-04-14
SI2470671T1 (en) 2015-04-30
BR112012004387A2 (en) 2015-09-08

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