JP2013503159A5 - - Google Patents

Info

Publication number

JP2013503159A5

JP2013503159A5 JP2012526724A JP2012526724A JP2013503159A5 JP 2013503159 A5 JP2013503159 A5 JP 2013503159A5 JP 2012526724 A JP2012526724 A JP 2012526724A JP 2012526724 A JP2012526724 A JP 2012526724A JP 2013503159 A5 JP2013503159 A5 JP 2013503159A5

Authority

JP

Japan

Prior art keywords

seq

linker

isolated nucleic

pharmaceutical composition

composition

Prior art date

2010-08-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 38
• 150000007523 nucleic acids Chemical class 0.000 claims 30
• 108020004707 nucleic acids Proteins 0.000 claims 26
• 102000039446 nucleic acids Human genes 0.000 claims 26
• 239000000203 mixture Substances 0.000 claims 23
• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 241000282414 Homo sapiens Species 0.000 claims 16
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 9
• 239000002539 nanocarrier Substances 0.000 claims 7
• 229920001184 polypeptide Polymers 0.000 claims 7
• 239000002552 dosage form Substances 0.000 claims 6
• 208000015181 infectious disease Diseases 0.000 claims 5
• 241000588724 Escherichia coli Species 0.000 claims 4
• 108010010378 HLA-DP Antigens Proteins 0.000 claims 4
• 102000015789 HLA-DP Antigens Human genes 0.000 claims 4
• 108010062347 HLA-DQ Antigens Proteins 0.000 claims 4
• 108010058597 HLA-DR Antigens Proteins 0.000 claims 4
• 102000006354 HLA-DR Antigens Human genes 0.000 claims 4
• 230000002458 infectious effect Effects 0.000 claims 4
• 108091005804 Peptidases Proteins 0.000 claims 3
• 239000004365 Protease Substances 0.000 claims 3
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 238000003776 cleavage reaction Methods 0.000 claims 3
• 230000002132 lysosomal effect Effects 0.000 claims 3
• 230000007017 scission Effects 0.000 claims 3
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 241000700605 Viruses Species 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 238000007385 chemical modification Methods 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 201000006082 Chickenpox Diseases 0.000 claims 1
• 241000193449 Clostridium tetani Species 0.000 claims 1
• 241000186227 Corynebacterium diphtheriae Species 0.000 claims 1
• 241000701022 Cytomegalovirus Species 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 241000700721 Hepatitis B virus Species 0.000 claims 1
• 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 1
• 241000598171 Human adenovirus sp. Species 0.000 claims 1
• 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
• 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
• 241000712079 Measles morbillivirus Species 0.000 claims 1
• 241000711386 Mumps virus Species 0.000 claims 1
• 241000714474 Rous sarcoma virus Species 0.000 claims 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
• 206010046980 Varicella Diseases 0.000 claims 1
• 241000700647 Variola virus Species 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
• 150000001336 alkenes Chemical class 0.000 claims 1
• 150000001408 amides Chemical group 0.000 claims 1
• 150000001409 amidines Chemical class 0.000 claims 1
• UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 229920002988 biodegradable polymer Polymers 0.000 claims 1
• 239000004621 biodegradable polymer Substances 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 230000008707 rearrangement Effects 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 241001529453 unidentified herpesvirus Species 0.000 claims 1
• 241000712461 unidentified influenza virus Species 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1