JP2013500302A - Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液 - Google Patents

Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液 Download PDF

Info

Publication number
JP2013500302A
JP2013500302A JP2012522123A JP2012522123A JP2013500302A JP 2013500302 A JP2013500302 A JP 2013500302A JP 2012522123 A JP2012522123 A JP 2012522123A JP 2012522123 A JP2012522123 A JP 2012522123A JP 2013500302 A JP2013500302 A JP 2013500302A
Authority
JP
Japan
Prior art keywords
acid
riboflavin
concentration
essential amino
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012522123A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013500302A5 (enExample
Inventor
トロイシ，サルバトーレ
プレテ，アントニオ デル
カルーソ，シロ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT000052A external-priority patent/ITVA20090052A1/it
Priority claimed from IT000044A external-priority patent/ITVA20100044A1/it
Application filed by Individual filed Critical Individual
Publication of JP2013500302A publication Critical patent/JP2013500302A/ja
Publication of JP2013500302A5 publication Critical patent/JP2013500302A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012522123A 2009-07-27 2010-07-23 Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液 Pending JP2013500302A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITVA2009A000052 2009-07-27
IT000052A ITVA20090052A1 (it) 2009-07-27 2009-07-27 Composizione per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale o per proteggere strutture interne del globo oculare da raggi uv-a
IT000044A ITVA20100044A1 (it) 2010-05-20 2010-05-20 Soluzione oftalmica per proteggere strutture interne del globo oculare da raggi uv-a o per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale
ITVA2010A000044 2010-05-20
PCT/EP2010/060752 WO2011012557A1 (en) 2009-07-27 2010-07-23 Ophthalmic solution for protecting internal structures of the eyeball against uv-a rays or for the treatment of keratoconus with a trans-epithelial cross-linking technique

Publications (2)

Publication Number Publication Date
JP2013500302A true JP2013500302A (ja) 2013-01-07
JP2013500302A5 JP2013500302A5 (enExample) 2013-08-29

Family

ID=42575807

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012522123A Pending JP2013500302A (ja) 2009-07-27 2010-07-23 Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液

Country Status (13)

Country Link
US (1) US9192594B2 (enExample)
EP (1) EP2459186B1 (enExample)
JP (1) JP2013500302A (enExample)
KR (1) KR20120038520A (enExample)
CN (1) CN102470120A (enExample)
AU (1) AU2010277668A1 (enExample)
BR (1) BR112012001998B8 (enExample)
CA (1) CA2805511C (enExample)
ES (1) ES2441227T3 (enExample)
PT (1) PT2459186E (enExample)
RU (1) RU2540481C2 (enExample)
WO (1) WO2011012557A1 (enExample)
ZA (1) ZA201201122B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180030892A (ko) * 2015-07-21 2018-03-26 아베드로 인코퍼레이티드 광증감제로 눈을 치료하기 위한 시스템 및 방법
JP2023502486A (ja) * 2019-11-21 2023-01-24 ビーエフ リサーチ エス．アール．エル ソフトコンタクトレンズおよびソフトコンタクトレンズを収容する包装体
WO2024225436A1 (ja) * 2023-04-28 2024-10-31 株式会社メドレックス 眼科用組成物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US8668727B2 (en) 2011-08-23 2014-03-11 Anthony Natale Systems and methods for treating pathogenic infection
US9023092B2 (en) 2011-08-23 2015-05-05 Anthony Natale Endoscopes enhanced with pathogenic treatment
CN102429767B (zh) * 2011-08-25 2016-03-09 广东福地新视野光电技术有限公司 激光角膜热成形术系统
ITMI20120355A1 (it) * 2012-03-07 2013-09-08 Ciro Caruso Sostanza colorante per uso diagnostico oftalmologico
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
EP2830637B1 (en) 2012-03-29 2024-08-21 Epion Therapeutics, Inc. Compositions and methods for treating or preventing diseases associated with oxidative stress
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
ITRM20130248A1 (it) * 2013-04-24 2014-10-25 Medivis S R L Formulazioni di riboflavina per il cross-linking transepiteliale.
RU2683651C2 (ru) * 2013-06-18 2019-04-01 Иван Дмитриевич Захаров Лекарственное средство для лечения кератоконуса и других дегенеративных заболеваний роговицы и фармацевтические препараты на его основе
US9931199B2 (en) * 2014-05-05 2018-04-03 Roberto Gustavo ALBERTAZZI Methods and apparatus for treating keratoconus
RU2556791C1 (ru) * 2014-06-09 2015-07-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения кератоконуса
WO2018156593A1 (en) * 2017-02-21 2018-08-30 Avedro, Inc. Formulations for eye treatments
IT201900011985A1 (it) * 2019-07-17 2021-01-17 Vision Eng Italy Srl Formulazione liquida, in particolare per trattare un tessuto corneale
CN118845755B (zh) * 2024-08-27 2025-08-15 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) 大豆异黄酮在制备用于治疗圆锥角膜药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037851A2 (en) * 1999-11-25 2001-05-31 Simonelli, Giuseppe Use of ubiquinone q10 for the local treatment and prevention of post-surgical ophthalmologic pathologies
JP2002520281A (ja) * 1998-07-10 2002-07-09 パニン，ジョルジオ 粘膜疾患の局所治療における使用のためのビタミンｅおよびそのエステル
JP2002527391A (ja) * 1998-10-14 2002-08-27 ノバルティス アクチエンゲゼルシャフト ビタミンａおよびビタミンｅを含む眼科用組成物の使用
JP2005060279A (ja) * 2003-08-08 2005-03-10 Rohto Pharmaceut Co Ltd 角膜障害抑制剤
WO2005084635A2 (en) * 2004-03-02 2005-09-15 Institute Of Ophthalmology Pharmaceutical ocular preparations suitable for the treatment of the ocular surface and related disorders/diseases
WO2009001396A1 (en) * 2007-06-26 2008-12-31 Sooft Italia Spa Disposable sterile ocular solution for corneal cross- linking of cheratocone, and process for production thereof
JP2009513586A (ja) * 2005-10-26 2009-04-02 ソーラーティウム エンタープライゼズ リミテッド アミノ酸とヒアルロン酸ナトリウムを基にした眼科用医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106669A (zh) 1994-10-10 1995-08-16 华中理工大学 一种防治白内障的滴眼液
US5780446A (en) 1996-07-09 1998-07-14 Baylor College Of Medicine Formulations of vesicant drugs and methods of use thereof
US6441050B1 (en) 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
RU2201213C1 (ru) * 2001-07-04 2003-03-27 Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" Глазные капли "карнозин"
JP4604515B2 (ja) 2004-03-05 2011-01-05 大正製薬株式会社 眼科用剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520281A (ja) * 1998-07-10 2002-07-09 パニン，ジョルジオ 粘膜疾患の局所治療における使用のためのビタミンｅおよびそのエステル
JP2002527391A (ja) * 1998-10-14 2002-08-27 ノバルティス アクチエンゲゼルシャフト ビタミンａおよびビタミンｅを含む眼科用組成物の使用
WO2001037851A2 (en) * 1999-11-25 2001-05-31 Simonelli, Giuseppe Use of ubiquinone q10 for the local treatment and prevention of post-surgical ophthalmologic pathologies
JP2005060279A (ja) * 2003-08-08 2005-03-10 Rohto Pharmaceut Co Ltd 角膜障害抑制剤
WO2005084635A2 (en) * 2004-03-02 2005-09-15 Institute Of Ophthalmology Pharmaceutical ocular preparations suitable for the treatment of the ocular surface and related disorders/diseases
JP2007526292A (ja) * 2004-03-02 2007-09-13 インスティテュート オブ オフタルモロジー 目の表面及びその他の障害のための調剤薬及び治療方法
JP2009513586A (ja) * 2005-10-26 2009-04-02 ソーラーティウム エンタープライゼズ リミテッド アミノ酸とヒアルロン酸ナトリウムを基にした眼科用医薬組成物
WO2009001396A1 (en) * 2007-06-26 2008-12-31 Sooft Italia Spa Disposable sterile ocular solution for corneal cross- linking of cheratocone, and process for production thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6014013434; Ｊｏｕｒｎａｌ　ｏｆ　Ｃａｔａｒａｃｔ　ａｎｄ　Ｒｅｆｒａｃｔｉｖｅ　Ｓｕｒｇｅｒｙ Ｖｏｌ．３５，　Ｎｏ．１, 200903, ｐ．５４０-５４６ *
JPN6014013437; あたらしい眼科 Ｖｏｌ．２５，　Ｎｏ．５, 2008, ｐ．６６１-６６２ *
JPN6014013439; あたらしい眼科 Ｖｏｌ．２５，　Ｎｏ．３, 2008, ｐ．３３９-３４０ *
JPN6014013441; Ｊｏｕｒｎａｌ　ｏｆ　Ｃａｔａｒａｃｔ　ａｎｄ　Ｒｅｆｒａｃｔｉｖｅ　Ｓｕｒｇｅｒｙ Ｖｏｌ．３５，　Ｎｏ．４, 200904, ｐ．７８８-７９１ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180030892A (ko) * 2015-07-21 2018-03-26 아베드로 인코퍼레이티드 광증감제로 눈을 치료하기 위한 시스템 및 방법
JP2018526341A (ja) * 2015-07-21 2018-09-13 アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． 光増感剤を用いた眼の処置用システム及び方法
KR102706856B1 (ko) * 2015-07-21 2024-09-19 아베드로 인코퍼레이티드 광증감제로 눈을 치료하기 위한 시스템 및 방법
JP2023502486A (ja) * 2019-11-21 2023-01-24 ビーエフ リサーチ エス．アール．エル ソフトコンタクトレンズおよびソフトコンタクトレンズを収容する包装体
US12321043B2 (en) 2019-11-21 2025-06-03 Cataltheia Group, Inc. Soft contact lens and a packaging comprising such a soft contact lens
WO2024225436A1 (ja) * 2023-04-28 2024-10-31 株式会社メドレックス 眼科用組成物

Also Published As

Publication number Publication date
AU2010277668A8 (en) 2012-04-19
CA2805511A1 (en) 2011-02-03
US20120121567A1 (en) 2012-05-17
ES2441227T3 (es) 2014-02-03
US9192594B2 (en) 2015-11-24
AU2010277668A1 (en) 2012-03-01
CA2805511C (en) 2017-04-11
EP2459186A1 (en) 2012-06-06
BR112012001998A2 (pt) 2017-01-31
ZA201201122B (en) 2013-05-29
BR112012001998B8 (pt) 2021-05-25
RU2540481C2 (ru) 2015-02-10
BR112012001998B1 (pt) 2020-12-01
PT2459186E (pt) 2013-12-24
CN102470120A (zh) 2012-05-23
KR20120038520A (ko) 2012-04-23
EP2459186B1 (en) 2013-10-09
WO2011012557A1 (en) 2011-02-03
RU2012106178A (ru) 2013-09-10

Similar Documents

Publication Publication Date Title
JP2013500302A (ja) Ｕｖ−ａ線に対する眼球内部構造保護用又は経上皮架橋術式による円錐角膜の治療用点眼液
ES2460578T3 (es) Uso de EDTA+trometamina o de foto-potenciadores, asociados a la riboflavina, para la reticulación de la córnea en el tratamiento del queratocono o de otros trastornos ectásicos de la córnea
TWI855319B (zh) 眼用組合物
JP5559540B2 (ja) 体組織の機械的および／または化学的性質に影響を及ぼすための光化学療法
RU2630968C2 (ru) Лекарственные средства и способы лечения пресбиопии, умеренной гиперметропии и неправильного астигматизма
CN1753683B (zh) 预防和治疗不良眼部病症的眼用制剂
BR112013017875B1 (pt) Composição oftálmica
JP2009501727A (ja) 巨大分子集合体の存在に関連した状態、特に眼科障害の治療
JP6450814B2 (ja) 医薬組成物及びその用途
RU2466699C1 (ru) Способ лечения кератоконуса роговицы
EP1858481B1 (fr) Compositions ophtalmologiques et leur utilisation
RU2522386C1 (ru) Способ лечения кератоконуса у пациентов с тонкой роговицей
ITVA20100044A1 (it) Soluzione oftalmica per proteggere strutture interne del globo oculare da raggi uv-a o per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale
EP2842557A1 (en) Mildronate in ophthalmic disorders
US20250302839A1 (en) Compositions and methods for delivery of riboflavin
Meier-Gibbons et al. Aqueous humor dynamics and its influence on glaucoma
CA2731871C (en) Use of enhancers, possibly associated to riboflavin, as well as corresponding ophthalmic compositions for corneal cross-linking in the treatment of the keratoconus or of other corneal ectasic disorders
Huynh Factors governing photodynamic cross-linking of ocular coat
BR102017026328A2 (pt) Método de reticulação do colágeno corneano com genipina para aplicação no tratamento de ceratocone
RU2438631C1 (ru) Способ консервативного лечения птеригиума
ALBÉ Epithelium Off and Transepithelial Cross-Linking: Techniques and Outcomes
ITVA20090052A1 (it) Composizione per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale o per proteggere strutture interne del globo oculare da raggi uv-a
Zhu et al. Metformin reduces ganglion cell loss in both acute and chronic glaucoma mouse models
Mamun-Al-Mahtab et al. Ciprofloxacin-induced Stevens-Johnson syndrome: First report from Bangladesh
KR20180089819A (ko) 인돌-3-카비놀 또는 이의 약제학적으로 허용되는 염을 포함하는 당뇨 망막병증의 예방 또는 치료용 조성물

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130709

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130709

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20140225

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20140312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140402

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140627

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140704

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141120