PT2459186E - Solução oftálmica para proteger as estruturas internas do olho contra os raios uv-a ou para tratar a ceratocone nas técnicas trans-epiteliais de & xa; reticulação corneana - Google Patents
Solução oftálmica para proteger as estruturas internas do olho contra os raios uv-a ou para tratar a ceratocone nas técnicas trans-epiteliais de & xa; reticulação corneanaInfo
- Publication number
- PT2459186E PT2459186E PT107378739T PT10737873T PT2459186E PT 2459186 E PT2459186 E PT 2459186E PT 107378739 T PT107378739 T PT 107378739T PT 10737873 T PT10737873 T PT 10737873T PT 2459186 E PT2459186 E PT 2459186E
- Authority
- PT
- Portugal
- Prior art keywords
- keratoconus
- trans
- rays
- treatment
- ophthalmic solution
- Prior art date
Links
- 201000002287 Keratoconus Diseases 0.000 title abstract 2
- 210000005252 bulbus oculi Anatomy 0.000 title abstract 2
- 238000004132 cross linking Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940054534 ophthalmic solution Drugs 0.000 title abstract 2
- 239000002997 ophthalmic solution Substances 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- 235000019454 L-leucine Nutrition 0.000 abstract 1
- 239000004395 L-leucine Substances 0.000 abstract 1
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 abstract 1
- 235000017471 coenzyme Q10 Nutrition 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- 235000020776 essential amino acid Nutrition 0.000 abstract 1
- 229960002449 glycine Drugs 0.000 abstract 1
- 229960003136 leucine Drugs 0.000 abstract 1
- 229960005337 lysine hydrochloride Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 229960002477 riboflavin Drugs 0.000 abstract 1
- 235000019192 riboflavin Nutrition 0.000 abstract 1
- 239000002151 riboflavin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000052A ITVA20090052A1 (it) | 2009-07-27 | 2009-07-27 | Composizione per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale o per proteggere strutture interne del globo oculare da raggi uv-a |
| IT000044A ITVA20100044A1 (it) | 2010-05-20 | 2010-05-20 | Soluzione oftalmica per proteggere strutture interne del globo oculare da raggi uv-a o per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2459186E true PT2459186E (pt) | 2013-12-24 |
Family
ID=42575807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT107378739T PT2459186E (pt) | 2009-07-27 | 2010-07-23 | Solução oftálmica para proteger as estruturas internas do olho contra os raios uv-a ou para tratar a ceratocone nas técnicas trans-epiteliais de & xa; reticulação corneana |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9192594B2 (pt) |
| EP (1) | EP2459186B1 (pt) |
| JP (1) | JP2013500302A (pt) |
| KR (1) | KR20120038520A (pt) |
| CN (1) | CN102470120A (pt) |
| AU (1) | AU2010277668A1 (pt) |
| BR (1) | BR112012001998B8 (pt) |
| CA (1) | CA2805511C (pt) |
| ES (1) | ES2441227T3 (pt) |
| PT (1) | PT2459186E (pt) |
| RU (1) | RU2540481C2 (pt) |
| WO (1) | WO2011012557A1 (pt) |
| ZA (1) | ZA201201122B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| US9023092B2 (en) | 2011-08-23 | 2015-05-05 | Anthony Natale | Endoscopes enhanced with pathogenic treatment |
| WO2013028833A1 (en) | 2011-08-23 | 2013-02-28 | Anthony Natale | Systems and methods for treating pathogenic infection |
| CN102429767B (zh) * | 2011-08-25 | 2016-03-09 | 广东福地新视野光电技术有限公司 | 激光角膜热成形术系统 |
| ITMI20120355A1 (it) * | 2012-03-07 | 2013-09-08 | Ciro Caruso | Sostanza colorante per uso diagnostico oftalmologico |
| WO2013148896A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| US9555111B2 (en) | 2012-03-29 | 2017-01-31 | Cxl Ophthalmics, Llc | Ocular cross-linking system and method for sealing corneal wounds |
| EP2830637A4 (en) | 2012-03-29 | 2016-03-16 | Cxl Ophthalmics Llc | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES RELATED TO OXIDATIVE STRESS |
| ITRM20130248A1 (it) * | 2013-04-24 | 2014-10-25 | Medivis S R L | Formulazioni di riboflavina per il cross-linking transepiteliale. |
| RU2683651C2 (ru) * | 2013-06-18 | 2019-04-01 | Иван Дмитриевич Захаров | Лекарственное средство для лечения кератоконуса и других дегенеративных заболеваний роговицы и фармацевтические препараты на его основе |
| US9931199B2 (en) * | 2014-05-05 | 2018-04-03 | Roberto Gustavo ALBERTAZZI | Methods and apparatus for treating keratoconus |
| RU2556791C1 (ru) * | 2014-06-09 | 2015-07-20 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ лечения кератоконуса |
| EP3324973B1 (en) * | 2015-07-21 | 2020-06-03 | Avedro, Inc. | Treament of an eye with a photosensitizer |
| US20180236077A1 (en) * | 2017-02-21 | 2018-08-23 | Avedro, Inc. | Formulations for eye treatments |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106669A (zh) | 1994-10-10 | 1995-08-16 | 华中理工大学 | 一种防治白内障的滴眼液 |
| US5780446A (en) * | 1996-07-09 | 1998-07-14 | Baylor College Of Medicine | Formulations of vesicant drugs and methods of use thereof |
| ITMI981586A1 (it) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
| US6291519B1 (en) * | 1998-10-14 | 2001-09-18 | Novartis Ag | Method of preventing damage to eye tissue |
| IT1307281B1 (it) * | 1999-11-25 | 2001-10-30 | Simonelli Giuseppe | Uso di ubichinone q10 per il trattamento locale e la prevenzione dipatalogie oftalmologiche secondarie alla terapia fotorefrattiva, |
| US6441050B1 (en) | 2000-08-29 | 2002-08-27 | Raj K. Chopra | Palatable oral coenzyme Q liquid |
| RU2201213C1 (ru) * | 2001-07-04 | 2003-03-27 | Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" | Глазные капли "карнозин" |
| JP5147156B2 (ja) * | 2003-08-08 | 2013-02-20 | ロート製薬株式会社 | 角膜障害抑制剤 |
| GB0404693D0 (en) * | 2004-03-02 | 2004-04-07 | Univ London | Pharmaceutical preparations for the treatment of ocular surface and other disorders |
| JP4604515B2 (ja) * | 2004-03-05 | 2011-01-05 | 大正製薬株式会社 | 眼科用剤 |
| ITMI20052036A1 (it) * | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | Composizioni farmaceutiche oftalmiche a base di amminoacidi e sodio ialuronato |
| ITRM20070356A1 (it) * | 2007-06-26 | 2008-12-27 | Sooft Italia Srl | Soluzione oculare sterile monouso e suo procedimento di produzione per il cross linking corneale del cheratocono |
-
2010
- 2010-07-23 US US13/387,668 patent/US9192594B2/en active Active
- 2010-07-23 JP JP2012522123A patent/JP2013500302A/ja active Pending
- 2010-07-23 BR BR112012001998A patent/BR112012001998B8/pt active IP Right Grant
- 2010-07-23 EP EP10737873.9A patent/EP2459186B1/en active Active
- 2010-07-23 WO PCT/EP2010/060752 patent/WO2011012557A1/en active Application Filing
- 2010-07-23 KR KR1020127004681A patent/KR20120038520A/ko not_active Application Discontinuation
- 2010-07-23 CN CN2010800328001A patent/CN102470120A/zh active Pending
- 2010-07-23 PT PT107378739T patent/PT2459186E/pt unknown
- 2010-07-23 ES ES10737873.9T patent/ES2441227T3/es active Active
- 2010-07-23 AU AU2010277668A patent/AU2010277668A1/en not_active Abandoned
- 2010-07-23 CA CA2805511A patent/CA2805511C/en active Active
- 2010-07-23 RU RU2012106178/15A patent/RU2540481C2/ru active
-
2012
- 2012-02-15 ZA ZA2012/01122A patent/ZA201201122B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120121567A1 (en) | 2012-05-17 |
| EP2459186A1 (en) | 2012-06-06 |
| CA2805511A1 (en) | 2011-02-03 |
| JP2013500302A (ja) | 2013-01-07 |
| AU2010277668A1 (en) | 2012-03-01 |
| CN102470120A (zh) | 2012-05-23 |
| ES2441227T3 (es) | 2014-02-03 |
| BR112012001998A2 (pt) | 2017-01-31 |
| CA2805511C (en) | 2017-04-11 |
| BR112012001998B8 (pt) | 2021-05-25 |
| BR112012001998B1 (pt) | 2020-12-01 |
| US9192594B2 (en) | 2015-11-24 |
| ZA201201122B (en) | 2013-05-29 |
| AU2010277668A8 (en) | 2012-04-19 |
| KR20120038520A (ko) | 2012-04-23 |
| EP2459186B1 (en) | 2013-10-09 |
| RU2012106178A (ru) | 2013-09-10 |
| WO2011012557A1 (en) | 2011-02-03 |
| RU2540481C2 (ru) | 2015-02-10 |
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