JP2013500256A5 - - Google Patents
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- Publication number
- JP2013500256A5 JP2013500256A5 JP2012521761A JP2012521761A JP2013500256A5 JP 2013500256 A5 JP2013500256 A5 JP 2013500256A5 JP 2012521761 A JP2012521761 A JP 2012521761A JP 2012521761 A JP2012521761 A JP 2012521761A JP 2013500256 A5 JP2013500256 A5 JP 2013500256A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- poly
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22739909P | 2009-07-21 | 2009-07-21 | |
| US61/227,399 | 2009-07-21 | ||
| US12/558,395 US8173666B2 (en) | 2007-03-12 | 2009-09-11 | Oligomer-opioid agonist conjugates |
| US12/558,395 | 2009-09-11 | ||
| US35085310P | 2010-06-02 | 2010-06-02 | |
| US61/350,853 | 2010-06-02 | ||
| PCT/US2010/042792 WO2011011543A1 (en) | 2009-07-21 | 2010-07-21 | Oligomer-opioid agonist conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015139389A Division JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500256A JP2013500256A (ja) | 2013-01-07 |
| JP2013500256A5 true JP2013500256A5 (enExample) | 2013-09-05 |
| JP5837491B2 JP5837491B2 (ja) | 2015-12-24 |
Family
ID=43499405
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521761A Expired - Fee Related JP5837491B2 (ja) | 2009-07-21 | 2010-07-21 | オリゴマー−オピオイドアゴニスト抱合体 |
| JP2015139389A Pending JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015139389A Pending JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP2456469A1 (enExample) |
| JP (2) | JP5837491B2 (enExample) |
| KR (1) | KR101788886B1 (enExample) |
| CN (1) | CN102573918A (enExample) |
| AU (1) | AU2010276244B2 (enExample) |
| CA (1) | CA2768392C (enExample) |
| IL (3) | IL217634B (enExample) |
| MX (1) | MX2012000980A (enExample) |
| WO (1) | WO2011011543A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| PE20140636A1 (es) | 2010-09-30 | 2014-06-18 | Astrazeneca Ab | Conjugado de naloxol-peg cristalino |
| US10525054B2 (en) | 2011-11-07 | 2020-01-07 | Inheris Biopharma, Inc. | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
| WO2013070617A1 (en) | 2011-11-07 | 2013-05-16 | Nektar Therapeutics | Compositions, dosage forms, and coadministration of an opioid agonist compound and an analgesic compound |
| SMT201800083T1 (it) * | 2012-10-30 | 2018-03-08 | Nektar Therapeutics | Forme saline solide di alfa-6-mpeg6-o-idrossicodone come oppioidi agonisti e relativi usi |
| ITRM20130223A1 (it) * | 2013-04-15 | 2014-10-16 | Rosario Nicoletti | Derivati della codeina come inibitori della glucuronazione della morfina |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| CN107019803B (zh) * | 2016-01-29 | 2020-09-15 | 北京键凯科技股份有限公司 | 具有低成瘾作用的聚乙二醇化阿片样物质 |
| CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| EP3778703B1 (en) | 2018-03-29 | 2022-08-03 | NOF Corporation | Method for purifying trityl group-containing monodispersed polyethylene glycol |
| CN111039764A (zh) * | 2018-10-12 | 2020-04-21 | 山东大学 | 一种双亲乙烯衍生物及制备方法 |
| EP4010078A4 (en) * | 2019-08-11 | 2023-08-09 | Kappa-Pharma LLC | COMPOSITIONS AND METHODS FOR ENHANCING OPIOID RECEPTOR MOBILIZATION BY OPIOID HEXADENOATES AND OPTIONALLY SUBSTITUTED HEXADIENATES |
| CN116925105B (zh) * | 2022-04-11 | 2025-11-25 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物的固体盐型、晶型及其制备方法、组合物和用途 |
| CN117567477A (zh) * | 2023-11-15 | 2024-02-20 | 宜昌人福药业有限责任公司 | 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
| US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
| US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
| EP0832106A2 (en) * | 1995-06-05 | 1998-04-01 | Cortech, Inc. | Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| EP1782834A3 (en) * | 2003-03-13 | 2007-08-01 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| HRP20140361T1 (hr) | 2003-12-16 | 2014-05-23 | Nektar Therapeutics | Monodisperzne smjese pegiliranog naloksola |
| WO2008112288A2 (en) * | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| CA2734333A1 (en) * | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
-
2010
- 2010-07-21 CA CA2768392A patent/CA2768392C/en not_active Expired - Fee Related
- 2010-07-21 KR KR1020127004344A patent/KR101788886B1/ko not_active Expired - Fee Related
- 2010-07-21 JP JP2012521761A patent/JP5837491B2/ja not_active Expired - Fee Related
- 2010-07-21 EP EP10735413A patent/EP2456469A1/en not_active Withdrawn
- 2010-07-21 MX MX2012000980A patent/MX2012000980A/es active IP Right Grant
- 2010-07-21 AU AU2010276244A patent/AU2010276244B2/en not_active Ceased
- 2010-07-21 EP EP13167519.1A patent/EP2628489B1/en active Active
- 2010-07-21 CN CN2010800376109A patent/CN102573918A/zh active Pending
- 2010-07-21 WO PCT/US2010/042792 patent/WO2011011543A1/en not_active Ceased
-
2012
- 2012-01-19 IL IL217634A patent/IL217634B/en active IP Right Grant
-
2015
- 2015-07-13 JP JP2015139389A patent/JP2015180698A/ja active Pending
-
2018
- 2018-01-09 IL IL256822A patent/IL256822B/en active IP Right Grant
- 2018-12-14 IL IL263713A patent/IL263713A/en unknown