JP2013500256A5 - - Google Patents
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- Publication number
- JP2013500256A5 JP2013500256A5 JP2012521761A JP2012521761A JP2013500256A5 JP 2013500256 A5 JP2013500256 A5 JP 2013500256A5 JP 2012521761 A JP2012521761 A JP 2012521761A JP 2012521761 A JP2012521761 A JP 2012521761A JP 2013500256 A5 JP2013500256 A5 JP 2013500256A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- poly
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22739909P | 2009-07-21 | 2009-07-21 | |
| US61/227,399 | 2009-07-21 | ||
| US12/558,395 US8173666B2 (en) | 2007-03-12 | 2009-09-11 | Oligomer-opioid agonist conjugates |
| US12/558,395 | 2009-09-11 | ||
| US35085310P | 2010-06-02 | 2010-06-02 | |
| US61/350,853 | 2010-06-02 | ||
| PCT/US2010/042792 WO2011011543A1 (en) | 2009-07-21 | 2010-07-21 | Oligomer-opioid agonist conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015139389A Division JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500256A JP2013500256A (ja) | 2013-01-07 |
| JP2013500256A5 true JP2013500256A5 (enExample) | 2013-09-05 |
| JP5837491B2 JP5837491B2 (ja) | 2015-12-24 |
Family
ID=43499405
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521761A Expired - Fee Related JP5837491B2 (ja) | 2009-07-21 | 2010-07-21 | オリゴマー−オピオイドアゴニスト抱合体 |
| JP2015139389A Pending JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015139389A Pending JP2015180698A (ja) | 2009-07-21 | 2015-07-13 | オリゴマー−オピオイドアゴニスト抱合体 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP2456469A1 (enExample) |
| JP (2) | JP5837491B2 (enExample) |
| KR (1) | KR101788886B1 (enExample) |
| CN (1) | CN102573918A (enExample) |
| AU (1) | AU2010276244B2 (enExample) |
| CA (1) | CA2768392C (enExample) |
| IL (3) | IL217634B (enExample) |
| MX (1) | MX2012000980A (enExample) |
| WO (1) | WO2011011543A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| PE20140636A1 (es) | 2010-09-30 | 2014-06-18 | Astrazeneca Ab | Conjugado de naloxol-peg cristalino |
| US10525054B2 (en) | 2011-11-07 | 2020-01-07 | Inheris Biopharma, Inc. | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
| MX348933B (es) | 2011-11-07 | 2017-07-03 | Nektar Therapeutics | Composiciones, formas de dosificacion y coadministracion de un compuesto agonista opioide y un compuesto analgesico. |
| CN104755481A (zh) * | 2012-10-30 | 2015-07-01 | 尼克塔治疗公司 | 作为阿片激动剂的α-6-mPEG6-O-羟基可酮的固体盐形式以及其用途 |
| ITRM20130223A1 (it) * | 2013-04-15 | 2014-10-16 | Rosario Nicoletti | Derivati della codeina come inibitori della glucuronazione della morfina |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| CN107019803B (zh) * | 2016-01-29 | 2020-09-15 | 北京键凯科技股份有限公司 | 具有低成瘾作用的聚乙二醇化阿片样物质 |
| CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| CN111936549B (zh) * | 2018-03-29 | 2023-03-10 | 日油株式会社 | 包含三苯甲基的单分散聚乙二醇的纯化方法 |
| CN111039764A (zh) * | 2018-10-12 | 2020-04-21 | 山东大学 | 一种双亲乙烯衍生物及制备方法 |
| CA3149152A1 (en) * | 2019-08-11 | 2021-02-18 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| CN116925105B (zh) * | 2022-04-11 | 2025-11-25 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物的固体盐型、晶型及其制备方法、组合物和用途 |
| CN117567477A (zh) * | 2023-11-15 | 2024-02-20 | 宜昌人福药业有限责任公司 | 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
| US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
| US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
| EP0832106A2 (en) * | 1995-06-05 | 1998-04-01 | Cortech, Inc. | Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| EP1782834A3 (en) * | 2003-03-13 | 2007-08-01 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| WO2005058367A2 (en) * | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
| AU2008226822B2 (en) * | 2007-03-12 | 2013-08-01 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| JP5827123B2 (ja) * | 2008-09-16 | 2015-12-02 | ウェルズ ファーゴ バンク ナショナル アソシエイション | 乱用の可能性が低いｐｅｇ化オピオイド |
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2010
- 2010-07-21 MX MX2012000980A patent/MX2012000980A/es active IP Right Grant
- 2010-07-21 CA CA2768392A patent/CA2768392C/en not_active Expired - Fee Related
- 2010-07-21 WO PCT/US2010/042792 patent/WO2011011543A1/en not_active Ceased
- 2010-07-21 EP EP10735413A patent/EP2456469A1/en not_active Withdrawn
- 2010-07-21 EP EP13167519.1A patent/EP2628489B1/en active Active
- 2010-07-21 KR KR1020127004344A patent/KR101788886B1/ko not_active Expired - Fee Related
- 2010-07-21 AU AU2010276244A patent/AU2010276244B2/en not_active Ceased
- 2010-07-21 CN CN2010800376109A patent/CN102573918A/zh active Pending
- 2010-07-21 JP JP2012521761A patent/JP5837491B2/ja not_active Expired - Fee Related
-
2012
- 2012-01-19 IL IL217634A patent/IL217634B/en active IP Right Grant
-
2015
- 2015-07-13 JP JP2015139389A patent/JP2015180698A/ja active Pending
-
2018
- 2018-01-09 IL IL256822A patent/IL256822B/en active IP Right Grant
- 2018-12-14 IL IL263713A patent/IL263713A/en unknown