JP2009541289A5 - - Google Patents
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- Publication number
- JP2009541289A5 JP2009541289A5 JP2009515958A JP2009515958A JP2009541289A5 JP 2009541289 A5 JP2009541289 A5 JP 2009541289A5 JP 2009515958 A JP2009515958 A JP 2009515958A JP 2009515958 A JP2009515958 A JP 2009515958A JP 2009541289 A5 JP2009541289 A5 JP 2009541289A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- alk
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000006413 ring segment Chemical group 0.000 claims 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 238000011109 contamination Methods 0.000 claims 3
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- SRSKXJVMVSSSHB-UHFFFAOYSA-N 1h-pyrrolo[3,2-c]pyridine Chemical class N1=CC=C2NC=CC2=C1 SRSKXJVMVSSSHB-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical class C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical class C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003216 pyrazines Chemical group 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 150000003230 pyrimidines Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 0 CC*=***(C)(C)C1=Nc2c(*)nc(*)cc2*1 Chemical compound CC*=***(C)(C)C1=Nc2c(*)nc(*)cc2*1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0612428.3 | 2006-06-22 | ||
| GBGB0612428.3A GB0612428D0 (en) | 2006-06-22 | 2006-06-22 | Antibacterial agents |
| PCT/GB2007/002314 WO2007148093A1 (en) | 2006-06-22 | 2007-06-21 | Antibacterial compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541289A JP2009541289A (ja) | 2009-11-26 |
| JP2009541289A5 true JP2009541289A5 (enExample) | 2010-08-05 |
| JP5309021B2 JP5309021B2 (ja) | 2013-10-09 |
Family
ID=36803739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515958A Expired - Fee Related JP5309021B2 (ja) | 2006-06-22 | 2007-06-21 | 抗菌組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7977340B2 (enExample) |
| EP (1) | EP2034997B1 (enExample) |
| JP (1) | JP5309021B2 (enExample) |
| KR (1) | KR101443795B1 (enExample) |
| CN (1) | CN101472585B (enExample) |
| AU (1) | AU2007262791B2 (enExample) |
| BR (1) | BRPI0713501A2 (enExample) |
| CA (1) | CA2655403C (enExample) |
| DK (1) | DK2034997T3 (enExample) |
| EA (1) | EA019748B1 (enExample) |
| ES (1) | ES2403005T3 (enExample) |
| GB (1) | GB0612428D0 (enExample) |
| IL (1) | IL195687A (enExample) |
| MX (1) | MX2008015706A (enExample) |
| MY (1) | MY148682A (enExample) |
| NZ (1) | NZ574313A (enExample) |
| PL (1) | PL2034997T3 (enExample) |
| PT (1) | PT2034997E (enExample) |
| SG (1) | SG172676A1 (enExample) |
| WO (1) | WO2007148093A1 (enExample) |
| ZA (1) | ZA200900240B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| GB0724349D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| US8481544B2 (en) | 2006-06-22 | 2013-07-09 | Biota Europe Limited | Antibacterial compositions |
| UA96964C2 (ru) | 2006-12-04 | 2011-12-26 | Астразенека Аб | Соединения полициклической мочевины с антибактериальными свойствами |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| EP2321309A1 (en) * | 2008-06-25 | 2011-05-18 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| EP2277870A1 (de) * | 2009-06-24 | 2011-01-26 | Bayer CropScience AG | Substituierte Benzoxa(thia)zole |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| EP2552893B1 (en) | 2010-03-31 | 2014-10-29 | Actelion Pharmaceuticals Ltd. | Antibacterial isoquinolin-3-ylurea derivatives |
| WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| CA2801274C (en) | 2010-06-01 | 2021-06-15 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| JP6085829B2 (ja) | 2011-01-14 | 2017-03-01 | スペロ トリネム， インコーポレイテッド | ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤 |
| MX341342B (es) | 2011-01-14 | 2016-08-17 | Vertex Pharma | Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea. |
| US8481552B2 (en) | 2011-01-14 | 2013-07-09 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea |
| KR101882172B1 (ko) | 2011-01-14 | 2018-07-26 | 스페로 트리넴, 인코포레이티드 | 자이라제 및 토포이소머라제 ⅳ 억제제의 제조방법 |
| AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
| ES2576298T3 (es) | 2011-06-20 | 2016-07-06 | Vertex Pharmaceuticals Incorporated | Ésteres de fosfato de inhibidores de girasa y topoisomerasa |
| WO2013106756A2 (en) | 2012-01-13 | 2013-07-18 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| EP2828245A1 (en) | 2012-03-21 | 2015-01-28 | Rutgers, The State University of New Jersey | Antimicrobial agents |
| HK1206031A1 (en) | 2012-03-22 | 2015-12-31 | 生物区欧洲有限公司 | Antibacterial compounds |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
| US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014087431A1 (en) * | 2012-12-09 | 2014-06-12 | Council Of Scientific & Industrial Research | One pot process for the conversion of aroyl chlorides to acyl thioureas |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| SG11201606332PA (en) | 2014-02-03 | 2016-09-29 | Spero Gyrase Inc | Antibacterial combinations comprising polymyxin |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| CN107207526A (zh) * | 2014-12-02 | 2017-09-26 | 拜耳作物科学股份公司 | 作为害虫防治剂的双环化合物 |
| US20180000793A1 (en) * | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CN106167486B (zh) * | 2015-05-22 | 2019-06-14 | 北京四环制药有限公司 | 单环类回旋酶和拓扑异构酶iv抑制剂 |
| WO2017147316A1 (en) | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| TW201837026A (zh) | 2017-01-10 | 2018-10-16 | 德商拜耳廠股份有限公司 | 作為除害劑之雜環衍生物（二） |
| RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
| CN110891566B (zh) | 2017-03-30 | 2023-12-19 | 塔克西斯医药股份有限公司 | 合成方法和合成中间体 |
| TWI820231B (zh) | 2018-10-11 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於製備經取代咪唑衍生物之方法 |
| JP7730803B2 (ja) | 2019-07-17 | 2025-08-28 | サミット （オックスフォード） リミティド | リジニラゾールの調製方法およびその結晶形態 |
| BR112022026904A2 (pt) | 2020-07-02 | 2023-01-24 | Bayer Ag | Derivados de heterocicleno como agentes de controle de pragas |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
| GB202100470D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Solid tablet dosage for of ridinilazole |
| US12220421B2 (en) | 2021-09-09 | 2025-02-11 | The Boards Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las | Inhibitors of C. difficile spore germination |
| CN116444376B (zh) * | 2023-04-19 | 2024-01-26 | 德兴市德邦化工有限公司 | 一种3,5-二氯硝基苯的生产工艺 |
| WO2025026738A1 (en) | 2023-07-31 | 2025-02-06 | Bayer Aktiengesellschaft | 6-[5-(ethylsulfonyl)-1-methyl-1h-imidazol-4-yl]-7-methyl-3-(pentafluoroethyl)-7h-imidazo[4,5-c]pyridazine derivatives as pesticides |
| KR102985559B1 (ko) | 2024-01-15 | 2026-07-06 | 주식회사 가피바이오 | 스트렙토코쿠스 뉴모니아 dna 자이라제와 토포아이소머라아제 iv 저해제 |
| WO2026015823A1 (en) * | 2024-07-11 | 2026-01-15 | Purdue Research Foundation | Bacterial carbonic anhydrase inhibitors with improved pharmacokinetics and efficacy |
| CN119350937B (zh) * | 2024-10-30 | 2025-08-12 | 广东豪之盛新材料有限公司 | 一种双组份气雾喷漆及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH505543A (de) | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
| US3810988A (en) * | 1968-11-01 | 1974-05-14 | Ciba Geigy Ag | Control of phytopathogenic fungi with n-benzothiazae-2-yl n-{40 {11 propylure |
| US4028374A (en) * | 1975-11-03 | 1977-06-07 | Morton-Norwich Products, Inc. | Antibacterial thiocyanatobenzothiazoles |
| PL357099A1 (en) * | 2000-02-07 | 2004-07-12 | Abbott Gmbh & Co.Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
| RU2251419C2 (ru) * | 2000-06-21 | 2005-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензотиазола |
| PL362691A1 (en) * | 2000-12-15 | 2004-11-02 | Vertex Pharmaceuticals Incorporated | Bacterial gyrase inhibitors and uses thereof |
| AR042956A1 (es) * | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| US20050130974A1 (en) | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
| KR20070106969A (ko) * | 2004-09-09 | 2007-11-06 | 추가이 세이야쿠 가부시키가이샤 | 신규 이미다졸리딘 유도체 및 그 용도 |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
-
2006
- 2006-06-22 GB GBGB0612428.3A patent/GB0612428D0/en not_active Ceased
-
2007
- 2007-06-21 KR KR1020097001499A patent/KR101443795B1/ko not_active Expired - Fee Related
- 2007-06-21 BR BRPI0713501-7A patent/BRPI0713501A2/pt not_active IP Right Cessation
- 2007-06-21 ES ES07733310T patent/ES2403005T3/es active Active
- 2007-06-21 DK DK07733310T patent/DK2034997T3/da active
- 2007-06-21 SG SG2011040847A patent/SG172676A1/en unknown
- 2007-06-21 AU AU2007262791A patent/AU2007262791B2/en not_active Ceased
- 2007-06-21 CN CN200780023251XA patent/CN101472585B/zh not_active Expired - Fee Related
- 2007-06-21 EP EP20070733310 patent/EP2034997B1/en not_active Not-in-force
- 2007-06-21 WO PCT/GB2007/002314 patent/WO2007148093A1/en not_active Ceased
- 2007-06-21 CA CA2655403A patent/CA2655403C/en not_active Expired - Fee Related
- 2007-06-21 MX MX2008015706A patent/MX2008015706A/es active IP Right Grant
- 2007-06-21 US US12/304,303 patent/US7977340B2/en not_active Expired - Fee Related
- 2007-06-21 EA EA200900047A patent/EA019748B1/ru not_active IP Right Cessation
- 2007-06-21 PT PT07733310T patent/PT2034997E/pt unknown
- 2007-06-21 NZ NZ574313A patent/NZ574313A/en not_active IP Right Cessation
- 2007-06-21 JP JP2009515958A patent/JP5309021B2/ja not_active Expired - Fee Related
- 2007-06-21 MY MYPI20085070 patent/MY148682A/en unknown
- 2007-06-21 PL PL07733310T patent/PL2034997T3/pl unknown
-
2008
- 2008-12-03 IL IL195687A patent/IL195687A/en active IP Right Grant
-
2009
- 2009-01-12 ZA ZA2009/00240A patent/ZA200900240B/en unknown
-
2011
- 2011-06-07 US US13/154,592 patent/US8389516B2/en not_active Expired - Fee Related
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