JP2009541289A5 - - Google Patents
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- Publication number
- JP2009541289A5 JP2009541289A5 JP2009515958A JP2009515958A JP2009541289A5 JP 2009541289 A5 JP2009541289 A5 JP 2009541289A5 JP 2009515958 A JP2009515958 A JP 2009515958A JP 2009515958 A JP2009515958 A JP 2009515958A JP 2009541289 A5 JP2009541289 A5 JP 2009541289A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- alk
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000006413 ring segment Chemical group 0.000 claims 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 238000011109 contamination Methods 0.000 claims 3
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- SRSKXJVMVSSSHB-UHFFFAOYSA-N 1h-pyrrolo[3,2-c]pyridine Chemical class N1=CC=C2NC=CC2=C1 SRSKXJVMVSSSHB-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical class C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical class C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003216 pyrazines Chemical group 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 150000003230 pyrimidines Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 0 CC*=***(C)(C)C1=Nc2c(*)nc(*)cc2*1 Chemical compound CC*=***(C)(C)C1=Nc2c(*)nc(*)cc2*1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0612428.3 | 2006-06-22 | ||
| GBGB0612428.3A GB0612428D0 (en) | 2006-06-22 | 2006-06-22 | Antibacterial agents |
| PCT/GB2007/002314 WO2007148093A1 (en) | 2006-06-22 | 2007-06-21 | Antibacterial compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541289A JP2009541289A (ja) | 2009-11-26 |
| JP2009541289A5 true JP2009541289A5 (enExample) | 2010-08-05 |
| JP5309021B2 JP5309021B2 (ja) | 2013-10-09 |
Family
ID=36803739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515958A Expired - Fee Related JP5309021B2 (ja) | 2006-06-22 | 2007-06-21 | 抗菌組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7977340B2 (enExample) |
| EP (1) | EP2034997B1 (enExample) |
| JP (1) | JP5309021B2 (enExample) |
| KR (1) | KR101443795B1 (enExample) |
| CN (1) | CN101472585B (enExample) |
| AU (1) | AU2007262791B2 (enExample) |
| BR (1) | BRPI0713501A2 (enExample) |
| CA (1) | CA2655403C (enExample) |
| DK (1) | DK2034997T3 (enExample) |
| EA (1) | EA019748B1 (enExample) |
| ES (1) | ES2403005T3 (enExample) |
| GB (1) | GB0612428D0 (enExample) |
| IL (1) | IL195687A (enExample) |
| MX (1) | MX2008015706A (enExample) |
| MY (1) | MY148682A (enExample) |
| NZ (1) | NZ574313A (enExample) |
| PL (1) | PL2034997T3 (enExample) |
| PT (1) | PT2034997E (enExample) |
| SG (1) | SG172676A1 (enExample) |
| WO (1) | WO2007148093A1 (enExample) |
| ZA (1) | ZA200900240B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481544B2 (en) | 2006-06-22 | 2013-07-09 | Biota Europe Limited | Antibacterial compositions |
| GB0724349D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| BRPI0720057A2 (pt) | 2006-12-04 | 2013-12-17 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de inibição de girase bacteriana de dna e/ou topoisomerase iv bacteriana em um animal de sangue quente, de produção de um efeito antibacteriano em um animal de sangue quente e de tratamento de uma infecção bacteriana em um animal de sangue quente, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| US20110166088A1 (en) * | 2008-06-25 | 2011-07-07 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| EP2277870A1 (de) * | 2009-06-24 | 2011-01-26 | Bayer CropScience AG | Substituierte Benzoxa(thia)zole |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| KR20130012072A (ko) | 2010-03-31 | 2013-01-31 | 액테리온 파마슈티칼 리미티드 | 항박테리아성 이소퀴놀린-３-일우레아 유도체 |
| WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| SI2575968T1 (sl) | 2010-06-01 | 2016-06-30 | Summit Therapeutics Plc | Spojine za zdravljenje bolezni, ki je povezana s clostridium difficile |
| WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| SG191946A1 (en) | 2011-01-14 | 2013-08-30 | Vertex Pharma | Pyrimidine gyrase and topoisomerase iv inhibitors |
| ES2705923T3 (es) | 2011-01-14 | 2019-03-27 | Spero Trinem Inc | Formas sólidas de inhibidor de girasa (R)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1H-bencimidazol-2-il]urea |
| EP2663558A1 (en) | 2011-01-14 | 2013-11-20 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea |
| EP2663556B1 (en) | 2011-01-14 | 2014-10-15 | Vertex Pharmaceuticals Incorporated | Process of making gyrase and topoisomerase iv inhibitors |
| AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
| CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
| WO2013106756A2 (en) | 2012-01-13 | 2013-07-18 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| EP2828245A1 (en) | 2012-03-21 | 2015-01-28 | Rutgers, The State University of New Jersey | Antimicrobial agents |
| CN104302645A (zh) * | 2012-03-22 | 2015-01-21 | 生物区欧洲有限公司 | 抗菌化合物 |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
| WO2014015105A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US20160194279A1 (en) * | 2012-12-09 | 2016-07-07 | Council Of Scientific & Industrial Research | One pot process for the conversion of aroyl chlorides to acyl thioureas |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| BR112016018048A2 (pt) | 2014-02-03 | 2017-08-08 | Spero Gyrase Inc | Método para o tratamento ou prevenção de uma infecção bacteriana, uso de um inibidor de topoisomerase tipo ii bacteriana em combinação com uma polimixina ou derivado de polimixina no tratamento ou prevenção de uma infecção bacteriana, uso de um inibidor de topoisomerase tipo ii bacteriana em combinação com uma polimixina ou derivado de polimixina na preparação de um medicamento para o tratamento ou prevenção de uma infecção bacteriana, método para melhorar a atividade antibacteriana de um inibidor de topoisomerase tipo ii bacteriana, método para melhorar a eficácia bactericida de um inibidor de topoisomerase tipo ii bacteriana, composição, agente antibacteriano, processo, e, composto |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| BR112017011791A2 (pt) * | 2014-12-02 | 2018-02-27 | Bayer Cropscience Aktiengesellschaft | compostos bicíclicos como agentes de controle de pragas |
| US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CN106167486B (zh) * | 2015-05-22 | 2019-06-14 | 北京四环制药有限公司 | 单环类回旋酶和拓扑异构酶iv抑制剂 |
| CA3015768A1 (en) | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| MX2019008230A (es) | 2017-01-10 | 2019-10-24 | Bayer Ag | Derivados heterociclicos como agentes de control de plagas. |
| RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
| EP3600298A4 (en) | 2017-03-30 | 2020-11-11 | Taxis Pharmaceuticals, Inc. | SYNTHESIS AND SYNTHESIS INTERMEDIARIES |
| TWI820231B (zh) | 2018-10-11 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於製備經取代咪唑衍生物之方法 |
| EP3999502A1 (en) | 2019-07-17 | 2022-05-25 | Summit (Oxford) Limited | Process for the preparation of ridinilazole and crystalline forms thereof |
| US20230247994A1 (en) | 2020-07-02 | 2023-08-10 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| GB202100470D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Solid tablet dosage for of ridinilazole |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
| US12220421B2 (en) | 2021-09-09 | 2025-02-11 | The Boards Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las | Inhibitors of C. difficile spore germination |
| CN116444376B (zh) * | 2023-04-19 | 2024-01-26 | 德兴市德邦化工有限公司 | 一种3,5-二氯硝基苯的生产工艺 |
| WO2025026738A1 (en) | 2023-07-31 | 2025-02-06 | Bayer Aktiengesellschaft | 6-[5-(ethylsulfonyl)-1-methyl-1h-imidazol-4-yl]-7-methyl-3-(pentafluoroethyl)-7h-imidazo[4,5-c]pyridazine derivatives as pesticides |
| CN119350937B (zh) * | 2024-10-30 | 2025-08-12 | 广东豪之盛新材料有限公司 | 一种双组份气雾喷漆及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3810988A (en) * | 1968-11-01 | 1974-05-14 | Ciba Geigy Ag | Control of phytopathogenic fungi with n-benzothiazae-2-yl n-{40 {11 propylure |
| CH505543A (de) * | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
| US4028374A (en) * | 1975-11-03 | 1977-06-07 | Morton-Norwich Products, Inc. | Antibacterial thiocyanatobenzothiazoles |
| US7091227B2 (en) | 2000-02-07 | 2006-08-15 | Abbott Gmbh & Co. Kg | Benzothiazole derivatives |
| BR0112395A (pt) | 2000-06-21 | 2003-07-08 | Hoffmann La Roche | Derivados de benzotiazol |
| SI1341769T1 (sl) | 2000-12-15 | 2008-02-29 | Vertex Pharma | Inhibitorji bakterijske giraze in njihove uporabe |
| AR042956A1 (es) * | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| US20050130974A1 (en) * | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
| EP1790640A4 (en) * | 2004-09-09 | 2009-07-29 | Chugai Pharmaceutical Co Ltd | NEW IMIDAZOLIDINE DERIVATIVE AND APPLICATION THEREOF |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
-
2006
- 2006-06-22 GB GBGB0612428.3A patent/GB0612428D0/en not_active Ceased
-
2007
- 2007-06-21 KR KR1020097001499A patent/KR101443795B1/ko not_active Expired - Fee Related
- 2007-06-21 JP JP2009515958A patent/JP5309021B2/ja not_active Expired - Fee Related
- 2007-06-21 EA EA200900047A patent/EA019748B1/ru not_active IP Right Cessation
- 2007-06-21 CN CN200780023251XA patent/CN101472585B/zh not_active Expired - Fee Related
- 2007-06-21 PL PL07733310T patent/PL2034997T3/pl unknown
- 2007-06-21 MY MYPI20085070 patent/MY148682A/en unknown
- 2007-06-21 DK DK07733310T patent/DK2034997T3/da active
- 2007-06-21 EP EP20070733310 patent/EP2034997B1/en not_active Not-in-force
- 2007-06-21 AU AU2007262791A patent/AU2007262791B2/en not_active Ceased
- 2007-06-21 WO PCT/GB2007/002314 patent/WO2007148093A1/en not_active Ceased
- 2007-06-21 US US12/304,303 patent/US7977340B2/en not_active Expired - Fee Related
- 2007-06-21 SG SG2011040847A patent/SG172676A1/en unknown
- 2007-06-21 BR BRPI0713501-7A patent/BRPI0713501A2/pt not_active IP Right Cessation
- 2007-06-21 MX MX2008015706A patent/MX2008015706A/es active IP Right Grant
- 2007-06-21 ES ES07733310T patent/ES2403005T3/es active Active
- 2007-06-21 NZ NZ574313A patent/NZ574313A/en not_active IP Right Cessation
- 2007-06-21 PT PT07733310T patent/PT2034997E/pt unknown
- 2007-06-21 CA CA2655403A patent/CA2655403C/en not_active Expired - Fee Related
-
2008
- 2008-12-03 IL IL195687A patent/IL195687A/en active IP Right Grant
-
2009
- 2009-01-12 ZA ZA2009/00240A patent/ZA200900240B/en unknown
-
2011
- 2011-06-07 US US13/154,592 patent/US8389516B2/en not_active Expired - Fee Related
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