JP2013500015A5 - - Google Patents

Download PDF

Info

Publication number
JP2013500015A5
JP2013500015A5 JP2012521778A JP2012521778A JP2013500015A5 JP 2013500015 A5 JP2013500015 A5 JP 2013500015A5 JP 2012521778 A JP2012521778 A JP 2012521778A JP 2012521778 A JP2012521778 A JP 2012521778A JP 2013500015 A5 JP2013500015 A5 JP 2013500015A5
Authority
JP
Japan
Prior art keywords
antigen
lentiviral vector
seq
virus
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2012521778A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013500015A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/042870 external-priority patent/WO2011011584A1/en
Publication of JP2013500015A publication Critical patent/JP2013500015A/ja
Publication of JP2013500015A5 publication Critical patent/JP2013500015A5/ja
Withdrawn legal-status Critical Current

Links

JP2012521778A 2009-07-24 2010-07-22 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター Withdrawn JP2013500015A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22849109P 2009-07-24 2009-07-24
US61/228,491 2009-07-24
PCT/US2010/042870 WO2011011584A1 (en) 2009-07-24 2010-07-22 Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015008415A Division JP6170952B2 (ja) 2009-07-24 2015-01-20 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター

Publications (2)

Publication Number Publication Date
JP2013500015A JP2013500015A (ja) 2013-01-07
JP2013500015A5 true JP2013500015A5 (https=) 2013-09-05

Family

ID=42727669

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012521778A Withdrawn JP2013500015A (ja) 2009-07-24 2010-07-22 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
JP2015008415A Expired - Fee Related JP6170952B2 (ja) 2009-07-24 2015-01-20 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
JP2017005594A Withdrawn JP2017060535A (ja) 2009-07-24 2017-01-17 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
JP2018153946A Expired - Fee Related JP6701280B2 (ja) 2009-07-24 2018-08-20 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2015008415A Expired - Fee Related JP6170952B2 (ja) 2009-07-24 2015-01-20 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
JP2017005594A Withdrawn JP2017060535A (ja) 2009-07-24 2017-01-17 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
JP2018153946A Expired - Fee Related JP6701280B2 (ja) 2009-07-24 2018-08-20 シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター

Country Status (27)

Country Link
US (3) US20110064763A1 (https=)
EP (2) EP2456786B2 (https=)
JP (4) JP2013500015A (https=)
KR (1) KR101790187B1 (https=)
CN (1) CN102482329B (https=)
AU (1) AU2010276194B2 (https=)
BR (1) BR112012001653A2 (https=)
CA (1) CA2768938C (https=)
CY (1) CY1121159T1 (https=)
DK (2) DK2770061T3 (https=)
EA (1) EA032403B1 (https=)
ES (2) ES2455544T5 (https=)
HR (2) HRP20140327T4 (https=)
HU (1) HUE043032T2 (https=)
IL (1) IL217679A (https=)
LT (1) LT2770061T (https=)
ME (1) ME01720B (https=)
MX (1) MX2012001075A (https=)
NZ (1) NZ597804A (https=)
PL (2) PL2456786T5 (https=)
PT (2) PT2456786E (https=)
RS (2) RS58042B1 (https=)
SG (1) SG177744A1 (https=)
SI (2) SI2456786T2 (https=)
SM (2) SMT201800656T1 (https=)
TR (1) TR201819229T4 (https=)
WO (1) WO2011011584A1 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3659435A1 (en) * 2009-07-15 2020-06-03 Calimmune, Inc. Dual vector for inhibition of human immunodeficiency virus
US20120263754A1 (en) * 2011-02-15 2012-10-18 Immune Design Corp. Methods for Enhancing Immunogen Specific Immune Responses by Vectored Vaccines
WO2012141984A1 (en) 2011-04-08 2012-10-18 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
CA2863658C (en) * 2012-02-03 2023-03-14 Emory University Immunostimulatory compositions, particles, and uses related thereto
WO2013148327A1 (en) 2012-03-26 2013-10-03 The Regents Of The University Of California Nipah virus envelope psuedotyped lentiviruses and methods of their use
US8323662B1 (en) * 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
PT2831095T (pt) * 2012-03-30 2019-01-30 Immune Design Corp Partículas de vectores lentivirais com melhor eficácia de transdução de células que expressam dc-sign
US9713635B2 (en) * 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
KR102136433B1 (ko) 2012-05-16 2020-07-22 이뮨 디자인 코포레이션 Hsv-2 백신
US20150352228A1 (en) * 2013-01-11 2015-12-10 Bruce TORBET Methods and compositions for enhancing transduction efficiency of retroviral vectors
GB201308772D0 (en) * 2013-05-15 2013-06-26 Imp Innovations Ltd Vectors
RS60902B1 (sr) 2014-03-09 2020-11-30 Univ Pennsylvania Kompozicije korisne u lečenju nedostatka ornitinske transkarbamilaze (otc)
EP3169352A1 (en) 2014-07-15 2017-05-24 Immune Design Corp. Prime-boost regimens with a tlr4 agonist adjuvant and a lentiviral vector
US11311632B2 (en) 2015-01-21 2022-04-26 Cornell University Viral vectors for prophylaxis and therapy of hemoglobinopathies
US20180112180A1 (en) * 2015-01-26 2018-04-26 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
JP6921053B2 (ja) 2015-03-18 2021-08-18 オムニサイト 改変アルファウイルス表面糖タンパク質と腫瘍関連抗原とを含む融合タンパク質、およびその手法
CN108026593A (zh) 2015-05-18 2018-05-11 卡琳缪恩股份有限公司 区分hiv-1与慢病毒载体的方法
WO2017044661A1 (en) 2015-09-09 2017-03-16 Immune Design Corp. Ny-eso-1 specific tcrs and methods of use thereof
KR20180074699A (ko) 2015-11-09 2018-07-03 이뮨 디자인 코포레이션 이종 핵산을 발현하는 rna 레플리콘의 발현 및 투여를 위한 레트로바이러스 벡터
CN108350037A (zh) * 2015-11-09 2018-07-31 免疫设计股份有限公司 包含表达il-12的慢病毒载体的组合物及其使用方法
HK1258353A1 (zh) 2016-02-23 2019-11-08 Immune Design Corp. 多基因组逆转录病毒载体制剂及用於制备及使用该制剂的方法和系统
AU2017226199A1 (en) * 2016-03-04 2018-09-13 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
EP4706777A2 (en) 2016-04-15 2026-03-11 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
IL262365B2 (en) 2016-04-15 2024-11-01 Alpine Immune Sciences Inc Immunomodulatory proteins ICOS ligand variants and uses thereof
EP3235828A1 (en) * 2016-04-21 2017-10-25 Genethon Stable pseudotyped lentiviral particles and uses thereof
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
CN110088127A (zh) 2016-07-28 2019-08-02 高山免疫科学股份有限公司 Cd155变体免疫调节蛋白及其用途
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
CA3040296A1 (en) 2016-10-20 2018-04-26 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
WO2018148180A2 (en) 2017-02-07 2018-08-16 Immune Design Corp. Materials and methods for identifying and treating cancer patients
JP2020511144A (ja) 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Pd−l2バリアント免疫調節タンパク質及びその使用
PT3596116T (pt) 2017-03-16 2023-12-04 Alpine Immune Sciences Inc Proteínas imunomoduladoras de pd-l1 variante e suas utilizações
EP3596114A2 (en) 2017-03-16 2020-01-22 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
AU2018266111B2 (en) 2017-05-08 2024-11-07 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
SMT202600062T1 (it) 2017-10-18 2026-03-09 Alpine Immune Sciences Inc Proteine immunomodulatrici del ligando di icos variante e composizioni e metodi correlati
SG11202006148UA (en) 2018-01-03 2020-07-29 Alpine Immune Sciences Inc Multi-domain immunomodulatory proteins and methods of use thereof
US11116833B2 (en) * 2018-02-08 2021-09-14 George Mason University Method and system for inactivating virus infectivity for producing live-attenuated vaccines
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
EP3820509A1 (en) 2018-07-09 2021-05-19 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
WO2020056400A1 (en) 2018-09-14 2020-03-19 The Children's Hospital Of Philadelphia Compositions and methods for hemoglobin production
US12496274B2 (en) 2018-11-14 2025-12-16 Flagship Pioneering Innovations V, Inc. Compositions and methods for compartment-specific cargo delivery
WO2020104694A1 (en) * 2018-11-23 2020-05-28 Vira Therapeutics Gmbh Vsv chimeric vectors
WO2020113141A2 (en) 2018-11-30 2020-06-04 Alpine Immune Sciences, Inc. Cd86 variant immunomodulatory proteins and uses thereof
US20220364119A1 (en) 2019-06-14 2022-11-17 The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst Compositions and methods for treating an immunodeficiency virus infection with a therapeutic interfering particle
US20220307050A1 (en) * 2019-08-01 2022-09-29 The Regents Of The University Of California Non-viral transgenesis
CN110982842B (zh) * 2019-12-31 2023-04-18 山西大学 一种慢病毒表达载体的设计及应用
US20230256084A1 (en) * 2020-07-15 2023-08-17 Institut Pasteur Sars-cov-2 immunogenic compositions, vaccines, and methods
IL307544A (en) 2021-04-08 2023-12-01 Sana Biotechnology Inc Cd8-specific antibody constructs and compositions thereof
AU2022377374A1 (en) * 2021-10-25 2024-05-02 Genvivo, Inc. Compositions and methods for therapeutic or vaccine delivery
CN119325517A (zh) * 2022-04-05 2025-01-17 生物辐射实验室股份有限公司 通过数字试验分析病毒颗粒
US20250302998A1 (en) 2022-05-09 2025-10-02 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
WO2025106748A1 (en) * 2023-11-15 2025-05-22 Genvivo, Inc. Compositions and methods for therapeutic delivery

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4886499A (en) 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
ES2060765T3 (es) 1988-05-17 1994-12-01 Lubrizol Genetics Inc Sistema promotor de ubiquitina en plantas.
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5298420A (en) 1990-08-03 1994-03-29 Tanox Biosystems, Inc. Antibodies specific for isotype specific domains of human IgM and human IgG expressed or the B cell surface
TW279133B (https=) 1990-12-13 1996-06-21 Elan Med Tech
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
ATE245703T1 (de) 1992-09-22 2003-08-15 Biofocus Discovery Ltd Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren
US6534051B1 (en) 1992-11-20 2003-03-18 University Of Medicine And Dentistry Of New Jersey Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins
US5279552A (en) 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
AU4594996A (en) 1994-11-30 1996-06-19 Chiron Viagene, Inc. Recombinant alphavirus vectors
US5660835A (en) 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
JPH11510050A (ja) 1995-07-25 1999-09-07 イントロヘーネ ベスローテン フェンノートシャップ 標的遺伝子送達のための方法および手段
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5910434A (en) 1995-12-15 1999-06-08 Systemix, Inc. Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
FR2747046B1 (fr) 1996-04-05 1998-06-19 Univ Paris Curie Nouveaux vaccins issus de plasmovirus
WO1999061639A2 (en) * 1998-05-22 1999-12-02 Oxford Biomedica (Uk) Limited Retroviral delivery system
EP0961830A1 (en) 1997-01-29 1999-12-08 Neurosearch A/S EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES
US6432699B1 (en) * 1997-03-28 2002-08-13 New York University Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
US6531123B1 (en) 1997-05-01 2003-03-11 Lung-Ji Chang Lentiviral vectors
WO1999013905A1 (en) 1997-09-18 1999-03-25 The Trustees Of The University Of Pennsylvania Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery
ZA988446B (en) 1997-09-18 2000-03-22 Res Dev Foundation Production of vaccines using arthropod vectored viruses.
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
US7078483B2 (en) 1998-04-29 2006-07-18 University Of Southern California Retroviral vectors including modified envelope escort proteins
JP2002538842A (ja) * 1999-03-16 2002-11-19 デイナ−ファーバー キャンサー インスティチュート,インコーポレイテッド 大量のスクリーニングのためのレンチウイルスベクター系
DK1175497T3 (da) 1999-04-14 2010-05-31 Novartis Vaccines & Diagnostic Præparater og fremgangsmåder til generering af et immunrespons ved udnyttelse af alfavirusbaserede vektorsystemer
EP1046651A1 (en) 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
CA2392010A1 (en) 1999-08-27 2001-03-08 Regents Of The University Of California Use of lentiviral vectors for antigen presentation in dendritic cells
DE60043708D1 (de) 1999-10-13 2010-03-04 Novartis Vaccines & Diagnostic Verfahren zur erhaltung zellimmuneantworten gegen proteinen
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US7241275B2 (en) 1999-10-14 2007-07-10 Becton, Dickinson And Company Intradermal needle
US6627442B1 (en) * 2000-08-31 2003-09-30 Virxsys Corporation Methods for stable transduction of cells with hiv-derived viral vectors
US20040091853A1 (en) * 2001-03-02 2004-05-13 Hazuda Daria J. Viral reporter particles
WO2002101057A1 (fr) * 2001-06-08 2002-12-19 Dnavec Research Inc. Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur
WO2003022228A2 (en) 2001-09-13 2003-03-20 California Institute Of Technology Method for producing transgenic birds and fish
US7195916B2 (en) 2001-09-13 2007-03-27 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
AU2002326906C1 (en) 2001-09-13 2009-01-29 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
US7737124B2 (en) 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
AU2002346399A1 (en) 2001-11-14 2003-05-26 Medical Instill Technologies, Inc. Intradermal delivery device and method
EP2111885B1 (en) 2002-02-04 2011-09-21 Becton, Dickinson and Company Device and method for delivering or withdrawing a substance through the skin
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US8338168B2 (en) * 2002-04-26 2012-12-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Chimeric glycoproteins and pseudotyped lentiviral vectors
US7455833B2 (en) 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
DE60322070D1 (de) 2002-08-16 2008-08-21 Dept Of Medical Sciences Minis Rekombinante bcg-vakzine
AU2003297474A1 (en) 2002-12-18 2004-07-14 Salk Institute For Biological Studies Methods of inhibiting gene expression by rna interference
WO2004067710A2 (en) 2003-01-21 2004-08-12 Salk Institute For Biological Studies Compositions and methods for tissue specific targeting of lentivirus vectors
US20050112139A1 (en) 2003-10-23 2005-05-26 Nmk Research, Llc Immunogenic composition and method of developing a vaccine based on factor H binding sites
US7108679B2 (en) 2004-03-11 2006-09-19 Becton, Dickinson And Company Intradermal syringe and needle assembly
WO2005113584A1 (en) * 2004-04-29 2005-12-01 Board Of Regents, University Of Texas System Methods and compositions comprising protein l immunoglobulin binding domains for cell-specific targeting
WO2005118802A2 (en) 2004-06-03 2005-12-15 The Regents Of The University Of California Targeting pseudotyped retroviral vectors
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
US7429481B2 (en) * 2004-09-14 2008-09-30 University Of Pittsburgh Targeting viruses using a modified sindbis glycoprotein
RU2007134371A (ru) * 2005-02-16 2009-03-27 Лентиджен Корпорейшн (Us) Лентивирусные векторы и их применение
AU2006252406B2 (en) 2005-06-01 2012-05-17 California Institute Of Technology Method of targeted gene delivery using viral vectors
BRPI0714495B8 (pt) * 2006-07-21 2021-05-25 California Inst Of Techn lentivírus deficiente para replicação recombinante pseudotipado
PT2468300T (pt) 2006-09-26 2018-01-30 Infectious Disease Res Inst Composição para vacina contendo adjuvante sintético
WO2009035528A2 (en) 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
RS56844B1 (sr) * 2007-12-11 2018-04-30 Univ North Carolina Chapel Hill Retrovirusni vektori sa modifikovanim polipurinskim nizom

Similar Documents

Publication Publication Date Title
JP2013500015A5 (https=)
JP6170952B2 (ja) シンドビスウイルスエンベロープ糖タンパク質により偽型化したレンチウイルスベクター
US8389275B2 (en) Fusion proteins of HIV regulatory/accessory proteins
JP2015512263A5 (https=)
JPWO2012053646A1 (ja) ワクシニアウイルスベクターおよびセンダイウイルスベクターからなるプライム/ブーストワクチン用ウイルスベクター
JP4989224B2 (ja) Dnaワクチン組成物およびその使用方法
US20240335531A1 (en) Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection
Wahren et al. Therapeutic vaccination against HIV
US20130302368A1 (en) Advanced Prime and Boost Vaccine
WO2022191801A2 (en) Integrase defective hiv-based lentivirus mediated new generation covid-19 vaccine encoding sars-cov-2 spike protein
CN109923212B (zh) 用于表达乙肝病毒(hbv)抗原的慢病毒载体
CN115843270A (zh) 包括缺失可变结构域的e2多肽的丙型肝炎核酸疫苗
EP4465999A2 (en) Versatile virus-like-vesicles (vlv) platform for infectious diseases and cancer immunotherapy applications
Bellier et al. 26 Retrovirus-Derived Virus-Like Particles
HK40007688A (en) Lentiviral vectors for expression of hepatitis b virus (hbv) antigens