CY1121159T1 - Μη-ενσωματουμενοι λεντiϊικοι φορεις - Google Patents
Μη-ενσωματουμενοι λεντiϊικοι φορειςInfo
- Publication number
- CY1121159T1 CY1121159T1 CY20181101398T CY181101398T CY1121159T1 CY 1121159 T1 CY1121159 T1 CY 1121159T1 CY 20181101398 T CY20181101398 T CY 20181101398T CY 181101398 T CY181101398 T CY 181101398T CY 1121159 T1 CY1121159 T1 CY 1121159T1
- Authority
- CY
- Cyprus
- Prior art keywords
- glycoprotein
- variant
- linter
- bodies
- integrated
- Prior art date
Links
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 101500008206 Sindbis virus Spike glycoprotein E2 Proteins 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 229920002971 Heparan sulfate Polymers 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/50—Colon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001192—Glycoprotein 100 [Gp100]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36145—Special targeting system for viral vectors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
Abstract
Παρέχονται σωματίδια λεντιϊικού φορέα τα οποία περιλαμβάνουν μια παραλλαγή Ε2 γλυκοπρωτεΐνης ιού Sindbis και ένα γονιδίωμα λεντιϊικού φορέα το οποίο περιλαμβάνει μια αλληλουχία ενδιαφέροντος. Ένα σωματίδιο λεντιϊικού φορέα το οποίο περιλαμβάνει: (α) έναν φάκελο ο οποίος περιλαμβάνει μια παραλλαγή Ε2 γλυκοπρωτεΐνης ιού Sindbis• και (β) ένα γονιδίωμα λεντιϊικού φορέα το οποίο περιλαμβάνει μια αλληλουχία ενδιαφέροντος• όπου η παραλλαγή Ε2 γλυκοπρωτεΐνης διευκολύνει τη μόλυνση δενδριτικών κυττάρων από το σωματίδιο λεντιϊικού φορέα, και όπου η παραλλαγή Ε2 γλυκοπρωτεΐνης έχει μειωμένη πρόσδεση σε θειική ηπαράνη σε σύγκριση με μια αλληλουχία αναφοράς (HR στέλεχος).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22849109P | 2009-07-24 | 2009-07-24 | |
EP10737715.2A EP2456786B2 (en) | 2009-07-24 | 2010-07-22 | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein |
PCT/US2010/042870 WO2011011584A1 (en) | 2009-07-24 | 2010-07-22 | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121159T1 true CY1121159T1 (el) | 2020-05-29 |
Family
ID=42727669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181101398T CY1121159T1 (el) | 2009-07-24 | 2018-12-27 | Μη-ενσωματουμενοι λεντiϊικοι φορεις |
Country Status (28)
Country | Link |
---|---|
US (3) | US20110064763A1 (el) |
EP (2) | EP2456786B2 (el) |
JP (4) | JP2013500015A (el) |
KR (1) | KR101790187B1 (el) |
CN (1) | CN102482329B (el) |
AU (1) | AU2010276194B2 (el) |
BR (1) | BR112012001653A2 (el) |
CA (1) | CA2768938C (el) |
CY (1) | CY1121159T1 (el) |
DK (2) | DK2456786T4 (el) |
EA (1) | EA032403B1 (el) |
ES (2) | ES2455544T5 (el) |
HK (1) | HK1201557A1 (el) |
HR (2) | HRP20140327T4 (el) |
HU (1) | HUE043032T2 (el) |
IL (1) | IL217679A (el) |
LT (1) | LT2770061T (el) |
ME (1) | ME01720B (el) |
MX (1) | MX2012001075A (el) |
NZ (1) | NZ597804A (el) |
PL (2) | PL2770061T3 (el) |
PT (2) | PT2770061T (el) |
RS (2) | RS58042B1 (el) |
SG (1) | SG177744A1 (el) |
SI (2) | SI2456786T2 (el) |
SM (1) | SMT201400041B (el) |
TR (1) | TR201819229T4 (el) |
WO (1) | WO2011011584A1 (el) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2015133046A (ru) * | 2009-07-15 | 2018-12-24 | Кэлиммьюн Инк. | Двойной вектор для подавления вируса иммунодефицита человека |
BR112013020875A2 (pt) * | 2011-02-15 | 2019-09-24 | Immune Design Corp | método para indução de uma resposta imune específica para um imunógeno em um indivíduo. |
AU2012243039B2 (en) * | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
CA2863658C (en) * | 2012-02-03 | 2023-03-14 | Emory University | Immunostimulatory compositions, particles, and uses related thereto |
WO2013148327A1 (en) | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Nipah virus envelope psuedotyped lentiviruses and methods of their use |
US8323662B1 (en) * | 2012-03-30 | 2012-12-04 | Immune Design Corp. | Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein |
US9713635B2 (en) * | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
NZ700340A (en) * | 2012-03-30 | 2017-02-24 | Immune Design Corp | Lentiviral vector particles having improved transduction efficiency for cells expressing dc- sign |
RS57420B1 (sr) | 2012-05-16 | 2018-09-28 | Immune Design Corp | Vakcine za hsv-2 |
WO2014109728A1 (en) * | 2013-01-11 | 2014-07-17 | The Scripps Research Institute | Methods and compositions for enchancing transduction efficiency of retroviral vectors |
GB201308772D0 (en) * | 2013-05-15 | 2013-06-26 | Imp Innovations Ltd | Vectors |
PL3116900T3 (pl) | 2014-03-09 | 2021-03-08 | The Trustees Of The University Of Pennsylvania | Kompozycje użyteczne w leczeniu niedoboru transkarbamylazy ornitynowej (otc) |
WO2016011083A1 (en) | 2014-07-15 | 2016-01-21 | Immune Design Corp. | Prime-boost regimens with a tlr4 agonist adjuvant and a lentiviral vector |
WO2016118715A1 (en) * | 2015-01-21 | 2016-07-28 | Cornell University | Viral vectors for prophylaxis and therapy of hemoglobinopathies |
AU2016211688A1 (en) * | 2015-01-26 | 2017-08-10 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
CA2979697A1 (en) | 2015-03-18 | 2016-09-22 | Omnicyte | Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof |
WO2016187151A1 (en) | 2015-05-18 | 2016-11-24 | Calimmune, Inc. | Methods of discriminating between hiv-1 and lentiviral vectors |
CA2997749A1 (en) | 2015-09-09 | 2017-03-16 | Immune Design Corp. | Ny-eso-1 specific tcrs and methods of use thereof |
US11135283B2 (en) | 2015-11-09 | 2021-10-05 | Immune Design Corp. | Retroviral vector for the administration and expression of replicon RNA expressing heterologous nucleic acids |
AU2016354000A1 (en) | 2015-11-09 | 2018-05-17 | Immune Design Corp. | Compositions comprising lentiviral vectors expressing IL-12 and methods of use thereof |
SG11201806976UA (en) | 2016-02-23 | 2018-09-27 | Immune Design Corp | Multigenome retroviral vector preparations and methods and systems for producing and using same |
US20180000912A1 (en) * | 2016-03-04 | 2018-01-04 | New York University | Virus Vectors Expressing Multiple Epitopes of Tumor Associated Antigens For Inducing Antitumor Immunity |
NZ746934A (en) | 2016-04-15 | 2023-11-24 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
KR20230051602A (ko) | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
EP3235828A1 (en) * | 2016-04-21 | 2017-10-25 | Genethon | Stable pseudotyped lentiviral particles and uses thereof |
EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
WO2018022946A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
CN110352245A (zh) | 2016-10-20 | 2019-10-18 | 高山免疫科学股份有限公司 | 可分泌变体免疫调节蛋白和工程化细胞疗法 |
WO2018148180A2 (en) | 2017-02-07 | 2018-08-16 | Immune Design Corp. | Materials and methods for identifying and treating cancer patients |
SG11201907769XA (en) | 2017-03-16 | 2019-09-27 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
RS64870B1 (sr) | 2017-03-16 | 2023-12-29 | Alpine Immune Sciences Inc | Imunomodulatorni proteini varijante pd-l1 i njihove upotrebe |
CN110809581A (zh) | 2017-03-16 | 2020-02-18 | 高山免疫科学股份有限公司 | Pd-l2变体免疫调节蛋白及其用途 |
IL270496B1 (en) | 2017-05-08 | 2024-07-01 | Flagship Pioneering Innovations V Inc | Intra-membrane aid preparations and their uses |
TW201925223A (zh) | 2017-10-18 | 2019-07-01 | 美商艾爾潘免疫科學有限公司 | 變異型icos 配位體免疫調節蛋白及相關組合物及方法 |
US11116833B2 (en) * | 2018-02-08 | 2021-09-14 | George Mason University | Method and system for inactivating virus infectivity for producing live-attenuated vaccines |
WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
EP3884043A1 (en) * | 2018-11-23 | 2021-09-29 | Vira Therapeutics GmbH | Vsv chimeric vectors |
WO2020113141A2 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
US20220364119A1 (en) | 2019-06-14 | 2022-11-17 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst | Compositions and methods for treating an immunodeficiency virus infection with a therapeutic interfering particle |
US20220307050A1 (en) * | 2019-08-01 | 2022-09-29 | The Regents Of The University Of California | Non-viral transgenesis |
CN110982842B (zh) * | 2019-12-31 | 2023-04-18 | 山西大学 | 一种慢病毒表达载体的设计及应用 |
EP4320242A1 (en) | 2021-04-08 | 2024-02-14 | Sana Biotechnology, Inc. | Cd8-specific antibody constructs and compositions thereof |
WO2023196442A1 (en) * | 2022-04-05 | 2023-10-12 | Bio-Rad Laboratories, Inc. | Analysis of viral particles by digital assay |
WO2023220603A1 (en) | 2022-05-09 | 2023-11-16 | Regeneron Pharmaceuticals, Inc. | Vectors and methods for in vivo antibody production |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US4569794A (en) | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
DE68918494T2 (de) | 1988-05-17 | 1995-03-23 | Lubrizol Genetics Inc | Pflanzliches Ubiquitinpromotorsystem. |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
US5298420A (en) | 1990-08-03 | 1994-03-29 | Tanox Biosystems, Inc. | Antibodies specific for isotype specific domains of human IgM and human IgG expressed or the B cell surface |
TW279133B (el) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
US5723287A (en) | 1992-09-22 | 1998-03-03 | Medical Research Council | Recombinant viruses displaying a nonviral polypeptide on their external surface |
US6534051B1 (en) | 1992-11-20 | 2003-03-18 | University Of Medicine And Dentistry Of New Jersey | Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins |
US5279552A (en) | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
AU4594996A (en) | 1994-11-30 | 1996-06-19 | Chiron Viagene, Inc. | Recombinant alphavirus vectors |
US5660835A (en) | 1995-02-24 | 1997-08-26 | East Carolina University | Method of treating adenosine depletion |
AU727531B2 (en) | 1995-07-25 | 2000-12-14 | Crucell Holland B.V. | Methods and means for targeted gene delivery |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US5910434A (en) | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
FR2747046B1 (fr) | 1996-04-05 | 1998-06-19 | Univ Paris Curie | Nouveaux vaccins issus de plasmovirus |
EP0961830A1 (en) | 1997-01-29 | 1999-12-08 | Neurosearch A/S | EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES |
US6432699B1 (en) * | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
US6531123B1 (en) | 1997-05-01 | 2003-03-11 | Lung-Ji Chang | Lentiviral vectors |
ZA988446B (en) | 1997-09-18 | 2000-03-22 | Res Dev Foundation | Production of vaccines using arthropod vectored viruses. |
WO1999013905A1 (en) | 1997-09-18 | 1999-03-25 | The Trustees Of The University Of Pennsylvania | Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery |
US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
US7078483B2 (en) | 1998-04-29 | 2006-07-18 | University Of Southern California | Retroviral vectors including modified envelope escort proteins |
CA2328491A1 (en) * | 1998-05-22 | 1999-12-02 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
WO2000055378A1 (en) * | 1999-03-16 | 2000-09-21 | Dana-Farber Cancer Institute, Inc. | Lentiviral vector system for high quantity screening |
EP1175497B1 (en) * | 1999-04-14 | 2010-04-07 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
EP1046651A1 (en) | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
CA2392010A1 (en) | 1999-08-27 | 2001-03-08 | Regents Of The University Of California | Use of lentiviral vectors for antigen presentation in dendritic cells |
US6534064B1 (en) | 1999-10-13 | 2003-03-18 | Chiron Corporation | Stabilized protein particles for inducing cellular immune responses |
US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US20020193740A1 (en) | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US7241275B2 (en) | 1999-10-14 | 2007-07-10 | Becton, Dickinson And Company | Intradermal needle |
US6776776B2 (en) | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
US6627442B1 (en) * | 2000-08-31 | 2003-09-30 | Virxsys Corporation | Methods for stable transduction of cells with hiv-derived viral vectors |
CA2439620A1 (en) * | 2001-03-02 | 2002-09-12 | Merck & Co., Inc. | Viral reporter particles |
CA2449589A1 (en) * | 2001-06-08 | 2002-12-19 | Dnavec Research Inc. | Gene transfer into primate embryonic stem cells using vsv-g pseudotyped simian immunodeficiency virus vector |
AU2002326906C1 (en) | 2001-09-13 | 2009-01-29 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
US7195916B2 (en) | 2001-09-13 | 2007-03-27 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
US7737124B2 (en) | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
AU2002336517B2 (en) | 2001-09-13 | 2008-09-11 | California Institute Of Technology | Method for producing transgenic animals |
US6971999B2 (en) | 2001-11-14 | 2005-12-06 | Medical Instill Technologies, Inc. | Intradermal delivery device and method |
MXPA04007389A (es) | 2002-02-04 | 2004-10-11 | Becton Dickinson Co | Dispositivo y metodo para entregar o retirar una substancia a traves de la piel. |
US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
JP4343708B2 (ja) * | 2002-04-26 | 2009-10-14 | アンスティテュ ナシナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル−イ.エヌ.エス.ウ.エール.エム. | 改良型キメラ糖タンパク質と、類型化されたレンチウイルス |
US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
US7638133B2 (en) | 2002-08-16 | 2009-12-29 | Department Of Medical Sciences Ministry Of Public Health Of Thailand | Recombinant BCG vaccine |
WO2004056966A2 (en) | 2002-12-18 | 2004-07-08 | Salk Institute For Biological Studies | Methods of inhibiting gene expression by rna interference |
WO2004067710A2 (en) | 2003-01-21 | 2004-08-12 | Salk Institute For Biological Studies | Compositions and methods for tissue specific targeting of lentivirus vectors |
US20050112139A1 (en) | 2003-10-23 | 2005-05-26 | Nmk Research, Llc | Immunogenic composition and method of developing a vaccine based on factor H binding sites |
US7108679B2 (en) | 2004-03-11 | 2006-09-19 | Becton, Dickinson And Company | Intradermal syringe and needle assembly |
US20070275873A1 (en) * | 2004-04-29 | 2007-11-29 | Heidner Hans W | Methods and Compositions Comprising Protein L Immunoglobulin Binding Domains for Cell-Specific Targeting |
US20080227736A1 (en) | 2004-06-03 | 2008-09-18 | Regents Of The University Of California, | Targeting Pseudotyped Retroviral Vectors |
GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
WO2006031996A2 (en) * | 2004-09-14 | 2006-03-23 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeting viruses using a modified sindbis glycoprotein |
RU2007134371A (ru) * | 2005-02-16 | 2009-03-27 | Лентиджен Корпорейшн (Us) | Лентивирусные векторы и их применение |
EP1885186B1 (en) | 2005-06-01 | 2015-09-02 | California Institute Of Technology | Method of targeted gene delivery using viral vectors |
DK2048955T3 (da) * | 2006-07-21 | 2013-09-02 | California Inst Of Techn | Målrettet gen-tilførsel til dendrit-cellevaccination |
TR201807756T4 (tr) | 2006-09-26 | 2018-06-21 | Infectious Disease Res Inst | Sentetik adjuvan içeren aşı bileşimi. |
US8563523B2 (en) | 2007-09-07 | 2013-10-22 | University Of Georgia Research Foundation, Inc. | Synthetic lipid A derivative |
PT2222861T (pt) | 2007-12-11 | 2018-02-16 | Univ North Carolina Chapel Hill | Vetores retrovirais modificados para segmento de polipurina |
-
2010
- 2010-07-22 SI SI201030576T patent/SI2456786T2/sl unknown
- 2010-07-22 ES ES10737715.2T patent/ES2455544T5/es active Active
- 2010-07-22 PT PT13194273T patent/PT2770061T/pt unknown
- 2010-07-22 SG SG2012005146A patent/SG177744A1/en unknown
- 2010-07-22 EP EP10737715.2A patent/EP2456786B2/en active Active
- 2010-07-22 PL PL13194273T patent/PL2770061T3/pl unknown
- 2010-07-22 WO PCT/US2010/042870 patent/WO2011011584A1/en active Application Filing
- 2010-07-22 ES ES13194273T patent/ES2702274T3/es active Active
- 2010-07-22 PL PL10737715T patent/PL2456786T5/pl unknown
- 2010-07-22 NZ NZ597804A patent/NZ597804A/xx not_active IP Right Cessation
- 2010-07-22 RS RS20181505A patent/RS58042B1/sr unknown
- 2010-07-22 CA CA2768938A patent/CA2768938C/en active Active
- 2010-07-22 SI SI201031821T patent/SI2770061T1/sl unknown
- 2010-07-22 MX MX2012001075A patent/MX2012001075A/es active IP Right Grant
- 2010-07-22 HU HUE13194273A patent/HUE043032T2/hu unknown
- 2010-07-22 EA EA201270191A patent/EA032403B1/ru not_active IP Right Cessation
- 2010-07-22 PT PT107377152T patent/PT2456786E/pt unknown
- 2010-07-22 JP JP2012521778A patent/JP2013500015A/ja not_active Withdrawn
- 2010-07-22 BR BR112012001653A patent/BR112012001653A2/pt not_active IP Right Cessation
- 2010-07-22 TR TR2018/19229T patent/TR201819229T4/tr unknown
- 2010-07-22 EP EP13194273.2A patent/EP2770061B1/en active Active
- 2010-07-22 LT LTEP13194273.2T patent/LT2770061T/lt unknown
- 2010-07-22 RS RS20140158A patent/RS53257B2/sr unknown
- 2010-07-22 KR KR1020127004625A patent/KR101790187B1/ko active IP Right Grant
- 2010-07-22 ME MEP-2014-29A patent/ME01720B/me unknown
- 2010-07-22 DK DK10737715.2T patent/DK2456786T4/en active
- 2010-07-22 DK DK13194273.2T patent/DK2770061T3/en active
- 2010-07-22 AU AU2010276194A patent/AU2010276194B2/en not_active Ceased
- 2010-07-22 CN CN201080040409.6A patent/CN102482329B/zh not_active Expired - Fee Related
- 2010-07-23 US US12/842,609 patent/US20110064763A1/en not_active Abandoned
-
2011
- 2011-10-20 US US13/277,900 patent/US8187872B2/en active Active
-
2012
- 2012-01-22 IL IL217679A patent/IL217679A/en active IP Right Grant
-
2014
- 2014-04-02 SM SM201400041T patent/SMT201400041B/xx unknown
- 2014-04-04 HR HRP20140327TT patent/HRP20140327T4/hr unknown
-
2015
- 2015-01-20 JP JP2015008415A patent/JP6170952B2/ja not_active Expired - Fee Related
- 2015-02-27 HK HK15102018.7A patent/HK1201557A1/xx not_active IP Right Cessation
- 2015-10-01 US US14/872,633 patent/US20160076055A1/en not_active Abandoned
-
2017
- 2017-01-17 JP JP2017005594A patent/JP2017060535A/ja not_active Withdrawn
-
2018
- 2018-08-20 JP JP2018153946A patent/JP6701280B2/ja not_active Expired - Fee Related
- 2018-11-27 HR HRP20181996TT patent/HRP20181996T1/hr unknown
- 2018-12-27 CY CY20181101398T patent/CY1121159T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1121159T1 (el) | Μη-ενσωματουμενοι λεντiϊικοι φορεις | |
CY1120911T1 (el) | Παραγομενες απο mdck κυτταρικες σειρες προσαρμοσμενες σε απαλλαγμενη απο ορο καλλιεργεια και καλλιεργεια εναιωρηματος και μεθοδος για παρασκευη ιου εμβολιου χρησιμοποιωντας τα κυτταρα | |
CY1120136T1 (el) | Μεθοδος για την αυξηση της ανοσοδραστικοτητας | |
CY1111378T1 (el) | Προερχομενα απο κυτταρα ιικα εμβολια με χαμηλα επιπεδα υπολειμματικου κυτταρικου dna | |
CY1121742T1 (el) | Αντισωματα s100a4 και θεραπευτικες χρησεις αυτων | |
CY1119284T1 (el) | ΣΩΜΑΤΙΔΙΑ ΠΑΡΟΜΟΙΑ ΜΕ ΙΟ ΓΛΥΚΟ-ΠΡΩΤΕΪΝΗΣ ΛΥΣΣΑΣ (VLPs) | |
MX2018008413A (es) | Virus oncolitico modificado. | |
CY1116835T1 (el) | Νεο ευρωπαϊκο στελεχος toy prrsv | |
CY1118970T1 (el) | Στελεχη shigella με υπερφλυκταινωση | |
CY1119173T1 (el) | Νεα μορια αναστολεα jnk | |
CY1118136T1 (el) | Αναστολεις πρωτεασης hcv | |
WO2009121004A3 (en) | Neutralizing molecules to viral antigens | |
CY1114736T1 (el) | Προερχομενες απο παπια εμβρυϊκες βλαστικες κυτταρικες σειρες για την παραγωγη ιικων εμβολιων | |
CY1114860T1 (el) | Χρηση τετρα-καρβοξιμιδιων διθιινης για την καταπολεμηση φυτοπαθογονων μυκητων | |
WO2010132604A3 (en) | Neutralizing molecules to influenza viruses | |
EA201390806A1 (ru) | Конструкция пептидного каркаса | |
IN2012DN01577A (el) | ||
PH12016500500A1 (en) | A viral vaccine and methods of manufacture thereof | |
MX2021009554A (es) | Produccion de virus en cultivos celulares. | |
EA201390856A1 (ru) | Инактивация вирусов с применением улучшенного способа растворитель-детергент | |
NZ702146A (en) | Peptides derived from viral proteins for use as immunogens and dosage reactants | |
MX2017009812A (es) | Composiciones y metodos para inhibir infeccion viral. | |
CY1113213T1 (el) | Παρασκευη χαρτιου μεταφορας για την εκτυπωση με εγχυση μελανης | |
CY1123424T1 (el) | Μεθοδος για την επικαλυψη σωματιδιων | |
CY1120606T1 (el) | Μπουνυαϊοι με προδρομα γονιδια κατακερματισμενης πρωτεϊνης και μεθοδοι δημιουργιας αυτων των ιων |