JP2013177406A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013177406A5 JP2013177406A5 JP2013092845A JP2013092845A JP2013177406A5 JP 2013177406 A5 JP2013177406 A5 JP 2013177406A5 JP 2013092845 A JP2013092845 A JP 2013092845A JP 2013092845 A JP2013092845 A JP 2013092845A JP 2013177406 A5 JP2013177406 A5 JP 2013177406A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- microparticles
- plga
- aggregating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000011859 microparticle Substances 0.000 claims description 13
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 4
- 108010016076 Octreotide Proteins 0.000 claims description 4
- 229960002700 octreotide Drugs 0.000 claims description 4
- 229920002959 polymer blend Polymers 0.000 claims description 4
- 239000010419 fine particle Substances 0.000 claims description 2
- 230000002744 anti-aggregatory effect Effects 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 4
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 3
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 239000012074 organic phase Substances 0.000 claims 2
- 239000003791 organic solvent mixture Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 239000008135 aqueous vehicle Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 238000000935 solvent evaporation Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 239000007943 implant Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0526247A GB0526247D0 (en) | 2005-12-22 | 2005-12-22 | Organic compounds |
| GB0526247.2 | 2005-12-22 | ||
| EP06119086.4 | 2006-08-17 | ||
| EP06119086 | 2006-08-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Division JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207464A Division JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Division JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013177406A JP2013177406A (ja) | 2013-09-09 |
| JP2013177406A5 true JP2013177406A5 (https=) | 2016-08-04 |
| JP6239851B2 JP6239851B2 (ja) | 2017-11-29 |
Family
ID=37772904
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Pending JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2013092845A Active JP6239851B2 (ja) | 2005-12-22 | 2013-04-25 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2014207464A Active JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Withdrawn JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Pending JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207464A Active JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Withdrawn JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (7) | US20090004283A1 (https=) |
| EP (3) | EP1968549B1 (https=) |
| JP (4) | JP2009520727A (https=) |
| KR (5) | KR101245919B1 (https=) |
| CN (1) | CN103251929A (https=) |
| AR (1) | AR058591A1 (https=) |
| AU (1) | AU2006328950B2 (https=) |
| BR (2) | BR122019027412B8 (https=) |
| CA (1) | CA2631811C (https=) |
| CL (1) | CL2018003398A1 (https=) |
| EC (1) | ECSP088560A (https=) |
| ES (2) | ES2755032T3 (https=) |
| IL (1) | IL191842A0 (https=) |
| IN (1) | IN2015DN03936A (https=) |
| MA (1) | MA30064B1 (https=) |
| NO (1) | NO20082988L (https=) |
| PE (1) | PE20071139A1 (https=) |
| PL (2) | PL1968549T3 (https=) |
| PT (2) | PT1968549E (https=) |
| RU (1) | RU2464972C2 (https=) |
| TW (2) | TWI469788B (https=) |
| WO (1) | WO2007071395A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2164467T3 (pl) | 2007-06-06 | 2017-07-31 | Debiopharm Research & Manufacturing Sa | Kompozycja farmaceutyczna o powolnym uwalnianiu wytworzona z mikrocząstek |
| US8470360B2 (en) * | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| ES2324009B1 (es) * | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
| AU2013201877B2 (en) * | 2008-01-30 | 2015-01-29 | Novartis Ag | Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers |
| JP5791278B2 (ja) * | 2008-01-30 | 2015-10-07 | ノバルティス アーゲー | オクトレオチドおよび３種の線状ポリラクチド−コ−グリコリドポリマーを含む徐放性製剤 |
| AU2015201581B2 (en) * | 2008-09-17 | 2017-03-09 | Amryt Endo, Inc. | Pharmaceutical Compositions and Related Methods of Delivery |
| CN102176900B (zh) | 2008-09-17 | 2017-09-26 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| US20100151033A1 (en) * | 2008-12-15 | 2010-06-17 | Novartis Ag | Octreotide depot formulation with constantly high exposure levels |
| JP2012515791A (ja) * | 2009-01-23 | 2012-07-12 | サーモディクス ファーマシューティカルズ， インコーポレイテッド | ポリマー混成物由来の放出制御システム |
| US20120022137A1 (en) * | 2010-07-21 | 2012-01-26 | Rivers Hongwen M | METHOD OF CONTROLLING INITIAL DRUG RELEASE OF siRNA FROM SUSTAINED-RELEASE IMPLANTS |
| GB201016433D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
| GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
| US20120156304A1 (en) * | 2010-12-15 | 2012-06-21 | Thomas Tice | Branched polyol polyesters, blends, and pharmaceutical formulations comprising same |
| ES2855349T3 (es) * | 2011-04-25 | 2021-09-23 | Shan Dong Luye Pharm Co Ltd | Composición de risperidona de microesferas de liberación controlada |
| CN102488619B (zh) * | 2011-12-05 | 2014-08-06 | 上海交通大学 | 连续生产艾塞那肽微球的装置及控制微球释放速度的方法 |
| DE112015005320T5 (de) * | 2014-11-25 | 2017-08-31 | Cbc Co., Ltd. | Janus Nanopartikel und Verfahren zur Herstellung derselben |
| HUE071943T2 (hu) | 2015-02-03 | 2025-10-28 | Amryt Endo Inc | Akromegália kezelése oktreotid orális alkalmazásával |
| CN107405059B (zh) * | 2015-06-26 | 2019-05-28 | 奥林巴斯株式会社 | 内窥镜电源供给系统 |
| US12396951B2 (en) * | 2016-12-27 | 2025-08-26 | Upexmed Co. Ltd. | Prevention of local tumor recurrence following surgery using sustainedand/or delayed release of medicaments contained in micro-particles |
| KR102142026B1 (ko) * | 2017-05-31 | 2020-08-06 | 주식회사 대웅제약 | 방출제어가 용이한 서방성 약물 미립자의 제조방법 |
| US12233177B2 (en) | 2019-09-16 | 2025-02-25 | Amgen Inc. | Method for external sterilization of drug delivery device |
| CN111214643A (zh) * | 2020-03-11 | 2020-06-02 | 苏州善湾生物医药科技有限公司 | 一种基于皮下凝胶缓释的奥曲肽组合物、制备方法及应用 |
| CN115551550A (zh) * | 2020-05-08 | 2022-12-30 | M技术株式会社 | 均匀分散有生理活性物质的微球及含有其的缓释制剂 |
| JP6852943B1 (ja) * | 2020-05-08 | 2021-03-31 | エム・テクニック株式会社 | 主剤が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤 |
| KR102947972B1 (ko) | 2020-05-08 | 2026-04-06 | 엠. 테크닉 가부시키가이샤 | 생리 활성 물질이 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| KR102464821B1 (ko) * | 2022-04-13 | 2022-11-09 | (주)인벤티지랩 | 목시덱틴을 포함하는 마이크로 입자 및 이를 포함하는 서방형 주사제 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| EP0029579B1 (en) | 1979-11-27 | 1983-02-16 | Sandoz Ag | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5538739A (en) | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| MY107937A (en) * | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| WO1993015722A1 (en) * | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| KR100260632B1 (ko) * | 1992-12-28 | 2000-07-01 | 성재갑 | 이식형 소마토트로핀 조성물 |
| US5603960A (en) * | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| WO1998027980A2 (en) * | 1996-12-20 | 1998-07-02 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
| AR012448A1 (es) * | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| CA2291659A1 (fr) * | 1997-06-04 | 1998-12-10 | Debio Recherche Pharmaceutique S.A. | Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication |
| ES2169980B1 (es) * | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| KR100392501B1 (ko) * | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
| ATE374598T1 (de) * | 2002-03-15 | 2007-10-15 | Alrise Biosystems Gmbh | Mikropartikel und verfahren zur deren herstellung |
| ATE418323T1 (de) * | 2002-11-06 | 2009-01-15 | Alza Corp | Depot-formulierungen mit verzögerter freisetzung |
| US20040097419A1 (en) * | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
| KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
| WO2005007122A2 (en) * | 2003-07-18 | 2005-01-27 | Oakwood Laboratories, L.L.C. | Polymer stabilization |
| WO2005009357A2 (en) * | 2003-07-23 | 2005-02-03 | Pr Pharmaceuticals, Inc. | Controlled release compositions |
| MY158342A (en) * | 2003-11-14 | 2016-09-30 | Novartis Ag | Pharmaceutical composition |
| CN101035512B (zh) * | 2004-08-12 | 2012-01-18 | 昌达生物科技公司 | 用于生物活性化合物可控制释放递送的药物组合物 |
-
2006
- 2006-12-20 CA CA2631811A patent/CA2631811C/en active Active
- 2006-12-20 PT PT68410596T patent/PT1968549E/pt unknown
- 2006-12-20 EP EP06841059.6A patent/EP1968549B1/en active Active
- 2006-12-20 BR BR122019027412A patent/BR122019027412B8/pt active IP Right Grant
- 2006-12-20 IN IN3936DEN2015 patent/IN2015DN03936A/en unknown
- 2006-12-20 WO PCT/EP2006/012313 patent/WO2007071395A1/en not_active Ceased
- 2006-12-20 PL PL06841059T patent/PL1968549T3/pl unknown
- 2006-12-20 AU AU2006328950A patent/AU2006328950B2/en active Active
- 2006-12-20 PT PT101753820T patent/PT2359809T/pt unknown
- 2006-12-20 KR KR1020087014985A patent/KR101245919B1/ko active Active
- 2006-12-20 JP JP2008546248A patent/JP2009520727A/ja active Pending
- 2006-12-20 AR ARP060105668A patent/AR058591A1/es unknown
- 2006-12-20 BR BRPI0620063A patent/BRPI0620063B8/pt active IP Right Grant
- 2006-12-20 KR KR1020137004518A patent/KR20130024987A/ko not_active Ceased
- 2006-12-20 ES ES10175382T patent/ES2755032T3/es active Active
- 2006-12-20 KR KR1020147031146A patent/KR20140133968A/ko not_active Ceased
- 2006-12-20 CN CN2013101523825A patent/CN103251929A/zh active Pending
- 2006-12-20 EP EP10175382.0A patent/EP2359809B1/en active Active
- 2006-12-20 RU RU2008129626/15A patent/RU2464972C2/ru active
- 2006-12-20 US US12/158,345 patent/US20090004283A1/en not_active Abandoned
- 2006-12-20 KR KR1020137004520A patent/KR20130024988A/ko not_active Ceased
- 2006-12-20 EP EP19188892.4A patent/EP3603623A1/en not_active Withdrawn
- 2006-12-20 PE PE2006001665A patent/PE20071139A1/es not_active Application Discontinuation
- 2006-12-20 PL PL10175382T patent/PL2359809T3/pl unknown
- 2006-12-20 ES ES06841059.6T patent/ES2492641T3/es active Active
- 2006-12-20 KR KR1020137004517A patent/KR101458728B1/ko active Active
- 2006-12-21 TW TW95148218A patent/TWI469788B/zh active
- 2006-12-21 TW TW103107772A patent/TWI468172B/zh active
-
2008
- 2008-05-29 IL IL191842A patent/IL191842A0/en unknown
- 2008-06-18 MA MA31048A patent/MA30064B1/fr unknown
- 2008-06-19 EC EC2008008560A patent/ECSP088560A/es unknown
- 2008-07-02 NO NO20082988A patent/NO20082988L/no not_active Application Discontinuation
-
2013
- 2013-04-25 JP JP2013092845A patent/JP6239851B2/ja active Active
-
2014
- 2014-10-08 JP JP2014207464A patent/JP6178772B2/ja active Active
- 2014-10-16 US US14/516,016 patent/US20150037420A1/en not_active Abandoned
-
2015
- 2015-12-22 US US14/977,801 patent/US20160120935A1/en not_active Abandoned
-
2016
- 2016-06-09 JP JP2016115579A patent/JP2016216467A/ja not_active Withdrawn
-
2018
- 2018-01-17 US US15/873,473 patent/US20180140662A1/en not_active Abandoned
- 2018-11-29 CL CL2018003398A patent/CL2018003398A1/es unknown
-
2020
- 2020-03-10 US US16/813,864 patent/US20200206306A1/en not_active Abandoned
-
2022
- 2022-06-07 US US17/834,014 patent/US20220296675A1/en not_active Abandoned
-
2024
- 2024-11-22 US US18/956,119 patent/US20250082718A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013177406A5 (https=) | ||
| JP2015044823A5 (https=) | ||
| JP6072121B2 (ja) | リスペリドン徐放性ミクロスフェア組成物 | |
| RU2008129626A (ru) | Композиции с замедленным высвобождением, включающие октреотид и два или более сополимера полилактида и глюколида | |
| JP5882993B2 (ja) | 抗精神病薬デポ型注射用組成物 | |
| ES2798103T3 (es) | Composición farmacéutica inyectable estable de antagonista del receptor de neuroquinina-1 y procedimiento para su preparación | |
| JP2013527213A (ja) | 注射用デポ型組成物調合法 | |
| Schnieders et al. | The effect of porosity on drug release kinetics from vancomycin microsphere/calcium phosphate cement composites | |
| CN112972388B (zh) | 卡利拉嗪释放制剂 | |
| WO2018166502A1 (zh) | 一种水难溶/微溶性药物缓释组合物 | |
| JP2011503213A5 (https=) | ||
| KR101930588B1 (ko) | 마이크로입자 중에 소마토스타틴 유도체를 포함하는 연장-방출 조성물 | |
| CN109414401B (zh) | 用于胃肠外给药的生物可降解聚合物微球组合物 | |
| CN110123779A (zh) | 一种用于关节腔内注射的微球及其制备方法 | |
| RU2010135629A (ru) | Репаративная форма с замедленным высвобождением, содержащая октреотид и три линейных полимера поли(лактид-со-гликолида) | |
| CN103948911B (zh) | 一种棘白菌素类抗真菌药物缓释微球制剂及其制备方法 | |
| CN1923189A (zh) | 一种紫杉碱类抗癌药物的缓释注射剂 | |
| RU2009101810A (ru) | Составы ингибиторов ароматазы с замедленным высвобождением | |
| WO2023116517A1 (zh) | 一种可平稳释放的持续性递送制剂及其制备方法 | |
| WO2024168022A2 (en) | Degarelix polymeric formulations | |
| CN101219113A (zh) | 含苯达莫司汀的复方抗癌缓释注射剂 | |
| KR101764004B1 (ko) | 골관절염 예방 또는 치료용, 또는 관절 통증 완화용 주사제 조성물 | |
| CN101219112A (zh) | 一种含苯达莫司汀的复方抗癌缓释注射剂 | |
| Mittal et al. | In vitro release behavior of paclitaxel and carboplatin from poly (L-lactide) microspheres dispersed in thermosensitive biodegradable gel for combination therapy | |
| Yan et al. | Pharmacokinetics and biodistribution of paclitaxel-loaded microspheres |