JP2013144719A5 - - Google Patents
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- Publication number
- JP2013144719A5 JP2013144719A5 JP2013094888A JP2013094888A JP2013144719A5 JP 2013144719 A5 JP2013144719 A5 JP 2013144719A5 JP 2013094888 A JP2013094888 A JP 2013094888A JP 2013094888 A JP2013094888 A JP 2013094888A JP 2013144719 A5 JP2013144719 A5 JP 2013144719A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- tetrahydrochromeno
- fluorophenyl
- trimethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 5
- 230000005176 gastrointestinal motility Effects 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 230000003042 antagnostic effect Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- QSSLNCOGGSGPGR-UHFFFAOYSA-N 1-(2-methoxyethyl)-n,n,2-trimethyl-8-phenyl-7,8-dihydro-6h-pyrano[2,3-e]benzimidazole-5-carboxamide Chemical compound O1C2=C3N(CCOC)C(C)=NC3=CC(C(=O)N(C)C)=C2CCC1C1=CC=CC=C1 QSSLNCOGGSGPGR-UHFFFAOYSA-N 0.000 claims 2
- -1 5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl Chemical group 0.000 claims 2
- CLIQCDHNPDMGSL-HNNXBMFYSA-N 7-[[(4s)-5,7-difluoro-3,4-dihydro-2h-chromen-4-yl]oxy]-n,n,2-trimethyl-3h-benzimidazole-5-carboxamide Chemical compound C1COC2=CC(F)=CC(F)=C2[C@H]1OC1=C(N=C(C)N2)C2=CC(C(=O)N(C)C)=C1 CLIQCDHNPDMGSL-HNNXBMFYSA-N 0.000 claims 2
- GHVIMBCFLRTFHI-UHFFFAOYSA-N 8-[(2,6-dimethylphenyl)methylamino]-n-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide Chemical compound C=1C(C(=O)NCCO)=CN2C(C)=C(C)N=C2C=1NCC1=C(C)C=CC=C1C GHVIMBCFLRTFHI-UHFFFAOYSA-N 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- LECZXZOBEZITCL-UHFFFAOYSA-N revaprazan Chemical compound C1CC2=CC=CC=C2C(C)N1C(C(=C(C)N=1)C)=NC=1NC1=CC=C(F)C=C1 LECZXZOBEZITCL-UHFFFAOYSA-N 0.000 claims 2
- BFDBKMOZYNOTPK-UHFFFAOYSA-N vonoprazan Chemical compound C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1F BFDBKMOZYNOTPK-UHFFFAOYSA-N 0.000 claims 2
- PWILYDZRJORZDR-MISYRCLQSA-N (7r,8r,9r)-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridin-8-ol Chemical compound C1([C@@H]2[C@@H](O)[C@@H](C3=C(C4=NC(C)=C(C)N4C=C3)N2)OCCOC)=CC=CC=C1 PWILYDZRJORZDR-MISYRCLQSA-N 0.000 claims 1
- GKYNXSVMESZZIF-UHFFFAOYSA-N 1-(4-fluoro-5-phenyl-1-pyridin-3-ylsulfonylpyrrol-3-yl)-n-methylmethanamine Chemical compound FC=1C(CNC)=CN(S(=O)(=O)C=2C=NC=CC=2)C=1C1=CC=CC=C1 GKYNXSVMESZZIF-UHFFFAOYSA-N 0.000 claims 1
- GLTCPTOZHSIXQA-UHFFFAOYSA-N 1-[5-(2-fluorophenyl)-1-(6-methylpyridin-3-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical compound C=1C=C(C)N=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1F GLTCPTOZHSIXQA-UHFFFAOYSA-N 0.000 claims 1
- ZBNZAJFNDPPMDT-UHFFFAOYSA-N 1h-imidazole-5-carboxamide Chemical compound NC(=O)C1=CNC=N1 ZBNZAJFNDPPMDT-UHFFFAOYSA-N 0.000 claims 1
- KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 claims 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- NXPLYKRKIFPEOA-BLLLJJGKSA-N 7-[(4-fluorophenyl)methoxy]-2,3-dimethyl-1-[[(1s,2s)-2-methylcyclopropyl]methyl]pyrrolo[2,3-d]pyridazine Chemical compound C[C@H]1C[C@@H]1CN1C2=C(OCC=3C=CC(F)=CC=3)N=NC=C2C(C)=C1C NXPLYKRKIFPEOA-BLLLJJGKSA-N 0.000 claims 1
- HZBLJOUWAZLDBZ-UHFFFAOYSA-N 8-(4-fluorophenyl)-1-(2-methoxyethyl)-n,n,2-trimethyl-7,8-dihydro-6h-pyrano[2,3-e]benzimidazole-5-carboxamide Chemical compound O1C2=C3N(CCOC)C(C)=NC3=CC(C(=O)N(C)C)=C2CCC1C1=CC=C(F)C=C1 HZBLJOUWAZLDBZ-UHFFFAOYSA-N 0.000 claims 1
- IXIKBVHRVRDEOS-UHFFFAOYSA-N 8-(4-fluorophenyl)-n,n,2-trimethyl-1-(1,2-oxazol-3-ylmethyl)-7,8-dihydro-6h-pyrano[2,3-e]benzimidazole-5-carboxamide Chemical compound C1=2C=3OC(C=4C=CC(F)=CC=4)CCC=3C(C(=O)N(C)C)=CC=2N=C(C)N1CC=1C=CON=1 IXIKBVHRVRDEOS-UHFFFAOYSA-N 0.000 claims 1
- NWRBYEHPMLPWEO-UHFFFAOYSA-N 8-(4-fluorophenyl)-n-(2-hydroxyethyl)-1-(2-methoxyethyl)-n,2-dimethyl-7,8-dihydro-6h-pyrano[2,3-e]benzimidazole-5-carboxamide Chemical compound O1C2=C3N(CCOC)C(C)=NC3=CC(C(=O)N(C)CCO)=C2CCC1C1=CC=C(F)C=C1 NWRBYEHPMLPWEO-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- LFNWUXXJSMKNKL-UHFFFAOYSA-N [8-(4-fluorophenyl)-1-(2-methoxyethyl)-2-methyl-7,8-dihydro-6h-pyrano[2,3-e]benzimidazol-5-yl]-morpholin-4-ylmethanone Chemical compound C=12CCC(C=3C=CC(F)=CC=3)OC2=C2N(CCOC)C(C)=NC2=CC=1C(=O)N1CCOCC1 LFNWUXXJSMKNKL-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims 1
- 230000002183 duodenal effect Effects 0.000 claims 1
- 230000007661 gastrointestinal function Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- ZKUKMWMSYCIYRD-ZXFNITATSA-N lenampicillin Chemical compound O1C(=O)OC(COC(=O)[C@H]2C(S[C@H]3N2C([C@H]3NC(=O)[C@H](N)C=2C=CC=CC=2)=O)(C)C)=C1C ZKUKMWMSYCIYRD-ZXFNITATSA-N 0.000 claims 1
- 229950005831 lenampicillin Drugs 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 230000007659 motor function Effects 0.000 claims 1
- SRTTWNYIEACZDL-UHFFFAOYSA-N n-methyl-1-[5-(2-methylphenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]methanamine Chemical compound C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1C SRTTWNYIEACZDL-UHFFFAOYSA-N 0.000 claims 1
- RXQZPPFNPSUVQJ-UHFFFAOYSA-N n-methyl-1-[5-(4-methylthiophen-3-yl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]methanamine Chemical compound C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CSC=C1C RXQZPPFNPSUVQJ-UHFFFAOYSA-N 0.000 claims 1
- 229960002292 piperacillin Drugs 0.000 claims 1
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013094888A JP5699309B2 (ja) | 2009-07-09 | 2013-04-30 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009163182 | 2009-07-09 | ||
| JP2009163182 | 2009-07-09 | ||
| JP2009188464 | 2009-08-17 | ||
| JP2009188464 | 2009-08-17 | ||
| JP2013094888A JP5699309B2 (ja) | 2009-07-09 | 2013-04-30 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521969A Division JP5802898B2 (ja) | 2009-07-09 | 2010-07-09 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217434A Division JP5978447B2 (ja) | 2009-07-09 | 2014-10-24 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013144719A JP2013144719A (ja) | 2013-07-25 |
| JP2013144719A5 true JP2013144719A5 (https=) | 2014-01-23 |
| JP5699309B2 JP5699309B2 (ja) | 2015-04-08 |
Family
ID=43429307
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521969A Active JP5802898B2 (ja) | 2009-07-09 | 2010-07-09 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| JP2013094888A Active JP5699309B2 (ja) | 2009-07-09 | 2013-04-30 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| JP2014217434A Active JP5978447B2 (ja) | 2009-07-09 | 2014-10-24 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| JP2016125015A Active JP6212765B2 (ja) | 2009-07-09 | 2016-06-23 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521969A Active JP5802898B2 (ja) | 2009-07-09 | 2010-07-09 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014217434A Active JP5978447B2 (ja) | 2009-07-09 | 2014-10-24 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| JP2016125015A Active JP6212765B2 (ja) | 2009-07-09 | 2016-06-23 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8648080B2 (https=) |
| EP (1) | EP2452680B1 (https=) |
| JP (4) | JP5802898B2 (https=) |
| KR (1) | KR101605063B1 (https=) |
| CN (2) | CN105919998B (https=) |
| BR (1) | BRPI1013288A2 (https=) |
| CA (1) | CA2765529C (https=) |
| ES (1) | ES2767251T3 (https=) |
| MX (1) | MX2012000275A (https=) |
| RU (1) | RU2586276C2 (https=) |
| WO (1) | WO2011004882A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3071206T3 (da) | 2013-11-22 | 2021-05-25 | CL BioSciences LLC | Gastrinantagonister (eg yf476, netazepid) til behandling og forebyggelse af osteoporose |
| CN105708812A (zh) * | 2014-12-02 | 2016-06-29 | 江苏柯菲平医药股份有限公司 | 一种5-（2-氟苯基）-n-甲基-1-（3-吡啶基磺酰基）-1h-吡咯-3-甲氨冻干粉针及其制备方法 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| MA41850A (fr) * | 2015-03-31 | 2018-02-06 | Takeda Pharmaceuticals Co | Nouvelles utilisations pharmaceutiques |
| MX374972B (es) | 2015-06-08 | 2025-03-06 | Hk Inno N Corp | Uso de derivados de bencimidazol para escape acido nocturno. |
| CN105078891B (zh) * | 2015-08-20 | 2018-04-24 | 寿光富康制药有限公司 | 一种tak-438脂质体及其制备方法和应用 |
| CN105168131B (zh) * | 2015-09-17 | 2018-04-24 | 寿光富康制药有限公司 | 一种tak-438纳米乳的制备方法 |
| CN106913859B (zh) * | 2015-12-25 | 2021-05-11 | 中美华世通生物医药科技(武汉)股份有限公司 | 药物组合物及制备方法 |
| CN105663096B (zh) * | 2016-01-25 | 2019-06-14 | 南京济群医药科技股份有限公司 | 一种沃诺拉赞口腔速溶膜剂及其制备方法 |
| KR101829706B1 (ko) | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 산부가염 |
| JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| CN112933091B (zh) * | 2020-09-07 | 2023-01-06 | 天地恒一制药股份有限公司 | 一种抗胃酸类疾病的药物组合物及应用 |
| AU2021364255B2 (en) * | 2020-10-23 | 2025-02-13 | Hk Inno.N Corporation | Orally disintegrating tablet comprising benzimidazole derivative compound and preparation method thereof |
| JP7566164B2 (ja) * | 2020-12-30 | 2024-10-11 | エイチケー イノ．エヌ コーポレーション | テゴプラザンおよび非ステロイド性抗炎症薬を含有する医薬組成物 |
| CN118355013A (zh) * | 2021-12-08 | 2024-07-16 | 制药基因科学株式会社 | 苯并咪唑衍生物化合物及其用途 |
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| AU2006243255A1 (en) | 2005-04-29 | 2006-11-09 | Nycomed Gmbh | Mutual prodrug compounds for use us antiinflammatory agents with gastrointestinal protective activity |
| AR057061A1 (es) | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
| WO2006136552A2 (en) | 2005-06-22 | 2006-12-28 | Nycomed Gmbh | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles |
| GB0513423D0 (en) | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| EP1926714A1 (en) | 2005-08-22 | 2008-06-04 | Nycomed GmbH | Isotopically substituted benzimidazole derivatives |
| AU2006285641A1 (en) * | 2005-08-30 | 2007-03-08 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
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| DE602006014996D1 (de) | 2005-12-19 | 2010-07-29 | Raqualia Pharma Inc | Chromansubstituierte benzimidazole und ihre verwendung als säurepumpenhemmer |
| WO2007114338A1 (ja) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
| WO2008015196A1 (en) | 2006-07-31 | 2008-02-07 | Nycomed Gmbh | 5-,7-bis-substituted imidazo[1,2-a]pyridines |
| ATE512969T1 (de) | 2006-09-21 | 2011-07-15 | Raqualia Pharma Inc | Benzimidazolderivate als selektive säurepumpenhemmer |
| WO2008058990A1 (en) | 2006-11-16 | 2008-05-22 | Nycomed Gmbh | 7,7-disubstituted pyrano-[2,3-c]-imidazo-[1,2-a]-pyridine derivatives and their use as gastric acid secretion inhibitors |
| WO2008071766A2 (en) | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion |
| WO2008071765A1 (en) | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Pharmaceutically active spiro-substituted benzimidazole derivatives |
| WO2008084067A2 (en) | 2007-01-12 | 2008-07-17 | Nycomed Gmbh | Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives |
| WO2008095912A2 (en) | 2007-02-06 | 2008-08-14 | Nycomed Gmbh | Enantiopure pharmacologically active tricyclic benzimidazoles |
| US8933105B2 (en) | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| WO2008151927A2 (en) | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| WO2009041705A2 (en) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compounds as proton pump inhibitors |
| WO2009041447A1 (ja) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
-
2010
- 2010-07-09 EP EP10797193.9A patent/EP2452680B1/en active Active
- 2010-07-09 BR BRPI1013288A patent/BRPI1013288A2/pt not_active Application Discontinuation
- 2010-07-09 KR KR1020127002781A patent/KR101605063B1/ko active Active
- 2010-07-09 US US13/383,056 patent/US8648080B2/en active Active
- 2010-07-09 MX MX2012000275A patent/MX2012000275A/es active IP Right Grant
- 2010-07-09 WO PCT/JP2010/061660 patent/WO2011004882A1/ja not_active Ceased
- 2010-07-09 JP JP2011521969A patent/JP5802898B2/ja active Active
- 2010-07-09 CA CA2765529A patent/CA2765529C/en active Active
- 2010-07-09 RU RU2012104533/15A patent/RU2586276C2/ru active
- 2010-07-09 CN CN201610246787.9A patent/CN105919998B/zh active Active
- 2010-07-09 ES ES10797193T patent/ES2767251T3/es active Active
- 2010-07-09 CN CN2010800308648A patent/CN102470126A/zh active Pending
-
2013
- 2013-04-30 JP JP2013094888A patent/JP5699309B2/ja active Active
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2014
- 2014-10-24 JP JP2014217434A patent/JP5978447B2/ja active Active
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2016
- 2016-06-23 JP JP2016125015A patent/JP6212765B2/ja active Active
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