CA2765529C - Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility - Google Patents
Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility Download PDFInfo
- Publication number
- CA2765529C CA2765529C CA2765529A CA2765529A CA2765529C CA 2765529 C CA2765529 C CA 2765529C CA 2765529 A CA2765529 A CA 2765529A CA 2765529 A CA2765529 A CA 2765529A CA 2765529 C CA2765529 C CA 2765529C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- acid pump
- antagonistic activity
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009163182 | 2009-07-09 | ||
| JP2009-163182 | 2009-07-09 | ||
| JP2009188464 | 2009-08-17 | ||
| JP2009-188464 | 2009-08-17 | ||
| PCT/JP2010/061660 WO2011004882A1 (ja) | 2009-07-09 | 2010-07-09 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2765529A1 CA2765529A1 (en) | 2011-01-13 |
| CA2765529C true CA2765529C (en) | 2017-02-07 |
Family
ID=43429307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2765529A Active CA2765529C (en) | 2009-07-09 | 2010-07-09 | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8648080B2 (https=) |
| EP (1) | EP2452680B1 (https=) |
| JP (4) | JP5802898B2 (https=) |
| KR (1) | KR101605063B1 (https=) |
| CN (2) | CN105919998B (https=) |
| BR (1) | BRPI1013288A2 (https=) |
| CA (1) | CA2765529C (https=) |
| ES (1) | ES2767251T3 (https=) |
| MX (1) | MX2012000275A (https=) |
| RU (1) | RU2586276C2 (https=) |
| WO (1) | WO2011004882A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3071206T3 (da) | 2013-11-22 | 2021-05-25 | CL BioSciences LLC | Gastrinantagonister (eg yf476, netazepid) til behandling og forebyggelse af osteoporose |
| CN105708812A (zh) * | 2014-12-02 | 2016-06-29 | 江苏柯菲平医药股份有限公司 | 一种5-（2-氟苯基）-n-甲基-1-（3-吡啶基磺酰基）-1h-吡咯-3-甲氨冻干粉针及其制备方法 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| MA41850A (fr) * | 2015-03-31 | 2018-02-06 | Takeda Pharmaceuticals Co | Nouvelles utilisations pharmaceutiques |
| MX374972B (es) | 2015-06-08 | 2025-03-06 | Hk Inno N Corp | Uso de derivados de bencimidazol para escape acido nocturno. |
| CN105078891B (zh) * | 2015-08-20 | 2018-04-24 | 寿光富康制药有限公司 | 一种tak-438脂质体及其制备方法和应用 |
| CN105168131B (zh) * | 2015-09-17 | 2018-04-24 | 寿光富康制药有限公司 | 一种tak-438纳米乳的制备方法 |
| CN106913859B (zh) * | 2015-12-25 | 2021-05-11 | 中美华世通生物医药科技(武汉)股份有限公司 | 药物组合物及制备方法 |
| CN105663096B (zh) * | 2016-01-25 | 2019-06-14 | 南京济群医药科技股份有限公司 | 一种沃诺拉赞口腔速溶膜剂及其制备方法 |
| KR101829706B1 (ko) | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 산부가염 |
| JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| CN112933091B (zh) * | 2020-09-07 | 2023-01-06 | 天地恒一制药股份有限公司 | 一种抗胃酸类疾病的药物组合物及应用 |
| AU2021364255B2 (en) * | 2020-10-23 | 2025-02-13 | Hk Inno.N Corporation | Orally disintegrating tablet comprising benzimidazole derivative compound and preparation method thereof |
| JP7566164B2 (ja) * | 2020-12-30 | 2024-10-11 | エイチケー イノ．エヌ コーポレーション | テゴプラザンおよび非ステロイド性抗炎症薬を含有する医薬組成物 |
| CN118355013A (zh) * | 2021-12-08 | 2024-07-16 | 制药基因科学株式会社 | 苯并咪唑衍生物化合物及其用途 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5996272A (ja) | 1982-11-26 | 1984-06-02 | Isuzu Motors Ltd | 金属表面の強化層形成方法 |
| TW282460B (https=) | 1993-12-28 | 1996-08-01 | Yamanouchi Pharma Co Ltd | |
| JP2896532B2 (ja) | 1994-08-13 | 1999-05-31 | ユーハン コーポレーション | 新規なピリミジン誘導体およびその製造方法 |
| SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE9802794D0 (sv) | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| SE9802793D0 (sv) | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| EE04677B1 (et) * | 1998-09-23 | 2006-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahdropridoeetrid, nende kasutamine ja ravim |
| JP2002528548A (ja) | 1998-11-03 | 2002-09-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | イミダゾナフチリジン |
| KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| TWI287014B (en) | 1999-06-15 | 2007-09-21 | Sankyo Co | Optically active pyrrolopyridazine compound |
| KR100860627B1 (ko) | 2000-03-29 | 2008-09-29 | 니코메드 게엠베하 | 이미다조피리딘 유도체의 프로드러그 |
| CA2425363A1 (en) | 2000-10-12 | 2003-04-10 | Fumihiko Sato | Benzimidazole compounds, process for producing the same and use thereof |
| MXPA04001277A (es) | 2001-08-10 | 2004-05-27 | Altana Pharma Ag | Imidazopiridinas triciclicas. |
| SE0102808D0 (sv) | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
| CA2506027A1 (en) | 2002-11-19 | 2004-06-03 | Altana Pharma Ag | 8-substituted imidazopyridines |
| AR043063A1 (es) | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| CN100393720C (zh) | 2003-04-04 | 2008-06-11 | 奥坦纳医药公司 | 环苯并咪唑化合物 |
| JP2006528231A (ja) | 2003-05-27 | 2006-12-14 | アルタナ ファルマ アクチエンゲゼルシャフト | プロトンポンプ阻害剤と胃腸運動性を変更する化合物との医薬品組合せ物 |
| SE0301905D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound I with therapeutic effect |
| BRPI0414046A (pt) | 2003-08-29 | 2006-10-24 | Dynogen Pharmaceuticals Inc | método de tratamento de um distúrbio de motilidade gastrintestinal, de tratamento de "gerd", de "gerd" noturno, composição farmacêutica, kit que compreende um composto e método para aumentar a motilidade esofágica em um paciente |
| WO2005026164A1 (en) | 2003-09-18 | 2005-03-24 | Altana Pharma Ag | Pharmacologically active imidazo[4,5-c]pyridines |
| AR046893A1 (es) | 2003-12-16 | 2005-12-28 | Altana Pharma Ag | Bencimidazoles triciclicos |
| AR046941A1 (es) | 2003-12-19 | 2006-01-04 | Altana Pharma Ag | Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico |
| US20080033006A1 (en) | 2004-01-26 | 2008-02-07 | Altana Pharma Ag | 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors |
| EP1718646A1 (en) | 2004-02-18 | 2006-11-08 | Altana Pharma AG | 1,2,4-triazolo[4,3-a]pyridines useful in the treatment of gastrointestinal disorders |
| US20070191334A1 (en) | 2004-03-17 | 2007-08-16 | Altana Pharma Ag | Tricyclic imidazopyridines |
| AR048869A1 (es) | 2004-04-26 | 2006-06-07 | Altana Pharma Ag | Bencimidazoles triciclicos |
| DE602005002751T2 (de) | 2004-06-09 | 2008-07-17 | Nycomed Gmbh | Substituierte tricyclische benzimidazole |
| MX2007002214A (es) | 2004-09-03 | 2007-05-07 | Yuhan Corp | Derivados de pirrolo[3,2-c]piridina y procesos para su preparacion. |
| ATE466013T1 (de) | 2004-09-03 | 2010-05-15 | Yuhan Corp | Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung |
| DK1784404T3 (da) | 2004-09-03 | 2012-02-13 | Yuhan Corp | Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
| WO2006037748A1 (en) | 2004-10-01 | 2006-04-13 | Altana Pharma Ag | Substituted tricyclic benzimidazoles |
| AR051041A1 (es) | 2004-10-04 | 2006-12-13 | Altana Pharma Ag | Bencimidazoles triciclicos condensados |
| AR051375A1 (es) | 2004-10-15 | 2007-01-10 | Altana Pharma Ag | Imidazopiridinas difluoro substituidas |
| CA2589448A1 (en) | 2004-12-09 | 2006-06-15 | Altana Pharma Ag | Substituted imidazo[4,5-b]pyridines as inhibitors of gastric acid secretion |
| KR101122376B1 (ko) | 2005-03-09 | 2012-03-26 | 주식회사유한양행 | 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법 |
| KR101137168B1 (ko) | 2005-03-09 | 2012-04-19 | 주식회사유한양행 | 피롤로［２,３-ｄ］피리다진 유도체 및 그의 제조방법 |
| PE20061110A1 (es) | 2005-03-24 | 2006-10-20 | Glaxo Group Ltd | Derivados de imidazopiridina como antagonistas de la bomba de acido (apa) |
| EP1863820A1 (en) | 2005-03-24 | 2007-12-12 | Nycomed GmbH | Thioamide-substituted tricyclic benzimidazoles useful for the treatment of gastrointestinal diseases |
| CA2601381A1 (en) | 2005-03-24 | 2006-09-28 | Nycomed Gmbh | 6-thioamide substituted benzimidazoles |
| AU2006243255A1 (en) | 2005-04-29 | 2006-11-09 | Nycomed Gmbh | Mutual prodrug compounds for use us antiinflammatory agents with gastrointestinal protective activity |
| AR057061A1 (es) | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
| WO2006136552A2 (en) | 2005-06-22 | 2006-12-28 | Nycomed Gmbh | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles |
| GB0513423D0 (en) | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| EP1926714A1 (en) | 2005-08-22 | 2008-06-04 | Nycomed GmbH | Isotopically substituted benzimidazole derivatives |
| AU2006285641A1 (en) * | 2005-08-30 | 2007-03-08 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
| US7776873B2 (en) | 2005-12-01 | 2010-08-17 | Yuhan Corporation | Method for treating damage to gastric mucosa |
| DE602006014996D1 (de) | 2005-12-19 | 2010-07-29 | Raqualia Pharma Inc | Chromansubstituierte benzimidazole und ihre verwendung als säurepumpenhemmer |
| WO2007114338A1 (ja) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
| WO2008015196A1 (en) | 2006-07-31 | 2008-02-07 | Nycomed Gmbh | 5-,7-bis-substituted imidazo[1,2-a]pyridines |
| ATE512969T1 (de) | 2006-09-21 | 2011-07-15 | Raqualia Pharma Inc | Benzimidazolderivate als selektive säurepumpenhemmer |
| WO2008058990A1 (en) | 2006-11-16 | 2008-05-22 | Nycomed Gmbh | 7,7-disubstituted pyrano-[2,3-c]-imidazo-[1,2-a]-pyridine derivatives and their use as gastric acid secretion inhibitors |
| WO2008071766A2 (en) | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion |
| WO2008071765A1 (en) | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Pharmaceutically active spiro-substituted benzimidazole derivatives |
| WO2008084067A2 (en) | 2007-01-12 | 2008-07-17 | Nycomed Gmbh | Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives |
| WO2008095912A2 (en) | 2007-02-06 | 2008-08-14 | Nycomed Gmbh | Enantiopure pharmacologically active tricyclic benzimidazoles |
| US8933105B2 (en) | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| WO2008151927A2 (en) | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| WO2009041705A2 (en) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compounds as proton pump inhibitors |
| WO2009041447A1 (ja) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
-
2010
- 2010-07-09 EP EP10797193.9A patent/EP2452680B1/en active Active
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- 2010-07-09 KR KR1020127002781A patent/KR101605063B1/ko active Active
- 2010-07-09 US US13/383,056 patent/US8648080B2/en active Active
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- 2010-07-09 WO PCT/JP2010/061660 patent/WO2011004882A1/ja not_active Ceased
- 2010-07-09 JP JP2011521969A patent/JP5802898B2/ja active Active
- 2010-07-09 CA CA2765529A patent/CA2765529C/en active Active
- 2010-07-09 RU RU2012104533/15A patent/RU2586276C2/ru active
- 2010-07-09 CN CN201610246787.9A patent/CN105919998B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5699309B2 (ja) | 2015-04-08 |
| CN105919998A (zh) | 2016-09-07 |
| RU2586276C2 (ru) | 2016-06-10 |
| JP2016166255A (ja) | 2016-09-15 |
| CN102470126A (zh) | 2012-05-23 |
| EP2452680B1 (en) | 2019-12-18 |
| JPWO2011004882A1 (ja) | 2012-12-20 |
| JP6212765B2 (ja) | 2017-10-18 |
| KR101605063B1 (ko) | 2016-03-21 |
| JP2013144719A (ja) | 2013-07-25 |
| RU2012104533A (ru) | 2013-08-20 |
| JP5978447B2 (ja) | 2016-08-24 |
| EP2452680A1 (en) | 2012-05-16 |
| KR20120052269A (ko) | 2012-05-23 |
| HK1225608A1 (zh) | 2017-09-15 |
| JP2015038140A (ja) | 2015-02-26 |
| WO2011004882A1 (ja) | 2011-01-13 |
| CA2765529A1 (en) | 2011-01-13 |
| US8648080B2 (en) | 2014-02-11 |
| CN105919998B (zh) | 2021-08-24 |
| EP2452680A4 (en) | 2013-12-04 |
| BRPI1013288A2 (pt) | 2016-03-29 |
| US20120115820A1 (en) | 2012-05-10 |
| ES2767251T3 (es) | 2020-06-17 |
| JP5802898B2 (ja) | 2015-11-04 |
| MX2012000275A (es) | 2012-02-08 |
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