JP2012533738A5 - - Google Patents
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- JP2012533738A5 JP2012533738A5 JP2012520794A JP2012520794A JP2012533738A5 JP 2012533738 A5 JP2012533738 A5 JP 2012533738A5 JP 2012520794 A JP2012520794 A JP 2012520794A JP 2012520794 A JP2012520794 A JP 2012520794A JP 2012533738 A5 JP2012533738 A5 JP 2012533738A5
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- 238000000034 method Methods 0.000 claims 17
- 230000004913 activation Effects 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 239000002246 antineoplastic agent Substances 0.000 claims 9
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 8
- 230000003321 amplification Effects 0.000 claims 8
- 229940041181 antineoplastic drug Drugs 0.000 claims 8
- 206010017758 gastric cancer Diseases 0.000 claims 8
- 238000003199 nucleic acid amplification method Methods 0.000 claims 8
- 201000011549 stomach cancer Diseases 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000000284 extract Substances 0.000 claims 6
- 230000004044 response Effects 0.000 claims 3
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 2
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 2
- 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 2
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 claims 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 2
- -1 c-Met Proteins 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000010790 dilution Methods 0.000 claims 2
- 239000012895 dilution Substances 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 102100037263 3-phosphoinositide-dependent protein kinase 1 Human genes 0.000 claims 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 1
- 101100481404 Danio rerio tie1 gene Proteins 0.000 claims 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 1
- 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 claims 1
- 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 claims 1
- 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
- 101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 claims 1
- 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 claims 1
- 101000974356 Homo sapiens Nuclear receptor coactivator 3 Proteins 0.000 claims 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 claims 1
- 101000864831 Homo sapiens Serine/threonine-protein kinase Sgk3 Proteins 0.000 claims 1
- 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 claims 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 101100268648 Mus musculus Abl1 gene Proteins 0.000 claims 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 1
- 101100481406 Mus musculus Tie1 gene Proteins 0.000 claims 1
- 102000011244 Nuclear receptor coactivator Human genes 0.000 claims 1
- 108050001461 Nuclear receptor coactivator Proteins 0.000 claims 1
- 102100022883 Nuclear receptor coactivator 3 Human genes 0.000 claims 1
- 101100248186 Oryza sativa subsp. japonica RFT1 gene Proteins 0.000 claims 1
- 102000038030 PI3Ks Human genes 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 1
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 1
- 102100030071 Serine/threonine-protein kinase Sgk3 Human genes 0.000 claims 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 102000037979 non-receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008046 non-receptor tyrosine kinases Proteins 0.000 claims 1
- 108020004017 nuclear receptors Proteins 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22586609P | 2009-07-15 | 2009-07-15 | |
| US61/225,866 | 2009-07-15 | ||
| US26521809P | 2009-11-30 | 2009-11-30 | |
| US61/265,218 | 2009-11-30 | ||
| US32500010P | 2010-04-16 | 2010-04-16 | |
| US61/325,000 | 2010-04-16 | ||
| PCT/US2010/042182 WO2011008990A1 (en) | 2009-07-15 | 2010-07-15 | Drug selection for gastric cancer therapy using antibody-based arrays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015159663A Division JP2016001187A (ja) | 2009-07-15 | 2015-08-12 | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533738A JP2012533738A (ja) | 2012-12-27 |
| JP2012533738A5 true JP2012533738A5 (https=) | 2013-08-29 |
| JP5795311B2 JP5795311B2 (ja) | 2015-10-14 |
Family
ID=43449806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520794A Expired - Fee Related JP5795311B2 (ja) | 2009-07-15 | 2010-07-15 | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
| JP2015159663A Pending JP2016001187A (ja) | 2009-07-15 | 2015-08-12 | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015159663A Pending JP2016001187A (ja) | 2009-07-15 | 2015-08-12 | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10473640B2 (https=) |
| EP (1) | EP2454598B1 (https=) |
| JP (2) | JP5795311B2 (https=) |
| AU (1) | AU2010273319B2 (https=) |
| CA (1) | CA2768013C (https=) |
| ES (1) | ES2627909T3 (https=) |
| WO (1) | WO2011008990A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
| ES2526211T3 (es) | 2007-07-13 | 2015-01-08 | Nestec S.A. | Selección de fármacos para la terapia del cáncer de pulmón utilizando matrices basadas en anticuerpos |
| NZ617520A (en) | 2008-02-25 | 2015-05-29 | Nestec Sa | Drug selection for breast cancer therapy using antibody-based arrays |
| US20120295259A1 (en) * | 2011-05-19 | 2012-11-22 | Laboratory Corporation Of America Holdings | Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients |
| US11401344B2 (en) | 2008-12-01 | 2022-08-02 | Laboratory Corporation Of America Holdings | Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients |
| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| EP2656077A1 (en) * | 2010-12-23 | 2013-10-30 | Nestec S.A. | Drug selection for malignant cancer therapy using antibody-based arrays |
| US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
| DK2676137T3 (en) | 2011-02-17 | 2015-01-19 | Nestec Sa | TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS |
| SG192270A1 (en) | 2011-02-17 | 2013-08-30 | Nestec Sa | Apparatus and method for isolating leukocytes and tumor cells by filtration |
| WO2012119113A2 (en) | 2011-03-02 | 2012-09-07 | Nestec Sa | Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures |
| EP2694972B8 (en) * | 2011-04-04 | 2017-08-16 | Pierian Holdings, Inc. | Methods for predicting and improving the survival of gastric cancer patients |
| JP2014517279A (ja) | 2011-05-10 | 2014-07-17 | ネステク ソシエテ アノニム | 個別治療管理のための疾患活動性プロファイリングの方法 |
| KR101317809B1 (ko) * | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
| JP6186575B2 (ja) * | 2011-09-02 | 2017-08-30 | ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． | 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング |
| CN103974720A (zh) * | 2011-09-09 | 2014-08-06 | 安姆根有限公司 | C-met蛋白质用于预测抗肝细胞生长因子(“hgf”)抗体在食管癌和胃癌患者中的功效的用途 |
| EP2788752B1 (en) * | 2011-12-05 | 2018-10-03 | Pierian Holdings, Inc. | Method of therapy selection for patients with lung cancer |
| GB201121914D0 (en) | 2011-12-20 | 2012-02-01 | Ge Healthcare Ltd | Method for patient selection |
| WO2013110030A2 (en) | 2012-01-19 | 2013-07-25 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| KR101938699B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도 |
| US9422602B2 (en) | 2012-08-15 | 2016-08-23 | Bio-Rad Laboratories, Inc. | Methods and compositions for determining nucleic acid degradation |
| JP2015532425A (ja) | 2012-10-05 | 2015-11-09 | ネステク ソシエテ アノニム | 粘膜治癒を予測及びモニタリングするための方法 |
| EP2954328A1 (en) | 2013-02-05 | 2015-12-16 | Nestec S.A. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
| EP2954068B8 (en) | 2013-02-05 | 2018-10-31 | Pierian Holdings, Inc. | Drug selection for non-small cell lung cancer therapy |
| WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| WO2014137420A1 (en) * | 2013-03-08 | 2014-09-12 | Harbor Therapeutics, Inc. | Receptor and kinase modulator screening methods |
| US9535055B2 (en) | 2013-03-28 | 2017-01-03 | Samsung Electronics Co., Ltd. | Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| WO2014188363A1 (en) | 2013-05-21 | 2014-11-27 | Nestec S.A. | Methods for predicting and improving the survival of colorectal cancer patients |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| WO2015105996A2 (en) * | 2014-01-09 | 2015-07-16 | Sloan-Kettering Institute For Cancer Research | Treatment of tumors expressing mutant p53 |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| KR102223502B1 (ko) | 2014-05-09 | 2021-03-05 | 삼성전자주식회사 | 항 c-Met/항 EGFR/항 Her3 다중 특이 항체 및 이의 이용 |
| US20170196953A1 (en) | 2014-07-07 | 2017-07-13 | Duke University | VACCINES AGAINST AN ONCOGENIC ISOFORM OF HER2 (ErbB2) AND METHODS OF USING THE SAME |
| EP3166630A4 (en) | 2014-07-07 | 2018-03-28 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| KR20160024639A (ko) | 2014-08-26 | 2016-03-07 | 삼성전자주식회사 | c-Met 표적 치료제의 저항성 또는 효능 예측을 위한 바이오마커 PDGF |
| US20170306415A1 (en) * | 2014-10-01 | 2017-10-26 | Merrimack Phamaceuticals, Inc. | Predicting tumor responses to antibodies against hepatocyte growth factor (hgf) and/or its cognate receptor, c-met |
| MX2017004742A (es) | 2014-10-20 | 2017-07-20 | Nestec Sa | Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos. |
| CN113552350B (zh) * | 2015-04-21 | 2024-10-11 | 基因泰克公司 | 用于前列腺癌分析的组合物和方法 |
| AU2016325715B2 (en) * | 2015-09-24 | 2019-04-04 | Expression Pathology, Inc. | Quantifying Met protein for cancer treatment |
| WO2017120576A1 (en) | 2016-01-07 | 2017-07-13 | Duke University | Cancer vaccines and methods of delivery |
| WO2017176946A1 (en) * | 2016-04-05 | 2017-10-12 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for targeted therapy based on single-cell stimulus perturbation response |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| SG11201909218RA (en) | 2017-04-03 | 2019-11-28 | Hoffmann La Roche | Antibodies binding to steap-1 |
| AU2018277256A1 (en) | 2017-05-31 | 2020-01-30 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in Crohn's disease patients |
| EP3727474A1 (en) * | 2017-12-18 | 2020-10-28 | Janssen Biotech, Inc. | Radiolabeling of polypeptides |
| WO2019131727A1 (ja) * | 2017-12-27 | 2019-07-04 | コニカミノルタ株式会社 | 医薬の評価方法 |
| JP2022551580A (ja) * | 2019-10-04 | 2022-12-12 | ゴールドフィンチ バイオ，インク． | 巣状分節性糸球体硬化症および糖尿病性腎症のバイオマーカーに基づく処置 |
| JP2023023327A (ja) * | 2021-08-05 | 2023-02-16 | 国立大学法人大阪大学 | 腫瘍のサブタイプ決定方法及びその応用、並びにサブタイプ決定のための方法 |
| GB202407076D0 (en) * | 2024-05-17 | 2024-07-03 | Genome Res Ltd | Methods of treatment |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4690890A (en) | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
| SE8500817D0 (sv) | 1985-02-20 | 1985-02-20 | Lars Jonsson | Halvoppet anestesisystem |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US4975532A (en) * | 1986-11-28 | 1990-12-04 | Sclavo, Inc. | Method to derivatize dextran |
| JPH01163661A (ja) | 1987-10-02 | 1989-06-27 | E I Du Pont De Nemours & Co | ＩｇＧ捕捉抗体および多重単クローン性抗体検出系を用いたイムノアツセイ |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5192660A (en) | 1989-04-24 | 1993-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | ELISA methods for the determination of human platelet derived growth factor (PDGF) dimer forms present in human tissues and fluids |
| US5089419A (en) | 1989-08-07 | 1992-02-18 | International Canine Genetics | Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals |
| US5120660A (en) | 1989-12-05 | 1992-06-09 | International Canine Genetics, Inc. | Method for canine fertility detection |
| US5532138A (en) | 1990-04-26 | 1996-07-02 | Behringwerke Ag | Method and kits for determining peroxidatively active catalysts |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| FR2672128B1 (fr) | 1991-01-28 | 1995-08-18 | Cis Bio Int | Procede de mesure de la luminescence emise dans un dosage par luminescence. |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| US6251581B1 (en) | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| ATE244763T1 (de) | 1992-02-11 | 2003-07-15 | Cell Genesys Inc | Erzielen von homozygotem durch zielgerichtete genetische ereignisse |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5332662A (en) | 1992-07-31 | 1994-07-26 | Syntex (U.S.A.) Inc. | Methods for determining peroxidatively active substances |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| JPH06109734A (ja) | 1992-09-30 | 1994-04-22 | S R L:Kk | 抗原の測定方法 |
| US6201109B1 (en) | 1993-01-13 | 2001-03-13 | Dade Behring Marburg Gmbh | Assay for bone alkaline phosphatase |
| WO1995006877A1 (en) | 1993-09-03 | 1995-03-09 | Behringwerke Ag | Fluorescent oxygen channeling immunoassays |
| JP3825815B2 (ja) * | 1994-01-31 | 2006-09-27 | 信義 清水 | 上皮細胞増殖因子レセプターに対するモノクローナル抗体の結合体ならびにその複合体およびその細胞への嵌入方法 |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| FI98961C (fi) | 1994-08-26 | 1997-09-10 | Medix Biochemica Ab Oy | Menetelmät ja määritysvälineet parodontaalisairauden aktiivisuuden ja/tai peri-implantiitin ja/tai niiden kohonneen riskin diagnosoimiseksi |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5876944A (en) | 1996-06-10 | 1999-03-02 | Bayer Corporation | Method for amplification of the response signal in a sandwich immunoassay |
| US5728541A (en) | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
| US20040023375A1 (en) | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
| US6416967B2 (en) | 1996-07-12 | 2002-07-09 | Precision Therapeutics, Inc. | Method of using multicellular particulates to analyze malignant or hyperproliferative tissue |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
| US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
| US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
| US6541214B1 (en) | 1998-11-13 | 2003-04-01 | Oregon Heath Science University | N-terminally truncated HER-2/neu protein as a cancer prognostic indicator |
| RU2165081C2 (ru) | 1999-01-05 | 2001-04-10 | Ставропольский научно-исследовательский противочумный институт | Способ индикации микроорганизмов |
| US6335173B1 (en) | 1999-01-12 | 2002-01-01 | Verve, Ltd. C/O James Bell | Methods for detecting an analyte of interest using tyramide coating technology |
| GB9901072D0 (en) | 1999-01-19 | 1999-03-10 | Imp Cancer Res Tech | Methods for detecting changes to a macromolecular component of a cell |
| US6972198B2 (en) | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
| RU2149404C1 (ru) | 1999-03-24 | 2000-05-20 | Московский НИИ глазных болезней им. Гельмгольца | Способ прогнозирования клинического течения увеальной меланомы |
| US6322980B1 (en) | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
| US6627400B1 (en) | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
| US6649351B2 (en) | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
| DE19926010C2 (de) | 1999-06-08 | 2003-01-30 | Bundesdruckerei Gmbh | Wert- und Sicherheitsdokument mit Sicherheitsmerkmal mit Piezo-Effekt-basierten Eigenschaften und dazugehöriges Nachweisverfahren |
| US7179638B2 (en) | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
| US7033781B1 (en) | 1999-09-29 | 2006-04-25 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
| WO2001027624A2 (en) | 1999-10-08 | 2001-04-19 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
| AU760486B2 (en) | 1999-10-13 | 2003-05-15 | Incyte Genomics, Inc. | Multiplex cytokine analysis |
| US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| US6511809B2 (en) * | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
| EP1307285A2 (en) | 2000-08-03 | 2003-05-07 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
| CA2422162C (en) | 2000-09-09 | 2012-10-23 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
| US6797481B1 (en) | 2000-10-17 | 2004-09-28 | Dade Behring Marburg Gmbh | Simultaneous screening of multiple analytes |
| US7635571B2 (en) | 2000-12-07 | 2009-12-22 | Siemens Healthcare Diagnostics Products Gmbh | Amplified signal in binding assays |
| DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
| US20070111944A1 (en) | 2001-02-16 | 2007-05-17 | Scrofani Sergio D B | Purification of vascular endothelial growth factor-B |
| US20020168641A1 (en) | 2001-03-09 | 2002-11-14 | Bruce Mortensen | Fluorescein-cyanine 5 as a fluorescence resonance energy transfer pair |
| US20020142361A1 (en) | 2001-03-27 | 2002-10-03 | Emmert-Buck Michael R. | Biodetection method |
| AU2002303384A1 (en) | 2001-04-17 | 2002-10-28 | William J. Dower | Epitope-captured antibody display |
| US20040265923A1 (en) | 2001-05-03 | 2004-12-30 | James Gilmore | Method and apparatus to determine the performance of protein arrays |
| EP1409982A4 (en) | 2001-06-14 | 2006-05-24 | Anadys Pharmaceuticals Inc | PROCESS FOR SCREENING ON LIGANDS OF TARGET MOLECULES |
| US7695926B2 (en) | 2001-07-10 | 2010-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting receptor-ligand interactions in single cells |
| US7381535B2 (en) | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
| WO2003006104A2 (en) | 2001-07-12 | 2003-01-23 | Ludwig Institute For Cancer Research | Lymphatic endothelial cells materials and methods |
| US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| WO2003040670A2 (en) | 2001-11-07 | 2003-05-15 | Sensor Technologies Llc | Method of identifying energy transfer sensors for analytes |
| US6949347B2 (en) | 2002-03-05 | 2005-09-27 | Aclara Biosciences, Inc. | Multiplex analysis using membrane-bound sensitizers |
| AU2003223495A1 (en) | 2002-04-05 | 2003-10-27 | Cell Signaling Technology, Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
| US20030190689A1 (en) | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
| US20040229380A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
| ES2392525T3 (es) | 2002-07-15 | 2012-12-11 | F. Hoffmann-La Roche Ag | Tratamiento del cáncer con el anticuerpo dirigido contra ErbB2 rhuMAb 2C4 |
| FR2843126B1 (fr) | 2002-08-01 | 2006-01-27 | Cis Bio Int | "methode de determination d'une activite enzymatique endoglycosidase" |
| US20040235002A1 (en) | 2002-09-20 | 2004-11-25 | Sangamo Biosciences, Inc. | Multiplex screening assays |
| US20030153013A1 (en) | 2002-11-07 | 2003-08-14 | Ruo-Pan Huang | Antibody-based protein array system |
| CA2515096A1 (en) * | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| CA2521077A1 (en) | 2003-04-01 | 2004-10-28 | Monogram Biosciences, Inc. | Erbb surface receptor complexes as biomarkers |
| US20040265938A1 (en) * | 2003-06-25 | 2004-12-30 | Jose Remacle | Method for the determination of cell activation |
| US7279286B2 (en) | 2003-09-11 | 2007-10-09 | Sanofi-Aventis Deutschland Gmbh | High-throughput-assay with high sensitivity for measuring of the activity of β-adrenergic receptor kinase and for determining the impact of test substances on such activity |
| FI20031370A0 (fi) | 2003-09-23 | 2003-09-23 | Wallac Oy | Automaattinen hemoglobiinin määritysmenetelmä vastasyntyneiden seulontaan |
| EP1681983A4 (en) | 2003-10-14 | 2008-12-10 | Monogram Biosciences Inc | RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY |
| EP1682512B1 (en) | 2003-11-04 | 2010-03-31 | Bayer Pharmaceuticals Corporation | IMMUNOHISTOCHEMICAL METHODS FOR MONITORING pERK LEVELS |
| JP2007526460A (ja) | 2004-03-03 | 2007-09-13 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
| WO2005117553A2 (en) | 2004-05-27 | 2005-12-15 | The Regents Of The University Of Colorado | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients |
| SV2006002143A (es) | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
| US20060263837A1 (en) | 2004-06-17 | 2006-11-23 | Liu George D | Immunoassay system and method for detection of antigens |
| DK2299275T3 (en) | 2004-07-30 | 2018-05-07 | Adeza Biomedical Corp | Classification of oncofetal fetronectin level for pregnancy-related indications |
| WO2006031815A2 (en) | 2004-09-13 | 2006-03-23 | Monogram Biosciences, Inc. | Methods and compositions for proximity assays |
| US20080254497A1 (en) | 2004-10-15 | 2008-10-16 | Monogram Biosciences, Inc. | Response Predictors for Erbb Pathway-Specific Drugs |
| WO2006045991A1 (en) * | 2004-10-25 | 2006-05-04 | Astrazeneca Ab | Method to predict whether a tumor will react to a chemotherapeutic treatment |
| WO2006054991A1 (en) | 2004-11-17 | 2006-05-26 | Immunivest Corporation | Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection |
| US20090068162A1 (en) | 2004-11-17 | 2009-03-12 | Robert Sack | Stationary Phase Antibody Arrays for Trace Protein Analysis |
| DE102004056794B4 (de) | 2004-11-24 | 2010-08-26 | Protagen Ag | Verwendung einer Anordnung und Verfahren zur Validierung von Bindern |
| WO2006105642A1 (en) | 2005-04-05 | 2006-10-12 | British Columbia Cancer Agency | Biomarkers for the detection of lung cancer and uses thereof |
| AR053272A1 (es) | 2005-05-11 | 2007-04-25 | Hoffmann La Roche | Determinacion de responsivos a la quimioterapia |
| US7771955B2 (en) | 2005-06-09 | 2010-08-10 | University Of Maryland | Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule |
| WO2007130677A2 (en) | 2006-05-05 | 2007-11-15 | Yale University | Use of subcellular localization profiles as prognostic or predictive indicators |
| CA2663595A1 (en) | 2006-08-07 | 2008-02-14 | The Board Of Regents Of The University Of Texas System | Proteomic patterns of cancer prognostic and predictive signatures |
| BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
| DK2064549T3 (da) | 2006-09-21 | 2013-02-04 | Nestec Sa | Antistof-baserede arrays til detektion af flere signaltransducere i sjældne cirkulerende celler |
| BRPI0718413A2 (pt) | 2006-10-23 | 2014-03-11 | The Uab Research Foundation | Métodos para prever a sensibilidade de uma célula concerosa a um primeiro agente anticâncer, para prever ou monitorar a eficácia de um agente anticâncer, e para determinar uma dose eficaz para um agente anticâncer, kit de detecção, e, sistema de ensaio multiplex |
| DK2080012T3 (da) | 2006-11-10 | 2013-06-17 | Dimerix Bioscience Pty Ltd | Fremgangsmåder til analyse af testforbindelser på forbundne receptorer. |
| JP5656406B2 (ja) | 2006-11-28 | 2015-01-21 | ユースリー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツングＵ３ Ｐｈａｒｍａ ＧｍｂＨ | 治療効力を予測するためのマーカーとしての活性化ｈｅｒ３ |
| EP2132327A2 (en) | 2007-03-27 | 2009-12-16 | Rosetta Genomics Ltd | Gene expression signature for classification of cancers |
| JP2008292424A (ja) * | 2007-05-28 | 2008-12-04 | Nippon Medical School | 腫瘍の検出方法 |
| ES2526211T3 (es) | 2007-07-13 | 2015-01-08 | Nestec S.A. | Selección de fármacos para la terapia del cáncer de pulmón utilizando matrices basadas en anticuerpos |
| EP2065475A1 (en) * | 2007-11-30 | 2009-06-03 | Siemens Healthcare Diagnostics GmbH | Method for therapy prediction in tumors having irregularities in the expression of at least one VEGF ligand and/or at least one ErbB-receptor |
| NZ617520A (en) | 2008-02-25 | 2015-05-29 | Nestec Sa | Drug selection for breast cancer therapy using antibody-based arrays |
| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
| US20120270745A1 (en) | 2009-07-15 | 2012-10-25 | Prometheus Laboratories Inc. | Drug selection for cancer therapy by profiling signal transduction proteins in ascites or pleural efflux samples |
| US20130315933A1 (en) | 2010-10-06 | 2013-11-28 | Christoph Renner | Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy |
| US20120231965A1 (en) | 2011-02-03 | 2012-09-13 | Prometheus Laboratories Inc. | Drug selection for colorectal cancer therapy using antibody-based arrays |
| US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
| US20130216523A1 (en) | 2011-03-31 | 2013-08-22 | Laboratory Corporation Of America Holdings | Methods for Facilitating Diagnosis, Prognosis and Treatment of Cancer by Detecting HER1 Expression |
| JP6186575B2 (ja) | 2011-09-02 | 2017-08-30 | ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． | 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング |
-
2010
- 2010-07-15 AU AU2010273319A patent/AU2010273319B2/en not_active Ceased
- 2010-07-15 JP JP2012520794A patent/JP5795311B2/ja not_active Expired - Fee Related
- 2010-07-15 WO PCT/US2010/042182 patent/WO2011008990A1/en not_active Ceased
- 2010-07-15 EP EP10800567.9A patent/EP2454598B1/en active Active
- 2010-07-15 CA CA2768013A patent/CA2768013C/en not_active Expired - Fee Related
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2011
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