JP2012533539A5 - - Google Patents
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- Publication number
- JP2012533539A5 JP2012533539A5 JP2012520571A JP2012520571A JP2012533539A5 JP 2012533539 A5 JP2012533539 A5 JP 2012533539A5 JP 2012520571 A JP2012520571 A JP 2012520571A JP 2012520571 A JP2012520571 A JP 2012520571A JP 2012533539 A5 JP2012533539 A5 JP 2012533539A5
- Authority
- JP
- Japan
- Prior art keywords
- ray diffraction
- salt according
- salt
- proliferative disorder
- theta scale
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 14
- 238000002441 X-ray diffraction Methods 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000002062 proliferating effect Effects 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- -1 2-pyrrolidin-1-yl-ethoxy Chemical group 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22560909P | 2009-07-15 | 2009-07-15 | |
| US61/225,609 | 2009-07-15 | ||
| PCT/SG2010/000265 WO2011008172A1 (en) | 2009-07-15 | 2010-07-14 | 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094972A Division JP2015164941A (ja) | 2009-07-15 | 2015-05-07 | ９ｅ−１５−（２−ピロリジン−１−イル−エトキシ）−７，１２，２５−トリオキサ−１９，２１，２４−トリアザ−テトラシクロ［１８．３．１．１（２，５）．１（１４，１８）］ヘキサコサ−１（２４），２，４，９，１４，１６，１８（２６），２０，２２−ノナエンのクエン酸塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533539A JP2012533539A (ja) | 2012-12-27 |
| JP2012533539A5 true JP2012533539A5 (enExample) | 2013-08-29 |
| JP6013911B2 JP6013911B2 (ja) | 2016-10-25 |
Family
ID=42790728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520571A Active JP6013911B2 (ja) | 2009-07-15 | 2010-07-14 | ９ｅ−１５−（２−ピロリジン−１−イル−エトキシ）−７，１２，２５−トリオキサ−１９，２１，２４−トリアザ−テトラシクロ［１８．３．１．１（２，５）．１（１４，１８）］ヘキサコサ−１（２４），２，４，９，１４，１６，１８（２６），２０，２２−ノナエンのクエン酸塩 |
| JP2015094972A Pending JP2015164941A (ja) | 2009-07-15 | 2015-05-07 | ９ｅ−１５−（２−ピロリジン−１−イル−エトキシ）−７，１２，２５−トリオキサ−１９，２１，２４−トリアザ−テトラシクロ［１８．３．１．１（２，５）．１（１４，１８）］ヘキサコサ−１（２４），２，４，９，１４，１６，１８（２６），２０，２２−ノナエンのクエン酸塩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094972A Pending JP2015164941A (ja) | 2009-07-15 | 2015-05-07 | ９ｅ−１５−（２−ピロリジン−１−イル−エトキシ）−７，１２，２５−トリオキサ−１９，２１，２４−トリアザ−テトラシクロ［１８．３．１．１（２，５）．１（１４，１８）］ヘキサコサ−１（２４），２，４，９，１４，１６，１８（２６），２０，２２−ノナエンのクエン酸塩 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9062074B2 (enExample) |
| EP (1) | EP2454266B1 (enExample) |
| JP (2) | JP6013911B2 (enExample) |
| CN (1) | CN102762577B (enExample) |
| AR (2) | AR077483A1 (enExample) |
| BR (1) | BR112012000750B1 (enExample) |
| CA (1) | CA2768210C (enExample) |
| DK (1) | DK2454266T3 (enExample) |
| ES (1) | ES2429525T3 (enExample) |
| HR (1) | HRP20130941T1 (enExample) |
| MX (1) | MX2012000680A (enExample) |
| PL (1) | PL2454266T3 (enExample) |
| PT (1) | PT2454266E (enExample) |
| RU (1) | RU2543721C2 (enExample) |
| SI (1) | SI2454266T1 (enExample) |
| SM (1) | SMT201300112B (enExample) |
| TW (1) | TWI537276B (enExample) |
| WO (1) | WO2011008172A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2966753A1 (en) | 2014-11-17 | 2016-05-26 | Arno Therapeutics, Inc. | Onapristone extended-release compositions and methods |
| AU2016326657B2 (en) | 2015-09-25 | 2019-10-24 | Context Biopharma, Inc. | Methods of making onapristone intermediates |
| CA3008422A1 (en) | 2015-12-15 | 2017-06-22 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY110603A (en) * | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| US7151096B2 (en) * | 2003-03-05 | 2006-12-19 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| CN101365703B (zh) * | 2005-11-16 | 2013-11-06 | S*Bio私人有限公司 | 杂烷基连接的嘧啶衍生物 |
-
2010
- 2010-07-14 EP EP10737645.1A patent/EP2454266B1/en active Active
- 2010-07-14 SI SI201030347T patent/SI2454266T1/sl unknown
- 2010-07-14 RU RU2012105044/04A patent/RU2543721C2/ru active
- 2010-07-14 PT PT107376451T patent/PT2454266E/pt unknown
- 2010-07-14 HR HRP20130941AT patent/HRP20130941T1/hr unknown
- 2010-07-14 BR BR112012000750-5A patent/BR112012000750B1/pt active IP Right Grant
- 2010-07-14 US US13/384,139 patent/US9062074B2/en active Active
- 2010-07-14 CN CN201080032627.5A patent/CN102762577B/zh active Active
- 2010-07-14 MX MX2012000680A patent/MX2012000680A/es active IP Right Grant
- 2010-07-14 PL PL10737645T patent/PL2454266T3/pl unknown
- 2010-07-14 ES ES10737645T patent/ES2429525T3/es active Active
- 2010-07-14 CA CA2768210A patent/CA2768210C/en active Active
- 2010-07-14 DK DK10737645.1T patent/DK2454266T3/da active
- 2010-07-14 JP JP2012520571A patent/JP6013911B2/ja active Active
- 2010-07-14 WO PCT/SG2010/000265 patent/WO2011008172A1/en not_active Ceased
- 2010-07-15 AR ARP100102594A patent/AR077483A1/es not_active Application Discontinuation
- 2010-07-15 TW TW099123331A patent/TWI537276B/zh active
-
2013
- 2013-10-04 SM SM201300112T patent/SMT201300112B/xx unknown
-
2015
- 2015-05-07 JP JP2015094972A patent/JP2015164941A/ja active Pending
-
2019
- 2019-08-05 AR ARP190102219A patent/AR114987A2/es unknown