CN102762577B - 9e-15-(2-吡咯烷-1-基-乙氧基)-7,12,25-三氧杂-19,21,24-三氮杂-四环[18.3.1.1(2,5).1(14,18)]二十六碳-1(24),2,4,9,14,16,18(26),20,22-壬烯柠檬酸盐 - Google Patents

9e-15-(2-吡咯烷-1-基-乙氧基)-7,12,25-三氧杂-19,21,24-三氮杂-四环[18.3.1.1(2,5).1(14,18)]二十六碳-1(24),2,4,9,14,16,18(26),20,22-壬烯柠檬酸盐 Download PDF

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Publication number
CN102762577B
CN102762577B CN201080032627.5A CN201080032627A CN102762577B CN 102762577 B CN102762577 B CN 102762577B CN 201080032627 A CN201080032627 A CN 201080032627A CN 102762577 B CN102762577 B CN 102762577B
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China
Prior art keywords
citrate
salt
batch
shows
pyrrolidin
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Chinese (zh)
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CN102762577A (zh
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B·迪莫克
李静霞
A·D·威廉
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Cell Therapeutics Europe SRL
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S bio Pte Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201080032627.5A 2009-07-15 2010-07-14 9e-15-(2-吡咯烷-1-基-乙氧基)-7,12,25-三氧杂-19,21,24-三氮杂-四环[18.3.1.1(2,5).1(14,18)]二十六碳-1(24),2,4,9,14,16,18(26),20,22-壬烯柠檬酸盐 Active CN102762577B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22560909P 2009-07-15 2009-07-15
US61/225,609 2009-07-15
PCT/SG2010/000265 WO2011008172A1 (en) 2009-07-15 2010-07-14 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt

Publications (2)

Publication Number Publication Date
CN102762577A CN102762577A (zh) 2012-10-31
CN102762577B true CN102762577B (zh) 2015-01-07

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CN201080032627.5A Active CN102762577B (zh) 2009-07-15 2010-07-14 9e-15-(2-吡咯烷-1-基-乙氧基)-7,12,25-三氧杂-19,21,24-三氮杂-四环[18.3.1.1(2,5).1(14,18)]二十六碳-1(24),2,4,9,14,16,18(26),20,22-壬烯柠檬酸盐

Country Status (18)

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US (1) US9062074B2 (enExample)
EP (1) EP2454266B1 (enExample)
JP (2) JP6013911B2 (enExample)
CN (1) CN102762577B (enExample)
AR (2) AR077483A1 (enExample)
BR (1) BR112012000750B1 (enExample)
CA (1) CA2768210C (enExample)
DK (1) DK2454266T3 (enExample)
ES (1) ES2429525T3 (enExample)
HR (1) HRP20130941T1 (enExample)
MX (1) MX2012000680A (enExample)
PL (1) PL2454266T3 (enExample)
PT (1) PT2454266E (enExample)
RU (1) RU2543721C2 (enExample)
SI (1) SI2454266T1 (enExample)
SM (1) SMT201300112B (enExample)
TW (1) TWI537276B (enExample)
WO (1) WO2011008172A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2966753A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
CA3008422A1 (en) 2015-12-15 2017-06-22 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
CN101360751A (zh) * 2005-11-16 2009-02-04 S*Bio私人有限公司 氧连接的嘧啶衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110603A (en) * 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
CN101360751A (zh) * 2005-11-16 2009-02-04 S*Bio私人有限公司 氧连接的嘧啶衍生物

Also Published As

Publication number Publication date
CN102762577A (zh) 2012-10-31
AR114987A2 (es) 2020-11-11
EP2454266A1 (en) 2012-05-23
JP2012533539A (ja) 2012-12-27
WO2011008172A1 (en) 2011-01-20
CA2768210C (en) 2017-08-15
ES2429525T3 (es) 2013-11-15
PL2454266T3 (pl) 2014-01-31
AR077483A1 (es) 2011-08-31
HRP20130941T1 (hr) 2013-11-08
MX2012000680A (es) 2012-02-28
BR112012000750A8 (pt) 2018-02-06
TWI537276B (zh) 2016-06-11
EP2454266B1 (en) 2013-07-10
CA2768210A1 (en) 2011-01-20
SI2454266T1 (sl) 2013-10-30
BR112012000750B1 (pt) 2021-05-25
BR112012000750A2 (pt) 2016-08-09
SMT201300112B (it) 2013-11-08
JP2015164941A (ja) 2015-09-17
US9062074B2 (en) 2015-06-23
RU2012105044A (ru) 2013-08-20
HK1178159A1 (en) 2013-09-06
DK2454266T3 (da) 2013-09-08
TW201107336A (en) 2011-03-01
US20120196876A1 (en) 2012-08-02
RU2543721C2 (ru) 2015-03-10
JP6013911B2 (ja) 2016-10-25
PT2454266E (pt) 2013-10-10

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