JP2012531219A5 - - Google Patents
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- Publication number
- JP2012531219A5 JP2012531219A5 JP2012518929A JP2012518929A JP2012531219A5 JP 2012531219 A5 JP2012531219 A5 JP 2012531219A5 JP 2012518929 A JP2012518929 A JP 2012518929A JP 2012518929 A JP2012518929 A JP 2012518929A JP 2012531219 A5 JP2012531219 A5 JP 2012531219A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- domain
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 241000725303 Human immunodeficiency virus Species 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 238000009739 binding Methods 0.000 claims 9
- 102000002110 C2 domains Human genes 0.000 claims 8
- 108050009459 C2 domains Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 7
- 208000030507 AIDS Diseases 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 108010087924 alanylproline Proteins 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000011225 antiretroviral therapy Methods 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000011191 terminal modification Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09164565.5 | 2009-07-03 | ||
| EP09164565 | 2009-07-03 | ||
| US22343609P | 2009-07-07 | 2009-07-07 | |
| US61/223,436 | 2009-07-07 | ||
| PCT/EP2010/059513 WO2011000962A2 (en) | 2009-07-03 | 2010-07-03 | Novel therapeutic and diagnostic means |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012531219A JP2012531219A (ja) | 2012-12-10 |
| JP2012531219A5 true JP2012531219A5 (enExample) | 2013-08-15 |
| JP5946766B2 JP5946766B2 (ja) | 2016-07-06 |
Family
ID=42752402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012518929A Expired - Fee Related JP5946766B2 (ja) | 2009-07-03 | 2010-07-03 | Ｈｉｖワクチン組成物における使用又は診断手段としての使用のためのｈｉｖ関連ペプチドの組合せ又は融合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9200065B2 (enExample) |
| EP (1) | EP2448593B1 (enExample) |
| JP (1) | JP5946766B2 (enExample) |
| CN (1) | CN102711791A (enExample) |
| BR (1) | BR112012000032A2 (enExample) |
| CA (1) | CA2767063A1 (enExample) |
| EA (1) | EA022788B1 (enExample) |
| NZ (1) | NZ597458A (enExample) |
| WO (1) | WO2011000962A2 (enExample) |
| ZA (1) | ZA201200370B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200065B2 (en) | 2009-07-03 | 2015-12-01 | Bionor Immuno As | Peptide constructs derived from the GP120 C5 domain and GP41 transmembrane domain |
| CN103347892B (zh) * | 2011-01-06 | 2016-11-02 | 比奥诺尔免疫有限公司 | 单体和多聚体免疫原性肽 |
| FR2987836A1 (fr) * | 2012-03-09 | 2013-09-13 | Biomerieux Sa | Peptides d'interference et procede de detection de microorganismes |
| KR20150029678A (ko) * | 2012-06-06 | 2015-03-18 | 바이오노르 이뮤노 에이에스 | 백신 |
| WO2013182661A1 (en) * | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
| WO2015007337A1 (en) | 2013-07-19 | 2015-01-22 | Bionor Immuno As | Method for the vaccination against hiv |
| WO2015110666A1 (en) * | 2014-01-27 | 2015-07-30 | Bionor Immuno As | Method for the vaccination against hiv |
| EP4140485A1 (en) | 2014-07-11 | 2023-03-01 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
| CA2983034A1 (en) * | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| CN106282214A (zh) * | 2016-08-03 | 2017-01-04 | 康众（北京）生物科技有限公司 | 一种快速获得纳米抗体的方法及其应用 |
| RU2642258C1 (ru) * | 2016-12-27 | 2018-01-24 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Рекомбинантный химерный полипептид-иммуноген nTBI, обладающий способностью индуцировать антитела, нейтрализующие вирус иммунодефицита человека 1 типа, и предназначенный для использования в качестве компонента вакцины против ВИЧ-1 |
| CN108593601A (zh) * | 2018-04-11 | 2018-09-28 | 珠海国际旅行卫生保健中心 | 一种快速检测HIV-1的SPRi生物芯片制备方法及其应用 |
| CN113143974B (zh) * | 2021-03-03 | 2023-06-06 | 武汉科技大学 | 一种hiv感染致神经损伤动物模型的建立方法及其用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US4596792A (en) | 1981-09-04 | 1986-06-24 | The Regents Of The University Of California | Safe vaccine for hepatitis containing polymerized serum albumin |
| JPS5938877A (ja) | 1982-08-30 | 1984-03-02 | Musashi Eng Kk | 紙葉判別方法 |
| US4599230A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4608251A (en) | 1984-11-09 | 1986-08-26 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5298419A (en) * | 1988-03-31 | 1994-03-29 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Human hybridomas and monoclonal antibodies which bind both gp41 and gp120 envelope proteins of human immunodeficiency virus |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| US5165424A (en) | 1990-08-09 | 1992-11-24 | Silverman Harvey N | Method and system for whitening teeth |
| AU641814B2 (en) * | 1990-09-25 | 1993-09-30 | Peptech (Uk) Limited | Aids therapy and vaccine |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| ATE249840T1 (de) | 1991-12-13 | 2003-10-15 | Xoma Corp | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5697151A (en) | 1995-08-07 | 1997-12-16 | General Electric Company | Method for repairing partitions of a turbine diaphragm |
| EP1837017A3 (en) | 1997-01-22 | 2009-12-23 | Eisai Inc. | Microparticles for delivery of nucleic acid |
| CN1195702A (zh) * | 1997-04-08 | 1998-10-14 | 军事医学科学院基础医学研究所 | Hiv－1多表位重组膜抗原及其表达 |
| WO1998049198A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
| DE69918146T2 (de) | 1998-10-05 | 2005-07-07 | Pharmexa A/S | Verfahren zur therapeutischen impfung |
| US6911527B1 (en) * | 1999-01-11 | 2005-06-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | HIV related peptides |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| WO2005040219A1 (en) | 2003-10-28 | 2005-05-06 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
| EP2205256A4 (en) | 2007-09-26 | 2012-10-24 | Dana Farber Cancer Inst Inc | REAGENTS FOR INDUCING AN IMMUNE RESPONSE |
| US20090203884A1 (en) * | 2008-01-31 | 2009-08-13 | Healthbanks Biotech Co., Ltd. | Chimeric hiv fusion proteins as vaccines |
| US9200065B2 (en) | 2009-07-03 | 2015-12-01 | Bionor Immuno As | Peptide constructs derived from the GP120 C5 domain and GP41 transmembrane domain |
-
2010
- 2010-07-03 US US13/382,137 patent/US9200065B2/en not_active Expired - Fee Related
- 2010-07-03 NZ NZ597458A patent/NZ597458A/en not_active IP Right Cessation
- 2010-07-03 EP EP10736997.7A patent/EP2448593B1/en active Active
- 2010-07-03 CN CN2010800392328A patent/CN102711791A/zh active Pending
- 2010-07-03 CA CA2767063A patent/CA2767063A1/en not_active Abandoned
- 2010-07-03 EA EA201270124A patent/EA022788B1/ru not_active IP Right Cessation
- 2010-07-03 WO PCT/EP2010/059513 patent/WO2011000962A2/en not_active Ceased
- 2010-07-03 BR BR112012000032A patent/BR112012000032A2/pt not_active IP Right Cessation
- 2010-07-03 JP JP2012518929A patent/JP5946766B2/ja not_active Expired - Fee Related
-
2012
- 2012-01-17 ZA ZA2012/00370A patent/ZA201200370B/en unknown
-
2015
- 2015-11-25 US US14/952,292 patent/US10251949B2/en active Active
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