JP2012528830A5 - - Google Patents
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- Publication number
- JP2012528830A5 JP2012528830A5 JP2012513621A JP2012513621A JP2012528830A5 JP 2012528830 A5 JP2012528830 A5 JP 2012528830A5 JP 2012513621 A JP2012513621 A JP 2012513621A JP 2012513621 A JP2012513621 A JP 2012513621A JP 2012528830 A5 JP2012528830 A5 JP 2012528830A5
- Authority
- JP
- Japan
- Prior art keywords
- range
- adrenergic compound
- compound
- pharmaceutical composition
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 35
- 230000001800 adrenalinergic effect Effects 0.000 claims 29
- 239000007788 liquid Substances 0.000 claims 20
- 239000003963 antioxidant agent Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 16
- 230000003078 antioxidant effect Effects 0.000 claims 14
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 8
- 229930182837 (R)-adrenaline Natural products 0.000 claims 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 8
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims 8
- 229960005139 epinephrine Drugs 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 2
- 230000036783 anaphylactic response Effects 0.000 claims 2
- 208000003455 anaphylaxis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- -1 salt compounds Chemical class 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18406609P | 2009-06-04 | 2009-06-04 | |
| DKPA200900705 | 2009-06-04 | ||
| US61/184,066 | 2009-06-04 | ||
| DKPA200900705 | 2009-06-04 | ||
| PCT/EP2010/057771 WO2010139751A2 (en) | 2009-06-04 | 2010-06-03 | Stabilised composition comprising at least one adrenergic compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012528830A JP2012528830A (ja) | 2012-11-15 |
| JP2012528830A5 true JP2012528830A5 (https=) | 2013-07-11 |
Family
ID=41364279
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513621A Pending JP2012528830A (ja) | 2009-06-04 | 2010-06-03 | 少なくとも１つのアドレナリン作動性化合物を含む安定化された組成物 |
| JP2012513622A Expired - Fee Related JP6087145B2 (ja) | 2009-06-04 | 2010-06-03 | 少なくとも１つのアドレナリン作動性化合物を含む安定化された組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513622A Expired - Fee Related JP6087145B2 (ja) | 2009-06-04 | 2010-06-03 | 少なくとも１つのアドレナリン作動性化合物を含む安定化された組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9155694B2 (https=) |
| EP (2) | EP2437781B1 (https=) |
| JP (2) | JP2012528830A (https=) |
| KR (2) | KR20120028344A (https=) |
| CN (3) | CN102497882A (https=) |
| AU (2) | AU2010255747B2 (https=) |
| BR (2) | BRPI1011074A2 (https=) |
| CA (2) | CA2764051A1 (https=) |
| DK (2) | DK2437781T3 (https=) |
| ES (2) | ES2432164T3 (https=) |
| MX (2) | MX2011012732A (https=) |
| PT (2) | PT2437782E (https=) |
| RU (2) | RU2527337C9 (https=) |
| SI (2) | SI2437781T1 (https=) |
| WO (2) | WO2010139752A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8628805B2 (en) * | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
| CN102525893B (zh) * | 2012-01-04 | 2013-11-20 | 上海禾丰制药有限公司 | 盐酸去氧肾上腺素注射液及其制剂工艺 |
| CN102525894A (zh) * | 2012-01-04 | 2012-07-04 | 上海禾丰制药有限公司 | 盐酸异丙肾上腺素注射液及其制剂工艺 |
| AU2013328393A1 (en) * | 2012-10-08 | 2015-04-09 | Wockhardt Limited | Stable injectable pharmaceutical composition of epinephrine or salts thereof |
| TWI780236B (zh) * | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
| US12239822B2 (en) | 2013-03-15 | 2025-03-04 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| EP3052095A4 (en) | 2013-10-03 | 2017-07-05 | Imprimis Pharmaceuticals Inc. | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| CN103520096B (zh) * | 2013-10-25 | 2015-02-25 | 成都晶博生物科技有限责任公司 | 一种硫酸特布他林注射液的生产工艺 |
| EP3082419A4 (en) * | 2013-12-18 | 2017-09-20 | Windgap Medical, Inc. | Drug mixing and delivery system and method |
| MX2016008979A (es) | 2014-01-09 | 2016-10-04 | Sanofi Sa | Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina. |
| UY35988A (es) * | 2014-02-27 | 2015-09-30 | Sint Sa | Proceso para la producción de una solución inyectable de noradrenalina de baja concentración |
| EP2990031B1 (en) * | 2014-08-28 | 2019-11-13 | Sun Pharmaceutical Industries Ltd | Parenteral dosage form of norepinephrine |
| CN107205938A (zh) * | 2014-12-18 | 2017-09-26 | 温德加普医疗股份有限公司 | 用于溶解或增溶治疗剂的方法和组合物 |
| US9119876B1 (en) | 2015-03-13 | 2015-09-01 | Par Pharmaceutical, Inc. | Epinephrine formulations |
| US20170189352A1 (en) | 2015-03-13 | 2017-07-06 | Par Pharmaceutical, Inc. | Epinephrine formulations |
| US10039710B2 (en) * | 2015-09-18 | 2018-08-07 | Insys Development Company, Inc. | Epinephrine spray formulations |
| US11517525B2 (en) * | 2015-09-18 | 2022-12-06 | Hikma Pharmaceuticals Usa Inc. | Epinephrine spray formulations |
| EP3503873A4 (en) | 2016-08-25 | 2020-04-15 | Harrow IP, LLC | EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHOD FOR THE PRODUCTION THEREOF |
| RU2635759C1 (ru) * | 2016-09-13 | 2017-11-15 | Интеллег Сосьете Анониме | Фармацевтическая композиция для парентерального введения и способ ее получения |
| US10835503B2 (en) * | 2017-01-13 | 2020-11-17 | Teva Pharmaceuticals Usa, Inc. | Pre-filled syringe |
| WO2018140894A1 (en) | 2017-01-30 | 2018-08-02 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
| US20250177328A1 (en) | 2017-01-30 | 2025-06-05 | Nevakar Injectables Inc. | Norepinephrine compositions and methods therefor |
| CN111050760A (zh) * | 2017-04-17 | 2020-04-21 | 希克玛制药美国公司 | 肾上腺素喷雾制剂 |
| WO2019067505A1 (en) | 2017-09-26 | 2019-04-04 | Ys Pharmtech | STABILIZATION OF EPINEPHRINE FORMULATIONS |
| BR112020006950A2 (pt) | 2017-10-10 | 2020-10-06 | Merck Patent Gmbh | composições farmacêuticas injetáveis estabilizadas de l-epinefrina |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| WO2019183416A1 (en) | 2018-03-23 | 2019-09-26 | Nevakar Inc. | Epinephrine compositions and containers |
| WO2019200076A1 (en) | 2018-04-11 | 2019-10-17 | QuVa Pharma, Inc. | Ready to use liquid reck formulation |
| US10952962B1 (en) | 2018-04-11 | 2021-03-23 | QuVa Pharma, Inc. | Ready to use liquid formulation |
| US10478406B2 (en) | 2019-03-18 | 2019-11-19 | HARC Therapeutics AG | High-pH solid-state epinephrine formulation |
| CN116474219A (zh) * | 2019-06-28 | 2023-07-25 | 四川普锐特药业有限公司 | 保持给药均一度的药物流体分配器及右美托咪定鼻喷器 |
| CN114286669A (zh) * | 2019-08-08 | 2022-04-05 | 太阳医药工业有限公司 | 去甲肾上腺素的输注剂型 |
| USD1004518S1 (en) | 2019-09-09 | 2023-11-14 | Brunswick Corporation | Railing for a marine vessel |
| EP4114336A1 (en) | 2020-03-06 | 2023-01-11 | Baxter International Inc. | Packaged, sealed container system for stable storage of an oxygen sensitive pharmaceutical formulation |
| USD984953S1 (en) | 2021-05-03 | 2023-05-02 | Brunswick Corporation | Safely railing having buoy holder |
| AU2021203856B2 (en) * | 2021-06-10 | 2023-03-09 | Animal Ethics Pty Ltd | Topical anaesthetic composition having improved vasoconstrictor stability |
| US20260027067A1 (en) * | 2022-08-27 | 2026-01-29 | Biophore India Pharmaceuticals Pvt. Ltd. | Trientine liquid dosage forms |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB425678A (en) | 1933-06-15 | 1935-03-15 | Novocol Chemical Mfg Co Inc | Improvements relating to anesthetics for hypodermic injection |
| US2047144A (en) * | 1934-03-26 | 1936-07-07 | Lilly Co Eli | Stabilized epinephrine-type compound, and process of stabilizing it |
| US2382546A (en) * | 1941-11-03 | 1945-08-14 | Curtis David | Anesthetic solutions |
| NL277824A (https=) | 1961-04-28 | |||
| US3419035A (en) * | 1965-05-25 | 1968-12-31 | Badger Meter Mfg Co | Air elimination device for liquid transport system |
| CA981182A (en) | 1972-01-07 | 1976-01-06 | Walter A. Borisenok | Stabilization of 1-epinephrine in local anesthetic solutions with a combination of three antioxidants |
| US3966905A (en) * | 1973-05-29 | 1976-06-29 | Barnes-Hind Pharmaceuticals, Inc. | Stabilized catechol amine solutions |
| DD150694A1 (de) | 1980-04-16 | 1981-09-16 | Gisela Raether | Verfahren zur stabilisierung von pharmazeutischen praeparaten mit oxidationsempfindlichen bestandteilen |
| US4734438A (en) | 1983-04-26 | 1988-03-29 | Macri Frank J | Norepinephrine potentiated compositions and method of use |
| AU5680994A (en) | 1992-12-10 | 1994-07-04 | Abbott Laboratories | Stabilized catecholamine solutions |
| JP3535537B2 (ja) * | 1993-04-15 | 2004-06-07 | 日本製薬株式会社 | 静脈注射剤 |
| US6077545A (en) | 1995-10-30 | 2000-06-20 | Matrix Pharmaceuticals, Inc. | Process and composition for therapeutic cisplatin (CDDP) |
| PT941085E (pt) | 1996-11-14 | 2003-08-29 | Alza Corp | Dispositivo para administracao electricamente assistida de agentes como a lidocaina e a epinefrina |
| PT948965E (pt) * | 1997-07-11 | 2004-08-31 | Toray Industries | Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinano |
| JP4393641B2 (ja) | 1998-11-26 | 2010-01-06 | 久光製薬株式会社 | イオントフォレーシス用粘着ゲル組成物及びその装置 |
| EP1326642A2 (en) | 2000-09-29 | 2003-07-16 | Board of Trustees operating Michigan State University | Catecholamine pharmaceutical compositions and methods |
| HUE026793T2 (en) | 2003-10-01 | 2016-07-28 | Kyowa Hakko Kirin Co Ltd | A method for stabilizing an antibody and a stabilized solution-type antibody preparation |
| UA71839C2 (uk) * | 2003-12-30 | 2007-06-25 | Товариство З Обмеженою Відповідальністю "Фарм-Стом" | Фармацевтична композиція на основі артикаїну та епінефрину |
| US20050228336A1 (en) | 2004-04-07 | 2005-10-13 | Preston Keusch | Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability |
| US20060129122A1 (en) | 2004-12-06 | 2006-06-15 | Wyrick Ronald E | Method and apparatus for delivering epinephrine |
| WO2007123800A2 (en) | 2006-04-03 | 2007-11-01 | Nutramax Laboratories, Inc. | Stabilized pentosan polysulfate (pps) formulations and methods of analyzing them |
| US20070249727A1 (en) * | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US20080269347A1 (en) * | 2006-09-28 | 2008-10-30 | Azopharma, Inc. | Epinephrine formulations |
| US8628805B2 (en) | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
-
2010
- 2010-06-03 ES ES10722704T patent/ES2432164T3/es active Active
- 2010-06-03 BR BRPI1011074A patent/BRPI1011074A2/pt not_active IP Right Cessation
- 2010-06-03 US US13/376,021 patent/US9155694B2/en active Active
- 2010-06-03 AU AU2010255747A patent/AU2010255747B2/en not_active Ceased
- 2010-06-03 BR BRPI1013019A patent/BRPI1013019A2/pt active Search and Examination
- 2010-06-03 CN CN201080024234XA patent/CN102497882A/zh active Pending
- 2010-06-03 EP EP10722704.3A patent/EP2437781B1/en active Active
- 2010-06-03 KR KR1020117031385A patent/KR20120028344A/ko not_active Ceased
- 2010-06-03 CN CN201080024241XA patent/CN102802668A/zh active Pending
- 2010-06-03 MX MX2011012732A patent/MX2011012732A/es active IP Right Grant
- 2010-06-03 CN CN201610726131.7A patent/CN106109397A/zh active Pending
- 2010-06-03 JP JP2012513621A patent/JP2012528830A/ja active Pending
- 2010-06-03 AU AU2010255748A patent/AU2010255748B2/en not_active Ceased
- 2010-06-03 PT PT107349276T patent/PT2437782E/pt unknown
- 2010-06-03 JP JP2012513622A patent/JP6087145B2/ja not_active Expired - Fee Related
- 2010-06-03 CA CA2764051A patent/CA2764051A1/en not_active Abandoned
- 2010-06-03 ES ES10734927T patent/ES2432241T3/es active Active
- 2010-06-03 DK DK10722704.3T patent/DK2437781T3/da active
- 2010-06-03 EP EP10734927.6A patent/EP2437782B1/en not_active Not-in-force
- 2010-06-03 SI SI201030409T patent/SI2437781T1/sl unknown
- 2010-06-03 CA CA2764050A patent/CA2764050C/en not_active Expired - Fee Related
- 2010-06-03 SI SI201030408T patent/SI2437782T1/sl unknown
- 2010-06-03 WO PCT/EP2010/057772 patent/WO2010139752A2/en not_active Ceased
- 2010-06-03 RU RU2011153410/15A patent/RU2527337C9/ru not_active IP Right Cessation
- 2010-06-03 DK DK10734927.6T patent/DK2437782T3/da active
- 2010-06-03 MX MX2011012735A patent/MX2011012735A/es active IP Right Grant
- 2010-06-03 WO PCT/EP2010/057771 patent/WO2010139751A2/en not_active Ceased
- 2010-06-03 PT PT107227043T patent/PT2437781E/pt unknown
- 2010-06-03 RU RU2011153403/15A patent/RU2527680C2/ru not_active IP Right Cessation
- 2010-06-03 KR KR1020117031383A patent/KR20120044309A/ko not_active Ceased
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