HRP20110459T1 - Upotreba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju ozljeda kralježnične moždine - Google Patents

Upotreba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju ozljeda kralježnične moždine Download PDF

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Publication number
HRP20110459T1
HRP20110459T1 HR20110459T HRP20110459T HRP20110459T1 HR P20110459 T1 HRP20110459 T1 HR P20110459T1 HR 20110459 T HR20110459 T HR 20110459T HR P20110459 T HRP20110459 T HR P20110459T HR P20110459 T1 HRP20110459 T1 HR P20110459T1
Authority
HR
Croatia
Prior art keywords
oxidopyridin
cyclopropylmethoxy
carboxamide
dichloro
pyridine
Prior art date
Application number
HR20110459T
Other languages
English (en)
Inventor
Delay-Goyet Philippe
Ferzaz Badia
Lolivier Jocelyne
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20110459T1 publication Critical patent/HRP20110459T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Upotreba 4-ciklopropilmetoksi-N-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u obliku hidrata, solvata, baze ili adicijske soli s kiselinom, naznačena time što je navedeni spoj namijenjen pripravi medikamenta namijenjenog upotrebi u liječenju ozljeda kralježnične moždine. Patent sadrži još jedan patentni zahtjev.

Claims (2)

1. Upotreba 4-ciklopropilmetoksi-N-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u obliku hidrata, solvata, baze ili adicijske soli s kiselinom, naznačena time što je navedeni spoj namijenjen pripravi medikamenta namijenjenog upotrebi u liječenju ozljeda kralježnične moždine.
2. Upotreba u s kladu s patentnim zahtjevom 1, naznačena time što 4-ciklopropilmetoksi-N-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamid je u obliku baze.
HR20110459T 2007-04-19 2011-06-17 Upotreba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju ozljeda kralježnične moždine HRP20110459T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0702851A FR2915098B1 (fr) 2007-04-19 2007-04-19 Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes de la moelle epiniere
PCT/FR2008/000533 WO2008145840A2 (fr) 2007-04-19 2008-04-16 Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1 -oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes de la moelle epiniere

Publications (1)

Publication Number Publication Date
HRP20110459T1 true HRP20110459T1 (hr) 2011-07-31

Family

ID=38779706

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110459T HRP20110459T1 (hr) 2007-04-19 2011-06-17 Upotreba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju ozljeda kralježnične moždine

Country Status (33)

Country Link
US (1) US8592443B2 (hr)
EP (1) EP2150253B1 (hr)
JP (1) JP5386477B2 (hr)
KR (1) KR101470043B1 (hr)
CN (1) CN101674829B (hr)
AR (1) AR066106A1 (hr)
AT (1) ATE503481T1 (hr)
AU (1) AU2008257321B2 (hr)
BR (1) BRPI0810446A2 (hr)
CA (1) CA2684172C (hr)
CL (1) CL2008001134A1 (hr)
CY (1) CY1111779T1 (hr)
DE (1) DE602008005873D1 (hr)
DK (1) DK2150253T3 (hr)
EA (1) EA015355B1 (hr)
ES (1) ES2363056T3 (hr)
FR (1) FR2915098B1 (hr)
HK (1) HK1142000A1 (hr)
HR (1) HRP20110459T1 (hr)
IL (1) IL201451A (hr)
JO (1) JO2662B1 (hr)
MA (1) MA31369B1 (hr)
ME (1) ME00934B (hr)
MX (1) MX2009011285A (hr)
MY (1) MY146657A (hr)
NZ (1) NZ580483A (hr)
PA (1) PA8776601A1 (hr)
PL (1) PL2150253T3 (hr)
PT (1) PT2150253E (hr)
SI (1) SI2150253T1 (hr)
TW (1) TWI411435B (hr)
UY (1) UY31033A1 (hr)
WO (1) WO2008145840A2 (hr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2915099B1 (fr) 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens
EP2935219A1 (en) * 2012-11-28 2015-10-28 Sanofi METHOD OF PREPARATION OF CRYSTAL FORMS OF 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDOPYRIDYN-4-yl)-5-METHOXYPYRIDINE-2-CARBOXAMIDE AND CRISTAL FORMS THEREOF
CN104955820A (zh) * 2012-11-28 2015-09-30 赛诺菲 4-(环丙基甲氧基)-n-(3,5-二氯-1-氧化-吡啶-4-基)-5-甲氧基吡啶-2-甲酰胺的制备方法
WO2022159632A1 (en) 2021-01-20 2022-07-28 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
ZA945609B (en) * 1993-07-28 1995-05-12 Rhone Poulenc Rorer Ltd [Di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
GB9507297D0 (en) 1995-04-07 1995-05-31 Rh Ne Poulenc Rorer Limited New composition of matter
US6196968B1 (en) 1997-06-02 2001-03-06 General Surgical Innovations, Inc. Direct vision subcutaneous tissue retractor and method for use
US6177077B1 (en) * 1999-02-24 2001-01-23 Edward L. Tobinick TNT inhibitors for the treatment of neurological disorders
PT1244649E (pt) * 1999-12-23 2005-06-30 Icos Corp Inibidores de fosfodiesterase especificos de mfa ciclica
CA2439691A1 (en) 2001-03-02 2002-09-12 Bristol-Myers Squibb Company Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders
JP2005538972A (ja) 2002-07-02 2005-12-22 メルク フロスト カナダ アンド カンパニー ジアリール置換エタンピリドンｐｄｅ４阻害剤
WO2004067006A1 (en) 2003-01-27 2004-08-12 Pharmacia Corporation Combination of a pde iv inhibitor and a tnf-alpha antagonist
US20050197364A1 (en) * 2003-10-07 2005-09-08 Kelly Michael G. Amide compounds as ion channel ligands and uses thereof
AU2006257863A1 (en) * 2005-06-10 2006-12-21 F. Hoffmann-La Roche Ag Trisubstituted amines as phosphodiesterase 4 inhibitors
US20070021451A1 (en) * 2005-07-20 2007-01-25 Hamamatsu University School Of Medicine Method for preventing or treating neurologic damage after spinal cord injury

Also Published As

Publication number Publication date
PA8776601A1 (es) 2008-11-19
MY146657A (en) 2012-09-14
HK1142000A1 (hr) 2010-11-26
KR20090130063A (ko) 2009-12-17
IL201451A0 (en) 2010-05-31
BRPI0810446A2 (pt) 2014-10-14
MA31369B1 (fr) 2010-05-03
PL2150253T3 (pl) 2011-08-31
ES2363056T3 (es) 2011-07-19
EP2150253B1 (fr) 2011-03-30
JO2662B1 (en) 2012-06-17
EA015355B1 (ru) 2011-06-30
EP2150253A2 (fr) 2010-02-10
CA2684172A1 (fr) 2008-12-04
AU2008257321A1 (en) 2008-12-04
MX2009011285A (es) 2009-11-02
FR2915098A1 (fr) 2008-10-24
EA200970969A1 (ru) 2010-02-26
ATE503481T1 (de) 2011-04-15
JP5386477B2 (ja) 2014-01-15
DE602008005873D1 (de) 2011-05-12
WO2008145840A2 (fr) 2008-12-04
NZ580483A (en) 2011-06-30
PT2150253E (pt) 2011-06-17
US8592443B2 (en) 2013-11-26
CY1111779T1 (el) 2015-10-07
ME00934B (me) 2012-06-20
TWI411435B (zh) 2013-10-11
CN101674829B (zh) 2012-01-18
DK2150253T3 (da) 2011-07-25
CA2684172C (fr) 2015-10-27
KR101470043B1 (ko) 2014-12-05
CL2008001134A1 (es) 2009-01-16
US20100137370A1 (en) 2010-06-03
AR066106A1 (es) 2009-07-22
IL201451A (en) 2013-04-30
TW200911248A (en) 2009-03-16
FR2915098B1 (fr) 2009-06-05
CN101674829A (zh) 2010-03-17
AU2008257321B2 (en) 2013-08-15
UY31033A1 (es) 2008-11-28
WO2008145840A3 (fr) 2009-06-25
JP2010524905A (ja) 2010-07-22
SI2150253T1 (sl) 2011-07-29

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