JP2012527902A5 - - Google Patents
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- Publication number
- JP2012527902A5 JP2012527902A5 JP2012513250A JP2012513250A JP2012527902A5 JP 2012527902 A5 JP2012527902 A5 JP 2012527902A5 JP 2012513250 A JP2012513250 A JP 2012513250A JP 2012513250 A JP2012513250 A JP 2012513250A JP 2012527902 A5 JP2012527902 A5 JP 2012527902A5
- Authority
- JP
- Japan
- Prior art keywords
- microcarrier
- hydrophilic
- monomer
- unsaturated monomer
- acrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical group C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 7
- SBWOBTUYQXLKSS-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propanoic acid Chemical compound CC(=C)C(=O)OCCC(O)=O SBWOBTUYQXLKSS-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical group OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 claims description 6
- ZCXVJRGWDAFVTK-UHFFFAOYSA-N 2,3-dihydroxyocta-2,6-dienediamide Chemical compound NC(=O)C=CCCC(O)=C(O)C(N)=O ZCXVJRGWDAFVTK-UHFFFAOYSA-N 0.000 claims description 4
- CYUZOYPRAQASLN-UHFFFAOYSA-N 3-prop-2-enoyloxypropanoic acid Chemical compound OC(=O)CCOC(=O)C=C CYUZOYPRAQASLN-UHFFFAOYSA-N 0.000 claims description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- MTPIZGPBYCHTGQ-UHFFFAOYSA-N 2-[2,2-bis(2-prop-2-enoyloxyethoxymethyl)butoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCC(CC)(COCCOC(=O)C=C)COCCOC(=O)C=C MTPIZGPBYCHTGQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- PSSYEWWHQGPWGA-UHFFFAOYSA-N [2-hydroxy-3-[2-hydroxy-3-(2-hydroxy-3-prop-2-enoyloxypropoxy)propoxy]propyl] prop-2-enoate Chemical compound C=CC(=O)OCC(O)COCC(O)COCC(O)COC(=O)C=C PSSYEWWHQGPWGA-UHFFFAOYSA-N 0.000 claims description 2
- 239000006143 cell culture medium Substances 0.000 claims description 2
- 125000004386 diacrylate group Chemical group 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- ZMLXKXHICXTSDM-UHFFFAOYSA-N n-[1,2-dihydroxy-2-(prop-2-enoylamino)ethyl]prop-2-enamide Chemical compound C=CC(=O)NC(O)C(O)NC(=O)C=C ZMLXKXHICXTSDM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims 1
- NDWUBGAGUCISDV-UHFFFAOYSA-N 4-hydroxybutyl prop-2-enoate Chemical compound OCCCCOC(=O)C=C NDWUBGAGUCISDV-UHFFFAOYSA-N 0.000 claims 1
- CNCOEDDPFOAUMB-UHFFFAOYSA-N N-Methylolacrylamide Chemical compound OCNC(=O)C=C CNCOEDDPFOAUMB-UHFFFAOYSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000007334 copolymerization reaction Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- UUORTJUPDJJXST-UHFFFAOYSA-N n-(2-hydroxyethyl)prop-2-enamide Chemical compound OCCNC(=O)C=C UUORTJUPDJJXST-UHFFFAOYSA-N 0.000 claims 1
- ZEMHQYNMVKDBFJ-UHFFFAOYSA-N n-(3-hydroxypropyl)prop-2-enamide Chemical compound OCCCNC(=O)C=C ZEMHQYNMVKDBFJ-UHFFFAOYSA-N 0.000 claims 1
- MVBJSQCJPSRKSW-UHFFFAOYSA-N n-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]prop-2-enamide Chemical compound OCC(CO)(CO)NC(=O)C=C MVBJSQCJPSRKSW-UHFFFAOYSA-N 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 2
- 102100035140 Vitronectin Human genes 0.000 description 2
- 108010031318 Vitronectin Proteins 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- IQIJRJNHZYUQSD-UHFFFAOYSA-N ethenyl(phenyl)diazene Chemical compound C=CN=NC1=CC=CC=C1 IQIJRJNHZYUQSD-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 1
- GRNHZMGFVFTJHF-UHFFFAOYSA-N 2-hydroxyacetic acid;prop-2-enamide Chemical compound NC(=O)C=C.OCC(O)=O GRNHZMGFVFTJHF-UHFFFAOYSA-N 0.000 description 1
- JTVJMQCYYSPEGY-UHFFFAOYSA-N 4-carbamoylpent-4-enoic acid Chemical compound NC(=O)C(=C)CCC(O)=O JTVJMQCYYSPEGY-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18177609P | 2009-05-28 | 2009-05-28 | |
| US61/181,776 | 2009-05-28 | ||
| PCT/US2010/036380 WO2010138702A1 (en) | 2009-05-28 | 2010-05-27 | Swellable synthetic microcarriers for culturing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527902A JP2012527902A (ja) | 2012-11-12 |
| JP2012527902A5 true JP2012527902A5 (https=) | 2013-07-18 |
| JP5792714B2 JP5792714B2 (ja) | 2015-10-14 |
Family
ID=42629547
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513247A Expired - Fee Related JP5818785B2 (ja) | 2009-05-28 | 2010-05-27 | 細胞培養用の合成マイクロキャリア |
| JP2012513250A Expired - Fee Related JP5792714B2 (ja) | 2009-05-28 | 2010-05-27 | 細胞培養のための膨潤性の合成マイクロキャリア |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513247A Expired - Fee Related JP5818785B2 (ja) | 2009-05-28 | 2010-05-27 | 細胞培養用の合成マイクロキャリア |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9115238B2 (https=) |
| EP (2) | EP2435490A1 (https=) |
| JP (2) | JP5818785B2 (https=) |
| CN (1) | CN102482385B (https=) |
| TW (1) | TW201042038A (https=) |
| WO (2) | WO2010138702A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5560393B2 (ja) * | 2005-06-22 | 2014-07-23 | アステリアス バイオセラピューティクス インコーポレイテッド | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
| US8354274B2 (en) * | 2008-01-30 | 2013-01-15 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
| SG188096A1 (en) | 2008-01-30 | 2013-03-28 | Geron Corp | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| EP2247718B1 (en) | 2008-01-30 | 2019-01-16 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived cardiomyocytes |
| WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
| US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
| US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
| US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| AU2012256403B2 (en) * | 2011-03-17 | 2016-10-20 | Corning Incorporated | Synthetic coating for cell culture |
| US9376655B2 (en) * | 2011-09-29 | 2016-06-28 | Life Technologies Corporation | Filter systems for separating microcarriers from cell culture solutions |
| KR101886432B1 (ko) * | 2011-12-23 | 2018-09-07 | 엘지디스플레이 주식회사 | 유기전계발광표시장치 및 이의 제조 방법 |
| NZ624195A (en) * | 2012-01-31 | 2015-07-31 | Rogosin Inst | Improved method for manufacture of macrobeads |
| BR112014019157B1 (pt) | 2012-02-02 | 2022-02-22 | Corning Incorporated | Meio de ligação sintético para cultura de célula |
| US10695440B2 (en) * | 2012-05-24 | 2020-06-30 | Biosphere Medical, Inc. | Biomaterials suitable for use as drug eluting, magnetic resonance imaging detectable implants for vascular occlusion |
| EP2666486A1 (en) * | 2012-05-25 | 2013-11-27 | Université de Mons | Micro-engineered hydrogels |
| TWI512103B (zh) * | 2012-11-12 | 2015-12-11 | Ind Tech Res Inst | 細胞培養系統、以及無血清細胞培養方法 |
| JP6299084B2 (ja) * | 2013-05-31 | 2018-03-28 | 大日本印刷株式会社 | 細胞培養方法及びそれに用いるマイクロキャリア |
| EP3013940B1 (en) * | 2013-06-24 | 2017-04-12 | Corning Incorporated | Cell culture article and methods thereof |
| SG11201707615YA (en) | 2013-09-19 | 2017-10-30 | Univ Leland Stanford Junior | Methods and compositions for producing hepatocyte-like cells |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| CN103980442B (zh) * | 2014-05-29 | 2016-05-18 | 西南石油大学 | 用于稠油乳化降粘的水溶性聚合物及其制备方法 |
| JP6104312B2 (ja) * | 2014-06-19 | 2017-03-29 | 日東電工株式会社 | 組織再生促進剤 |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11873508B2 (en) | 2017-01-20 | 2024-01-16 | Agency For Science, Technology And Research | Thermoresponsive microcarrier system and uses thereof |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| EP3830237A1 (en) * | 2018-08-16 | 2021-06-09 | TERUMO Kabushiki Kaisha | Cell culture substrate |
| JP7378212B2 (ja) * | 2019-02-28 | 2023-11-13 | 浜松ホトニクス株式会社 | 細胞接着用組成物及び細胞接着用基材 |
| WO2020251799A1 (en) | 2019-06-13 | 2020-12-17 | Corning Incorporated | Dissolvable microcarriers for culturing cells and related methods |
| US20240052301A1 (en) * | 2021-02-03 | 2024-02-15 | Sekisui Chemical Co., Ltd. | Microcarrier for cell culture and cell culture method |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| JP7281116B2 (ja) | 2021-05-11 | 2023-05-25 | 大日本印刷株式会社 | 乾燥マイクロキャリアおよびその製造方法 |
| WO2023049884A2 (en) * | 2021-09-27 | 2023-03-30 | The Regents Of The University Of California | Multivariate biomimetic biomaterial arrays for precision medicine and screening applications |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US127878A (en) * | 1872-06-11 | Improvement in plows | ||
| US4070348A (en) | 1973-07-25 | 1978-01-24 | Rohm Gmbh | Water-swellable, bead copolymer |
| SE464816B (sv) | 1985-10-15 | 1991-06-17 | Nilsson Kjell | Makroporoesa partiklar, foerfarande foer dess framstaellning och dess anvaendning |
| WO1989005150A1 (en) | 1987-12-10 | 1989-06-15 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
| US5073612A (en) * | 1987-12-28 | 1991-12-17 | Nippon Shokubai Kagaku Kogyo, Co., Ltd. | Hydrophilic polymer and method for production thereof |
| EP0816393B1 (de) * | 1996-07-02 | 2003-11-19 | Vantico AG | Härter für Epoxidharze |
| CN100384958C (zh) * | 1998-12-15 | 2008-04-30 | 艾弗里·丹尼森公司 | 可去除的乳液压敏粘合剂 |
| US20070026518A1 (en) * | 2005-03-29 | 2007-02-01 | The Regents Of The University Of California | Controlling stem cell destiny with tunable matrices |
| WO2004055057A1 (en) | 2002-12-18 | 2004-07-01 | The University Of Melbourne | Hydrogel preparation and process of manufacture thereof |
| US7645827B2 (en) | 2006-03-08 | 2010-01-12 | 3M Innovative Properties Company | High shear pressure-sensitive adhesive |
| MX2009007101A (es) | 2006-12-29 | 2009-12-01 | Univ Washington | Superficies y materiales antibioincrustación bifuncionales. |
| US8354274B2 (en) * | 2008-01-30 | 2013-01-15 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
| US8329469B2 (en) * | 2008-01-30 | 2012-12-11 | Geron Corporation | Swellable (meth)acrylate surfaces for culturing cells in chemically defined media |
-
2010
- 2010-05-27 TW TW099117055A patent/TW201042038A/zh unknown
- 2010-05-27 US US12/788,917 patent/US9115238B2/en not_active Expired - Fee Related
- 2010-05-27 JP JP2012513247A patent/JP5818785B2/ja not_active Expired - Fee Related
- 2010-05-27 CN CN201080033364.XA patent/CN102482385B/zh not_active Expired - Fee Related
- 2010-05-27 EP EP10721604A patent/EP2435490A1/en not_active Withdrawn
- 2010-05-27 WO PCT/US2010/036380 patent/WO2010138702A1/en not_active Ceased
- 2010-05-27 JP JP2012513250A patent/JP5792714B2/ja not_active Expired - Fee Related
- 2010-05-27 US US12/788,942 patent/US8426176B2/en active Active
- 2010-05-27 EP EP10721249A patent/EP2435489A1/en not_active Withdrawn
- 2010-05-27 WO PCT/US2010/036351 patent/WO2010138687A1/en not_active Ceased
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