JP2012527447A5 - - Google Patents
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- Publication number
- JP2012527447A5 JP2012527447A5 JP2012511409A JP2012511409A JP2012527447A5 JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5 JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutically acceptable
- liquid composition
- levodopa
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 9
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 5
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 5
- 229960004502 levodopa Drugs 0.000 claims 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229960003337 entacapone Drugs 0.000 claims 2
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960004603 tolcapone Drugs 0.000 claims 2
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 2
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 150000001483 arginine derivatives Chemical class 0.000 claims 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims 1
- 229960000911 benserazide Drugs 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17951109P | 2009-05-19 | 2009-05-19 | |
| US61/179,511 | 2009-05-19 | ||
| PCT/IL2010/000400 WO2010134074A1 (en) | 2009-05-19 | 2010-05-17 | Compositions for continuous administration of dopa decarboxylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Division JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527447A JP2012527447A (ja) | 2012-11-08 |
| JP2012527447A5 true JP2012527447A5 (enExample) | 2014-05-29 |
| JP5643297B2 JP5643297B2 (ja) | 2014-12-17 |
Family
ID=42320738
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511409A Active JP5643297B2 (ja) | 2009-05-19 | 2010-05-17 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US8193243B2 (enExample) |
| EP (3) | EP3777839A1 (enExample) |
| JP (3) | JP5643297B2 (enExample) |
| KR (2) | KR101709904B1 (enExample) |
| CN (2) | CN102438587B (enExample) |
| AR (3) | AR078413A1 (enExample) |
| AU (1) | AU2010250766B2 (enExample) |
| BR (1) | BRPI1011031B8 (enExample) |
| CA (1) | CA2761624C (enExample) |
| CL (1) | CL2011002895A1 (enExample) |
| CY (1) | CY1119495T1 (enExample) |
| DK (2) | DK3192500T3 (enExample) |
| ES (2) | ES2840748T3 (enExample) |
| HR (2) | HRP20170805T1 (enExample) |
| HU (2) | HUE052685T2 (enExample) |
| IL (1) | IL216383A (enExample) |
| LT (1) | LT2432454T (enExample) |
| MX (2) | MX364974B (enExample) |
| NZ (1) | NZ596963A (enExample) |
| PL (2) | PL2432454T3 (enExample) |
| PT (2) | PT2432454T (enExample) |
| RU (3) | RU2559083C9 (enExample) |
| SG (3) | SG10201505101VA (enExample) |
| SI (1) | SI2432454T1 (enExample) |
| WO (1) | WO2010134074A1 (enExample) |
| ZA (1) | ZA201109037B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN192600B (enExample) * | 1996-10-18 | 2004-05-08 | Hoechst Celanese Corp | |
| EP3777839A1 (en) | 2009-05-19 | 2021-02-17 | Neuroderm Ltd | Compositions for continuous administration of dopa decarboxylase inhibitors |
| NZ610911A (en) * | 2010-11-15 | 2015-02-27 | Neuroderm Ltd | Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same |
| EP2854764B1 (en) | 2012-06-05 | 2018-12-12 | Neuroderm Ltd | Compositions comprising apomorphine and organic acids and uses thereof |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| CN103845318A (zh) * | 2012-12-07 | 2014-06-11 | 天津市汉康医药生物技术有限公司 | 恩他卡朋分散片 |
| US20160022573A1 (en) * | 2013-03-13 | 2016-01-28 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| JP6538063B2 (ja) * | 2013-11-05 | 2019-07-03 | シンアジャル コーポレイション | 口を介する連続的薬物送達のためのデバイスおよび方法 |
| EP3777833B1 (en) * | 2014-03-13 | 2023-10-18 | Neuroderm Ltd. | Dopa decarboxylase inhibitor compositions |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| CN107072973A (zh) | 2014-09-04 | 2017-08-18 | 劳波索尔制药有限公司 | 含左旋多巴、多巴胺脱羧酶抑制剂和comt抑制剂的药物组合物及其施用方法 |
| CA2965379A1 (en) | 2014-10-21 | 2016-04-28 | Abbvie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
| MA41377A (fr) | 2015-01-20 | 2017-11-28 | Abbvie Inc | Gel intestinal de lévodopa et de carbidona et procédés d'utilisation |
| KR20180004756A (ko) | 2015-05-06 | 2018-01-12 | 신애질 코포레이션 | 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법 |
| US10555922B2 (en) | 2015-09-04 | 2020-02-11 | Lobsor Pharmaceuticals Aktiebolag | Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor |
| AU2016358511A1 (en) | 2015-11-24 | 2018-06-21 | Neuroderm Ltd. | Pharmaceutical compositions comprising levodopa amide and uses thereof |
| MY190011A (en) * | 2016-04-11 | 2022-03-22 | Univ Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
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| IL271169B (en) | 2017-06-05 | 2022-09-01 | Dizlin Pharmaceuticals Ab | An infusion of levodopa |
| US20230123806A1 (en) * | 2017-07-07 | 2023-04-20 | Neuroderm, Ltd. | Device for subcutaneous delivery of fluid medicament |
| CA3095341A1 (en) * | 2018-03-29 | 2019-10-03 | Avion Pharmaceuticals, Llc | Levodopa fractionated dose composition and use |
| AU2019379806B2 (en) | 2018-11-15 | 2025-08-14 | Abbvie Inc. | Pharmaceutical formulations for subcutaneous administration |
| WO2020252257A1 (en) * | 2019-06-12 | 2020-12-17 | President And Fellows Of Harvard College | Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism |
| US20230181508A1 (en) * | 2020-08-31 | 2023-06-15 | Purdue Pharma L.P. | Compositions and methods for levodopa delivery |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| WO2022140448A1 (en) | 2020-12-22 | 2022-06-30 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| EP4460289A4 (en) * | 2022-01-03 | 2025-09-03 | Neuroderm Ltd | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON'S DISEASE |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
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| EP3777833B1 (en) | 2014-03-13 | 2023-10-18 | Neuroderm Ltd. | Dopa decarboxylase inhibitor compositions |
-
2010
- 2010-05-17 EP EP20197759.2A patent/EP3777839A1/en active Pending
- 2010-05-17 ES ES17158360T patent/ES2840748T3/es active Active
- 2010-05-17 PT PT107258808T patent/PT2432454T/pt unknown
- 2010-05-17 RU RU2011149976/15A patent/RU2559083C9/ru active
- 2010-05-17 SG SG10201505101VA patent/SG10201505101VA/en unknown
- 2010-05-17 RU RU2015115064A patent/RU2678839C2/ru active
- 2010-05-17 PT PT171583602T patent/PT3192500T/pt unknown
- 2010-05-17 BR BRPI1011031A patent/BRPI1011031B8/pt active IP Right Grant
- 2010-05-17 CN CN201080022208.3A patent/CN102438587B/zh active Active
- 2010-05-17 HR HRP20170805TT patent/HRP20170805T1/hr unknown
- 2010-05-17 MX MX2015001674A patent/MX364974B/es unknown
- 2010-05-17 HU HUE17158360A patent/HUE052685T2/hu unknown
- 2010-05-17 SI SI201031466T patent/SI2432454T1/sl unknown
- 2010-05-17 NZ NZ596963A patent/NZ596963A/en not_active IP Right Cessation
- 2010-05-17 EP EP10725880.8A patent/EP2432454B1/en active Active
- 2010-05-17 MX MX2011012315A patent/MX2011012315A/es active IP Right Grant
- 2010-05-17 PL PL10725880T patent/PL2432454T3/pl unknown
- 2010-05-17 PL PL17158360T patent/PL3192500T3/pl unknown
- 2010-05-17 US US12/781,357 patent/US8193243B2/en active Active
- 2010-05-17 ES ES10725880.8T patent/ES2627655T3/es active Active
- 2010-05-17 LT LTEP10725880.8T patent/LT2432454T/lt unknown
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2019
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