EA201490748A1 - Лечение рассеянного склероза комбинацией лахинимода и финголимода - Google Patents

Лечение рассеянного склероза комбинацией лахинимода и финголимода

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Publication number
EA201490748A1
EA201490748A1 EA201490748A EA201490748A EA201490748A1 EA 201490748 A1 EA201490748 A1 EA 201490748A1 EA 201490748 A EA201490748 A EA 201490748A EA 201490748 A EA201490748 A EA 201490748A EA 201490748 A1 EA201490748 A1 EA 201490748A1
Authority
EA
Eurasian Patent Office
Prior art keywords
multiple sclerosis
combination
treatment
fingolimod
relates
Prior art date
Application number
EA201490748A
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English (en)
Inventor
Хуссейн Халлак
Нора Тарсик
Джоэл Флаксман Кайе
Original Assignee
Тева Фармасьютикал Индастриз Лтд.
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Application filed by Тева Фармасьютикал Индастриз Лтд. filed Critical Тева Фармасьютикал Индастриз Лтд.
Publication of EA201490748A1 publication Critical patent/EA201490748A1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Данное изобретение относится к способу лечения субъекта, страдающего рассеянным склерозом или проявляющего признаки клинически изолированного синдрома, включающему введение субъекту лахинимода в качестве дополнительной терапии к финголимоду или в комбинации с ним. Данное изобретение также относится к комплекту и фармацевтической композиции, включающим лахинимод и финголимод, для лечения субъекта, страдающего рассеянным склерозом или проявляющего признаки клинически изолированного синдрома. Данное изобретение также относится к лахинимоду для применения в качестве дополнительной терапии или в комбинации с финголимодом в лечении субъекта, страдающего рассеянным склерозом или проявляющего признаки клинически изолированного синдрома. Данное изобретение также относится к применению лахинимода и финголимода в получении комбинации для лечения субъекта, страдающего рассеянным склерозом или проявляющего признаки клинически изолированного синдрома.
EA201490748A 2011-10-12 2012-10-11 Лечение рассеянного склероза комбинацией лахинимода и финголимода EA201490748A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161546102P 2011-10-12 2011-10-12
PCT/US2012/059733 WO2013055907A1 (en) 2011-10-12 2012-10-11 Treatment of multiple sclerosis with combination of laquinimod and fingolimod

Publications (1)

Publication Number Publication Date
EA201490748A1 true EA201490748A1 (ru) 2014-12-30

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Country Status (18)

Country Link
US (4) US8889627B2 (ru)
EP (1) EP2766020A4 (ru)
JP (2) JP2014530821A (ru)
KR (1) KR20140101333A (ru)
CN (2) CN103974704A (ru)
AR (1) AR088458A1 (ru)
AU (2) AU2012322706A1 (ru)
BR (1) BR112014008731A2 (ru)
CA (1) CA2851525A1 (ru)
EA (1) EA201490748A1 (ru)
HK (1) HK1199820A1 (ru)
IL (1) IL231724A0 (ru)
MX (1) MX2014004420A (ru)
SG (1) SG11201401330YA (ru)
TW (1) TW201321001A (ru)
UY (1) UY34395A (ru)
WO (1) WO2013055907A1 (ru)
ZA (1) ZA201403378B (ru)

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