JP2015502974A5 - - Google Patents
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- Publication number
- JP2015502974A5 JP2015502974A5 JP2014548243A JP2014548243A JP2015502974A5 JP 2015502974 A5 JP2015502974 A5 JP 2015502974A5 JP 2014548243 A JP2014548243 A JP 2014548243A JP 2014548243 A JP2014548243 A JP 2014548243A JP 2015502974 A5 JP2015502974 A5 JP 2015502974A5
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- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutical composition
- infection
- microbial
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 4
- 241000588626 Acinetobacter baumannii Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 206010062207 Mycobacterial infection Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010062255 Soft tissue infection Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579271P | 2011-12-22 | 2011-12-22 | |
| US61/579,271 | 2011-12-22 | ||
| PCT/IB2012/002880 WO2013093615A1 (en) | 2011-12-22 | 2012-12-20 | Tricyclic boron compounds for antimicrobial therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502974A JP2015502974A (ja) | 2015-01-29 |
| JP2015502974A5 true JP2015502974A5 (enExample) | 2016-02-12 |
| JP6031122B2 JP6031122B2 (ja) | 2016-11-24 |
Family
ID=47664367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548243A Expired - Fee Related JP6031122B2 (ja) | 2011-12-22 | 2012-12-20 | 抗微生物療法のための三環式ホウ素化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8530452B2 (enExample) |
| EP (1) | EP2793901A1 (enExample) |
| JP (1) | JP6031122B2 (enExample) |
| KR (1) | KR20140114380A (enExample) |
| CN (1) | CN104136032B (enExample) |
| CA (1) | CA2858799A1 (enExample) |
| WO (1) | WO2013093615A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| ES2636962T3 (es) * | 2013-01-30 | 2017-10-10 | Agrofresh Inc. | Uso de benzoxaboroles como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas |
| KR101636431B1 (ko) * | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| KR102093783B1 (ko) * | 2013-08-09 | 2020-03-26 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 트리시클릭 벤족사보롤 화합물 및 이의 용도 |
| EA038093B1 (ru) * | 2013-12-20 | 2021-07-05 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли |
| ES2732465T3 (es) | 2014-07-01 | 2019-11-22 | Daiichi Sankyo Co Ltd | Benzoxaboroles tricíclicos como agentes antibacterianos |
| CN104177226A (zh) * | 2014-07-31 | 2014-12-03 | 河北国蓬化工有限公司 | 一种聚醚用催化剂的制备方法 |
| MA41494B1 (fr) * | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
| NZ745681A (en) | 2016-03-07 | 2022-05-27 | Agrofresh Inc | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| KR101925338B1 (ko) | 2016-12-22 | 2018-12-05 | 엘에스산전 주식회사 | 전력기기 진단 장치 |
| WO2021029836A1 (en) | 2019-08-09 | 2021-02-18 | Safaş Saf Plasti̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Boron-modified flexible polyurethane foam for hygiene and a method of production therefor |
| KR20250026145A (ko) * | 2022-06-23 | 2025-02-25 | 상하이 미큐알엑스 파마슈티컬 컴퍼니 리미티드 | 비결핵성 마이코박테리움 감염 치료에서의 붕소 화합물의 방법 및 용도 및 상기 감염의 치료를 위한 제약 조성물 |
| CN119233977A (zh) * | 2022-06-23 | 2024-12-31 | 上海盟科药业股份有限公司 | 硼化合物的前药及其在治疗细菌感染中的用途 |
| WO2025140370A1 (zh) * | 2023-12-27 | 2025-07-03 | 上海盟科药业股份有限公司 | 硼化合物前药的盐型、晶型及其药物组合物和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| CA2529792A1 (en) | 2003-06-16 | 2005-02-17 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| BRPI0708051A2 (pt) * | 2006-02-16 | 2011-05-17 | Anacor Pharmaceuticals Inc | moléculas pequenas contendo boro como agentes antiflamatórios |
| WO2007131072A2 (en) | 2006-05-02 | 2007-11-15 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| US20070286822A1 (en) * | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| EP2285384A4 (en) | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
| WO2010022337A2 (en) * | 2008-08-21 | 2010-02-25 | Mcknight James T | Systems and methods for converting biomass in the field to a combustible fluid for direct replacement or supplement to liquid fossil fuels |
| US8461364B2 (en) | 2008-12-17 | 2013-06-11 | Glaxosmithkline Llc | Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[C][1,2]oxaborol-1-OL |
| JP2013500974A (ja) | 2009-07-28 | 2013-01-10 | アナコール ファーマシューティカルズ，インコーポレイテッド | 三置換ホウ素含有分子 |
| SG184268A1 (en) | 2010-04-07 | 2012-10-30 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| BR112013005426B1 (pt) * | 2010-09-07 | 2021-08-24 | Anacor Pharmaceuticals, Inc | Composto, composição, combinação, e, formulação farmacêutica |
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2012
- 2012-12-20 CN CN201280064147.6A patent/CN104136032B/zh active Active
- 2012-12-20 JP JP2014548243A patent/JP6031122B2/ja not_active Expired - Fee Related
- 2012-12-20 WO PCT/IB2012/002880 patent/WO2013093615A1/en not_active Ceased
- 2012-12-20 US US13/722,912 patent/US8530452B2/en active Active
- 2012-12-20 EP EP12821181.0A patent/EP2793901A1/en not_active Withdrawn
- 2012-12-20 KR KR1020147019950A patent/KR20140114380A/ko not_active Withdrawn
- 2012-12-20 CA CA2858799A patent/CA2858799A1/en not_active Abandoned