JP2015502974A5 - - Google Patents
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- JP2015502974A5 JP2015502974A5 JP2014548243A JP2014548243A JP2015502974A5 JP 2015502974 A5 JP2015502974 A5 JP 2015502974A5 JP 2014548243 A JP2014548243 A JP 2014548243A JP 2014548243 A JP2014548243 A JP 2014548243A JP 2015502974 A5 JP2015502974 A5 JP 2015502974A5
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- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutical composition
- infection
- microbial
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 4
- 241000588626 Acinetobacter baumannii Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 206010062207 Mycobacterial infection Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010062255 Soft tissue infection Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 206010040872 skin infection Diseases 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579271P | 2011-12-22 | 2011-12-22 | |
| US61/579,271 | 2011-12-22 | ||
| PCT/IB2012/002880 WO2013093615A1 (en) | 2011-12-22 | 2012-12-20 | Tricyclic boron compounds for antimicrobial therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502974A JP2015502974A (ja) | 2015-01-29 |
| JP2015502974A5 true JP2015502974A5 (enExample) | 2016-02-12 |
| JP6031122B2 JP6031122B2 (ja) | 2016-11-24 |
Family
ID=47664367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548243A Expired - Fee Related JP6031122B2 (ja) | 2011-12-22 | 2012-12-20 | 抗微生物療法のための三環式ホウ素化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8530452B2 (enExample) |
| EP (1) | EP2793901A1 (enExample) |
| JP (1) | JP6031122B2 (enExample) |
| KR (1) | KR20140114380A (enExample) |
| CN (1) | CN104136032B (enExample) |
| CA (1) | CA2858799A1 (enExample) |
| WO (1) | WO2013093615A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2950644T3 (en) * | 2013-01-30 | 2017-09-04 | Agrofresh Inc | USE OF BENZOXABOROLS AS VOLATIVE ANTIMICROBIAL AGENTS IN MEAT, PLANTS OR PARTS |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| KR101636431B1 (ko) * | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| CN105492388B (zh) | 2013-08-09 | 2018-12-21 | 葛兰素史克知识产权第二有限公司 | 三环苯并氧杂硼杂环戊烯化合物及其用途 |
| EA038093B1 (ru) * | 2013-12-20 | 2021-07-05 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли |
| JP6605513B2 (ja) | 2014-07-01 | 2019-11-13 | 第一三共株式会社 | 抗菌剤としての三環式ベンゾオキサボロール |
| CN104177226A (zh) * | 2014-07-31 | 2014-12-03 | 河北国蓬化工有限公司 | 一种聚醚用催化剂的制备方法 |
| MA41495A (fr) | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
| NZ745681A (en) | 2016-03-07 | 2022-05-27 | Agrofresh Inc | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| KR101925338B1 (ko) | 2016-12-22 | 2018-12-05 | 엘에스산전 주식회사 | 전력기기 진단 장치 |
| EP3850029A1 (en) | 2019-08-09 | 2021-07-21 | Safas Saf Plastik Sanayi Ve Ticaret Anonim Sirketi | Boron-modified flexible polyurethane foam for hygiene and a method of production therefor |
| CN119233977B (zh) * | 2022-06-23 | 2026-03-17 | 上海盟科药业股份有限公司 | 硼化合物的前药及其在治疗细菌感染中的用途 |
| CN119233823A (zh) * | 2022-06-23 | 2024-12-31 | 上海盟科药业股份有限公司 | 硼化合物治疗非结核分枝杆菌感染的方法和用途及用于治疗相同疾病的药物组合物 |
| WO2025140370A1 (zh) * | 2023-12-27 | 2025-07-03 | 上海盟科药业股份有限公司 | 硼化合物前药的盐型、晶型及其药物组合物和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| BRPI0411582A (pt) | 2003-06-16 | 2006-08-08 | Anacor Pharmaceuticals Inc | substáncias terapêuticas contendo boro hidroliticamente resistentes e método de uso |
| NZ570257A (en) * | 2006-02-16 | 2011-11-25 | Anacor Pharmaceuticals Inc | Boron-containing small molecules as anti-inflammatory agents |
| CA2651212A1 (en) | 2006-05-02 | 2007-11-15 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| US20070286822A1 (en) * | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| US20100256092A1 (en) * | 2008-05-12 | 2010-10-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US20110259250A1 (en) * | 2008-08-21 | 2011-10-27 | Mcknight James T | Systems And Methods For Converting Biomass In The Field To A Combustible Fluid For Direct Replacement Or Supplement To Liquid Fossil Fuels |
| MX2011006334A (es) | 2008-12-17 | 2011-09-22 | Anacor Pharmaceuticals Inc | Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c] [1,2]-oxaborol-1-ol. |
| KR20130031233A (ko) | 2009-07-28 | 2013-03-28 | 아나코르 파마슈티칼스 인코포레이티드 | 삼치환된 붕소 함유 분자 |
| JP5603998B2 (ja) | 2010-04-07 | 2014-10-08 | グラクソスミスクライン エルエルシー | ベンゾオキサボロールの調製方法 |
| SG10201507032YA (en) | 2010-09-07 | 2015-10-29 | Anacor Pharmaceuticals Inc | Benzoxaborole derivatives for treating bacterial infections |
-
2012
- 2012-12-20 US US13/722,912 patent/US8530452B2/en active Active
- 2012-12-20 JP JP2014548243A patent/JP6031122B2/ja not_active Expired - Fee Related
- 2012-12-20 KR KR1020147019950A patent/KR20140114380A/ko not_active Withdrawn
- 2012-12-20 CN CN201280064147.6A patent/CN104136032B/zh active Active
- 2012-12-20 CA CA2858799A patent/CA2858799A1/en not_active Abandoned
- 2012-12-20 WO PCT/IB2012/002880 patent/WO2013093615A1/en not_active Ceased
- 2012-12-20 EP EP12821181.0A patent/EP2793901A1/en not_active Withdrawn