CA2858799A1 - Tricyclic boron compounds for antimicrobial therapy - Google Patents

Tricyclic boron compounds for antimicrobial therapy Download PDF

Info

Publication number
CA2858799A1
CA2858799A1 CA2858799A CA2858799A CA2858799A1 CA 2858799 A1 CA2858799 A1 CA 2858799A1 CA 2858799 A CA2858799 A CA 2858799A CA 2858799 A CA2858799 A CA 2858799A CA 2858799 A1 CA2858799 A1 CA 2858799A1
Authority
CA
Canada
Prior art keywords
compound
compounds
mixture
hci
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2858799A
Other languages
English (en)
French (fr)
Inventor
Mikhail Fedorovich Gordeev
Jinqian Liu
Zhengyu Yuan
Xinghai Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MicuRx Pharmaceuticals Inc Cayman Islands
Original Assignee
MicuRx Pharmaceuticals Inc Cayman Islands
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MicuRx Pharmaceuticals Inc Cayman Islands filed Critical MicuRx Pharmaceuticals Inc Cayman Islands
Publication of CA2858799A1 publication Critical patent/CA2858799A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2858799A 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy Abandoned CA2858799A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579271P 2011-12-22 2011-12-22
US61/579,271 2011-12-22
PCT/IB2012/002880 WO2013093615A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Publications (1)

Publication Number Publication Date
CA2858799A1 true CA2858799A1 (en) 2013-06-27

Family

ID=47664367

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2858799A Abandoned CA2858799A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Country Status (7)

Country Link
US (1) US8530452B2 (enExample)
EP (1) EP2793901A1 (enExample)
JP (1) JP6031122B2 (enExample)
KR (1) KR20140114380A (enExample)
CN (1) CN104136032B (enExample)
CA (1) CA2858799A1 (enExample)
WO (1) WO2013093615A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
AR094666A1 (es) * 2013-01-30 2015-08-19 Dow Agrosciences Llc Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
KR101636431B1 (ko) * 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) * 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
CN106459097A (zh) * 2014-07-01 2017-02-22 第三共株式会社 作为抗菌剂的三环苯并氧杂硼杂环戊烯类
CN104177226A (zh) * 2014-07-31 2014-12-03 河北国蓬化工有限公司 一种聚醚用催化剂的制备方法
MA41495A (fr) * 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
KR101925338B1 (ko) 2016-12-22 2018-12-05 엘에스산전 주식회사 전력기기 진단 장치
EP3850029A1 (en) 2019-08-09 2021-07-21 Safas Saf Plastik Sanayi Ve Ticaret Anonim Sirketi Boron-modified flexible polyurethane foam for hygiene and a method of production therefor
CA3239097A1 (en) 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
JP2025520237A (ja) 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
WO2025140370A1 (zh) * 2023-12-27 2025-07-03 上海盟科药业股份有限公司 硼化合物前药的盐型、晶型及其药物组合物和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
CN1829521B (zh) 2003-06-16 2011-01-26 安纳考尔医药公司 耐水解的含硼治疗剂和使用方法
RU2642628C2 (ru) * 2006-02-16 2018-01-25 Анакор Фармасьютикалз, Инк. Бор-содержащие малые молекулы в качестве противовоспалительных средств
BRPI0711155A2 (pt) 2006-05-02 2011-08-23 Anacor Pharmaceuticals Inc terapêuticos contendo boro resistentes hidroliticamente e métodos de uso
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
US20100256092A1 (en) * 2008-05-12 2010-10-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20110259250A1 (en) 2008-08-21 2011-10-27 Mcknight James T Systems And Methods For Converting Biomass In The Field To A Combustible Fluid For Direct Replacement Or Supplement To Liquid Fossil Fuels
SG172040A1 (en) 2008-12-17 2011-07-28 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
AU2011237681B2 (en) 2010-04-07 2015-01-22 Glaxosmithkline Llc Process for preparing benzoxaboroles
DK2613788T3 (en) 2010-09-07 2017-08-07 Anacor Pharmaceuticals Inc BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS

Also Published As

Publication number Publication date
WO2013093615A1 (en) 2013-06-27
CN104136032A (zh) 2014-11-05
JP2015502974A (ja) 2015-01-29
JP6031122B2 (ja) 2016-11-24
EP2793901A1 (en) 2014-10-29
US20130165411A1 (en) 2013-06-27
KR20140114380A (ko) 2014-09-26
CN104136032B (zh) 2018-11-13
US8530452B2 (en) 2013-09-10

Similar Documents

Publication Publication Date Title
WO2013093615A1 (en) Tricyclic boron compounds for antimicrobial therapy
TWI828358B (zh) 囊性纖維化跨膜傳導調節因子之調節劑、醫藥組合物、治療方法及製造該調節劑之方法
CA2695616C (en) Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections
KR20240040742A (ko) Kif18a 억제제로서의 화합물
JP7212142B2 (ja) Ｈｐｋ１阻害剤およびその調製方法と応用
CA3190609A1 (en) Inhibitors of apol1 and methods of using same
KR20230123522A (ko) 낭성 섬유증 막관통 전도도 조절제로서 사용하기 위한 1,3,4-옥사디아졸 고리를 함유하는 거대환
CA3116141C (en) Cycloalkane-1,3-diamine derivative
TWI834127B (zh) 噻吩類化合物及其應用
WO2010120112A2 (en) Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof
JP7774326B2 (ja) 芳香族化合物、その医薬組成物及びその使用
US20120065170A1 (en) Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
CN121779394A (zh) 作为bcl-2抑制剂的化合物
SA04250095A (ar) مركبات كيميائية
KR102951756B1 (ko) 신규 트리시클릭 방향족 헤테로시클릭 화합물, 및 이의 제조 방법, 약학적 조성물과 응용
JP2024514251A (ja) 二環式化合物の製造方法及び抗菌剤としての使用
WO2025214344A1 (zh) 一种kras抑制剂及其在药学上的应用
CN115244051B (zh) 苯并五元环类化合物
KR101872264B1 (ko) 신규한 유형의 시티딘 유도체 이량체 및 그의 용도
KR100729980B1 (ko) 항종양제로서비스-(ｎ,ｎ'-비스-(2-할로에틸)아미노)포스포라미데이트
AU2023335416A1 (en) Egfr inhibitors and uses thereof
JP2025541435A (ja) Ｋｒａｓ ｇ１２ｄ阻害剤及びその応用
EP3717490A1 (en) Anti-bacterial heterocyclic compounds and their synthesis
CA2968090A1 (en) 4h-pyrido[1,2-a]pyrimidin-4-one compounds
CN116239600B (zh) 并环类化合物的制备方法及作为抗真菌剂的应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20171220

FZDE Discontinued

Effective date: 20200831