CN104136032B - 可用于抗菌治疗的三环类硼化合物 - Google Patents

可用于抗菌治疗的三环类硼化合物 Download PDF

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Publication number
CN104136032B
CN104136032B CN201280064147.6A CN201280064147A CN104136032B CN 104136032 B CN104136032 B CN 104136032B CN 201280064147 A CN201280064147 A CN 201280064147A CN 104136032 B CN104136032 B CN 104136032B
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compound
compounds
mixture
added
acid
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CN104136032A (zh
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M·F·高德福
刘进前
袁征宇
王星海
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Shanghai Mengke Pharmaceutical Co ltd
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Mengke Medical Technology Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201280064147.6A 2011-12-22 2012-12-20 可用于抗菌治疗的三环类硼化合物 Active CN104136032B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579271P 2011-12-22 2011-12-22
US61/579,271 2011-12-22
PCT/IB2012/002880 WO2013093615A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Publications (2)

Publication Number Publication Date
CN104136032A CN104136032A (zh) 2014-11-05
CN104136032B true CN104136032B (zh) 2018-11-13

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ID=47664367

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CN201280064147.6A Active CN104136032B (zh) 2011-12-22 2012-12-20 可用于抗菌治疗的三环类硼化合物

Country Status (7)

Country Link
US (1) US8530452B2 (enExample)
EP (1) EP2793901A1 (enExample)
JP (1) JP6031122B2 (enExample)
KR (1) KR20140114380A (enExample)
CN (1) CN104136032B (enExample)
CA (1) CA2858799A1 (enExample)
WO (1) WO2013093615A1 (enExample)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
EP2950644B1 (en) * 2013-01-30 2017-07-19 AgroFresh Inc. Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
WO2015021396A2 (en) * 2013-08-09 2015-02-12 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
ES2732465T3 (es) * 2014-07-01 2019-11-22 Daiichi Sankyo Co Ltd Benzoxaboroles tricíclicos como agentes antibacterianos
CN104177226A (zh) * 2014-07-31 2014-12-03 河北国蓬化工有限公司 一种聚醚用催化剂的制备方法
MA41495A (fr) 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
KR101925338B1 (ko) 2016-12-22 2018-12-05 엘에스산전 주식회사 전력기기 진단 장치
WO2021029836A1 (en) 2019-08-09 2021-02-18 Safaş Saf Plasti̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Boron-modified flexible polyurethane foam for hygiene and a method of production therefor
JP2025520237A (ja) 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
CA3239097A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
WO2025140370A1 (zh) * 2023-12-27 2025-07-03 上海盟科药业股份有限公司 硼化合物前药的盐型、晶型及其药物组合物和用途

Citations (1)

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CN101772302A (zh) * 2007-06-20 2010-07-07 安纳考尔医药公司 含硼小分子

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
WO2005013892A2 (en) 2003-06-16 2005-02-17 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
CA2642583C (en) * 2006-02-16 2016-08-23 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
WO2007131072A2 (en) 2006-05-02 2007-11-15 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
EP2285384A4 (en) 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
US20110259250A1 (en) 2008-08-21 2011-10-27 Mcknight James T Systems And Methods For Converting Biomass In The Field To A Combustible Fluid For Direct Replacement Or Supplement To Liquid Fossil Fuels
AU2009335744A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy) -3H-benzo[c][1,2] oxaborol-1-ol
JP2013500974A (ja) 2009-07-28 2013-01-10 アナコール ファーマシューティカルズ，インコーポレイテッド 三置換ホウ素含有分子
AU2011237681B2 (en) 2010-04-07 2015-01-22 Glaxosmithkline Llc Process for preparing benzoxaboroles
SMT202100643T1 (it) 2010-09-07 2022-01-10 Anacor Pharmaceuticals Inc Derivati del benzossaborolo per il trattamento delle infezioni batteriche

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CN101772302A (zh) * 2007-06-20 2010-07-07 安纳考尔医药公司 含硼小分子

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Convenient and versatile synthesis of formyl-substituted benzoxaboroles;Long Ye 等;《Tetrahedron》;20091231;第65卷;8738–8744 *

Also Published As

Publication number Publication date
JP6031122B2 (ja) 2016-11-24
US8530452B2 (en) 2013-09-10
JP2015502974A (ja) 2015-01-29
WO2013093615A1 (en) 2013-06-27
CN104136032A (zh) 2014-11-05
EP2793901A1 (en) 2014-10-29
CA2858799A1 (en) 2013-06-27
US20130165411A1 (en) 2013-06-27
KR20140114380A (ko) 2014-09-26

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Effective date of registration: 20191031

Address after: 201203 room B301, floor 3, building 1, No. 1976, Gaoke Middle Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai

Patentee after: SHANGHAI MICURX Ltd.

Address before: Greater Cayman, Cayman Islands

Co-patentee before: MF Gao Defu

Patentee before: Mengke Medical Technology Co.

Co-patentee before: Liu Jinqian

Co-patentee before: Yuan Zhengyu

Co-patentee before: Wang Xinghai

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Effective date of registration: 20200812

Address after: Room 139, 1 / F, 8 Hongfu Road, Daxing District, Beijing 100162

Patentee after: Crix (Beijing) Pharmaceutical Co.,Ltd.

Address before: 201203 room B301, floor 3, building 1, No. 1976, Gaoke Middle Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai

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Address after: 201,203 Buildings 101 and 2, 1-4 floors, Building 1, No. 53 Edison Road, Pudong New Area, Shanghai

Patentee after: Shanghai mengke Pharmaceutical Co.,Ltd.

Address before: 100162 room 139, 1 / F, 8 Hongfu Road, Daxing District, Beijing

Patentee before: Crix (Beijing) Pharmaceutical Co.,Ltd.