JP2012526563A5 - - Google Patents
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- JP2012526563A5 JP2012526563A5 JP2012511069A JP2012511069A JP2012526563A5 JP 2012526563 A5 JP2012526563 A5 JP 2012526563A5 JP 2012511069 A JP2012511069 A JP 2012511069A JP 2012511069 A JP2012511069 A JP 2012511069A JP 2012526563 A5 JP2012526563 A5 JP 2012526563A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- alk
- cancer
- primer
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 34
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 34
- 238000000034 method Methods 0.000 claims 33
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 14
- 230000035772 mutation Effects 0.000 claims 12
- 238000003757 reverse transcription PCR Methods 0.000 claims 10
- 238000003753 real-time PCR Methods 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 206010029260 Neuroblastoma Diseases 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 102220640011 ALK tyrosine kinase receptor_L560F_mutation Human genes 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000002291 Histiocytic Sarcoma Diseases 0.000 claims 2
- 206010067917 Inflammatory myofibroblastic tumour Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 2
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 claims 2
- 102200003029 c.2629G>T Human genes 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 claims 2
- 201000008825 fibrosarcoma of bone Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 201000006812 malignant histiocytosis Diseases 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102200003022 rs1057519698 Human genes 0.000 claims 2
- 102200003021 rs1057520019 Human genes 0.000 claims 2
- 102200003101 rs113994087 Human genes 0.000 claims 2
- 102200003104 rs113994089 Human genes 0.000 claims 2
- 102200003098 rs113994092 Human genes 0.000 claims 2
- 102200003024 rs281864719 Human genes 0.000 claims 2
- 102200003097 rs281864720 Human genes 0.000 claims 2
- 102220084991 rs281864720 Human genes 0.000 claims 2
- 102200003041 rs35093491 Human genes 0.000 claims 2
- 102220256797 rs371005946 Human genes 0.000 claims 2
- 102200003102 rs863225281 Human genes 0.000 claims 2
- 102200003096 rs863225283 Human genes 0.000 claims 2
- 102220084990 rs863225284 Human genes 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 102100024638 Cytochrome c oxidase subunit 5B, mitochondrial Human genes 0.000 claims 1
- 101000908835 Homo sapiens Cytochrome c oxidase subunit 5B, mitochondrial Proteins 0.000 claims 1
- 206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17893709P | 2009-05-15 | 2009-05-15 | |
| US61/178,937 | 2009-05-15 | ||
| PCT/US2010/035147 WO2010132888A2 (en) | 2009-05-15 | 2010-05-17 | Methods and compositions relating to fusions of alk for diagnosing and treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000290A Division JP6397833B2 (ja) | 2009-05-15 | 2016-01-04 | 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012526563A JP2012526563A (ja) | 2012-11-01 |
| JP2012526563A5 true JP2012526563A5 (enExample) | 2013-07-04 |
Family
ID=43085621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511069A Pending JP2012526563A (ja) | 2009-05-15 | 2010-05-17 | 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 |
| JP2016000290A Expired - Fee Related JP6397833B2 (ja) | 2009-05-15 | 2016-01-04 | 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000290A Expired - Fee Related JP6397833B2 (ja) | 2009-05-15 | 2016-01-04 | 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20120208713A1 (enExample) |
| EP (2) | EP3133167B1 (enExample) |
| JP (2) | JP2012526563A (enExample) |
| CN (1) | CN102575287B (enExample) |
| AU (1) | AU2010248782B2 (enExample) |
| BR (1) | BRPI1012140A2 (enExample) |
| CA (1) | CA2762108A1 (enExample) |
| ES (1) | ES2700098T3 (enExample) |
| MX (1) | MX338297B (enExample) |
| RU (1) | RU2562144C2 (enExample) |
| WO (1) | WO2010132888A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE035732T2 (en) | 2006-04-14 | 2018-05-28 | Cell Signaling Technology Inc | Gene defects and mutant ALK kinase in human solid tumors |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| TWI518325B (zh) | 2010-02-04 | 2016-01-21 | 自治醫科大學 | 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療 |
| WO2012019132A2 (en) | 2010-08-06 | 2012-02-09 | Cell Signaling Technology, Inc. | Anaplastic lymphoma kinase in kidney cancer |
| AU2013216904A1 (en) * | 2012-02-08 | 2014-08-28 | Insight Genetics, Inc. | Methods and compositions relating to fusions of ROS1 for diagnosing and treating cancer |
| CN102888452B (zh) * | 2012-05-18 | 2014-08-27 | 复旦大学附属肿瘤医院 | 一种筛查alk融合基因的方法 |
| US9084456B1 (en) * | 2012-05-28 | 2015-07-21 | Jack Zemer | Linkage for jewelry components |
| WO2014026133A1 (en) * | 2012-08-09 | 2014-02-13 | Insight Genetics, Inc. | Methods and compositions relating to alk for diagnosing and treating inflammatory breast and other human cancers |
| JP6223451B2 (ja) * | 2012-08-31 | 2017-11-01 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト | がんの診断及び治療方法 |
| CN103805687B (zh) * | 2012-11-09 | 2016-06-01 | 益善生物技术股份有限公司 | Alk融合基因检测的pcr引物、试剂盒和液相芯片 |
| RU2509153C1 (ru) * | 2012-11-28 | 2014-03-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии |
| US10072298B2 (en) | 2013-04-17 | 2018-09-11 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| CN105378110B (zh) * | 2013-04-17 | 2024-06-25 | 生命技术公司 | 与癌症相关的基因融合体和基因变异体 |
| CN103290120B (zh) * | 2013-05-24 | 2015-03-25 | 厦门艾德生物医药科技有限公司 | 一种用于检测alk基因表达的探针、引物及试剂盒 |
| WO2015149034A2 (en) * | 2014-03-27 | 2015-10-01 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| US9428812B2 (en) * | 2014-04-28 | 2016-08-30 | Insight Genetics, Inc. | Kit comprising primers for amplifying ALK kinase domain nucleic acids |
| WO2016106701A1 (zh) * | 2014-12-31 | 2016-07-07 | 深圳华大基因股份有限公司 | 检测非小细胞肺癌的qRT-PCR引物、探针、芯片、试剂盒、应用和方法 |
| EP3283645B1 (en) * | 2015-04-17 | 2019-03-27 | Roche Diagnostics GmbH | Multiplex pcr to detect gene fusions |
| CN107022610B (zh) * | 2017-04-01 | 2019-02-05 | 常州桐树生物科技有限公司 | 肿瘤驱动基因的检测芯片及其应用 |
| KR101987065B1 (ko) * | 2017-08-07 | 2019-06-10 | 주식회사 싸이토젠 | Eml4-alk유전자 변이 분석방법 |
| RU2681165C1 (ru) * | 2017-12-01 | 2019-03-04 | Общество с ограниченной ответственностью "Научно-Исследовательский Центр Молекулярной Биомедицины" (ООО "НИЦ МолБиоМед") | Способ определения активности теломеразы методом двойной амплификации теломерных повторов в реальном времени |
| CN111235272B (zh) * | 2020-01-10 | 2023-07-07 | 厦门艾德生物医药科技股份有限公司 | 一次性检测肺癌多重基因突变的组合物及其应用 |
| CN113005200B (zh) * | 2021-04-14 | 2023-07-04 | 深圳乐土生物科技有限公司 | 一种检测肉瘤融合基因突变的引物组合物、试剂盒及应用 |
| CN114807124B (zh) * | 2022-04-01 | 2023-09-12 | 上海信诺佰世医学检验有限公司 | 一种检测alk融合基因的引物和探针组合物、试剂盒及方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| WO1995011995A1 (en) * | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US6696548B2 (en) * | 1993-12-03 | 2004-02-24 | St. Jude Children's Research Hospital | Antibodies for recognition of alk protein tyrosine/kinase receptor |
| US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US7339033B2 (en) * | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
| GB0319227D0 (en) * | 2003-08-15 | 2003-09-17 | Novartis Ag | Organic compounds |
| JP2008527996A (ja) * | 2005-01-25 | 2008-07-31 | スカイ、ジェネティクス、インク | 癌細胞のアポトーシスのための核酸 |
| WO2006085326A2 (en) * | 2005-02-10 | 2006-08-17 | Siano Mobile Silicon Ltd. | System and method for mitigating memory requirements |
| WO2006094073A2 (en) * | 2005-03-02 | 2006-09-08 | Acadia Pharmaceuticals Inc. | Functional bioluminescence energy resonance transfer (bret) assay to screen, identify and characterize receptor tyrosine kinase ligands |
| US20060286558A1 (en) * | 2005-06-15 | 2006-12-21 | Natalia Novoradovskaya | Normalization of samples for amplification reactions |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| KR101274092B1 (ko) * | 2007-04-13 | 2013-06-25 | 셀 시그널링 테크놀러지, 인크. | 인간 고형 종양에서 유전자 결손 및 돌연변이 ａｌｋ 카이네이즈 |
-
2010
- 2010-05-17 CN CN201080031440.3A patent/CN102575287B/zh not_active Expired - Fee Related
- 2010-05-17 ES ES16175320T patent/ES2700098T3/es active Active
- 2010-05-17 WO PCT/US2010/035147 patent/WO2010132888A2/en not_active Ceased
- 2010-05-17 RU RU2011151049/10A patent/RU2562144C2/ru not_active IP Right Cessation
- 2010-05-17 BR BRPI1012140A patent/BRPI1012140A2/pt not_active IP Right Cessation
- 2010-05-17 US US13/320,303 patent/US20120208713A1/en not_active Abandoned
- 2010-05-17 EP EP16175320.7A patent/EP3133167B1/en not_active Not-in-force
- 2010-05-17 JP JP2012511069A patent/JP2012526563A/ja active Pending
- 2010-05-17 MX MX2011012162A patent/MX338297B/es active IP Right Grant
- 2010-05-17 AU AU2010248782A patent/AU2010248782B2/en not_active Ceased
- 2010-05-17 CA CA2762108A patent/CA2762108A1/en not_active Abandoned
- 2010-05-17 EP EP10775673A patent/EP2432900A4/en not_active Ceased
-
2016
- 2016-01-04 JP JP2016000290A patent/JP6397833B2/ja not_active Expired - Fee Related
- 2016-10-26 US US15/334,974 patent/US20170183743A1/en not_active Abandoned
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