JP2012526563A - 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 - Google Patents

癌を診断および治療するためのａｌｋの融合に関する方法および組成物 Download PDF

Info

Publication number
JP2012526563A
JP2012526563A JP2012511069A JP2012511069A JP2012526563A JP 2012526563 A JP2012526563 A JP 2012526563A JP 2012511069 A JP2012511069 A JP 2012511069A JP 2012511069 A JP2012511069 A JP 2012511069A JP 2012526563 A JP2012526563 A JP 2012526563A
Authority
JP
Japan
Prior art keywords
seq
alk
primer
cancer
primers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012511069A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012526563A5 (enExample
Inventor
ジョシュ ニコルス
エリック ダールハウザー
デビッド ハウト
キム ノーマン
Original Assignee
インサイト ジェネティクス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インサイト ジェネティクス インコーポレイテッド filed Critical インサイト ジェネティクス インコーポレイテッド
Publication of JP2012526563A publication Critical patent/JP2012526563A/ja
Publication of JP2012526563A5 publication Critical patent/JP2012526563A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012511069A 2009-05-15 2010-05-17 癌を診断および治療するためのａｌｋの融合に関する方法および組成物 Pending JP2012526563A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17893709P 2009-05-15 2009-05-15
US61/178,937 2009-05-15
PCT/US2010/035147 WO2010132888A2 (en) 2009-05-15 2010-05-17 Methods and compositions relating to fusions of alk for diagnosing and treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016000290A Division JP6397833B2 (ja) 2009-05-15 2016-01-04 癌を診断および治療するためのａｌｋの融合に関する方法および組成物

Publications (2)

Publication Number Publication Date
JP2012526563A true JP2012526563A (ja) 2012-11-01
JP2012526563A5 JP2012526563A5 (enExample) 2013-07-04

Family

ID=43085621

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012511069A Pending JP2012526563A (ja) 2009-05-15 2010-05-17 癌を診断および治療するためのａｌｋの融合に関する方法および組成物
JP2016000290A Expired - Fee Related JP6397833B2 (ja) 2009-05-15 2016-01-04 癌を診断および治療するためのａｌｋの融合に関する方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016000290A Expired - Fee Related JP6397833B2 (ja) 2009-05-15 2016-01-04 癌を診断および治療するためのａｌｋの融合に関する方法および組成物

Country Status (11)

Country Link
US (2) US20120208713A1 (enExample)
EP (2) EP3133167B1 (enExample)
JP (2) JP2012526563A (enExample)
CN (1) CN102575287B (enExample)
AU (1) AU2010248782B2 (enExample)
BR (1) BRPI1012140A2 (enExample)
CA (1) CA2762108A1 (enExample)
ES (1) ES2700098T3 (enExample)
MX (1) MX338297B (enExample)
RU (1) RU2562144C2 (enExample)
WO (1) WO2010132888A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018514202A (ja) * 2015-04-17 2018-06-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 遺伝子融合体を検出するための多重ｐｃｒ
JP2022532289A (ja) * 2020-01-10 2022-07-14 厦門艾徳生物医薬科技股▲フン▼有限公司 肺癌の複数遺伝子突然変異を一括検出する試薬キット

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
ES2561406T3 (es) 2006-04-14 2016-02-26 Cell Signaling Technology, Inc. Defectos de genes y quinasa ALK mutante en tumores sólidos humanos
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
JP2015508644A (ja) * 2012-02-08 2015-03-23 インサイト ジェネティクス インコーポレイテッド 癌の診断および治療のためのｒｏｓ１の融合体に関する方法および組成物
CN102888452B (zh) * 2012-05-18 2014-08-27 复旦大学附属肿瘤医院 一种筛查alk融合基因的方法
US9084456B1 (en) * 2012-05-28 2015-07-21 Jack Zemer Linkage for jewelry components
WO2014026133A1 (en) * 2012-08-09 2014-02-13 Insight Genetics, Inc. Methods and compositions relating to alk for diagnosing and treating inflammatory breast and other human cancers
CA2882759C (en) * 2012-08-31 2018-11-20 The Regents Of The University Of Colorado Detection of the ntrk1-mprip gene fusion for cancer diagnosis
CN103805687B (zh) * 2012-11-09 2016-06-01 益善生物技术股份有限公司 Alk融合基因检测的pcr引物、试剂盒和液相芯片
RU2509153C1 (ru) * 2012-11-28 2014-03-10 Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
EP2986736B1 (en) * 2013-04-17 2019-09-18 Life Technologies Corporation Gene fusions and gene variants associated with cancer
CN103290120B (zh) * 2013-05-24 2015-03-25 厦门艾德生物医药科技有限公司 一种用于检测alk基因表达的探针、引物及试剂盒
CN106414768B (zh) * 2014-03-27 2020-05-29 生命技术公司 与癌症相关的基因融合体和基因变异体
US9428812B2 (en) * 2014-04-28 2016-08-30 Insight Genetics, Inc. Kit comprising primers for amplifying ALK kinase domain nucleic acids
WO2016106701A1 (zh) * 2014-12-31 2016-07-07 深圳华大基因股份有限公司 检测非小细胞肺癌的qRT-PCR引物、探针、芯片、试剂盒、应用和方法
CN107022610B (zh) * 2017-04-01 2019-02-05 常州桐树生物科技有限公司 肿瘤驱动基因的检测芯片及其应用
KR101987065B1 (ko) * 2017-08-07 2019-06-10 주식회사 싸이토젠 Eml4-alk유전자 변이 분석방법
RU2681165C1 (ru) * 2017-12-01 2019-03-04 Общество с ограниченной ответственностью "Научно-Исследовательский Центр Молекулярной Биомедицины" (ООО "НИЦ МолБиоМед") Способ определения активности теломеразы методом двойной амплификации теломерных повторов в реальном времени
CN113005200B (zh) * 2021-04-14 2023-07-04 深圳乐土生物科技有限公司 一种检测肉瘤融合基因突变的引物组合物、试剂盒及应用
CN114807124B (zh) * 2022-04-01 2023-09-12 上海信诺佰世医学检验有限公司 一种检测alk融合基因的引物和探针组合物、试剂盒及方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU8126694A (en) * 1993-10-26 1995-05-22 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US6696548B2 (en) * 1993-12-03 2004-02-24 St. Jude Children's Research Hospital Antibodies for recognition of alk protein tyrosine/kinase receptor
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
US7339033B2 (en) * 1998-06-26 2008-03-04 Genentech, Inc. Pro1481
GB0319227D0 (en) * 2003-08-15 2003-09-17 Novartis Ag Organic compounds
ATE429495T1 (de) * 2005-01-25 2009-05-15 Sky Genetics Inc Nukleinsäuren für die apoptose von krebszellen
WO2006085326A2 (en) * 2005-02-10 2006-08-17 Siano Mobile Silicon Ltd. System and method for mitigating memory requirements
WO2006094073A2 (en) * 2005-03-02 2006-09-08 Acadia Pharmaceuticals Inc. Functional bioluminescence energy resonance transfer (bret) assay to screen, identify and characterize receptor tyrosine kinase ligands
US20060286558A1 (en) * 2005-06-15 2006-12-21 Natalia Novoradovskaya Normalization of samples for amplification reactions
CA2598893C (en) * 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
JP5562640B2 (ja) * 2007-04-13 2014-07-30 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6014038316; Ｉｎｔ．　Ｊ．　Ｃａｎｃｅｒ，　（２００２），　１００，　［１］，　ｐ．４９-５６ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018514202A (ja) * 2015-04-17 2018-06-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 遺伝子融合体を検出するための多重ｐｃｒ
JP2022532289A (ja) * 2020-01-10 2022-07-14 厦門艾徳生物医薬科技股▲フン▼有限公司 肺癌の複数遺伝子突然変異を一括検出する試薬キット
JP7204004B2 (ja) 2020-01-10 2023-01-13 厦門艾徳生物医薬科技股▲フン▼有限公司 肺癌の複数遺伝子突然変異を一括検出する試薬キット

Also Published As

Publication number Publication date
RU2011151049A (ru) 2013-06-20
WO2010132888A3 (en) 2011-01-20
MX338297B (es) 2016-04-11
EP3133167B1 (en) 2018-09-12
RU2562144C2 (ru) 2015-09-10
AU2010248782A1 (en) 2012-01-19
CN102575287B (zh) 2016-11-16
CA2762108A1 (en) 2010-11-18
AU2010248782B2 (en) 2015-06-11
MX2011012162A (es) 2012-01-30
CN102575287A (zh) 2012-07-11
US20120208713A1 (en) 2012-08-16
EP3133167A1 (en) 2017-02-22
JP2016052332A (ja) 2016-04-14
US20170183743A1 (en) 2017-06-29
BRPI1012140A2 (pt) 2016-05-03
EP2432900A2 (en) 2012-03-28
ES2700098T3 (es) 2019-02-14
JP6397833B2 (ja) 2018-09-26
WO2010132888A2 (en) 2010-11-18
EP2432900A4 (en) 2012-11-21

Similar Documents

Publication Publication Date Title
JP6397833B2 (ja) 癌を診断および治療するためのａｌｋの融合に関する方法および組成物
EP1851339B1 (en) Methods and compositions for detecting a drug resistant egfr mutant
WO2013119950A2 (en) Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer
CA2886397A1 (en) Methods and compositions relating to next generation sequencing for genetic testing in alk related cancers
US9428812B2 (en) Kit comprising primers for amplifying ALK kinase domain nucleic acids
US20150232940A1 (en) Methods and compositions relating to diagnosing and treating receptor tyrosine kinase related cancers
JP6153758B2 (ja) 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット
JP6205216B2 (ja) 変異検出用プローブ、変異検出方法、薬効判定方法及び変異検出用キット
US20180208993A1 (en) Highly sensitive methods for detecting btk resistance mutations in rna and dna
US20150240301A1 (en) Methods and compositions relating to next generation sequencing for genetic testing in alk related cancers
WO2014026133A1 (en) Methods and compositions relating to alk for diagnosing and treating inflammatory breast and other human cancers
JP2005110606A (ja) 高血圧性腎障害素因の検査方法
WO2012146251A1 (en) Method for detecting mutations using a three primer system and differently melting amplicons

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130517

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130517

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140908

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141208

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150309

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150902

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160104

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160217

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160223

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20160415