CA2762108A1 - Methods and compositions relating to fusions of alk for diagnosing and treating cancer - Google Patents

Methods and compositions relating to fusions of alk for diagnosing and treating cancer Download PDF

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Publication number
CA2762108A1
CA2762108A1 CA2762108A CA2762108A CA2762108A1 CA 2762108 A1 CA2762108 A1 CA 2762108A1 CA 2762108 A CA2762108 A CA 2762108A CA 2762108 A CA2762108 A CA 2762108A CA 2762108 A1 CA2762108 A1 CA 2762108A1
Authority
CA
Canada
Prior art keywords
seq
alk
primer
cancer
pcr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2762108A
Other languages
English (en)
French (fr)
Inventor
Josh Nickols
Eric Dahlhauser
David Haut
Kim Norman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Genetics Inc
Original Assignee
Insight Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Genetics Inc filed Critical Insight Genetics Inc
Publication of CA2762108A1 publication Critical patent/CA2762108A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2762108A 2009-05-15 2010-05-17 Methods and compositions relating to fusions of alk for diagnosing and treating cancer Abandoned CA2762108A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17893709P 2009-05-15 2009-05-15
US61/178,937 2009-05-15
PCT/US2010/035147 WO2010132888A2 (en) 2009-05-15 2010-05-17 Methods and compositions relating to fusions of alk for diagnosing and treating cancer

Publications (1)

Publication Number Publication Date
CA2762108A1 true CA2762108A1 (en) 2010-11-18

Family

ID=43085621

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2762108A Abandoned CA2762108A1 (en) 2009-05-15 2010-05-17 Methods and compositions relating to fusions of alk for diagnosing and treating cancer

Country Status (11)

Country Link
US (2) US20120208713A1 (enExample)
EP (2) EP3133167B1 (enExample)
JP (2) JP2012526563A (enExample)
CN (1) CN102575287B (enExample)
AU (1) AU2010248782B2 (enExample)
BR (1) BRPI1012140A2 (enExample)
CA (1) CA2762108A1 (enExample)
ES (1) ES2700098T3 (enExample)
MX (1) MX338297B (enExample)
RU (1) RU2562144C2 (enExample)
WO (1) WO2010132888A2 (enExample)

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US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
ES2561406T3 (es) 2006-04-14 2016-02-26 Cell Signaling Technology, Inc. Defectos de genes y quinasa ALK mutante en tumores sólidos humanos
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
JP2015508644A (ja) * 2012-02-08 2015-03-23 インサイト ジェネティクス インコーポレイテッド 癌の診断および治療のためのｒｏｓ１の融合体に関する方法および組成物
CN102888452B (zh) * 2012-05-18 2014-08-27 复旦大学附属肿瘤医院 一种筛查alk融合基因的方法
US9084456B1 (en) * 2012-05-28 2015-07-21 Jack Zemer Linkage for jewelry components
WO2014026133A1 (en) * 2012-08-09 2014-02-13 Insight Genetics, Inc. Methods and compositions relating to alk for diagnosing and treating inflammatory breast and other human cancers
CA2882759C (en) * 2012-08-31 2018-11-20 The Regents Of The University Of Colorado Detection of the ntrk1-mprip gene fusion for cancer diagnosis
CN103805687B (zh) * 2012-11-09 2016-06-01 益善生物技术股份有限公司 Alk融合基因检测的pcr引物、试剂盒和液相芯片
RU2509153C1 (ru) * 2012-11-28 2014-03-10 Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
EP2986736B1 (en) * 2013-04-17 2019-09-18 Life Technologies Corporation Gene fusions and gene variants associated with cancer
CN103290120B (zh) * 2013-05-24 2015-03-25 厦门艾德生物医药科技有限公司 一种用于检测alk基因表达的探针、引物及试剂盒
CN106414768B (zh) * 2014-03-27 2020-05-29 生命技术公司 与癌症相关的基因融合体和基因变异体
US9428812B2 (en) * 2014-04-28 2016-08-30 Insight Genetics, Inc. Kit comprising primers for amplifying ALK kinase domain nucleic acids
WO2016106701A1 (zh) * 2014-12-31 2016-07-07 深圳华大基因股份有限公司 检测非小细胞肺癌的qRT-PCR引物、探针、芯片、试剂盒、应用和方法
CN107532209A (zh) * 2015-04-17 2018-01-02 豪夫迈·罗氏有限公司 检测基因融合的多重pcr
CN107022610B (zh) * 2017-04-01 2019-02-05 常州桐树生物科技有限公司 肿瘤驱动基因的检测芯片及其应用
KR101987065B1 (ko) * 2017-08-07 2019-06-10 주식회사 싸이토젠 Eml4-alk유전자 변이 분석방법
RU2681165C1 (ru) * 2017-12-01 2019-03-04 Общество с ограниченной ответственностью "Научно-Исследовательский Центр Молекулярной Биомедицины" (ООО "НИЦ МолБиоМед") Способ определения активности теломеразы методом двойной амплификации теломерных повторов в реальном времени
CN111235272B (zh) * 2020-01-10 2023-07-07 厦门艾德生物医药科技股份有限公司 一次性检测肺癌多重基因突变的组合物及其应用
CN113005200B (zh) * 2021-04-14 2023-07-04 深圳乐土生物科技有限公司 一种检测肉瘤融合基因突变的引物组合物、试剂盒及应用
CN114807124B (zh) * 2022-04-01 2023-09-12 上海信诺佰世医学检验有限公司 一种检测alk融合基因的引物和探针组合物、试剂盒及方法

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US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU8126694A (en) * 1993-10-26 1995-05-22 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US6696548B2 (en) * 1993-12-03 2004-02-24 St. Jude Children's Research Hospital Antibodies for recognition of alk protein tyrosine/kinase receptor
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
US7339033B2 (en) * 1998-06-26 2008-03-04 Genentech, Inc. Pro1481
GB0319227D0 (en) * 2003-08-15 2003-09-17 Novartis Ag Organic compounds
ATE429495T1 (de) * 2005-01-25 2009-05-15 Sky Genetics Inc Nukleinsäuren für die apoptose von krebszellen
WO2006085326A2 (en) * 2005-02-10 2006-08-17 Siano Mobile Silicon Ltd. System and method for mitigating memory requirements
WO2006094073A2 (en) * 2005-03-02 2006-09-08 Acadia Pharmaceuticals Inc. Functional bioluminescence energy resonance transfer (bret) assay to screen, identify and characterize receptor tyrosine kinase ligands
US20060286558A1 (en) * 2005-06-15 2006-12-21 Natalia Novoradovskaya Normalization of samples for amplification reactions
CA2598893C (en) * 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
JP5562640B2 (ja) * 2007-04-13 2014-07-30 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ

Also Published As

Publication number Publication date
JP2012526563A (ja) 2012-11-01
RU2011151049A (ru) 2013-06-20
WO2010132888A3 (en) 2011-01-20
MX338297B (es) 2016-04-11
EP3133167B1 (en) 2018-09-12
RU2562144C2 (ru) 2015-09-10
AU2010248782A1 (en) 2012-01-19
CN102575287B (zh) 2016-11-16
AU2010248782B2 (en) 2015-06-11
MX2011012162A (es) 2012-01-30
CN102575287A (zh) 2012-07-11
US20120208713A1 (en) 2012-08-16
EP3133167A1 (en) 2017-02-22
JP2016052332A (ja) 2016-04-14
US20170183743A1 (en) 2017-06-29
BRPI1012140A2 (pt) 2016-05-03
EP2432900A2 (en) 2012-03-28
ES2700098T3 (es) 2019-02-14
JP6397833B2 (ja) 2018-09-26
WO2010132888A2 (en) 2010-11-18
EP2432900A4 (en) 2012-11-21

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Effective date: 20130607

FZDE Discontinued

Effective date: 20200831