JP2012525836A - セリンプロテアーゼインヒビターの改変方法 - Google Patents
セリンプロテアーゼインヒビターの改変方法 Download PDFInfo
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Classifications
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
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| US25041209P | 2009-10-09 | 2009-10-09 | |
| US61/250,412 | 2009-10-09 | ||
| PCT/GB2010/000889 WO2010128285A2 (en) | 2009-05-05 | 2010-05-05 | Method of modifying serine protease inhibitors |
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| JP2012525836A true JP2012525836A (ja) | 2012-10-25 |
| JP2012525836A5 JP2012525836A5 (enExample) | 2013-06-20 |
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| WO (1) | WO2010128285A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020501561A (ja) * | 2016-12-16 | 2020-01-23 | ザ・ユニバーシティ・オブ・シドニー | 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 |
| JP2021052793A (ja) * | 2013-10-29 | 2021-04-08 | オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． | トロンビン活性を安定化させるための化合物及び方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225966B (zh) | 2004-10-19 | 2012-12-26 | 隆萨股份公司 | 用于固相肽合成的方法 |
| AU2011336345B2 (en) * | 2010-12-02 | 2016-07-07 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent |
| CN103044542B (zh) * | 2012-08-17 | 2015-08-19 | 常熟理工学院 | 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用 |
| GB201310949D0 (en) * | 2013-06-19 | 2013-07-31 | Cambridge Entpr Ltd | Binding Motif |
| CN103641911B (zh) * | 2013-12-17 | 2015-07-15 | 华中农业大学 | 大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用 |
| JP2018516272A (ja) * | 2015-04-16 | 2018-06-21 | インノ・バイオ‐ドラッグ・ディヴェロップメント・リミテッドＩｎｎｏ Ｂｉｏ‐Ｄｒｕｇ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | ヒト脂肪由来幹細胞と肝細胞とにおけるｃ型肝炎ウイルスの複製を抑制することができるペプチドとその誘導体 |
| WO2020024142A1 (en) * | 2018-08-01 | 2020-02-06 | Vanford Bio-Drug Development Limited | Novel peptides and its derivatives capable of stimulating cytokine release |
| CN112759625B (zh) * | 2019-10-18 | 2023-05-05 | 沛尔生技医药股份有限公司 | 肽作为制备治疗发炎性疾病及疼痛的药物的用途 |
| WO2021152554A1 (en) * | 2020-01-31 | 2021-08-05 | Fernando Biyagamage Ruchika | Use of an anticoagulant inhibitor for the prevention of blood feeding by parasites or insects |
| CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
| CN115677850B (zh) * | 2021-07-24 | 2024-03-08 | 王大勇 | 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法 |
| CN120230192B (zh) * | 2025-03-18 | 2025-10-24 | 中山大学 | 一种丽鱼三代虫重组kunitz蛋白及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076484A1 (en) * | 2003-02-27 | 2004-09-10 | National Research Council Of Canada | Peptide inhibitors of thrombin as potent anticoagulants |
| WO2008155658A2 (en) * | 2007-06-18 | 2008-12-24 | Institute Of Zoology Of The Slovak Academy Of Sciences | Thrombin inhibitor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| US5985833A (en) * | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
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- 2010-05-05 EP EP10718258A patent/EP2427487A2/en not_active Withdrawn
- 2010-05-05 WO PCT/GB2010/000889 patent/WO2010128285A2/en not_active Ceased
- 2010-05-05 CN CN2010800300966A patent/CN102574909A/zh active Pending
- 2010-05-05 US US13/319,051 patent/US20120135931A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076484A1 (en) * | 2003-02-27 | 2004-09-10 | National Research Council Of Canada | Peptide inhibitors of thrombin as potent anticoagulants |
| WO2008155658A2 (en) * | 2007-06-18 | 2008-12-24 | Institute Of Zoology Of The Slovak Academy Of Sciences | Thrombin inhibitor |
Non-Patent Citations (2)
| Title |
|---|
| JPN5012012539; ＫＯＨ ＣＨＯ ＹＥＯＷ: 'ＶＡＲＩＥＧＩＮ，Ａ ＮＯＶＥＬ ＦＡＳＴ ＡＮＤ ＴＩＧＨＴ ＢＩＮＤＩＮＧ ＴＨＲＯＭＢＩＮ ＩＮＨＩＢＩＴＯＲ ＦＲＯＭ ＴＨＥ ＴＲＯＰＩＣＡＬ ＢＯＮＴ ＴＩＣＫ' ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ２８２ Ｎ４０, 20070806, Ｐ２９１０１-２９１１３, ＡＭＥＲＩＣＡＮ ＳＯＣＩＥＴＹ ＦＯＲ ＢＩＯＣＨＥＭＩＳＴＲＹ ＡＮＤ ＭＯＬＥＣＵＬＡＲ ＢＩ * |
| JPN5012012540; ＫＯＨ ＣＨＯ ＹＥＯＷ: 'ＮＯＮＣＯＭＰＥＴＩＴＩＶＥ ＩＮＨＩＢＩＴＯＲ ＯＦ ＴＨＲＯＭＢＩＮ' ＣＨＥＭＢＩＯＣＨＥＭ Ｖ１０ Ｎ１３, 200909, Ｐ２１５５-２１５８ * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021052793A (ja) * | 2013-10-29 | 2021-04-08 | オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． | トロンビン活性を安定化させるための化合物及び方法 |
| JP7102498B2 (ja) | 2013-10-29 | 2022-07-19 | オムリックス・バイオファーマシューティカルズ・リミテッド | トロンビン活性を安定化させるための化合物及び方法 |
| JP2020501561A (ja) * | 2016-12-16 | 2020-01-23 | ザ・ユニバーシティ・オブ・シドニー | 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 |
| JP2022130527A (ja) * | 2016-12-16 | 2022-09-06 | ザ・ユニバーシティ・オブ・シドニー | 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2427487A2 (en) | 2012-03-14 |
| US20120135931A1 (en) | 2012-05-31 |
| WO2010128285A2 (en) | 2010-11-11 |
| GB0907698D0 (en) | 2009-06-10 |
| WO2010128285A3 (en) | 2011-03-31 |
| CN102574909A (zh) | 2012-07-11 |
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