GB0907698D0 - Method of modifying serine protease inhibitors - Google Patents

Method of modifying serine protease inhibitors

Info

Publication number
GB0907698D0
GB0907698D0 GBGB0907698.5A GB0907698A GB0907698D0 GB 0907698 D0 GB0907698 D0 GB 0907698D0 GB 0907698 A GB0907698 A GB 0907698A GB 0907698 D0 GB0907698 D0 GB 0907698D0
Authority
GB
United Kingdom
Prior art keywords
protease inhibitors
serine protease
modifying
modifying serine
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0907698.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natural Environment Research Council
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Singapore filed Critical National University of Singapore
Priority to GBGB0907698.5A priority Critical patent/GB0907698D0/en
Publication of GB0907698D0 publication Critical patent/GB0907698D0/en
Priority to US13/319,051 priority patent/US20120135931A1/en
Priority to EP10718258A priority patent/EP2427487A2/en
Priority to PCT/GB2010/000889 priority patent/WO2010128285A2/en
Priority to JP2012509082A priority patent/JP2012525836A/ja
Priority to CN2010800300966A priority patent/CN102574909A/zh
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GBGB0907698.5A 2009-05-05 2009-05-05 Method of modifying serine protease inhibitors Ceased GB0907698D0 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GBGB0907698.5A GB0907698D0 (en) 2009-05-05 2009-05-05 Method of modifying serine protease inhibitors
US13/319,051 US20120135931A1 (en) 2009-05-05 2010-05-05 Method of modifying serine protease inhibitors
EP10718258A EP2427487A2 (en) 2009-05-05 2010-05-05 Method of modifying serine protease inhibitors
PCT/GB2010/000889 WO2010128285A2 (en) 2009-05-05 2010-05-05 Method of modifying serine protease inhibitors
JP2012509082A JP2012525836A (ja) 2009-05-05 2010-05-05 セリンプロテアーゼインヒビターの改変方法
CN2010800300966A CN102574909A (zh) 2009-05-05 2010-05-05 修饰丝氨酸蛋白酶抑制剂的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0907698.5A GB0907698D0 (en) 2009-05-05 2009-05-05 Method of modifying serine protease inhibitors

Publications (1)

Publication Number Publication Date
GB0907698D0 true GB0907698D0 (en) 2009-06-10

Family

ID=40792252

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0907698.5A Ceased GB0907698D0 (en) 2009-05-05 2009-05-05 Method of modifying serine protease inhibitors

Country Status (6)

Country Link
US (1) US20120135931A1 (enExample)
EP (1) EP2427487A2 (enExample)
JP (1) JP2012525836A (enExample)
CN (1) CN102574909A (enExample)
GB (1) GB0907698D0 (enExample)
WO (1) WO2010128285A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225966B (zh) 2004-10-19 2012-12-26 隆萨股份公司 用于固相肽合成的方法
AU2011336345B2 (en) * 2010-12-02 2016-07-07 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent
CN103044542B (zh) * 2012-08-17 2015-08-19 常熟理工学院 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
GB201310949D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Binding Motif
IL229134A0 (en) * 2013-10-29 2014-03-31 Omrix Biopharmaceuticals Ltd Compounds and methods for stabilizing thrombin activity
CN103641911B (zh) * 2013-12-17 2015-07-15 华中农业大学 大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用
JP2018516272A (ja) * 2015-04-16 2018-06-21 インノ・バイオ‐ドラッグ・ディヴェロップメント・リミテッドＩｎｎｏ Ｂｉｏ‐Ｄｒｕｇ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ ヒト脂肪由来幹細胞と肝細胞とにおけるｃ型肝炎ウイルスの複製を抑制することができるペプチドとその誘導体
NZ754781A (en) * 2016-12-16 2021-12-24 Univ Sydney Thrombin inhibitors for treatment of stroke and related coagulative disorders
WO2020024142A1 (en) * 2018-08-01 2020-02-06 Vanford Bio-Drug Development Limited Novel peptides and its derivatives capable of stimulating cytokine release
CN112759625B (zh) * 2019-10-18 2023-05-05 沛尔生技医药股份有限公司 肽作为制备治疗发炎性疾病及疼痛的药物的用途
WO2021152554A1 (en) * 2020-01-31 2021-08-05 Fernando Biyagamage Ruchika Use of an anticoagulant inhibitor for the prevention of blood feeding by parasites or insects
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN120230192B (zh) * 2025-03-18 2025-10-24 中山大学 一种丽鱼三代虫重组kunitz蛋白及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
WO2004076484A1 (en) * 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor

Also Published As

Publication number Publication date
EP2427487A2 (en) 2012-03-14
US20120135931A1 (en) 2012-05-31
WO2010128285A2 (en) 2010-11-11
WO2010128285A3 (en) 2011-03-31
JP2012525836A (ja) 2012-10-25
CN102574909A (zh) 2012-07-11

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Legal Events

Date Code Title Description
COOA Change in applicant's name or ownership of the application

Owner name: NATURAL ENVIRONMENT RESEARCH COUNCIL

Free format text: FORMER OWNER: NATIONAL UNIVERSITY OF SINGAPORE

AT Applications terminated before publication under section 16(1)