CN102574909A - 修饰丝氨酸蛋白酶抑制剂的方法 - Google Patents

修饰丝氨酸蛋白酶抑制剂的方法 Download PDF

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Publication number
CN102574909A
CN102574909A CN2010800300966A CN201080030096A CN102574909A CN 102574909 A CN102574909 A CN 102574909A CN 2010800300966 A CN2010800300966 A CN 2010800300966A CN 201080030096 A CN201080030096 A CN 201080030096A CN 102574909 A CN102574909 A CN 102574909A
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seq
modification
leech
spi
plain
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CN2010800300966A
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English (en)
Chinese (zh)
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R·曼朱纳塔·基尼
许祖尧
昆奇塔帕丹姆·斯瓦米纳坦
库玛·顺德拉墨尔西
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National University of Singapore
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Natural Environment Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2010800300966A 2009-05-05 2010-05-05 修饰丝氨酸蛋白酶抑制剂的方法 Pending CN102574909A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0907698.5A GB0907698D0 (en) 2009-05-05 2009-05-05 Method of modifying serine protease inhibitors
GB0907698.5 2009-05-05
US25041209P 2009-10-09 2009-10-09
US61/250,412 2009-10-09
PCT/GB2010/000889 WO2010128285A2 (en) 2009-05-05 2010-05-05 Method of modifying serine protease inhibitors

Publications (1)

Publication Number Publication Date
CN102574909A true CN102574909A (zh) 2012-07-11

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CN2010800300966A Pending CN102574909A (zh) 2009-05-05 2010-05-05 修饰丝氨酸蛋白酶抑制剂的方法

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Country Link
US (1) US20120135931A1 (enExample)
EP (1) EP2427487A2 (enExample)
JP (1) JP2012525836A (enExample)
CN (1) CN102574909A (enExample)
GB (1) GB0907698D0 (enExample)
WO (1) WO2010128285A2 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044542A (zh) * 2012-08-17 2013-04-17 常熟理工学院 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN103641911A (zh) * 2013-12-17 2014-03-19 华中农业大学 大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用
CN107849091A (zh) * 2015-04-16 2018-03-27 医诺生药开发有限公司 能够在人脂肪衍生的干细胞和肝细胞中抑制丙肝病毒复制的肽及其衍生物
CN110139871A (zh) * 2016-12-16 2019-08-16 悉尼大学 用于治疗中风和相关凝血障碍的凝血酶抑制剂
CN112543765A (zh) * 2018-08-01 2021-03-23 宏福生物发展有限公司 能够刺激细胞因子释放的新型肽及其衍生物
CN112759625A (zh) * 2019-10-18 2021-05-07 沛尔生技医药股份有限公司 肽及其作为制备治疗发炎性疾病及疼痛的药物的用途
CN115572329A (zh) * 2021-06-21 2023-01-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850A (zh) * 2021-07-24 2023-02-03 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN120230192A (zh) * 2025-03-18 2025-07-01 中山大学 一种丽鱼三代虫重组kunitz蛋白及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225966B (zh) 2004-10-19 2012-12-26 隆萨股份公司 用于固相肽合成的方法
AU2011336345B2 (en) * 2010-12-02 2016-07-07 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent
GB201310949D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Binding Motif
IL229134A0 (en) * 2013-10-29 2014-03-31 Omrix Biopharmaceuticals Ltd Compounds and methods for stabilizing thrombin activity
WO2021152554A1 (en) * 2020-01-31 2021-08-05 Fernando Biyagamage Ruchika Use of an anticoagulant inhibitor for the prevention of blood feeding by parasites or insects

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076484A1 (en) * 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
WO2008155658A2 (en) * 2007-06-18 2008-12-24 Institute Of Zoology Of The Slovak Academy Of Sciences Thrombin inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076484A1 (en) * 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
WO2008155658A2 (en) * 2007-06-18 2008-12-24 Institute Of Zoology Of The Slovak Academy Of Sciences Thrombin inhibitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOH CHO YEOW ET AL: "Variegin,a novel fast and tight binding thrombin inhibitor from the tropical bont tick", 《JOURNAL OF BIOLOGICAL CHEMISTRY》 *
MARAGANORE J M ET AL: "Design and characterization of hirulogs:a novel class of bivalent peptide inhibitors of thrombin", 《BIOCHEMISTRY》 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044542A (zh) * 2012-08-17 2013-04-17 常熟理工学院 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN103044542B (zh) * 2012-08-17 2015-08-19 常熟理工学院 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN103641911A (zh) * 2013-12-17 2014-03-19 华中农业大学 大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用
CN103641911B (zh) * 2013-12-17 2015-07-15 华中农业大学 大腹园蛛丝氨酸蛋白酶抑制剂AvSPI基因及其编码蛋白和应用
CN107849091B (zh) * 2015-04-16 2021-09-10 医诺生药开发有限公司 能够在人脂肪衍生的干细胞和肝细胞中抑制丙肝病毒复制的肽及其衍生物
CN107849091A (zh) * 2015-04-16 2018-03-27 医诺生药开发有限公司 能够在人脂肪衍生的干细胞和肝细胞中抑制丙肝病毒复制的肽及其衍生物
CN110139871A (zh) * 2016-12-16 2019-08-16 悉尼大学 用于治疗中风和相关凝血障碍的凝血酶抑制剂
CN112543765A (zh) * 2018-08-01 2021-03-23 宏福生物发展有限公司 能够刺激细胞因子释放的新型肽及其衍生物
CN112759625A (zh) * 2019-10-18 2021-05-07 沛尔生技医药股份有限公司 肽及其作为制备治疗发炎性疾病及疼痛的药物的用途
CN112759625B (zh) * 2019-10-18 2023-05-05 沛尔生技医药股份有限公司 肽作为制备治疗发炎性疾病及疼痛的药物的用途
CN115572329A (zh) * 2021-06-21 2023-01-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850A (zh) * 2021-07-24 2023-02-03 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN120230192A (zh) * 2025-03-18 2025-07-01 中山大学 一种丽鱼三代虫重组kunitz蛋白及其制备方法和应用
CN120230192B (zh) * 2025-03-18 2025-10-24 中山大学 一种丽鱼三代虫重组kunitz蛋白及其制备方法和应用

Also Published As

Publication number Publication date
EP2427487A2 (en) 2012-03-14
US20120135931A1 (en) 2012-05-31
WO2010128285A2 (en) 2010-11-11
GB0907698D0 (en) 2009-06-10
WO2010128285A3 (en) 2011-03-31
JP2012525836A (ja) 2012-10-25

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