JP2012525836A5 - - Google Patents

Info

Publication number

JP2012525836A5

JP2012525836A5 JP2012509082A JP2012509082A JP2012525836A5 JP 2012525836 A5 JP2012525836 A5 JP 2012525836A5 JP 2012509082 A JP2012509082 A JP 2012509082A JP 2012509082 A JP2012509082 A JP 2012509082A JP 2012525836 A5 JP2012525836 A5 JP 2012525836A5

Authority

JP

Japan

Prior art keywords

spi

modified

region

target

sequence

Prior art date

2010-05-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003001 serine protease inhibitor Substances 0.000 claims 34
• 229940122055 Serine protease inhibitor Drugs 0.000 claims 32
• 101710102218 Serine protease inhibitor Proteins 0.000 claims 32
• 108010022999 Serine Proteases Proteins 0.000 claims 12
• 102000012479 Serine Proteases Human genes 0.000 claims 12
• 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims 7
• 229940122388 Thrombin inhibitor Drugs 0.000 claims 7
• 239000003868 thrombin inhibitor Substances 0.000 claims 7
• 125000000539 amino acid group Chemical group 0.000 claims 6
• 230000003197 catalytic effect Effects 0.000 claims 6
• 230000005764 inhibitory process Effects 0.000 claims 6
• 235000001014 amino acid Nutrition 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 230000003472 neutralizing effect Effects 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 102000007327 Protamines Human genes 0.000 claims 3
• 108010007568 Protamines Proteins 0.000 claims 3
• 239000003112 inhibitor Substances 0.000 claims 3
• 238000006386 neutralization reaction Methods 0.000 claims 3
• 229950008679 protamine sulfate Drugs 0.000 claims 3
• 125000003607 serino group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 3
• 108050000761 Serpin Proteins 0.000 claims 2
• 102000008847 Serpin Human genes 0.000 claims 2
• 108090000190 Thrombin Proteins 0.000 claims 2
• 230000002378 acidificating effect Effects 0.000 claims 2
• 125000000129 anionic group Chemical group 0.000 claims 2
• 208000015294 blood coagulation disease Diseases 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 238000003776 cleavage reaction Methods 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 230000000717 retained effect Effects 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 229960004072 thrombin Drugs 0.000 claims 2
• 108010039627 Aprotinin Proteins 0.000 claims 1
• 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 claims 1
• 108091035707 Consensus sequence Proteins 0.000 claims 1
• 235000010469 Glycine max Nutrition 0.000 claims 1
• 244000068988 Glycine max Species 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 102000007625 Hirudins Human genes 0.000 claims 1
• 108010007267 Hirudins Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 229940122618 Trypsin inhibitor Drugs 0.000 claims 1
• 101710162629 Trypsin inhibitor Proteins 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 238000006073 displacement reaction Methods 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 229940006607 hirudin Drugs 0.000 claims 1
• WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000002715 modification method Methods 0.000 claims 1
• 230000002035 prolonged effect Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 239000002753 trypsin inhibitor Substances 0.000 claims 1