JP2012524885A - 生物学的試料から標的バイオエンティティを分離する方法及び装置 - Google Patents

生物学的試料から標的バイオエンティティを分離する方法及び装置 Download PDF

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JP2012524885A
JP2012524885A JP2012506281A JP2012506281A JP2012524885A JP 2012524885 A JP2012524885 A JP 2012524885A JP 2012506281 A JP2012506281 A JP 2012506281A JP 2012506281 A JP2012506281 A JP 2012506281A JP 2012524885 A JP2012524885 A JP 2012524885A
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flow path
magnetic
module
fluid flow
biological sample
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JP2012524885A5 (https=
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ハワード・ミルン・チャンドラー
マイケル・ブルース・チャンドラー
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Clinical Genomics Pty Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012506281A 2009-04-22 2010-04-22 生物学的試料から標的バイオエンティティを分離する方法及び装置 Ceased JP2012524885A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17153209P 2009-04-22 2009-04-22
US61/171,532 2009-04-22
US18266109P 2009-05-29 2009-05-29
US61/182,661 2009-05-29
US28528609P 2009-12-10 2009-12-10
US61/285,286 2009-12-10
PCT/AU2010/000459 WO2010121315A1 (en) 2009-04-22 2010-04-22 Method and apparatus for isolating a target bioentity from a biological sample

Publications (2)

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JP2012524885A true JP2012524885A (ja) 2012-10-18
JP2012524885A5 JP2012524885A5 (https=) 2013-06-13

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JP2012506281A Ceased JP2012524885A (ja) 2009-04-22 2010-04-22 生物学的試料から標的バイオエンティティを分離する方法及び装置

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US (1) US20120115167A1 (https=)
EP (1) EP2421654A1 (https=)
JP (1) JP2012524885A (https=)
CN (1) CN102458665A (https=)
AU (1) AU2010239154A1 (https=)
IL (1) IL215807A0 (https=)
NZ (1) NZ595982A (https=)
RU (1) RU2011147219A (https=)
WO (1) WO2010121315A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2018534588A (ja) * 2015-09-22 2018-11-22 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 稀少細胞の遠心分離なしの単離および検出

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HRP20171468T1 (hr) * 2010-11-09 2017-12-15 Arcedi Biotech Aps Obogaćivanje i identificiranje fetalnih stanica u majčinskoj krvi, te ligandi namijenjenu u tu svrhu
WO2012113028A1 (en) * 2011-02-23 2012-08-30 Clinical Genomics Pty. Ltd. Isolation of a target bioentity from a biological sample
US20140295420A1 (en) * 2011-06-15 2014-10-02 Koninklijke Philips N.V. Processing of biological sample components
WO2013003898A1 (en) * 2011-07-07 2013-01-10 Clinical Genomics Pty. Ltd Method for detection of cancer in a patient
DE102011088741B4 (de) 2011-12-15 2013-07-25 Institut für Bioprozess- und Analysenmesstechnik e.V. Verfahren und Anordnung zum Markieren und Separieren von Zellen aus einer Zellsuspension
WO2013123035A1 (en) 2012-02-13 2013-08-22 Molecular Systems Corporation System and method for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US20140024136A1 (en) * 2012-07-19 2014-01-23 Derek L. Chappell Magnetic particle separator
CN102911864B (zh) * 2012-10-15 2014-08-06 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离仪
US20140120544A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
CN103131634B (zh) * 2013-02-25 2014-09-03 宁波美晶医疗技术有限公司 一种基于微磁场的免疫肿瘤细胞筛选系统
CN103131693B (zh) * 2013-02-25 2014-12-24 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离方法
EP3058316B1 (en) * 2013-10-18 2019-03-13 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
CN103940997B (zh) * 2014-03-21 2017-01-04 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
US10690662B2 (en) 2014-11-28 2020-06-23 Indian Institute Of Technology Delhi Magnetic capturing of rare cells
EP3061529A1 (en) * 2015-02-24 2016-08-31 AdnaGen GmbH Apparatus and method for the analysis, isolation and/or enrichment of target structures in a fluid sample
WO2016183032A1 (en) 2015-05-08 2016-11-17 Biomagnetic Solutions Llc Apparatus and method for immunomagnetic cell separation
CN115655825A (zh) * 2015-09-18 2023-01-31 紫荆实验室股份有限公司 利用表面附着结构的流动池，以及相关的系统和方法
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
JP7396777B2 (ja) * 2018-09-28 2023-12-12 オクタン バイオテック インコーポレーテッド 磁気分離
EP3870969A4 (en) * 2018-10-24 2022-07-27 Path Ex, Inc. PROCESS FOR RECOVERING AND ISOLATION OF DISEASE MATERIAL FROM FLOWING MATERIAL
IL308999B2 (en) 2019-06-07 2026-02-01 Arcedi Biotech Aps Isolation of fetal cells using FACS
JP2022545485A (ja) * 2019-08-30 2022-10-27 フロデザイン ソニックス， インク． 複数の標的受容体のための音響親和性細胞の選択
CN113125707A (zh) * 2020-01-10 2021-07-16 陈琪 一种分离磁微粒的方法、装置及设备
EP4616195A1 (en) * 2022-11-08 2025-09-17 Zhong Li Methods for detecting target compounds and uses thereof
CN120838569B (zh) * 2025-07-30 2026-01-06 上海迪化科技股份有限公司 一种磁珠连续分离工艺及装置
CN120644311B (zh) * 2025-07-30 2026-02-06 上海迪化科技股份有限公司 一种磁珠连续分离系统和控制方法

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JP2000500871A (ja) * 1996-05-07 2000-01-25 ビオコム エス エー 生物学的分析用流体内の磁気粒子の分離方法及び設備ならびにその方法の応用
JP2005528584A (ja) * 2001-08-31 2005-09-22 バッテル・メモリアル・インスティチュート フロー制御された磁性粒子の操作
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WO2009026566A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species
JP2009530606A (ja) * 2006-03-13 2009-08-27 ギロス パテント アーべー 増強型磁気粒子ステアリング
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JPH04505547A (ja) * 1988-01-04 1992-10-01 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー 細胞混合物から特定の細胞を単離するための多段アフィニティー法
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018534588A (ja) * 2015-09-22 2018-11-22 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 稀少細胞の遠心分離なしの単離および検出

Also Published As

Publication number Publication date
EP2421654A1 (en) 2012-02-29
CN102458665A (zh) 2012-05-16
AU2010239154A1 (en) 2011-11-10
RU2011147219A (ru) 2013-05-27
US20120115167A1 (en) 2012-05-10
WO2010121315A1 (en) 2010-10-28
NZ595982A (en) 2013-10-25
IL215807A0 (en) 2012-01-31

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