JP2012524885A5 - - Google Patents
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- Publication number
- JP2012524885A5 JP2012524885A5 JP2012506281A JP2012506281A JP2012524885A5 JP 2012524885 A5 JP2012524885 A5 JP 2012524885A5 JP 2012506281 A JP2012506281 A JP 2012506281A JP 2012506281 A JP2012506281 A JP 2012506281A JP 2012524885 A5 JP2012524885 A5 JP 2012524885A5
- Authority
- JP
- Japan
- Prior art keywords
- flow path
- module
- biological sample
- fluid flow
- magnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003446 ligand Substances 0.000 claims 25
- 238000000926 separation method Methods 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 239000012530 fluid Substances 0.000 claims 20
- 239000012472 biological sample Substances 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 11
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- 108091005461 Nucleic proteins Proteins 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- 230000000781 anti-lymphocytic effect Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 229920002457 flexible plastic Polymers 0.000 claims 1
- 238000011010 flushing procedure Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000008774 maternal effect Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 229910052761 rare earth metal Inorganic materials 0.000 claims 1
- 150000002910 rare earth metals Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17153209P | 2009-04-22 | 2009-04-22 | |
| US61/171,532 | 2009-04-22 | ||
| US18266109P | 2009-05-29 | 2009-05-29 | |
| US61/182,661 | 2009-05-29 | ||
| US28528609P | 2009-12-10 | 2009-12-10 | |
| US61/285,286 | 2009-12-10 | ||
| PCT/AU2010/000459 WO2010121315A1 (en) | 2009-04-22 | 2010-04-22 | Method and apparatus for isolating a target bioentity from a biological sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012524885A JP2012524885A (ja) | 2012-10-18 |
| JP2012524885A5 true JP2012524885A5 (https=) | 2013-06-13 |
Family
ID=43010599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506281A Ceased JP2012524885A (ja) | 2009-04-22 | 2010-04-22 | 生物学的試料から標的バイオエンティティを分離する方法及び装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120115167A1 (https=) |
| EP (1) | EP2421654A1 (https=) |
| JP (1) | JP2012524885A (https=) |
| CN (1) | CN102458665A (https=) |
| AU (1) | AU2010239154A1 (https=) |
| IL (1) | IL215807A0 (https=) |
| NZ (1) | NZ595982A (https=) |
| RU (1) | RU2011147219A (https=) |
| WO (1) | WO2010121315A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20171468T1 (hr) * | 2010-11-09 | 2017-12-15 | Arcedi Biotech Aps | Obogaćivanje i identificiranje fetalnih stanica u majčinskoj krvi, te ligandi namijenjenu u tu svrhu |
| WO2012113028A1 (en) * | 2011-02-23 | 2012-08-30 | Clinical Genomics Pty. Ltd. | Isolation of a target bioentity from a biological sample |
| US20140295420A1 (en) * | 2011-06-15 | 2014-10-02 | Koninklijke Philips N.V. | Processing of biological sample components |
| WO2013003898A1 (en) * | 2011-07-07 | 2013-01-10 | Clinical Genomics Pty. Ltd | Method for detection of cancer in a patient |
| DE102011088741B4 (de) | 2011-12-15 | 2013-07-25 | Institut für Bioprozess- und Analysenmesstechnik e.V. | Verfahren und Anordnung zum Markieren und Separieren von Zellen aus einer Zellsuspension |
| WO2013123035A1 (en) | 2012-02-13 | 2013-08-22 | Molecular Systems Corporation | System and method for processing and detecting nucleic acids |
| US9604213B2 (en) | 2012-02-13 | 2017-03-28 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US11648561B2 (en) | 2012-02-13 | 2023-05-16 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US9637775B2 (en) | 2012-02-13 | 2017-05-02 | Neumodx Molecular, Inc. | System and method for processing biological samples |
| US20140024136A1 (en) * | 2012-07-19 | 2014-01-23 | Derek L. Chappell | Magnetic particle separator |
| CN102911864B (zh) * | 2012-10-15 | 2014-08-06 | 宁波美晶医疗技术有限公司 | 一种血液中稀有细胞的分离仪 |
| US20140120544A1 (en) | 2012-10-25 | 2014-05-01 | Neumodx Molecular, Inc. | Method and materials for isolation of nucleic acid materials |
| CN103131634B (zh) * | 2013-02-25 | 2014-09-03 | 宁波美晶医疗技术有限公司 | 一种基于微磁场的免疫肿瘤细胞筛选系统 |
| CN103131693B (zh) * | 2013-02-25 | 2014-12-24 | 宁波美晶医疗技术有限公司 | 一种血液中稀有细胞的分离方法 |
| EP3058316B1 (en) * | 2013-10-18 | 2019-03-13 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| CN103940997B (zh) * | 2014-03-21 | 2017-01-04 | 上海柏慧康生物科技有限公司 | 一种乳腺癌循环肿瘤细胞检测系统及试剂盒 |
| US10690662B2 (en) | 2014-11-28 | 2020-06-23 | Indian Institute Of Technology Delhi | Magnetic capturing of rare cells |
| EP3061529A1 (en) * | 2015-02-24 | 2016-08-31 | AdnaGen GmbH | Apparatus and method for the analysis, isolation and/or enrichment of target structures in a fluid sample |
| WO2016183032A1 (en) | 2015-05-08 | 2016-11-17 | Biomagnetic Solutions Llc | Apparatus and method for immunomagnetic cell separation |
| CN115655825A (zh) * | 2015-09-18 | 2023-01-31 | 紫荆实验室股份有限公司 | 利用表面附着结构的流动池，以及相关的系统和方法 |
| WO2017053630A1 (en) * | 2015-09-22 | 2017-03-30 | Purdue Research Foundation | Centrifuge-free isolation and detection of rare cells |
| EP3735281B1 (en) | 2018-01-05 | 2024-11-27 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| JP7396777B2 (ja) * | 2018-09-28 | 2023-12-12 | オクタン バイオテック インコーポレーテッド | 磁気分離 |
| EP3870969A4 (en) * | 2018-10-24 | 2022-07-27 | Path Ex, Inc. | PROCESS FOR RECOVERING AND ISOLATION OF DISEASE MATERIAL FROM FLOWING MATERIAL |
| IL308999B2 (en) | 2019-06-07 | 2026-02-01 | Arcedi Biotech Aps | Isolation of fetal cells using FACS |
| JP2022545485A (ja) * | 2019-08-30 | 2022-10-27 | フロデザイン ソニックス， インク． | 複数の標的受容体のための音響親和性細胞の選択 |
| CN113125707A (zh) * | 2020-01-10 | 2021-07-16 | 陈琪 | 一种分离磁微粒的方法、装置及设备 |
| EP4616195A1 (en) * | 2022-11-08 | 2025-09-17 | Zhong Li | Methods for detecting target compounds and uses thereof |
| CN120838569B (zh) * | 2025-07-30 | 2026-01-06 | 上海迪化科技股份有限公司 | 一种磁珠连续分离工艺及装置 |
| CN120644311B (zh) * | 2025-07-30 | 2026-02-06 | 上海迪化科技股份有限公司 | 一种磁珠连续分离系统和控制方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1575805A (en) * | 1976-03-12 | 1980-10-01 | Technicon Instr | Automatic diagnostic apparatus |
| AU2613988A (en) * | 1988-01-04 | 1989-08-01 | E.I. Du Pont De Nemours And Company | Multiple stage affinity process for isolation of specific cells from a cell mixture |
| US5795470A (en) * | 1991-03-25 | 1998-08-18 | Immunivest Corporation | Magnetic separation apparatus |
| JP3962789B2 (ja) * | 1995-02-21 | 2007-08-22 | ダブリュー． シディキー，イクバール | 磁性粒子を利用した混合／分離装置及びその方法 |
| US5705059A (en) * | 1995-02-27 | 1998-01-06 | Miltenyi; Stefan | Magnetic separation apparatus |
| FR2748569B1 (fr) * | 1996-05-07 | 1998-08-07 | Biocom Sa | Procede et installation de separation de particules magnetiques dans un fluide pour l'analyse biologique, et application dudit procede |
| US20030095897A1 (en) * | 2001-08-31 | 2003-05-22 | Grate Jay W. | Flow-controlled magnetic particle manipulation |
| CN1230531C (zh) * | 2002-12-09 | 2005-12-07 | 清华大学 | 从样品中分离细胞粒子的方法 |
| US7553625B2 (en) * | 2003-12-22 | 2009-06-30 | John Wayne Cancer Institute | Method and apparatus for in vivo collection of circulating biological components |
| JP2006010529A (ja) * | 2004-06-25 | 2006-01-12 | Canon Inc | 磁性粒子分離装置および分離方法 |
| JP2006051850A (ja) * | 2004-08-10 | 2006-02-23 | Matsushita Electric Ind Co Ltd | 運転支援装置及び運転支援方法 |
| CA2651367A1 (en) * | 2005-05-11 | 2006-11-16 | Genetic Technologies Limited | Methods of enriching fetal cells |
| JP2007010500A (ja) * | 2005-06-30 | 2007-01-18 | Canon Inc | サンプル検出装置とそれを含む検体分析装置 |
| WO2007092713A2 (en) * | 2006-02-02 | 2007-08-16 | Trustees Of The University Of Pennsylvania | Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease |
| WO2007106013A1 (en) * | 2006-03-13 | 2007-09-20 | Gyros Patent Ab | Enhanced magnetic particle steering |
| CN100546724C (zh) * | 2006-06-30 | 2009-10-07 | 上海师范大学 | 磁性分离柱及其在生物样品分离中的应用 |
| WO2009026566A1 (en) * | 2007-08-23 | 2009-02-26 | Cynvenio Biosystems, Llc | Trapping magnetic sorting system for target species |
| WO2009117611A2 (en) * | 2008-03-19 | 2009-09-24 | Cynvenio Biosystems, Llc | Trapping magnetic cell sorting system |
| US20110137018A1 (en) * | 2008-04-16 | 2011-06-09 | Cynvenio Biosystems, Inc. | Magnetic separation system with pre and post processing modules |
| US8377669B2 (en) * | 2009-11-17 | 2013-02-19 | Abbott Point Of Care Inc. | Reducing leukocyte interference in non-competitive immunoassays |
-
2010
- 2010-04-22 JP JP2012506281A patent/JP2012524885A/ja not_active Ceased
- 2010-04-22 RU RU2011147219/15A patent/RU2011147219A/ru not_active Application Discontinuation
- 2010-04-22 CN CN2010800262983A patent/CN102458665A/zh active Pending
- 2010-04-22 AU AU2010239154A patent/AU2010239154A1/en not_active Abandoned
- 2010-04-22 WO PCT/AU2010/000459 patent/WO2010121315A1/en not_active Ceased
- 2010-04-22 NZ NZ595982A patent/NZ595982A/xx not_active IP Right Cessation
- 2010-04-22 US US13/265,674 patent/US20120115167A1/en not_active Abandoned
- 2010-04-22 EP EP10766508A patent/EP2421654A1/en not_active Withdrawn
-
2011
- 2011-10-23 IL IL215807A patent/IL215807A0/en unknown
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