JP2012522232A5 - - Google Patents

Info

Publication number

JP2012522232A5

JP2012522232A5 JP2012502616A JP2012502616A JP2012522232A5 JP 2012522232 A5 JP2012522232 A5 JP 2012522232A5 JP 2012502616 A JP2012502616 A JP 2012502616A JP 2012502616 A JP2012502616 A JP 2012502616A JP 2012522232 A5 JP2012522232 A5 JP 2012522232A5

Authority

JP

Japan

Prior art keywords

seq

biomarker

group

fragments

peptide

Prior art date

2010-03-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000090 biomarker Substances 0.000 claims 39
• 239000012634 fragment Substances 0.000 claims 24
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 239000012472 biological sample Substances 0.000 claims 17
• 238000000034 method Methods 0.000 claims 13
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
• 238000000338 in vitro Methods 0.000 claims 10
• 102100035037 Calpastatin Human genes 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 230000015572 biosynthetic process Effects 0.000 claims 4
• 108010044208 calpastatin Proteins 0.000 claims 4
• ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 238000001514 detection method Methods 0.000 claims 4
• 230000003796 beauty Effects 0.000 claims 3
• 239000003550 marker Substances 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 238000003745 diagnosis Methods 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 108010074051 C-Reactive Protein Proteins 0.000 claims 1
• 102100032752 C-reactive protein Human genes 0.000 claims 1
• 102000004889 Interleukin-6 Human genes 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 102000005482 Lipopolysaccharide Receptors Human genes 0.000 claims 1
• 108010031801 Lipopolysaccharide Receptors Proteins 0.000 claims 1
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 1
• 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 1
• 102000004264 Osteopontin Human genes 0.000 claims 1
• 108010081689 Osteopontin Proteins 0.000 claims 1
• 102000013674 S-100 Human genes 0.000 claims 1
• 108700021018 S100 Proteins 0.000 claims 1
• 108700028909 Serum Amyloid A Proteins 0.000 claims 1
• 102000054727 Serum Amyloid A Human genes 0.000 claims 1
• 102100030416 Stromelysin-1 Human genes 0.000 claims 1
• 230000002491 angiogenic effect Effects 0.000 claims 1
• 230000003460 anti-nuclear Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 229940100601 interleukin-6 Drugs 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• -1 rheumatoid factor Proteins 0.000 claims 1