JP2012522018A5 - - Google Patents
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- Publication number
- JP2012522018A5 JP2012522018A5 JP2012502314A JP2012502314A JP2012522018A5 JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5 JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012502314 A JP2012502314 A JP 2012502314A JP 2012522018 A5 JP2012522018 A5 JP 2012522018A5
- Authority
- JP
- Japan
- Prior art keywords
- inhalation
- dry powder
- powder suitable
- salt
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000843 powder Substances 0.000 claims 36
- 235000002639 sodium chloride Nutrition 0.000 claims 18
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 239000002245 particle Substances 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- -1 cation salt Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical group [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 150000001768 cations Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 4
- 159000000000 sodium salts Chemical class 0.000 claims 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 3
- 239000001354 calcium citrate Substances 0.000 claims 3
- 229960004256 calcium citrate Drugs 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 229960002713 calcium chloride Drugs 0.000 claims 2
- 235000011148 calcium chloride Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 2
- 235000011152 sodium sulphate Nutrition 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000003068 static effect Effects 0.000 claims 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 159000000009 barium salts Chemical class 0.000 claims 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 1
- 239000001639 calcium acetate Substances 0.000 claims 1
- 235000011092 calcium acetate Nutrition 0.000 claims 1
- 229960005147 calcium acetate Drugs 0.000 claims 1
- 239000004227 calcium gluconate Substances 0.000 claims 1
- 235000013927 calcium gluconate Nutrition 0.000 claims 1
- 229960004494 calcium gluconate Drugs 0.000 claims 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 claims 1
- 235000011086 calcium lactate Nutrition 0.000 claims 1
- 229960002401 calcium lactate Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 229940095672 calcium sulfate Drugs 0.000 claims 1
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical group 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 229940005581 sodium lactate Drugs 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16377209P | 2009-03-26 | 2009-03-26 | |
| US16376709P | 2009-03-26 | 2009-03-26 | |
| US16376309P | 2009-03-26 | 2009-03-26 | |
| US61/163,763 | 2009-03-26 | ||
| US61/163,767 | 2009-03-26 | ||
| US61/163,772 | 2009-03-26 | ||
| US25576409P | 2009-10-28 | 2009-10-28 | |
| US61/255,764 | 2009-10-28 | ||
| US26774709P | 2009-12-08 | 2009-12-08 | |
| US61/267,747 | 2009-12-08 | ||
| US29809210P | 2010-01-25 | 2010-01-25 | |
| US61/298,092 | 2010-01-25 | ||
| US30581910P | 2010-02-18 | 2010-02-18 | |
| US61/305,819 | 2010-02-18 | ||
| PCT/US2010/028961 WO2010111680A2 (en) | 2009-03-26 | 2010-03-26 | Dry powder formulations and methods for treating pulmonary diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Division JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522018A JP2012522018A (ja) | 2012-09-20 |
| JP2012522018A5 true JP2012522018A5 (cg-RX-API-DMAC10.html) | 2013-05-23 |
| JP5671001B2 JP5671001B2 (ja) | 2015-02-18 |
Family
ID=42635067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502314A Active JP5671001B2 (ja) | 2009-03-26 | 2010-03-26 | 肺疾患を治療するための乾燥粉末製剤および方法 |
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014256325A Active JP5964939B2 (ja) | 2009-03-26 | 2014-12-18 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Country Status (15)
Families Citing this family (32)
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| EP2448571B1 (en) * | 2010-08-30 | 2013-06-12 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| WO2012050945A1 (en) | 2010-09-29 | 2012-04-19 | Pulmatrix, Inc. | Cationic dry powders |
| EP2621484A1 (en) * | 2010-09-29 | 2013-08-07 | Pulmatrix, Inc. | Monovalent metal cation dry powders for inhalation |
| WO2012058719A1 (en) * | 2010-11-02 | 2012-05-10 | The Universtity Of Sydney | Inhalable compositions |
| WO2012159103A1 (en) * | 2011-05-19 | 2012-11-22 | Savara, Inc. | Dry powder vancomycin compositions and associated methods |
| US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
| US20140336159A1 (en) | 2011-10-07 | 2014-11-13 | Pulmatrix, Inc. | Methods for treating and diagnosing respiratory tract infections |
| US10022303B2 (en) * | 2012-02-28 | 2018-07-17 | Iceutica Pty Ltd. | Inhalable pharmaceutical compositions |
| EP2819672A1 (en) * | 2012-02-29 | 2015-01-07 | Pulmatrix, Inc. | Inhalable dry powders |
| ES2604855T3 (es) | 2012-08-01 | 2017-03-09 | Purac Biochem Bv | Polvo de lactato y procedimiento de preparación del mismo |
| WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| US8545878B1 (en) | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2754356A1 (en) | 2013-01-15 | 2014-07-16 | Purac Biochem N.V. | Improved nisin production process |
| EP2769630B1 (en) | 2013-02-26 | 2016-04-27 | Purac Biochem N.V. | Improved nisin production process |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
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| EP3212212B1 (en) | 2014-10-31 | 2020-09-23 | Monash University | Powder formulation |
| US10046007B2 (en) | 2015-06-24 | 2018-08-14 | Prescient Pharma, Llc | Compositions and methods for treatment of short telomere disorders |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| US10568894B2 (en) * | 2016-06-03 | 2020-02-25 | Otitopic Inc. | Dry powder formulations for inhalation |
| JP2019526638A (ja) | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | ビオチン酸マグネシウム組成物および使用方法 |
| WO2020096686A2 (en) | 2018-09-05 | 2020-05-14 | Sensory Cloud, Llc | Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles |
| CN113329680A (zh) | 2018-11-02 | 2021-08-31 | 营养21有限责任公司 | 用于改善视频游戏者认知功能的含有肌醇稳定的精氨酸硅酸盐复合物和肌醇的组合物 |
| GB2613672A (en) * | 2019-12-16 | 2023-06-14 | Nutrition 21 Llc | Methods of production of aginine-silicate complexes |
| JP2025500933A (ja) * | 2021-12-16 | 2025-01-15 | アルヴィアラス バイオ，インコーポレイテッド | 慢性肺疾患の治療のための吸入可能又は摂取可能な乳酸組成物 |
| WO2024046582A1 (en) * | 2022-09-02 | 2024-03-07 | Liita Care Aps | Pharmaceutical dry powder composition and methods for treating respiratory tract infections |
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-
2010
- 2010-03-26 AU AU2010229668A patent/AU2010229668C1/en active Active
- 2010-03-26 PT PT107132839T patent/PT2410981T/pt unknown
- 2010-03-26 JP JP2012502314A patent/JP5671001B2/ja active Active
- 2010-03-26 CA CA2754691A patent/CA2754691C/en active Active
- 2010-03-26 CN CN201810147094.3A patent/CN108434126B/zh active Active
- 2010-03-26 BR BRPI1011721-0A patent/BRPI1011721B1/pt active IP Right Grant
- 2010-03-26 US US13/259,635 patent/US20120064126A1/en not_active Abandoned
- 2010-03-26 KR KR1020117024843A patent/KR101639098B1/ko active Active
- 2010-03-26 CN CN201080023554.3A patent/CN102497853B/zh not_active Expired - Fee Related
- 2010-03-26 DK DK10713283.9T patent/DK2410981T4/da active
- 2010-03-26 EP EP10713283.9A patent/EP2410981B2/en active Active
- 2010-03-26 WO PCT/US2010/028961 patent/WO2010111680A2/en not_active Ceased
- 2010-03-26 RU RU2011137960/15A patent/RU2577698C2/ru active
- 2010-03-26 EP EP17000124.2A patent/EP3184099A1/en active Pending
- 2010-03-26 ES ES10713283T patent/ES2625260T5/es active Active
- 2010-03-26 MX MX2011009957A patent/MX354829B/es active IP Right Grant
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2011
- 2011-09-21 IL IL215276A patent/IL215276A/en active IP Right Grant
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2014
- 2014-12-18 JP JP2014256325A patent/JP5964939B2/ja active Active
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2015
- 2015-03-25 US US14/667,857 patent/US9119778B2/en active Active
- 2015-07-21 US US14/804,940 patent/US9238005B2/en active Active
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