JP2013536845A5 - - Google Patents
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- Publication number
- JP2013536845A5 JP2013536845A5 JP2013527146A JP2013527146A JP2013536845A5 JP 2013536845 A5 JP2013536845 A5 JP 2013536845A5 JP 2013527146 A JP2013527146 A JP 2013527146A JP 2013527146 A JP2013527146 A JP 2013527146A JP 2013536845 A5 JP2013536845 A5 JP 2013536845A5
- Authority
- JP
- Japan
- Prior art keywords
- dry powder
- inhalation
- magnesium
- inhalation according
- dry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 13
- 159000000003 magnesium salts Chemical class 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 239000002245 particle Substances 0.000 claims 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims 7
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- 108010067396 dornase alfa Proteins 0.000 claims 3
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims 3
- 239000000626 magnesium lactate Substances 0.000 claims 3
- 229960004658 magnesium lactate Drugs 0.000 claims 3
- 235000015229 magnesium lactate Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- PZSMUPGANZGPBF-UHFFFAOYSA-N 4-[5-(dithiolan-3-yl)pentanoylamino]butanoic acid Chemical compound OC(=O)CCCNC(=O)CCCCC1CCSS1 PZSMUPGANZGPBF-UHFFFAOYSA-N 0.000 claims 2
- 235000017274 Diospyros sandwicensis Nutrition 0.000 claims 2
- 241000282838 Lama Species 0.000 claims 2
- 229940110339 Long-acting muscarinic antagonist Drugs 0.000 claims 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 229940125389 long-acting beta agonist Drugs 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 229960002337 magnesium chloride Drugs 0.000 claims 2
- 229910001425 magnesium ion Inorganic materials 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 229960003390 magnesium sulfate Drugs 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- 239000003195 sodium channel blocking agent Substances 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 claims 1
- -1 Magnesium cations Chemical class 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims 1
- 229960002576 amiloride Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229960003376 levofloxacin Drugs 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 239000001095 magnesium carbonate Substances 0.000 claims 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 1
- 229960001708 magnesium carbonate Drugs 0.000 claims 1
- 235000014380 magnesium carbonate Nutrition 0.000 claims 1
- 235000011147 magnesium chloride Nutrition 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 1
- 239000004137 magnesium phosphate Substances 0.000 claims 1
- 229960002261 magnesium phosphate Drugs 0.000 claims 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims 1
- 235000010994 magnesium phosphates Nutrition 0.000 claims 1
- 229940091250 magnesium supplement Drugs 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 229940110309 tiotropium Drugs 0.000 claims 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37814610P | 2010-08-30 | 2010-08-30 | |
| US61/378,146 | 2010-08-30 | ||
| US38792510P | 2010-09-29 | 2010-09-29 | |
| US61/387,925 | 2010-09-29 | ||
| US201161431242P | 2011-01-10 | 2011-01-10 | |
| US61/431,242 | 2011-01-10 | ||
| PCT/US2011/049435 WO2012030664A1 (en) | 2010-08-30 | 2011-08-26 | Dry powder formulations and methods for treating pulmonary diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536845A JP2013536845A (ja) | 2013-09-26 |
| JP2013536845A5 true JP2013536845A5 (cg-RX-API-DMAC10.html) | 2014-10-09 |
| JP5877201B2 JP5877201B2 (ja) | 2016-03-02 |
Family
ID=45773220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527146A Active JP5877201B2 (ja) | 2010-08-30 | 2011-08-26 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9061352B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2611438B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5877201B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN105640925B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2011296343B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2809666C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012030664A1 (cg-RX-API-DMAC10.html) |
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-
2011
- 2011-08-26 AU AU2011296343A patent/AU2011296343B2/en active Active
- 2011-08-26 WO PCT/US2011/049435 patent/WO2012030664A1/en not_active Ceased
- 2011-08-26 EP EP11751775.5A patent/EP2611438B1/en active Active
- 2011-08-26 JP JP2013527146A patent/JP5877201B2/ja active Active
- 2011-08-26 CA CA2809666A patent/CA2809666C/en active Active
- 2011-08-26 CN CN201610054941.2A patent/CN105640925B/zh active Active
- 2011-08-26 US US13/817,963 patent/US9061352B2/en active Active
- 2011-08-26 CN CN201180052479.8A patent/CN103200938B/zh not_active Expired - Fee Related
-
2015
- 2015-05-20 US US14/717,243 patent/US9233158B2/en active Active
-
2017
- 2017-09-29 US US15/720,445 patent/US20180153996A1/en not_active Abandoned
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