JP2012520313A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012520313A5 JP2012520313A5 JP2011554176A JP2011554176A JP2012520313A5 JP 2012520313 A5 JP2012520313 A5 JP 2012520313A5 JP 2011554176 A JP2011554176 A JP 2011554176A JP 2011554176 A JP2011554176 A JP 2011554176A JP 2012520313 A5 JP2012520313 A5 JP 2012520313A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- formula
- chemotherapeutic agent
- lymphoma
- medicament according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15962209P | 2009-03-12 | 2009-03-12 | |
| US61/159,622 | 2009-03-12 | ||
| PCT/US2010/026903 WO2010105008A2 (en) | 2009-03-12 | 2010-03-11 | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520313A JP2012520313A (ja) | 2012-09-06 |
| JP2012520313A5 true JP2012520313A5 (https=) | 2014-08-21 |
| JP5709766B2 JP5709766B2 (ja) | 2015-04-30 |
Family
ID=42236787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554176A Expired - Fee Related JP5709766B2 (ja) | 2009-03-12 | 2010-03-11 | 造血器腫瘍の治療のためのホスホイノシチド３キナーゼ阻害剤化合物と化学療法剤の併用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8536161B2 (https=) |
| EP (1) | EP2405916B1 (https=) |
| JP (1) | JP5709766B2 (https=) |
| KR (1) | KR101781654B1 (https=) |
| CN (1) | CN102369011A (https=) |
| AU (1) | AU2010224125B2 (https=) |
| BR (1) | BRPI1006189A2 (https=) |
| CA (1) | CA2753285A1 (https=) |
| IL (1) | IL214132A (https=) |
| MX (1) | MX2011009167A (https=) |
| WO (1) | WO2010105008A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| AU2010203512C1 (en) | 2009-01-08 | 2013-10-17 | Curis, Inc. | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
| WO2011121317A1 (en) | 2010-04-01 | 2011-10-06 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Imidazo [2,1-b] [1,3,4] thiadiazoles as protein or lipid kinase inhibitors |
| WO2012052745A1 (en) | 2010-10-21 | 2012-04-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Combinations of pi3k inhibitors with a second anti -tumor agent |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| US20140213630A1 (en) * | 2011-03-08 | 2014-07-31 | Thomas Diacovo | Methods and pharmaceutical compositions for treating lymphoid malignancy |
| DK3111938T3 (da) | 2011-04-01 | 2019-07-01 | Curis Inc | Phosphoinositid 3-kinase-hæmmer med en zink-bindende gruppe |
| TW201311683A (zh) * | 2011-04-29 | 2013-03-16 | Exelixis Inc | 使用吡啶并嘧啶酮ｐｉ３ｋ／ｍｔｏｒ抑制劑治療淋巴瘤之方法 |
| AU2012257513B2 (en) | 2011-05-19 | 2017-05-11 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Macrocyclic compounds as protein kinase inhibitors |
| EP2524918A1 (en) | 2011-05-19 | 2012-11-21 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyrazines derivates as kinase inhibitors |
| KR20140040728A (ko) | 2011-06-03 | 2014-04-03 | 에프. 호프만-라 로슈 아게 | Pi3k 억제제 화합물을 사용한 중피종 치료 방법 |
| CA2849331A1 (en) | 2011-10-13 | 2013-04-18 | Genentech, Inc. | Treatment of pharmacological-induced hypochlorhydria |
| SG11201401386XA (en) | 2011-11-09 | 2014-10-30 | Bristol Myers Squibb Co | Treatment of hematologic malignancies with an anti-cxcr4 antibody |
| AU2013235479A1 (en) * | 2012-03-23 | 2014-10-02 | Memorial Sloan-Kettering Cancer Center | Potentiating antibody-induced complement-mediated cytotoxicity via PI3K inhibition |
| CN103467482B (zh) | 2012-04-10 | 2017-05-10 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用 |
| JP6301316B2 (ja) | 2012-05-23 | 2018-03-28 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 内胚葉細胞および肝実質細胞の組成物ならびにそれらの細胞を入手および使用する方法 |
| WO2013182668A1 (en) | 2012-06-08 | 2013-12-12 | F. Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| EP2906566B1 (en) * | 2012-10-10 | 2016-08-24 | F. Hoffmann-La Roche AG | Process for making thienopyrimidine compounds |
| SG11201503393SA (en) * | 2012-11-02 | 2015-06-29 | Tg Therapeutics Inc | Combination of anti-cd20 antibody and pi3 kinase selective inhibitor |
| US20160022757A1 (en) * | 2013-03-15 | 2016-01-28 | Icahn School Of Medicine At Mount Sinai | Therapeutic methods for treating solid tumors and related diagnostic methods |
| MA40271A (fr) | 2014-05-21 | 2017-03-29 | Hoffmann La Roche | Procédés pour traiter le cancer du sein luminal a pr-positif, avec un inhibiteur de pi3k, pictilisib |
| AU2016278040B2 (en) | 2015-06-16 | 2019-07-04 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| HK1249866A1 (zh) | 2015-06-29 | 2018-11-16 | 豪夫迈‧罗氏有限公司 | 用他塞利昔布进行治疗的方法 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| EP3476949A1 (en) * | 2017-10-31 | 2019-05-01 | Centre National De La Recherche Scientifique | Prognosis method of multiple myeloma |
| SG11202102343QA (en) | 2018-09-11 | 2021-04-29 | Curis Inc | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| CN113453721B (zh) * | 2018-10-26 | 2025-09-16 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
| WO2020146613A1 (en) * | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US12448375B2 (en) | 2019-09-11 | 2025-10-21 | Ohio State Innovation Foundation | Kinase inhibitors for the treatment of neurodegenerative diseases |
| JP2025540246A (ja) * | 2022-12-07 | 2025-12-11 | エスケー バイオファーマシューティカルズ カンパニー リミテッド | Ｋｒａｓ ｇ１２ｄ阻害剤として新規な３環化合物およびその用途 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2579479A (en) | 1950-01-23 | 1951-12-25 | Syntex Sa | delta 1, 4-pregnadiene-17alpha-ol-3-ones |
| US2670347A (en) | 1952-01-08 | 1954-02-23 | American Cyanamid Co | Thiophosphoric acid derivatives and method of preparing the same |
| GB750155A (en) | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US2837464A (en) | 1955-01-11 | 1958-06-03 | Schering Corp | Process for production of dienes by corynebacteria |
| US2897216A (en) | 1954-11-01 | 1959-07-28 | Schering Corp | Process for the preparation of steroidal dienes and intermediates obtained thereby |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| US3116282A (en) | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
| US3134718A (en) | 1963-12-12 | 1964-05-26 | Schering Corp | Pregna-1,4-dienes and compositions containing same |
| DE1470356A1 (de) | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| BE759493A (fr) | 1969-11-26 | 1971-05-25 | Thomae Gmbh Dr K | Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer |
| US3763156A (en) | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| RO62428A (fr) | 1971-05-04 | 1978-01-15 | Thomae Gmbh Dr K | Procede pour la preparation des thyeno-(3,2-d)-pyrimidines |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5075305A (en) | 1991-03-18 | 1991-12-24 | Warner-Lambert Company | Compound, composition and use |
| WO1993013664A2 (en) | 1992-01-11 | 1993-07-22 | Schering Agrochemicals Limited | Biheterocyclic fungicidal compounds |
| GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US5846824A (en) | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| JPH08176070A (ja) | 1994-12-19 | 1996-07-09 | Mitsubishi Chem Corp | ジデプシド誘導体及びｐｉ３キナーゼ阻害剤 |
| JPH08175990A (ja) | 1994-12-19 | 1996-07-09 | Mitsubishi Chem Corp | Ｐｉ３キナーゼ阻害剤とその製造法 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| GB9521987D0 (en) | 1995-10-26 | 1996-01-03 | Ludwig Inst Cancer Res | Phosphoinositide 3-kinase modulators |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| AUPO903897A0 (en) | 1997-09-08 | 1997-10-02 | Commonwealth Scientific And Industrial Research Organisation | Organic boronic acid derivatives |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| CA2309690A1 (en) | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| JP2001247477A (ja) | 2000-03-03 | 2001-09-11 | Teikoku Hormone Mfg Co Ltd | 抗腫瘍剤 |
| AU5914201A (en) * | 2000-04-25 | 2001-11-07 | Idec Pharma Corp | Intrathecal administration of rituximab for treatment of central nervous system lymphomas |
| US6403588B1 (en) | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| US6608053B2 (en) | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| DE60203260T2 (de) | 2001-01-16 | 2006-02-02 | Glaxo Group Ltd., Greenford | Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs |
| JP4162491B2 (ja) | 2001-01-25 | 2008-10-08 | アメリカ合衆国 | ボロン酸化合物製剤 |
| US20040242545A1 (en) | 2001-07-26 | 2004-12-02 | Santen Phamaceutical Co., Ltd. | Remedy for glaucoma comprising as the active ingredient compound having p13 kinase inhibitory effect |
| US6703414B2 (en) | 2001-09-14 | 2004-03-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Device and method for treating restenosis |
| WO2003035099A1 (en) | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Biphasic mixtures of glp-1 and insulin |
| AU2002349912A1 (en) | 2001-10-24 | 2003-05-06 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| US6894055B2 (en) | 2001-10-24 | 2005-05-17 | Iconix Pharmaceuticals Inc. | Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase |
| AU2002356871A1 (en) | 2001-10-30 | 2003-05-12 | Pharmacia Corporation | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
| US20040092561A1 (en) | 2002-11-07 | 2004-05-13 | Thomas Ruckle | Azolidinone-vinyl fused -benzene derivatives |
| JP2006500327A (ja) | 2002-07-10 | 2006-01-05 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 精子の運動性を増大させるための化合物の使用 |
| CN1681811B (zh) | 2002-07-10 | 2010-05-26 | 默克雪兰诺有限公司 | 唑烷酮-乙烯基稠合的-苯衍生物 |
| WO2004017950A2 (en) | 2002-08-22 | 2004-03-04 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| HRP20110498T1 (hr) | 2005-10-07 | 2011-08-31 | Exelixis | Azetidini kao inhibitori mek za liječenje proliferativnih bolesti |
| GB0520657D0 (en) | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
| CN101511840A (zh) | 2006-04-26 | 2009-08-19 | 吉宁特有限公司 | 磷酸肌醇3-激酶抑制剂化合物及其使用方法 |
| MX2008013578A (es) | 2006-04-26 | 2009-03-23 | Hoffmann La Roche | Derivados de tieno [3,2-d]pirimidina utiles como inhibidores de fosfatidilinositol 3-cinasa(p13k). |
| TWI498332B (zh) * | 2006-04-26 | 2015-09-01 | Hoffmann La Roche | 作為pi3k抑制劑之嘧啶衍生物及相關製備方法、醫藥組合物、用途、套組及產物 |
| WO2008070740A1 (en) * | 2006-12-07 | 2008-06-12 | F.Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| ES2571028T3 (es) | 2006-12-07 | 2016-05-23 | Genentech Inc | Compuestos inhibidores de fosfoinositida 3-cinasa y métodos de uso |
| FR2920336B1 (fr) * | 2007-09-05 | 2012-09-28 | Eads Europ Aeronautic Defence | Methode et dispositif d'analyse des procedes de fabrication de pieces en materiaux composites, par infusion ou injection, et de caracterisation de ces materiaux composites. |
| AU2008298948B2 (en) | 2007-09-12 | 2014-09-04 | F. Hoffmann-La Roche Ag | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| NZ602675A (en) * | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| FR2934492B1 (fr) | 2008-07-31 | 2012-08-17 | Hospices Civils Lyon | Association d'un ligand de tlr3 et d'un agent agissant sur la voie intrinseque de "l'apoptose" dans le traitement d'un cancer. |
-
2010
- 2010-03-11 CN CN2010800116648A patent/CN102369011A/zh active Pending
- 2010-03-11 WO PCT/US2010/026903 patent/WO2010105008A2/en not_active Ceased
- 2010-03-11 US US12/721,645 patent/US8536161B2/en not_active Expired - Fee Related
- 2010-03-11 KR KR1020117023849A patent/KR101781654B1/ko not_active Expired - Fee Related
- 2010-03-11 BR BRPI1006189-4A patent/BRPI1006189A2/pt not_active IP Right Cessation
- 2010-03-11 CA CA2753285A patent/CA2753285A1/en not_active Abandoned
- 2010-03-11 MX MX2011009167A patent/MX2011009167A/es active IP Right Grant
- 2010-03-11 JP JP2011554176A patent/JP5709766B2/ja not_active Expired - Fee Related
- 2010-03-11 AU AU2010224125A patent/AU2010224125B2/en not_active Ceased
- 2010-03-11 EP EP10708866.8A patent/EP2405916B1/en active Active
-
2011
- 2011-07-18 IL IL214132A patent/IL214132A/en not_active IP Right Cessation
-
2013
- 2013-08-15 US US13/968,202 patent/US9335320B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012520313A5 (https=) | ||
| TWI854573B (zh) | 藥物組合物、其用途及癌症的治療方法 | |
| JP7288482B2 (ja) | がんの処置のための、Ｎｏｔｃｈ阻害剤およびＣＤＫ４／６阻害剤の併用療法 | |
| US10251876B2 (en) | Method for treating tumour, pharmaceutical composition and medicinal kit | |
| TWI724990B (zh) | 醫藥組合 | |
| CN103764144B (zh) | Pi3k抑制剂与mek抑制剂的协同组合 | |
| US20160287605A1 (en) | Combination therapy | |
| EP2501385B1 (en) | Therapeutic combination comprising a cdc7 inhibitor and an antineoplastic agent | |
| CN106488776B (zh) | 包含糖皮质激素和edo-s101的组合 | |
| EP3153170A1 (en) | Methods and uses of quinoline derivatives in the treatment of soft tissue sarcomas and pharmaceutical compositions for treatment of same | |
| CN102065865B (zh) | 多发性骨髓瘤治疗 | |
| JP2018525358A (ja) | アピリモドを用いる癌の処置方法 | |
| US20190290627A1 (en) | Pim kinase inhibitor combinations | |
| CN105338980A (zh) | 药物组合 | |
| AU2015342876A1 (en) | Apilimod for use in the treatment of colorectal cancer | |
| AU2017205749A1 (en) | Use of quinoline derivatives for treating oesophageal cancer and treatment method, pharmaceutical composition and kit thereof | |
| CN112294965A (zh) | Mdm2抑制剂的药物组合物及其在预防和/或治疗疾病中的用途 | |
| JP2019514864A (ja) | 肝癌の治療方法 | |
| AU2007347370B2 (en) | Novel therapeutic use for treating leukaemia | |
| KR20240144146A (ko) | Malt1 저해약을 유효 성분으로서 포함하는 암 치료제 | |
| ES2415907T3 (es) | Combinación terapéutica que comprende un inhibidor de cinasas aurora y agentes antiproliferativos | |
| JP2024506314A (ja) | がん治療のための併用療法 | |
| CN103933539B (zh) | 一种含有四环素的药物组合物及其应用 | |
| WO2025070603A1 (ja) | 血液がんの新規併用療法 | |
| JP2024516848A (ja) | 血液がんを処置する方法 |