JP2012517799A5 - - Google Patents
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- JP2012517799A5 JP2012517799A5 JP2011535341A JP2011535341A JP2012517799A5 JP 2012517799 A5 JP2012517799 A5 JP 2012517799A5 JP 2011535341 A JP2011535341 A JP 2011535341A JP 2011535341 A JP2011535341 A JP 2011535341A JP 2012517799 A5 JP2012517799 A5 JP 2012517799A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- ctl
- apc
- isolated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 13
- 239000002157 polynucleotide Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 9
- 230000001939 inductive effect Effects 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 229940024606 amino acid Drugs 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 229930182817 methionine Natural products 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 3
- 108091008874 T cell receptors Proteins 0.000 claims description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 210000001808 exosome Anatomy 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15340809P | 2009-02-18 | 2009-02-18 | |
| US61/153,408 | 2009-02-18 | ||
| PCT/JP2010/001005 WO2010095428A1 (en) | 2009-02-18 | 2010-02-17 | Foxm1 peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012517799A JP2012517799A (ja) | 2012-08-09 |
| JP2012517799A5 true JP2012517799A5 (https=) | 2013-03-28 |
| JP5728717B2 JP5728717B2 (ja) | 2015-06-03 |
Family
ID=42633716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535341A Active JP5728717B2 (ja) | 2009-02-18 | 2010-02-17 | Ｆｏｘｍ１ペプチドおよびそれを含むワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8617562B2 (https=) |
| EP (1) | EP2408912B1 (https=) |
| JP (1) | JP5728717B2 (https=) |
| KR (1) | KR101713586B1 (https=) |
| CN (1) | CN102405285B (https=) |
| BR (1) | BRPI1008887A2 (https=) |
| CA (1) | CA2752560C (https=) |
| DK (1) | DK2408912T3 (https=) |
| ES (1) | ES2618896T3 (https=) |
| IL (1) | IL214435A0 (https=) |
| MX (1) | MX2011008763A (https=) |
| RU (1) | RU2560431C2 (https=) |
| SG (1) | SG173751A1 (https=) |
| TW (1) | TWI469791B (https=) |
| WO (1) | WO2010095428A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2189471B1 (en) | 2007-08-20 | 2017-10-04 | Oncotherapy Science, Inc. | Foxm1 peptide and medicinal agent comprising the same |
| SG11201405578TA (en) * | 2012-03-09 | 2014-11-27 | Oncotherapy Science Inc | Pharmaceutical composition containing peptide |
| GB201410686D0 (en) * | 2014-06-16 | 2014-07-30 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| SG11201802881YA (en) * | 2015-10-08 | 2018-05-30 | Oncotherapy Science Inc | Foxm1-derived peptide, and vaccine including same |
| CN105524159B (zh) * | 2015-11-16 | 2021-04-09 | 西南交通大学 | 具有癌细胞选择性杀伤和迁移抑制作用的多肽分子与用途 |
| CN105999227B (zh) * | 2016-08-12 | 2019-08-06 | 湖南大学 | FOXM1蛋白氮端（1-234 aa）的表达及其用途 |
| WO2018067869A1 (en) | 2016-10-07 | 2018-04-12 | Board Of Regents, The University Of Texas System | Hla-restricted vgll1 peptides and use thereof |
| EP3691662A4 (en) * | 2017-10-06 | 2021-05-12 | The University of Chicago | SCREENING OF T LYMPHOCYTE FOR CANCER SPECIFIC ANTIGENS |
| CN112118863B (zh) * | 2018-04-11 | 2025-05-30 | 恩特罗姆公司 | 用于预防和治疗癌症的抗原肽 |
| CN109055327B (zh) * | 2018-07-23 | 2021-04-06 | 浙江工业大学 | 醛酮还原酶突变体及其应用 |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| AU2021275239A1 (en) | 2020-05-21 | 2022-12-15 | Board Of Regents, The University Of Texas System | T cell receptors with VGLL1 specificity and uses thereof |
| CN114591400B (zh) * | 2022-03-29 | 2022-10-21 | 西南交通大学 | 一组靶向FoxM1-DBD多肽及其应用 |
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| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| US20030198642A1 (en) | 1995-08-03 | 2003-10-23 | Johannes J. Geuze | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| EP0960204A4 (en) | 1996-07-26 | 2002-01-23 | Sloan Kettering Inst Cancer | METHODS AND REAGENTS FOR GENETIC IMMUNIZATION |
| US5861278A (en) | 1996-11-01 | 1999-01-19 | Genetics Institute, Inc. | HNF3δ compositions |
| EP0846761A1 (en) | 1996-12-09 | 1998-06-10 | Introgene B.V. | A novel transcription factor expressed in cycling cells, nucleic acid molecules encoding said transcription factor and its promoter region and uses thereof |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| JP4413429B2 (ja) | 1998-06-25 | 2010-02-10 | 株式会社グリーンペプタイド | サイクロフィリンｂ由来の腫瘍抗原ペプチド |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| CA2448881A1 (en) | 2001-06-04 | 2002-12-12 | Basf Plant Science Gmbh | Sugar and lipid metabolism regulators in plants ii |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| WO2003050140A1 (fr) | 2001-12-10 | 2003-06-19 | Kyogo Itoh | Antigenes tumoraux |
| US20040109844A1 (en) * | 2002-08-28 | 2004-06-10 | The Board Of Trustees Of The University Of Illinois | Methods of treating age-related defects and diseases |
| ES2320443T3 (es) * | 2002-09-30 | 2009-05-22 | Oncotherapy Science, Inc. | Genes y polipeptidos relacionados con canceres pancreaticos humanos. |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| US20050260639A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| EP1615658A1 (en) | 2003-03-25 | 2006-01-18 | The Board Of Trustees Of The University Of Illinois | Inhibition of tumor cell proliferation by foxm1b inhibitors |
| CN1898563B (zh) | 2003-09-24 | 2011-11-23 | 肿瘤疗法科学股份有限公司 | 诊断乳腺癌的方法 |
| JP5060134B2 (ja) | 2003-12-12 | 2012-10-31 | ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ・アズ リプレゼンテッド バイ ザ セクレタリー・デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ヒト細胞傷害性Ｔリンパ球のエピトープ及びそのＭＵＣ−１の非ＶＮＴＲ（ｎｏｎ−ｖａｒｉａｂｌｅｎｕｍｂｅｒｏｆｔａｎｄｅｍｒｅｐｅａｔｓｅｑｕｅｎｃｅ）由来のアゴニストエピトープ |
| AU2005213464A1 (en) | 2004-02-06 | 2005-08-25 | Wyeth | Diagnosis and therapeutics for cancer |
| ATE496142T1 (de) * | 2004-03-23 | 2011-02-15 | Oncotherapy Science Inc | Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs |
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| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| EP1806413A1 (en) * | 2006-01-06 | 2007-07-11 | Oligene GmbH | An in-vitro-method and means for determination of different tumor types and predicting success of surgical procedures in ovarian cancer |
| JP2009536516A (ja) | 2006-04-20 | 2009-10-15 | オンコセラピー・サイエンス株式会社 | 肺癌の治療標的としてのＮＭＵ−ＧＨＳＲ１ｂ／ＮＴＳＲ１発癌シグナル伝達経路 |
| CN101835892B (zh) | 2007-08-20 | 2013-11-06 | 肿瘤疗法科学股份有限公司 | Cdca1肽和包含cdca1肽的药剂 |
| EP2189471B1 (en) | 2007-08-20 | 2017-10-04 | Oncotherapy Science, Inc. | Foxm1 peptide and medicinal agent comprising the same |
| RU2733985C2 (ru) | 2009-03-18 | 2020-10-09 | Онкотерапи Сайенс, Инк. | Пептиды neil3 и включающие их вакцины |
-
2010
- 2010-02-11 TW TW99104319A patent/TWI469791B/zh not_active IP Right Cessation
- 2010-02-17 KR KR1020117021513A patent/KR101713586B1/ko not_active Expired - Fee Related
- 2010-02-17 ES ES10743558.8T patent/ES2618896T3/es active Active
- 2010-02-17 MX MX2011008763A patent/MX2011008763A/es active IP Right Grant
- 2010-02-17 WO PCT/JP2010/001005 patent/WO2010095428A1/en not_active Ceased
- 2010-02-17 CA CA2752560A patent/CA2752560C/en not_active Expired - Fee Related
- 2010-02-17 BR BRPI1008887A patent/BRPI1008887A2/pt not_active IP Right Cessation
- 2010-02-17 JP JP2011535341A patent/JP5728717B2/ja active Active
- 2010-02-17 RU RU2011138160/10A patent/RU2560431C2/ru not_active IP Right Cessation
- 2010-02-17 DK DK10743558.8T patent/DK2408912T3/en active
- 2010-02-17 CN CN201080017145.2A patent/CN102405285B/zh active Active
- 2010-02-17 SG SG2011059441A patent/SG173751A1/en unknown
- 2010-02-17 EP EP10743558.8A patent/EP2408912B1/en active Active
- 2010-02-17 US US13/202,078 patent/US8617562B2/en active Active
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2011
- 2011-08-03 IL IL214435A patent/IL214435A0/en unknown