JP2012514473A5 - - Google Patents

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JP2012514473A5
JP2012514473A5 JP2011545427A JP2011545427A JP2012514473A5 JP 2012514473 A5 JP2012514473 A5 JP 2012514473A5 JP 2011545427 A JP2011545427 A JP 2011545427A JP 2011545427 A JP2011545427 A JP 2011545427A JP 2012514473 A5 JP2012514473 A5 JP 2012514473A5
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JP
Japan
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seq
variable region
chain variable
light chain
cdr
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JP2011545427A
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Japanese (ja)
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JP5818688B2 (ja
JP2012514473A (ja
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Priority claimed from PCT/US2010/020371 external-priority patent/WO2010080910A1/en
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Publication of JP2012514473A5 publication Critical patent/JP2012514473A5/ja
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JP2011545427A 2009-01-08 2010-01-07 核酸増幅反応の効率を改善するための方法および組成物 Active JP5818688B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14335009P 2009-01-08 2009-01-08
US61/143,350 2009-01-08
PCT/US2010/020371 WO2010080910A1 (en) 2009-01-08 2010-01-07 Methods and compositions for improving efficiency of nucleic acids amplification reactions

Publications (3)

Publication Number Publication Date
JP2012514473A JP2012514473A (ja) 2012-06-28
JP2012514473A5 true JP2012514473A5 (https=) 2013-02-14
JP5818688B2 JP5818688B2 (ja) 2015-11-18

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JP2011545427A Active JP5818688B2 (ja) 2009-01-08 2010-01-07 核酸増幅反応の効率を改善するための方法および組成物

Country Status (7)

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US (3) US8859205B2 (https=)
EP (2) EP2382321A4 (https=)
JP (1) JP5818688B2 (https=)
CN (1) CN102272319B (https=)
CA (1) CA2749093C (https=)
SG (2) SG172925A1 (https=)
WO (1) WO2010080910A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
JP5818688B2 (ja) * 2009-01-08 2015-11-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 核酸増幅反応の効率を改善するための方法および組成物
CN103703141B (zh) * 2011-04-08 2016-08-17 伯乐实验室公司 具有降低的非特异性活性的pcr反应混合物
JP6060447B2 (ja) * 2011-04-08 2017-01-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 非特異的活性が低下したＳｓｏ７ポリメラーゼコンジュゲート
US8470573B2 (en) 2011-06-21 2013-06-25 Bio-Rad Laboratories, Inc. Hybrid polymerases having the ability to produce long amplicons
CN103045554B (zh) * 2012-11-29 2014-10-29 成都福际生物技术有限公司 一种制备热启动Taq酶的方法
JP2016512696A (ja) * 2013-03-15 2016-05-09 アーノルド, ライル, ジェイ.ARNOLD, Lyle, J. アセンブラ配列を利用する断片化された標的核酸の増幅方法
CN105452451B (zh) 2013-12-06 2020-06-05 生物辐射实验室股份有限公司 融合聚合酶
US9963687B2 (en) 2014-08-27 2018-05-08 New England Biolabs, Inc. Fusion polymerase and method for using the same
EP3778891A1 (en) * 2014-08-27 2021-02-17 New England Biolabs, Inc. Synthon formation
WO2017121836A1 (en) 2016-01-15 2017-07-20 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
WO2017121843A1 (en) * 2016-01-15 2017-07-20 Thermo Fisher Scientific Baltics Uab Antibodies that bind thermophilic dna polymerases
EP3645710A1 (en) 2017-06-26 2020-05-06 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
WO2019045532A2 (en) 2017-08-31 2019-03-07 Seegene, Inc. EVALUATION OF COMPONENT PERFORMANCE USING A PAIR OF DIMER FORMER PRIMERS
CN109988817B (zh) * 2017-12-30 2020-12-04 安诺优达基因科技(北京)有限公司 一种随机打断dna的方法
WO2020264067A1 (en) 2019-06-25 2020-12-30 Bio-Rad Laboratories, Inc Compositions and methods for enhancing reverse transcriptase activity and/or reducing the inhibition of reverse transcriptase
US12173335B2 (en) 2020-01-06 2024-12-24 Pairwise Plants Services, Inc. Recruitment of DNA polymerase for templated editing
JP2021153393A (ja) * 2020-03-25 2021-10-07 東洋紡株式会社 核酸増幅反応用組成物
US20250145989A1 (en) * 2022-01-26 2025-05-08 Seegene, Inc. Method for detecting target nucleic acids in sample
WO2025116499A1 (en) * 2023-11-27 2025-06-05 Seegene, Inc. Method for analyzing activity of nucleic acid polymerase using self-dimer primer

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4545985A (en) 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5679543A (en) 1985-08-29 1997-10-21 Genencor International, Inc. DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US6025545A (en) * 1990-01-22 2000-02-15 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5489523A (en) 1990-12-03 1996-02-06 Stratagene Exonuclease-deficient thermostable Pyrococcus furiosus DNA polymerase I
DK0528767T3 (da) * 1991-08-21 2000-04-17 Novartis Ag antistofderivater
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
DE69531487T2 (de) * 1994-01-31 2004-06-17 The Regents Of The University Of California, Oakland Methode zur eliminierung von sequenzierartefakten
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US6015668A (en) 1994-09-30 2000-01-18 Life Technologies, Inc. Cloned DNA polymerases from thermotoga and mutants thereof
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
WO1997009451A1 (en) 1995-09-08 1997-03-13 Life Technologies, Inc. Cloned dna polymerases from thermotoga and mutants thereof
JP4540754B2 (ja) * 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｐｃｒ中のハイブリダイゼーションのモニタリング
US6458556B1 (en) * 1996-07-25 2002-10-01 The Institute Of Physical & Chemical Research Method for enhancing enzyme activity at elevated temperature
JP3206894B2 (ja) * 1996-07-25 2001-09-10 理化学研究所 酵素を熱活性化する方法
US6972323B1 (en) * 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
US5882904A (en) 1997-08-04 1999-03-16 Amersham Pharmacia Biotech Inc. Thermococcus barossii DNA polymerase mutants
AU3534199A (en) * 1998-04-23 1999-11-08 Takara Shuzo Co., Ltd. Method For Synthesizing DNA
EP1111044A4 (en) * 1998-09-08 2003-06-04 Takara Shuzo Co METHOD OF DNA SYNTHESIS
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
JP3589912B2 (ja) * 1999-09-03 2004-11-17 泰久 福井 ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体
IT1307309B1 (it) * 1999-12-30 2001-10-30 Enea Ente Nuove Tec Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
US20040038339A1 (en) * 2000-03-24 2004-02-26 Peter Kufer Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
US6627424B1 (en) 2000-05-26 2003-09-30 Mj Bioworks, Inc. Nucleic acid modifying enzymes
US7408041B2 (en) * 2000-12-08 2008-08-05 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US20040131607A1 (en) * 2001-06-08 2004-07-08 Carroll Michael C. Methods and compositions for inhibiting immunoglobulin-mediated reperfusion injury
EP1275735A1 (en) 2001-07-11 2003-01-15 Roche Diagnostics GmbH Composition and method for hot start nucleic acid amplification
US7365167B2 (en) * 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
EP1456394B2 (en) 2001-11-28 2011-04-27 Bio-Rad Laboratories, Inc. Methods of using improved polymerases
DE60235491D1 (de) 2001-11-28 2010-04-08 Bio Rad Laboratories Paralleles scoring von polymorphismen mittels amplifikation und fehlerkorrektur
ATE486931T1 (de) 2002-07-25 2010-11-15 Bio Rad Laboratories Hybridpolymerase-verfahren und -zusammensetzungen
US7560260B2 (en) * 2002-07-25 2009-07-14 Bio-Rad Laboratories, Inc. Compositions with polymerase activity
US7666645B2 (en) 2002-10-23 2010-02-23 Bio-Rad Laboratories, Inc. Sso7-polymerase conjugate proteins
WO2004038007A2 (en) * 2002-10-25 2004-05-06 Stratagene Dna polymerases with reduced base analog detection activity
US8283148B2 (en) * 2002-10-25 2012-10-09 Agilent Technologies, Inc. DNA polymerase compositions for quantitative PCR and methods thereof
AU2004225520A1 (en) 2003-03-25 2004-10-14 Stratagene DNA polymerase fusions and uses thereof
US20040214194A1 (en) 2003-04-17 2004-10-28 Mj Bioworks, Inc. Methods of making hybrid proteins
US20050025763A1 (en) * 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7445898B2 (en) 2004-04-01 2008-11-04 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3′ to 5′ exonuclease activity
US20060005174A1 (en) 2004-07-01 2006-01-05 International Business Machines Corporation Defining hierarchical structures with markup languages and reflection
US20060172324A1 (en) * 2005-01-28 2006-08-03 Roche Molecular Systems, Inc. Methods of genotyping using differences in melting temperature
CA2615151A1 (en) * 2005-07-15 2007-01-25 Stratagene California Dna binding protein-polymerase chimeras
ES2543341T3 (es) * 2005-09-13 2015-08-18 National Research Council Of Canada Métodos y composiciones para modular la actividad de células tumorales
EP1966243B1 (en) * 2005-12-23 2012-02-15 Eli Lilly And Company Tgf-beta binding antibodies
US9085762B2 (en) * 2006-12-29 2015-07-21 Agilent Technologies, Inc. Compositions and methods using split polymerases
MX2009008430A (es) * 2007-02-09 2009-10-28 Genentech Inc Anticuerpos anti-robo4 y sus usos.
WO2009140497A1 (en) 2008-05-16 2009-11-19 New England Biolabs, Inc. Enzyme reagents for amplification of polynucleotides in the presence of inhibitors
JP5818688B2 (ja) * 2009-01-08 2015-11-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 核酸増幅反応の効率を改善するための方法および組成物

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