JP2012514473A5 - - Google Patents

Download PDF

Info

Publication number
JP2012514473A5
JP2012514473A5 JP2011545427A JP2011545427A JP2012514473A5 JP 2012514473 A5 JP2012514473 A5 JP 2012514473A5 JP 2011545427 A JP2011545427 A JP 2011545427A JP 2011545427 A JP2011545427 A JP 2011545427A JP 2012514473 A5 JP2012514473 A5 JP 2012514473A5
Authority
JP
Japan
Prior art keywords
seq
variable region
chain variable
light chain
cdr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011545427A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012514473A (ja
JP5818688B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/020371 external-priority patent/WO2010080910A1/en
Publication of JP2012514473A publication Critical patent/JP2012514473A/ja
Publication of JP2012514473A5 publication Critical patent/JP2012514473A5/ja
Application granted granted Critical
Publication of JP5818688B2 publication Critical patent/JP5818688B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011545427A 2009-01-08 2010-01-07 核酸増幅反応の効率を改善するための方法および組成物 Active JP5818688B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14335009P 2009-01-08 2009-01-08
US61/143,350 2009-01-08
PCT/US2010/020371 WO2010080910A1 (en) 2009-01-08 2010-01-07 Methods and compositions for improving efficiency of nucleic acids amplification reactions

Publications (3)

Publication Number Publication Date
JP2012514473A JP2012514473A (ja) 2012-06-28
JP2012514473A5 true JP2012514473A5 (https=) 2013-02-14
JP5818688B2 JP5818688B2 (ja) 2015-11-18

Family

ID=42316809

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011545427A Active JP5818688B2 (ja) 2009-01-08 2010-01-07 核酸増幅反応の効率を改善するための方法および組成物

Country Status (7)

Country Link
US (3) US8859205B2 (https=)
EP (2) EP2382321A4 (https=)
JP (1) JP5818688B2 (https=)
CN (1) CN102272319B (https=)
CA (1) CA2749093C (https=)
SG (2) SG10201500705YA (https=)
WO (1) WO2010080910A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP2382321A4 (en) * 2009-01-08 2012-12-19 Bio Rad Laboratories METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF NUCLEIC ACID AMPLIFICATION REACTIONS
SG193990A1 (en) * 2011-04-08 2013-11-29 Bio Rad Laboratories Pcr reaction mixtures with decreased non-specific activity
JP6060447B2 (ja) * 2011-04-08 2017-01-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 非特異的活性が低下したＳｓｏ７ポリメラーゼコンジュゲート
US8470573B2 (en) * 2011-06-21 2013-06-25 Bio-Rad Laboratories, Inc. Hybrid polymerases having the ability to produce long amplicons
CN103045554B (zh) * 2012-11-29 2014-10-29 成都福际生物技术有限公司 一种制备热启动Taq酶的方法
EP2971134B1 (en) * 2013-03-15 2023-10-25 Aegea Biotechnologies, Inc. Methods for amplifying fragmented target nucleic acids utilizing an assembler sequence
EP2986719B1 (en) 2013-12-06 2020-07-29 Bio-Rad Laboratories, Inc. Fusion polymerases
US9963687B2 (en) 2014-08-27 2018-05-08 New England Biolabs, Inc. Fusion polymerase and method for using the same
JP6594955B2 (ja) * 2014-08-27 2019-10-23 ニユー・イングランド・バイオレイブス・インコーポレイテツド シントン形成
US10273530B2 (en) 2016-01-15 2019-04-30 Thermo Fisher Scientific Baltics Uab Antibodies that bind thermophilic DNA polymerases
US10626383B2 (en) 2016-01-15 2020-04-21 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
KR102380264B1 (ko) * 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
CN112375807B (zh) * 2017-12-30 2023-02-21 浙江安诺优达生物科技有限公司 一种随机打断dna的方法
WO2020264067A1 (en) 2019-06-25 2020-12-30 Bio-Rad Laboratories, Inc Compositions and methods for enhancing reverse transcriptase activity and/or reducing the inhibition of reverse transcriptase
WO2021141970A1 (en) * 2020-01-06 2021-07-15 Pairwise Plants Services, Inc. Recruitment of dna polymerase for templated editing
JP2021153393A (ja) * 2020-03-25 2021-10-07 東洋紡株式会社 核酸増幅反応用組成物
KR20240141247A (ko) * 2022-01-26 2024-09-26 주식회사 씨젠 샘플 내 타겟 핵산을 검출하는 방법
WO2025116499A1 (en) * 2023-11-27 2025-06-05 Seegene, Inc. Method for analyzing activity of nucleic acid polymerase using self-dimer primer

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4545985A (en) 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5679543A (en) 1985-08-29 1997-10-21 Genencor International, Inc. DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US6025545A (en) 1990-01-22 2000-02-15 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5489523A (en) 1990-12-03 1996-02-06 Stratagene Exonuclease-deficient thermostable Pyrococcus furiosus DNA polymerase I
DE69230545T2 (de) * 1991-08-21 2000-07-06 Novartis Ag, Basel Antikörperderivate
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
DE69531487T2 (de) * 1994-01-31 2004-06-17 The Regents Of The University Of California, Oakland Methode zur eliminierung von sequenzierartefakten
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US6015668A (en) 1994-09-30 2000-01-18 Life Technologies, Inc. Cloned DNA polymerases from thermotoga and mutants thereof
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
EP0871775A4 (en) 1995-09-08 2002-07-31 Life Technologies Inc CLONED DNA POLYMERASES FROM THERMOTOGA AND MUTANTS THEREOF
EP1033411B1 (en) * 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
JP3206894B2 (ja) * 1996-07-25 2001-09-10 理化学研究所 酵素を熱活性化する方法
US6458556B1 (en) * 1996-07-25 2002-10-01 The Institute Of Physical & Chemical Research Method for enhancing enzyme activity at elevated temperature
US6972323B1 (en) * 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
US5882904A (en) 1997-08-04 1999-03-16 Amersham Pharmacia Biotech Inc. Thermococcus barossii DNA polymerase mutants
CA2326725A1 (en) * 1998-04-23 1999-10-28 Takara Shuzo Co., Ltd. Method for synthesizing dna
EP1111044A4 (en) * 1998-09-08 2003-06-04 Takara Shuzo Co METHOD OF DNA SYNTHESIS
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
JP3589912B2 (ja) * 1999-09-03 2004-11-17 泰久 福井 ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体
IT1307309B1 (it) * 1999-12-30 2001-10-30 Enea Ente Nuove Tec Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
CN1423700A (zh) * 2000-03-24 2003-06-11 麦克美特股份公司 含有针对nkg2d受体复合物的表位的结合位点的多功能多肽
US6627424B1 (en) 2000-05-26 2003-09-30 Mj Bioworks, Inc. Nucleic acid modifying enzymes
US7408041B2 (en) * 2000-12-08 2008-08-05 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US20040131607A1 (en) * 2001-06-08 2004-07-08 Carroll Michael C. Methods and compositions for inhibiting immunoglobulin-mediated reperfusion injury
EP1275735A1 (en) 2001-07-11 2003-01-15 Roche Diagnostics GmbH Composition and method for hot start nucleic acid amplification
US7365167B2 (en) * 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
AU2002351193A1 (en) 2001-11-28 2003-06-10 Mj Bioworks Incorporated Parallel polymorphism scoring by amplification and error correction
JP4689163B2 (ja) 2001-11-28 2011-05-25 バイオ−ラッド ラボラトリーズ インコーポレーティッド 改良型ポリメラーゼの使用方法
US7560260B2 (en) * 2002-07-25 2009-07-14 Bio-Rad Laboratories, Inc. Compositions with polymerase activity
JP4575160B2 (ja) * 2002-07-25 2010-11-04 バイオ−ラッド ラボラトリーズ インコーポレーティッド ハイブリッドタンパク質方法および組成物
US7666645B2 (en) 2002-10-23 2010-02-23 Bio-Rad Laboratories, Inc. Sso7-polymerase conjugate proteins
US8283148B2 (en) 2002-10-25 2012-10-09 Agilent Technologies, Inc. DNA polymerase compositions for quantitative PCR and methods thereof
CA2503038A1 (en) * 2002-10-25 2004-05-06 Stratagene California Dna polymerases with reduced base analog detection activity
JP4722035B2 (ja) * 2003-03-25 2011-07-13 アジレント・テクノロジーズ・インク Ｄｎａポリメラーゼ融合物およびその使用
US20040214194A1 (en) 2003-04-17 2004-10-28 Mj Bioworks, Inc. Methods of making hybrid proteins
US20050025763A1 (en) * 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
CA2560945C (en) 2004-04-01 2013-06-18 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity
US20060005174A1 (en) 2004-07-01 2006-01-05 International Business Machines Corporation Defining hierarchical structures with markup languages and reflection
US20060172324A1 (en) * 2005-01-28 2006-08-03 Roche Molecular Systems, Inc. Methods of genotyping using differences in melting temperature
JP5241493B2 (ja) 2005-07-15 2013-07-17 アジレント・テクノロジーズ・インク Ｄｎａ結合タンパク質−ポリメラーゼのキメラ
AU2006291990B2 (en) * 2005-09-13 2012-05-31 National Research Council Of Canada Methods and compositions for modulating tumor cell activity
JP2009521496A (ja) * 2005-12-23 2009-06-04 イーライ リリー アンド カンパニー ＴＧＦ−β結合組成物
JP5386367B2 (ja) * 2006-12-29 2014-01-15 アジレント・テクノロジーズ・インク 分断ポリメラーゼを使用する組成物および方法
AR065271A1 (es) * 2007-02-09 2009-05-27 Genentech Inc Anticuerpos anti-robo4 y sus usos
WO2009140497A1 (en) 2008-05-16 2009-11-19 New England Biolabs, Inc. Enzyme reagents for amplification of polynucleotides in the presence of inhibitors
EP2382321A4 (en) * 2009-01-08 2012-12-19 Bio Rad Laboratories METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF NUCLEIC ACID AMPLIFICATION REACTIONS

Similar Documents

Publication Publication Date Title
JP2012514473A5 (https=)
AU2018392709B2 (en) CRISPR effector system based multiplex diagnostics
KR102628577B1 (ko) Crispr 이펙터 시스템 기반 진단법
AU2017371324B2 (en) CRISPR effector system based diagnostics
CN112020562A (zh) 基于crispr效应系统的诊断
KR20190140918A (ko) 바이러스 검출을 위한 crispr 이펙터 시스템 기반 진단
CA2938731A1 (en) Methods of treating alzheimer's disease
RU2018144299A (ru) Способ амплификации кольцевой днк
WO2009135093A3 (en) Rnase-h-based assays utilizing modified rna monomers
WO2008034110A3 (en) Use of taq polymerase mutant enzymes for dna amplification in the presence of pcr inhibitors
JP2016537005A5 (https=)
RU2016116333A (ru) Определение нуклеиновых кислот путем амплификации, основанной на встраивании в цепь
RU2015150098A (ru) Способ амплификации днк на основе внедрения в цепь
JP6876785B2 (ja) 単分子配列決定のための一本鎖環状ｄｎａライブラリーを生成するための方法
RU2016145448A (ru) Способ амплификации днк на основе внедрения в цепь
EP2817420A1 (en) Multimodal pcr target detection
CN102676637A (zh) 一种高专一性的测定小rna的方法
CA2917924A1 (en) Compositions and methods for multimodal analysis of cmet nucleic acids
WO2011104695A3 (en) Detection of kras mutation in exon 2 by allele specific real time quantitative pcr (as-qpcr)
US20160060710A1 (en) Compas-pcr method and methods for detecting, identifying or monitoring salmonid species
JP2022093239A (ja) Ｄｎａポリメラーゼの５’→３’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
EP4627107A1 (en) Gap-fill ligation and primer extension reactions employing exonuclease-resistant or capture moiety means
RU2011141514A (ru) Олигонуклеотиды и способ определения днк бактерий, относящихся к семейству chlamydiaceae
CA3102642A1 (en) Cleavable co-operative primers and method of amplifying nucleic acid sequences using same
WO2019068205A1 (en) METHOD, KITS, AND COMPOSITIONS FOR AMPLIFYING NUCLEIC ACID SEQUENCES USING NICKASE-EMBEDDED MONOBRIN ROLLER-ASSISTED STRAND DISPLACEMENT AMPLIFICATION