SG10201500705YA - Methods and compositions for improving efficiency of nucleic acids amplification reactions - Google Patents
Methods and compositions for improving efficiency of nucleic acids amplification reactionsInfo
- Publication number
- SG10201500705YA SG10201500705YA SG10201500705YA SG10201500705YA SG10201500705YA SG 10201500705Y A SG10201500705Y A SG 10201500705YA SG 10201500705Y A SG10201500705Y A SG 10201500705YA SG 10201500705Y A SG10201500705Y A SG 10201500705YA SG 10201500705Y A SG10201500705Y A SG 10201500705YA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- nucleic acids
- amplification reactions
- improving efficiency
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14335009P | 2009-01-08 | 2009-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201500705YA true SG10201500705YA (en) | 2015-04-29 |
Family
ID=42316809
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201500705YA SG10201500705YA (en) | 2009-01-08 | 2010-01-07 | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
| SG2011050093A SG172925A1 (en) | 2009-01-08 | 2010-01-07 | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2011050093A SG172925A1 (en) | 2009-01-08 | 2010-01-07 | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8859205B2 (en) |
| EP (2) | EP2382321A4 (en) |
| JP (1) | JP5818688B2 (en) |
| CN (1) | CN102272319B (en) |
| CA (1) | CA2749093C (en) |
| SG (2) | SG10201500705YA (en) |
| WO (1) | WO2010080910A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| WO2010080910A1 (en) * | 2009-01-08 | 2010-07-15 | Bio-Rad Laboratories, Inc. | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
| US8916352B2 (en) | 2011-04-08 | 2014-12-23 | Bio-Rad Laboratories, Inc. | PCR reaction mixtures with decreased non-specific activity |
| CN103562410B (en) * | 2011-04-08 | 2016-09-28 | 伯乐实验室公司 | There is the SSO7-polymerase conjugate of the nonspecific activity of reduction |
| US8470573B2 (en) * | 2011-06-21 | 2013-06-25 | Bio-Rad Laboratories, Inc. | Hybrid polymerases having the ability to produce long amplicons |
| CN103045554B (en) * | 2012-11-29 | 2014-10-29 | 成都福际生物技术有限公司 | Method for preparing hot start Taq polymerase |
| WO2014145176A1 (en) * | 2013-03-15 | 2014-09-18 | Arnold Lyle J | Methods for amplifying fragmented target nucleic acids utilizing an assembler sequence |
| US9840697B2 (en) | 2013-12-06 | 2017-12-12 | Bio-Rad Laboratories, Inc. | Fusion polymerases |
| CN113584015A (en) | 2014-08-27 | 2021-11-02 | 新英格兰生物实验室公司 | Formation of synthons |
| US9963687B2 (en) | 2014-08-27 | 2018-05-08 | New England Biolabs, Inc. | Fusion polymerase and method for using the same |
| WO2017121836A1 (en) | 2016-01-15 | 2017-07-20 | Thermo Fisher Scientific Baltics Uab | Thermophilic dna polymerase mutants |
| WO2017121843A1 (en) * | 2016-01-15 | 2017-07-20 | Thermo Fisher Scientific Baltics Uab | Antibodies that bind thermophilic dna polymerases |
| US11618891B2 (en) | 2017-06-26 | 2023-04-04 | Thermo Fisher Scientific Baltics Uab | Thermophilic DNA polymerase mutants |
| US11591645B2 (en) | 2017-08-31 | 2023-02-28 | Seegene, Inc. | Evaluation of performance of components using a pair of dimer-forming primers |
| CN109988817B (en) * | 2017-12-30 | 2020-12-04 | 安诺优达基因科技(北京)有限公司 | Method for randomly breaking DNA |
| WO2020264067A1 (en) | 2019-06-25 | 2020-12-30 | Bio-Rad Laboratories, Inc | Compositions and methods for enhancing reverse transcriptase activity and/or reducing the inhibition of reverse transcriptase |
| AU2021206639A1 (en) * | 2020-01-06 | 2022-07-14 | Pairwise Plants Services, Inc. | Recruitment of DNA polymerase for templated editing |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (en) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE |
| US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5679543A (en) | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US6025545A (en) * | 1990-01-22 | 2000-02-15 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5489523A (en) | 1990-12-03 | 1996-02-06 | Stratagene | Exonuclease-deficient thermostable Pyrococcus furiosus DNA polymerase I |
| DE69230545T2 (en) * | 1991-08-21 | 2000-07-06 | Novartis Ag | Antibody derivatives |
| US5436149A (en) | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
| US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| JP3616394B2 (en) * | 1994-01-31 | 2005-02-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Method for removal of DNA sequencing artifacts |
| US5512462A (en) | 1994-02-25 | 1996-04-30 | Hoffmann-La Roche Inc. | Methods and reagents for the polymerase chain reaction amplification of long DNA sequences |
| US6015668A (en) | 1994-09-30 | 2000-01-18 | Life Technologies, Inc. | Cloned DNA polymerases from thermotoga and mutants thereof |
| US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| JP2000502882A (en) | 1995-09-08 | 2000-03-14 | ライフ・テクノロジーズ・インコーポレイテッド | Cloned DNA polymerases from Thermotoga and variants thereof |
| CA2591550C (en) * | 1996-06-04 | 2009-04-28 | University Of Utah Research Foundation | Monitoring hybridization during pcr |
| JP3206894B2 (en) * | 1996-07-25 | 2001-09-10 | 理化学研究所 | How to heat activate enzymes |
| US6458556B1 (en) * | 1996-07-25 | 2002-10-01 | The Institute Of Physical & Chemical Research | Method for enhancing enzyme activity at elevated temperature |
| US6972323B1 (en) * | 1997-04-01 | 2005-12-06 | Sankyo Company, Limited | Anti-Fas antibodies |
| US5882904A (en) | 1997-08-04 | 1999-03-16 | Amersham Pharmacia Biotech Inc. | Thermococcus barossii DNA polymerase mutants |
| US7521178B1 (en) * | 1998-04-23 | 2009-04-21 | Takara Bio Inc. | Method for synthesizing DNA |
| CA2342393A1 (en) * | 1998-09-08 | 2000-03-16 | Takara Shuzo Co., Ltd. | A rapid pcr method for synthesizing dna |
| US20040031072A1 (en) * | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| JP3589912B2 (en) * | 1999-09-03 | 2004-11-17 | 泰久 福井 | Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate |
| IT1307309B1 (en) * | 1999-12-30 | 2001-10-30 | Enea Ente Nuove Tec | STABILIZING PEPTIDES, POLYPEPTIDES AND ANTIBODIES THAT INCLUDE THEM. |
| JP2004500108A (en) * | 2000-03-24 | 2004-01-08 | マイクロメット アーゲー | Multifunctional polypeptide containing a binding site to an epitope of the NKG2D receptor complex |
| US6627424B1 (en) | 2000-05-26 | 2003-09-30 | Mj Bioworks, Inc. | Nucleic acid modifying enzymes |
| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US20040131607A1 (en) * | 2001-06-08 | 2004-07-08 | Carroll Michael C. | Methods and compositions for inhibiting immunoglobulin-mediated reperfusion injury |
| EP1275735A1 (en) | 2001-07-11 | 2003-01-15 | Roche Diagnostics GmbH | Composition and method for hot start nucleic acid amplification |
| US7365167B2 (en) * | 2001-11-26 | 2008-04-29 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
| EP1456409B1 (en) | 2001-11-28 | 2010-02-24 | Bio-Rad Laboratories, Inc. | Parallel polymorphism scoring by amplification and error correction |
| ATE406456T1 (en) | 2001-11-28 | 2008-09-15 | Bio Rad Laboratories | METHOD OF USING IMPROVED POLYMERASES |
| US7560260B2 (en) * | 2002-07-25 | 2009-07-14 | Bio-Rad Laboratories, Inc. | Compositions with polymerase activity |
| CA2518588A1 (en) * | 2002-07-25 | 2004-02-05 | Mj Bioworks Incorporated | Hybrid dna polymerase proteins having increased polymerase to exonuclease activity |
| US7666645B2 (en) | 2002-10-23 | 2010-02-23 | Bio-Rad Laboratories, Inc. | Sso7-polymerase conjugate proteins |
| US8283148B2 (en) | 2002-10-25 | 2012-10-09 | Agilent Technologies, Inc. | DNA polymerase compositions for quantitative PCR and methods thereof |
| JP2006507012A (en) * | 2002-10-25 | 2006-03-02 | ストラタジーン カリフォルニア | DNA polymerase with reduced base analog detection activity |
| ATE459710T1 (en) | 2003-03-25 | 2010-03-15 | Stratagene California | DNA POLYMERASE FUSIONS AND USES THEREOF |
| US20040214194A1 (en) | 2003-04-17 | 2004-10-28 | Mj Bioworks, Inc. | Methods of making hybrid proteins |
| US20050025763A1 (en) * | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| JP4972541B2 (en) | 2004-04-01 | 2012-07-11 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | Quantitative amplification method using labeled probe and 3 '→ 5' exonuclease activity |
| US20060005174A1 (en) | 2004-07-01 | 2006-01-05 | International Business Machines Corporation | Defining hierarchical structures with markup languages and reflection |
| US20060172324A1 (en) | 2005-01-28 | 2006-08-03 | Roche Molecular Systems, Inc. | Methods of genotyping using differences in melting temperature |
| CA2615151A1 (en) | 2005-07-15 | 2007-01-25 | Stratagene California | Dna binding protein-polymerase chimeras |
| DK1937815T3 (en) * | 2005-09-13 | 2015-08-03 | Nat Res Council Canada | Methods and compositions for the modulation of tumor cell activity |
| ES2379194T3 (en) * | 2005-12-23 | 2012-04-23 | Eli Lilly And Company | TGF-beta binding antibodies |
| EP2097523B1 (en) * | 2006-12-29 | 2014-10-29 | Agilent Technologies, Inc. | Compositions and methods using split polymerases |
| AU2008216495A1 (en) * | 2007-02-09 | 2008-08-21 | Genentech, Inc. | Anti-Robo4 antibodies and uses therefor |
| EP2297343A1 (en) | 2008-05-16 | 2011-03-23 | New England Biolabs, Inc. | Enzyme reagents for amplification of polynucleotides in the presence of inhibitors |
| WO2010080910A1 (en) * | 2009-01-08 | 2010-07-15 | Bio-Rad Laboratories, Inc. | Methods and compositions for improving efficiency of nucleic acids amplification reactions |
-
2010
- 2010-01-07 WO PCT/US2010/020371 patent/WO2010080910A1/en active Application Filing
- 2010-01-07 SG SG10201500705YA patent/SG10201500705YA/en unknown
- 2010-01-07 US US12/683,950 patent/US8859205B2/en active Active
- 2010-01-07 JP JP2011545427A patent/JP5818688B2/en active Active
- 2010-01-07 EP EP10729512A patent/EP2382321A4/en not_active Withdrawn
- 2010-01-07 EP EP15155113.2A patent/EP2894226B1/en active Active
- 2010-01-07 CN CN201080004057.9A patent/CN102272319B/en active Active
- 2010-01-07 CA CA2749093A patent/CA2749093C/en active Active
- 2010-01-07 SG SG2011050093A patent/SG172925A1/en unknown
-
2014
- 2014-09-10 US US14/482,756 patent/US9994887B2/en active Active
-
2018
- 2018-05-11 US US15/977,254 patent/US10787694B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2382321A4 (en) | 2012-12-19 |
| SG172925A1 (en) | 2011-08-29 |
| EP2894226A1 (en) | 2015-07-15 |
| US20110104760A1 (en) | 2011-05-05 |
| CN102272319A (en) | 2011-12-07 |
| WO2010080910A1 (en) | 2010-07-15 |
| JP5818688B2 (en) | 2015-11-18 |
| US20180258455A1 (en) | 2018-09-13 |
| CN102272319B (en) | 2014-08-27 |
| US10787694B2 (en) | 2020-09-29 |
| CA2749093C (en) | 2019-03-26 |
| EP2894226B1 (en) | 2021-04-14 |
| JP2012514473A (en) | 2012-06-28 |
| US8859205B2 (en) | 2014-10-14 |
| EP2382321A1 (en) | 2011-11-02 |
| US20140377767A1 (en) | 2014-12-25 |
| US9994887B2 (en) | 2018-06-12 |
| CA2749093A1 (en) | 2010-07-15 |
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